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Species | Thomas JessellSummaryAffiliation: Columbia University Country: USA Publications
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Motor neurons and the sense of placeThomas M Jessell
Howard Hughes Medical Institute, Kavli Institute for Brain Science, Depts of Neuroscience, and Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
Neuron 72:419-24. 2011..Romanes's findings reveal how and why neuronal positioning contributes to sensory-motor connectivity and may have relevance to circuit organization in other regions of the central nervous system...
Motor neurons with axial muscle projections specified by Wnt4/5 signalingDritan Agalliu
Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Neuron 61:708-20. 2009..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...- Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusS Srinivas
Department of Genetics and Development, Columbia University, New York, USA
BMC Dev Biol 1:4. 2001.... 
Development. The decade of the developing brainT M Jessell
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, NY, New York 10032, USA
Curr Opin Neurobiol 10:599-611. 2000....- Neuronal specification in the spinal cord: inductive signals and transcriptional codesT M Jessell
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Nat Rev Genet 1:20-9. 2000..The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules... - The specification of dorsal cell fates in the vertebrate central nervous systemK J Lee
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Annu Rev Neurosci 22:261-94. 1999..Additional signals involving members of the Wnt and fibroblast growth factor (FGF) families may also contribute to the proliferation and differentiation of dorsal neuronal cell types... - Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signallingJ Briscoe
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Nature 398:622-7. 1999..Thus, Nkx2.2 has an essential role in interpreting graded Shh signals and selecting neuronal identity... - Genetic ablation reveals that the roof plate is essential for dorsal interneuron specificationK J Lee
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Centre for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Nature 403:734-40. 2000..These results reveal that the roof plate is essential for specifying multiple classes of neurons in the mammalian central nervous system... - A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cordA Pierani
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Cell 97:903-15. 1999..Retinoids appear to mediate this parallel pathway. These findings reveal an unanticipated Shh-independent signaling pathway that controls progenitor cell identity and interneuron diversity in the ventral spinal cord... - Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2B G Novitch
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Neuron 31:773-89. 2001..Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord... - Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signalingJ Ericson
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Cell 90:169-80. 1997..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain... - Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor PintallavisA Ruiz i Altaba
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
Proc Natl Acad Sci U S A 90:8268-72. 1993..The expression of Pintallavis in midline cells may therefore contribute to the establishment of the floor plate fate... - Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryosA Ruiz i Altaba
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Mol Cell Neurosci 6:106-21. 1995..The ability of winged-helix and vertebrate hedgehog genes to induce floor plate differentiation in vivo may, therefore, be constrained by additional signals that specify the time and position of floor plate differentiation... - Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neuronsM A Hynes
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032
J Neurosci 10:1004-13. 1990..5 on the same neurons, are consistent with the idea that carbohydrate-mediated interactions contribute to the development of this subset of mammalian neurons... - The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activityA J Furley
Department of Biochemistry and Molecular Biophysics, New York, New York
Cell 61:157-70. 1990.... - A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tubeJ Briscoe
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Cell 101:435-45. 2000..The combinatorial expression of three of these proteins--Nkx6.1, Nkx2.2, and Irx3--specifies the identity of three classes of neurons generated in the ventral third of the neural tube... - Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoidsJ P Liu
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Neuron 32:997-1012. 2001.... - Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1A Pierani
Howard Hughes Medical Institute, Department of Biochemistry and, Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Neuron 29:367-84. 2001..Thus, a single progenitor homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord... - Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limbA Kania
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Cell 102:161-73. 2000..Thus, LIM homeodomain proteins act within motor neurons and cells that guide motor axons to establish the fidelity of a binary choice in axonal trajectory... - Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identityS Arber
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Neuron 23:659-74. 1999..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs... - Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genesT Tsuchida
Howard Hughes Medical Institute Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
Cell 79:957-70. 1994.... - Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiationS L Pfaff
Howard Hughes Medical Institute, Department of Biochemistry and Molecule Biophysics, Columbia University, New York, New York 10032, USA
Cell 84:309-20. 1996..These results show that ISL1 is required for the generation of motor neurons and suggest that motor neuron generation is required for the subsequent differentiation of certain interneurons... - Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryoA Streit
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Development 125:507-19. 1998..These results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue... - Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neuronsS Sockanathan
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Cell 94:503-14. 1998..Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons... - Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cordK J Lee
Howard Hughes Medical Institute HHMI, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032 USA
Genes Dev 12:3394-407. 1998..More generally, these results suggest that BMP signaling may have a prominent role in the assignment of neuronal identity within the mammalian CNS... - Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expressionJ H Lin
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
Cell 95:393-407. 1998..ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord... - F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extensionA Klar
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
Cell 69:95-110. 1992..Recombinant F-spondin promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. F-spondin may contribute to the growth and guidance of axons in both the spinal cord and the PNS... - Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neuronsJ Dodd
Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032
Neuron 1:105-16. 1988..These observations provide evidence that axonal guidance and pathway selection in vertebrates may be regulated in part by the transient and selective expression of distinct surface glycoproteins on subsets of developing neurons... - A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversificationIna Kramer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Neuron 49:379-93. 2006..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification... - Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic painChih Li Chen
Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Neuron 49:365-77. 2006..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy... - Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivoYoh suke Mukouyama
Howard Hughes Medical Institute and Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 103:1551-6. 2006..These results do not support the commonly held view that most neuroepithelial cells in the embryonic CNS VZ are stem cells in vivo... - A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivityJeremy S Dasen
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, NY 10032, USA
Cell 123:477-91. 2005..This Hox regulatory network directs the downstream transcriptional identity of motor neuron pools and defines the pattern of target-muscle connectivity... - A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axonsIvo Lieberam
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
Neuron 47:667-79. 2005..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons... - Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cordAlbert I Chen
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, New York 10032, USA
Neuron 49:395-408. 2006..Our findings suggest that the selectivity of Runx3 expression, and its level of activity, control sensory afferent targeting in the developing spinal cord... - An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identityUlrika Nordström
1Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
PLoS Biol 4:e252. 2006.... - PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cordYutaka Yoshida
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Neuron 52:775-88. 2006..Our findings reveal a dedicated program of axonal shaft positioning in the mammalian CNS and establish a role for plexinA1-mediated axonal exclusion in organizing the projection pattern of spinal sensory afferents... - Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neuronsMakiko Nagai
Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
Nat Neurosci 10:615-22. 2007..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint... - Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain developmentSophie Chauvet
Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
Neuron 56:807-22. 2007..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits... - Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activityNatalia V De Marco Garcia
Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Neuron 57:217-31. 2008..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity... - Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1Jeremy S Dasen
Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
Cell 134:304-16. 2008..Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map... - Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cordSteven A Crone
Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA
Neuron 60:70-83. 2008..Our findings imply that the neural substrate for left-right coordination consists of at least two components; commissural neurons and a class of ipsilateral interneurons that activate commissural pathways... - Distinct roles for secreted semaphorin signaling in spinal motor axon guidanceAndrea B Huber
Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 48:949-64. 2005..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections... - Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain proteinJennifer M Wilson
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
J Neurosci 25:5710-9. 2005.... - Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilinsChenghua Gu
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
Science 307:265-8. 2005..These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning... - Functional properties of motoneurons derived from mouse embryonic stem cellsGareth B Miles
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
J Neurosci 24:7848-58. 2004..In summary, our findings demonstrate that MNs derived from ES cells develop appropriate transmitter receptors, intrinsic properties necessary for appropriate patterns of action potential firing and functional synapses with muscle fibers... - Regulation of motor neuron pool sorting by differential expression of type II cadherinsStephen R Price
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Cell 109:205-16. 2002..Type II cadherins are also expressed by proprioceptive sensory neurons, raising the possibility that cadherins regulate additional steps in the development of sensory-motor circuits... - The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cordThomas Muller
Department of Medical Genetics, Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
Neuron 34:551-62. 2002..We conclude that Lbx1 distinguishes two major neuronal classes in the dorsal spinal cord and is an important determinant of their distinct differentiation programs... - Directed differentiation of embryonic stem cells into motor neuronsHynek Wichterle
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Cell 110:385-97. 2002..Thus, inductive signals involved in normal pathways of neurogenesis can direct ES cells to form specific classes of CNS neurons... - ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron poolsJean Livet
INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, Marseille, France
Neuron 35:877-92. 2002..Thus, the induction of an intrinsic program of ETS gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons... - A role for neuregulin1 signaling in muscle spindle differentiationSimon Hippenmeyer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
Neuron 36:1035-49. 2002.... - Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteinsChristopher M William
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168 Street, New York, NY 10032, USA
Development 130:1523-36. 2003..Finally, MNR2 appears to regulate motor neuron identity by acting as a transcriptional repressor, providing further evidence for the key role of transcriptional repression in motor neuron specification... - Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferentsTushar D Patel
Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
Neuron 38:403-16. 2003..Finally, addition of NT3 to DRG explant cultures resulted in induction of ER81 protein. Our data indicate that NT3 mediates the formation of proprioceptive afferent-motor neuron connections via regulation of ER81... - Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactionsArtur Kania
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Neuron 38:581-96. 2003..These topographic projections are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells... - Specification of dorsal telencephalic character by sequential Wnt and FGF signalingLena Gunhaga
, Building 6M, 4th Floor, , S-901 87 Ume, Sweden
Nat Neurosci 6:701-7. 2003..Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character... - A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specificationBennett G Novitch
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Neuron 40:81-95. 2003..Moreover, joint exposure of neural progenitors to retinoids and FGFs suffices to induce motor neuron differentiation in a Shh-independent manner... - Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection patternShanthini Sockanathan
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Neuron 40:97-111. 2003..These findings provide evidence for a regionally restricted role for retinoid signaling in the postmitotic specification of motor neuron columnar identity... - Motor neuron columnar fate imposed by sequential phases of Hox-c activityJeremy S Dasen
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, New York 10032, USA
Nature 425:926-33. 2003..Hox proteins also direct the expression of genes that establish motor topographic projections, thus implicating Hox proteins as critical determinants of spinal motor neuron identity and organization... - A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identityJoshua P Thaler
Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Neuron 41:337-50. 2004..Thus, an early phase of high Isl expression and activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord... - Retinoic acid signalling specifies intermediate character in the developing telencephalonMatthew Marklund
, Building 6M, 4th Floor, , S-901 87 Ume, Sweden
Development 131:4323-32. 2004..We provide evidence here that retinoic acid has a crucial role in specifying telencephalic progenitor cells of intermediate character... - Progressive induction of caudal neural character by graded Wnt signalingUlrika Nordström
Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
Nat Neurosci 5:525-32. 2002.... - Type II cadherin ectodomain structures: implications for classical cadherin specificitySaurabh D Patel
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Cell 124:1255-68. 2006.... - Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movementsGuillermo M Lanuza
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuron 42:375-86. 2004..Together, these findings identify Dbx1-dependent interneurons as key components of the spinal locomotor circuits that control stepping movements in mammals...
Research Grants
- CONTROL OF MOTOR NEURON DIFFERENTIATIONThomas Jessell; Fiscal Year: 2004..In addition, the study of the molecular basis of motor axon outgrowth may aid the development of more effective therapies for recovery of motor function after traumatic injury to the spinal cord. ..
- CONTROL OF MOTOR NEURON DIFFERENTIATIONThomas Jessell; Fiscal Year: 2000..In the long term, these studies will be important in defining and interpreting the underlying causes of a wide variety of neurological disorders that result in the degeneration and death of motor neurons. ..
- CONTROL OF MOTOR NEURON DIFFERENTIATIONThomas Jessell; Fiscal Year: 2009..Together, these studies should help to define the link between mechanisms of early neuronal specification and the formation of selective connections in a classical vertebrate motor circuit. ..