Thomas Jessell

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord
    Soha Ashrafi
    Neuroscience Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Neuron 81:120-9. 2014
  2. pmc Clarke's column neurons as the focus of a corticospinal corollary circuit
    Adam W Hantman
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA
    Nat Neurosci 13:1233-9. 2010
  3. doi request reprint Motor neurons and the sense of place
    Thomas M Jessell
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Depts of Neuroscience, and Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Neuron 72:419-24. 2011
  4. pmc Motor neurons with axial muscle projections specified by Wnt4/5 signaling
    Dritan Agalliu
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 61:708-20. 2009
  5. pmc Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
  6. ncbi request reprint Development. The decade of the developing brain
    T M Jessell
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, NY, New York 10032, USA
    Curr Opin Neurobiol 10:599-611. 2000
  7. ncbi request reprint Neuronal specification in the spinal cord: inductive signals and transcriptional codes
    T M Jessell
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Rev Genet 1:20-9. 2000
  8. ncbi request reprint The specification of dorsal cell fates in the vertebrate central nervous system
    K J Lee
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Annu Rev Neurosci 22:261-94. 1999
  9. ncbi request reprint Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 398:622-7. 1999
  10. ncbi request reprint Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    B G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 31:773-89. 2001

Research Grants

  1. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2007
  2. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2006
  3. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2005
  4. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2003
  5. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2002
  6. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2001
  7. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2000
  8. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 1999
  9. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2009
  10. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2004

Collaborators

Detail Information

Publications64

  1. pmc Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord
    Soha Ashrafi
    Neuroscience Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Neuron 81:120-9. 2014
    ..Our findings define a recognition complex that contributes to the assembly and organization of a specialized GABAergic microcircuit. ..
  2. pmc Clarke's column neurons as the focus of a corticospinal corollary circuit
    Adam W Hantman
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA
    Nat Neurosci 13:1233-9. 2010
    ..Together, our genetic, anatomical and physiological results indicate that Clarke's column spinocerebellar neurons nucleate local spinal corollary circuits that are relevant to motor planning and evaluation...
  3. doi request reprint Motor neurons and the sense of place
    Thomas M Jessell
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Depts of Neuroscience, and Biochemistry and Molecular Biophysics, Columbia University, NY 10032, USA
    Neuron 72:419-24. 2011
    ..Romanes's findings reveal how and why neuronal positioning contributes to sensory-motor connectivity and may have relevance to circuit organization in other regions of the central nervous system...
  4. pmc Motor neurons with axial muscle projections specified by Wnt4/5 signaling
    Dritan Agalliu
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 61:708-20. 2009
    ..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
  5. pmc Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    S Srinivas
    Department of Genetics and Development, Columbia University, New York, USA
    BMC Dev Biol 1:4. 2001
    ....
  6. ncbi request reprint Development. The decade of the developing brain
    T M Jessell
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, NY, New York 10032, USA
    Curr Opin Neurobiol 10:599-611. 2000
    ....
  7. ncbi request reprint Neuronal specification in the spinal cord: inductive signals and transcriptional codes
    T M Jessell
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Rev Genet 1:20-9. 2000
    ..The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules...
  8. ncbi request reprint The specification of dorsal cell fates in the vertebrate central nervous system
    K J Lee
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Annu Rev Neurosci 22:261-94. 1999
    ..Additional signals involving members of the Wnt and fibroblast growth factor (FGF) families may also contribute to the proliferation and differentiation of dorsal neuronal cell types...
  9. ncbi request reprint Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nature 398:622-7. 1999
    ..Thus, Nkx2.2 has an essential role in interpreting graded Shh signals and selecting neuronal identity...
  10. ncbi request reprint Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    B G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 31:773-89. 2001
    ..Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord...
  11. ncbi request reprint A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 101:435-45. 2000
    ..The combinatorial expression of three of these proteins--Nkx6.1, Nkx2.2, and Irx3--specifies the identity of three classes of neurons generated in the ventral third of the neural tube...
  12. ncbi request reprint Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
    K J Lee
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Centre for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Nature 403:734-40. 2000
    ..These results reveal that the roof plate is essential for specifying multiple classes of neurons in the mammalian central nervous system...
  13. ncbi request reprint A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 97:903-15. 1999
    ..Retinoids appear to mediate this parallel pathway. These findings reveal an unanticipated Shh-independent signaling pathway that controls progenitor cell identity and interneuron diversity in the ventral spinal cord...
  14. ncbi request reprint Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos
    A Ruiz i Altaba
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Mol Cell Neurosci 6:106-21. 1995
    ..The ability of winged-helix and vertebrate hedgehog genes to induce floor plate differentiation in vivo may, therefore, be constrained by additional signals that specify the time and position of floor plate differentiation...
  15. ncbi request reprint The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity
    A J Furley
    Department of Biochemistry and Molecular Biophysics, New York, New York
    Cell 61:157-70. 1990
    ....
  16. ncbi request reprint Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain...
  17. ncbi request reprint Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons
    M A Hynes
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    J Neurosci 10:1004-13. 1990
    ..5 on the same neurons, are consistent with the idea that carbohydrate-mediated interactions contribute to the development of this subset of mammalian neurons...
  18. pmc Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis
    A Ruiz i Altaba
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 90:8268-72. 1993
    ..The expression of Pintallavis in midline cells may therefore contribute to the establishment of the floor plate fate...
  19. ncbi request reprint Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
    J H Lin
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 95:393-407. 1998
    ..ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord...
  20. ncbi request reprint Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons
    J Dodd
    Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Neuron 1:105-16. 1988
    ..These observations provide evidence that axonal guidance and pathway selection in vertebrates may be regulated in part by the transient and selective expression of distinct surface glycoproteins on subsets of developing neurons...
  21. ncbi request reprint Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids
    J P Liu
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 32:997-1012. 2001
    ....
  22. ncbi request reprint Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
    T Tsuchida
    Howard Hughes Medical Institute Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Cell 79:957-70. 1994
    ....
  23. ncbi request reprint Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    S L Pfaff
    Howard Hughes Medical Institute, Department of Biochemistry and Molecule Biophysics, Columbia University, New York, New York 10032, USA
    Cell 84:309-20. 1996
    ..These results show that ISL1 is required for the generation of motor neurons and suggest that motor neuron generation is required for the subsequent differentiation of certain interneurons...
  24. ncbi request reprint Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and, Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 29:367-84. 2001
    ..Thus, a single progenitor homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord...
  25. pmc Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord
    K J Lee
    Howard Hughes Medical Institute HHMI, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032 USA
    Genes Dev 12:3394-407. 1998
    ..More generally, these results suggest that BMP signaling may have a prominent role in the assignment of neuronal identity within the mammalian CNS...
  26. ncbi request reprint Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  27. ncbi request reprint Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons
    S Sockanathan
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 94:503-14. 1998
    ..Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons...
  28. ncbi request reprint Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo
    A Streit
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 125:507-19. 1998
    ..These results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue...
  29. ncbi request reprint Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb
    A Kania
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 102:161-73. 2000
    ..Thus, LIM homeodomain proteins act within motor neurons and cells that guide motor axons to establish the fidelity of a binary choice in axonal trajectory...
  30. ncbi request reprint F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension
    A Klar
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Cell 69:95-110. 1992
    ..Recombinant F-spondin promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. F-spondin may contribute to the growth and guidance of axons in both the spinal cord and the PNS...
  31. ncbi request reprint A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity
    Jeremy S Dasen
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, NY 10032, USA
    Cell 123:477-91. 2005
    ..This Hox regulatory network directs the downstream transcriptional identity of motor neuron pools and defines the pattern of target-muscle connectivity...
  32. pmc Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo
    Yoh suke Mukouyama
    Howard Hughes Medical Institute and Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:1551-6. 2006
    ..These results do not support the commonly held view that most neuroepithelial cells in the embryonic CNS VZ are stem cells in vivo...
  33. ncbi request reprint Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain
    Chih Li Chen
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Neuron 49:365-77. 2006
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
  34. ncbi request reprint A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
    Ina Kramer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Neuron 49:379-93. 2006
    ..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification...
  35. ncbi request reprint Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord
    Albert I Chen
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, New York 10032, USA
    Neuron 49:395-408. 2006
    ..Our findings suggest that the selectivity of Runx3 expression, and its level of activity, control sensory afferent targeting in the developing spinal cord...
  36. pmc An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity
    Ulrika Nordström
    1Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS Biol 4:e252. 2006
    ....
  37. pmc PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord
    Yutaka Yoshida
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 52:775-88. 2006
    ..Our findings reveal a dedicated program of axonal shaft positioning in the mammalian CNS and establish a role for plexinA1-mediated axonal exclusion in organizing the projection pattern of spinal sensory afferents...
  38. pmc Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    Makiko Nagai
    Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:615-22. 2007
    ..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint...
  39. pmc Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development
    Sophie Chauvet
    Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, University of Mediterranee, Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Neuron 56:807-22. 2007
    ..Our data therefore reveal a "gating" function of neuropilins in semaphorin-plexin signaling during the assembly of forebrain neuronal circuits...
  40. pmc Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
    Natalia V De Marco Garcia
    Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:217-31. 2008
    ..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity...
  41. doi request reprint Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1
    Jeremy S Dasen
    Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
    Cell 134:304-16. 2008
    ..Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map...
  42. doi request reprint Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord
    Steven A Crone
    Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Neuron 60:70-83. 2008
    ..Our findings imply that the neural substrate for left-right coordination consists of at least two components; commissural neurons and a class of ipsilateral interneurons that activate commissural pathways...
  43. ncbi request reprint Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
    ..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections...
  44. ncbi request reprint A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons
    Ivo Lieberam
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, New York, New York 10032, USA
    Neuron 47:667-79. 2005
    ..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons...
  45. ncbi request reprint Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein
    Jennifer M Wilson
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    J Neurosci 25:5710-9. 2005
    ....
  46. ncbi request reprint Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins
    Chenghua Gu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Science 307:265-8. 2005
    ..These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning...
  47. ncbi request reprint Regulation of motor neuron pool sorting by differential expression of type II cadherins
    Stephen R Price
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Cell 109:205-16. 2002
    ..Type II cadherins are also expressed by proprioceptive sensory neurons, raising the possibility that cadherins regulate additional steps in the development of sensory-motor circuits...
  48. ncbi request reprint The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
    Thomas Muller
    Department of Medical Genetics, Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Neuron 34:551-62. 2002
    ..We conclude that Lbx1 distinguishes two major neuronal classes in the dorsal spinal cord and is an important determinant of their distinct differentiation programs...
  49. ncbi request reprint Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
    ..Thus, inductive signals involved in normal pathways of neurogenesis can direct ES cells to form specific classes of CNS neurons...
  50. ncbi request reprint ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools
    Jean Livet
    INSERM U 382, Developmental Biology Institute of Marseille, CNRS INSERM Univ Mediterranee, Campus de Luminy, Case 907, Marseille, France
    Neuron 35:877-92. 2002
    ..Thus, the induction of an intrinsic program of ETS gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons...
  51. ncbi request reprint A role for neuregulin1 signaling in muscle spindle differentiation
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Neuron 36:1035-49. 2002
    ....
  52. ncbi request reprint Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins
    Christopher M William
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168 Street, New York, NY 10032, USA
    Development 130:1523-36. 2003
    ..Finally, MNR2 appears to regulate motor neuron identity by acting as a transcriptional repressor, providing further evidence for the key role of transcriptional repression in motor neuron specification...
  53. ncbi request reprint Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents
    Tushar D Patel
    Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 38:403-16. 2003
    ..Finally, addition of NT3 to DRG explant cultures resulted in induction of ER81 protein. Our data indicate that NT3 mediates the formation of proprioceptive afferent-motor neuron connections via regulation of ER81...
  54. ncbi request reprint Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions
    Artur Kania
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 38:581-96. 2003
    ..These topographic projections are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells...
  55. ncbi request reprint Specification of dorsal telencephalic character by sequential Wnt and FGF signaling
    Lena Gunhaga
    Umeå Center for Molecular Medicine, Building 6M, 4th Floor, Umea University, S 901 87 Umea, Sweden
    Nat Neurosci 6:701-7. 2003
    ..Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character...
  56. ncbi request reprint A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification
    Bennett G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 40:81-95. 2003
    ..Moreover, joint exposure of neural progenitors to retinoids and FGFs suffices to induce motor neuron differentiation in a Shh-independent manner...
  57. ncbi request reprint Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern
    Shanthini Sockanathan
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 40:97-111. 2003
    ..These findings provide evidence for a regionally restricted role for retinoid signaling in the postmitotic specification of motor neuron columnar identity...
  58. ncbi request reprint Motor neuron columnar fate imposed by sequential phases of Hox-c activity
    Jeremy S Dasen
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, New York 10032, USA
    Nature 425:926-33. 2003
    ..Hox proteins also direct the expression of genes that establish motor topographic projections, thus implicating Hox proteins as critical determinants of spinal motor neuron identity and organization...
  59. ncbi request reprint A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity
    Joshua P Thaler
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Neuron 41:337-50. 2004
    ..Thus, an early phase of high Isl expression and activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord...
  60. ncbi request reprint Retinoic acid signalling specifies intermediate character in the developing telencephalon
    Matthew Marklund
    Umeå Center for Molecular Medicine, Building 6M, 4th Floor, Umea University, S 901 87 Umea, Sweden
    Development 131:4323-32. 2004
    ..We provide evidence here that retinoic acid has a crucial role in specifying telencephalic progenitor cells of intermediate character...
  61. ncbi request reprint Functional properties of motoneurons derived from mouse embryonic stem cells
    Gareth B Miles
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Neurosci 24:7848-58. 2004
    ..In summary, our findings demonstrate that MNs derived from ES cells develop appropriate transmitter receptors, intrinsic properties necessary for appropriate patterns of action potential firing and functional synapses with muscle fibers...
  62. ncbi request reprint Progressive induction of caudal neural character by graded Wnt signaling
    Ulrika Nordström
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    Nat Neurosci 5:525-32. 2002
    ....
  63. ncbi request reprint Type II cadherin ectodomain structures: implications for classical cadherin specificity
    Saurabh D Patel
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 124:1255-68. 2006
    ....
  64. ncbi request reprint Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements
    Guillermo M Lanuza
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 42:375-86. 2004
    ..Together, these findings identify Dbx1-dependent interneurons as key components of the spinal locomotor circuits that control stepping movements in mammals...

Research Grants15

  1. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2007
    ..Together, these studies should help to define the link between mechanisms of early neuronal specification and the formation of selective connections in a classical vertebrate motor circuit. ..
  2. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2006
    ..Together, these studies should help to define the link between mechanisms of early neuronal specification and the formation of selective connections in a classical vertebrate motor circuit. ..
  3. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2005
    ..Together, these studies should help to define the link between mechanisms of early neuronal specification and the formation of selective connections in a classical vertebrate motor circuit. ..
  4. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2003
    ..In addition, the study of the molecular basis of motor axon outgrowth may aid the development of more effective therapies for recovery of motor function after traumatic injury to the spinal cord. ..
  5. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2002
    ..In addition, the study of the molecular basis of motor axon outgrowth may aid the development of more effective therapies for recovery of motor function after traumatic injury to the spinal cord. ..
  6. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2001
    ..In addition, the study of the molecular basis of motor axon outgrowth may aid the development of more effective therapies for recovery of motor function after traumatic injury to the spinal cord. ..
  7. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2000
    ..In the long term, these studies will be important in defining and interpreting the underlying causes of a wide variety of neurological disorders that result in the degeneration and death of motor neurons. ..
  8. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 1999
    ..In the long term, these studies will be important in defining and interpreting the underlying causes of a wide variety of neurological disorders that result in the degeneration and death of motor neurons. ..
  9. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2009
    ..Together, these studies should help to define the link between mechanisms of early neuronal specification and the formation of selective connections in a classical vertebrate motor circuit. ..
  10. CONTROL OF MOTOR NEURON DIFFERENTIATION
    Thomas Jessell; Fiscal Year: 2004
    ..In addition, the study of the molecular basis of motor axon outgrowth may aid the development of more effective therapies for recovery of motor function after traumatic injury to the spinal cord. ..