X C Jiang

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 103:907-14. 1999
  2. ncbi request reprint Plasma sphingomyelin level as a risk factor for coronary artery disease
    X C Jiang
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 20:2614-8. 2000
  3. ncbi request reprint Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York 10032, USA
    J Biol Chem 273:15714-8. 1998
  4. ncbi request reprint Receptors and lipid transfer proteins in HDL metabolism
    D L Silver
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 902:103-11; discussion 111-2. 2000
  5. ncbi request reprint Cholesteryl ester transfer protein and phospholipid transfer protein have nonoverlapping functions in vivo
    K Kawano
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:29477-81. 2000
  6. ncbi request reprint Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    Nat Med 7:847-52. 2001
  7. ncbi request reprint Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet
    X C Jiang
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 270:17133-8. 1995
  8. ncbi request reprint ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice
    W Weng
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Lipid Res 40:1064-70. 1999
  9. pmc Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels
    L Masucci-Magoulas
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    J Clin Invest 97:154-61. 1996
  10. ncbi request reprint Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    D L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:4140-6. 1999

Detail Information

Publications14

  1. pmc Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 103:907-14. 1999
    ..Vesicular lipoproteins accumulating in PLTP-/- mice on a high-fat diet could influence the development of atherosclerosis...
  2. ncbi request reprint Plasma sphingomyelin level as a risk factor for coronary artery disease
    X C Jiang
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 20:2614-8. 2000
    ..Plasma SM levels could be a marker for atherogenic remnant lipoprotein accumulation and may predict lipoprotein susceptibility to arterial wall sphingomyelinase...
  3. ncbi request reprint Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York 10032, USA
    J Biol Chem 273:15714-8. 1998
    ..These observations suggest that a hypoxic stimulus occurring in emphysema may be a novel mechanism that contributes to enhanced expression of PLTP...
  4. ncbi request reprint Receptors and lipid transfer proteins in HDL metabolism
    D L Silver
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 902:103-11; discussion 111-2. 2000
    ..Lastly, we highlight our findings that overexpression of SR-BI in LDL receptor-deficient mice results in decreased atherosclerosis...
  5. ncbi request reprint Cholesteryl ester transfer protein and phospholipid transfer protein have nonoverlapping functions in vivo
    K Kawano
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:29477-81. 2000
    ....
  6. ncbi request reprint Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency
    X C Jiang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    Nat Med 7:847-52. 2001
    ..The studies reveal a major, unexpected role of PLTP in regulating the secretion of BLp and identify PLTP as a therapeutic target...
  7. ncbi request reprint Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet
    X C Jiang
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 270:17133-8. 1995
    ....
  8. ncbi request reprint ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice
    W Weng
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Lipid Res 40:1064-70. 1999
    ..In summary, these results strongly suggest that apoA-II is a physiological inhibitor of hepatic lipase and that this is at least part of the mechanism whereby apoA-II maintains HDL cholesterol levels...
  9. pmc Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels
    L Masucci-Magoulas
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    J Clin Invest 97:154-61. 1996
    ..Hepatic sterol-sensitive genes have mechanisms to sense hypercholesterolemia that do not require classical receptor-mediated lipoprotein uptake...
  10. ncbi request reprint Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    D L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:4140-6. 1999
    ..The studies reveal a specific HDL particle catabolic pathway that is down-regulated in ob/ob mice and suggest that HDL apolipoprotein turnover may be regulated by obesity and/or leptin signaling...
  11. pmc IFN-gamma potentiates atherosclerosis in ApoE knock-out mice
    S Gupta
    Department of Medicine, Columbia University, New York 10032, USA
    J Clin Invest 99:2752-61. 1997
    ..Therefore, therapeutic inhibition of IFN-gamma signaling may lead to the formation of more lipid-poor and stable atheromata...
  12. ncbi request reprint Mammalian adipose tissue and muscle are major sources of lipid transfer protein mRNA
    X C Jiang
    Department of Medicine, Columbia University, New York, New York 10032
    J Biol Chem 266:4631-9. 1991
    ....
  13. ncbi request reprint Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate
    M Bouly
    Department of Atherosclerosis-INSERM U545, Institut Pasteur de Lille, rue du Professeur Calmette, 59019 Lille Cedex, France
    J Biol Chem 276:25841-7. 2001
    ....
  14. pmc A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins
    K Takahashi
    Second Department of Internal Medicine, Chiba University, Japan
    J Clin Invest 92:2060-4. 1993
    ....