Antonio Iavarone

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma
    Anna Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:301-6. 2002
  2. ncbi request reprint Id proteins in neural cancer
    Antonio Iavarone
    Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, 10032 New York, USA
    Cancer Lett 204:189-96. 2004
  3. ncbi request reprint Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 432:1040-5. 2004
  4. pmc Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum
    Domenico D'Arca
    Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:5875-80. 2010
  5. pmc Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis
    Francesco Niola
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA
    J Clin Invest 123:405-17. 2013
  6. pmc The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:210-21. 2009
  7. pmc E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells
    Gerson Rothschild
    Institute for Cancer Genetics, 1150 St Nicholas Ave, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 26:4351-61. 2006
  8. doi request reprint The transcriptional network for mesenchymal transformation of brain tumours
    Maria Stella Carro
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 463:318-25. 2010
  9. pmc Transforming fusions of FGFR and TACC genes in human glioblastoma
    Devendra Singh
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    Science 337:1231-5. 2012
  10. pmc The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Cell Biol 10:643-53. 2008

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma
    Anna Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:301-6. 2002
    ..We suggest that Id2 overexpression may be a better prognostic indicator than N-myc gene amplification in neuroblastoma. Thus, disrupting Id2 function may lead to new and useful therapeutic strategies for cancer patients...
  2. ncbi request reprint Id proteins in neural cancer
    Antonio Iavarone
    Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, 10032 New York, USA
    Cancer Lett 204:189-96. 2004
    ..Future work will be required to fully elucidate the molecular networks engaged by Id proteins to contribute to the essential hallmarks of neural cancer...
  3. ncbi request reprint Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 432:1040-5. 2004
    ..1, a master regulator of macrophage differentiation. Thus, Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythropoiesis...
  4. pmc Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum
    Domenico D'Arca
    Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:5875-80. 2010
    ....
  5. pmc Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis
    Francesco Niola
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA
    J Clin Invest 123:405-17. 2013
    ....
  6. pmc The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:210-21. 2009
    ..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors...
  7. pmc E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells
    Gerson Rothschild
    Institute for Cancer Genetics, 1150 St Nicholas Ave, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 26:4351-61. 2006
    ....
  8. doi request reprint The transcriptional network for mesenchymal transformation of brain tumours
    Maria Stella Carro
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 463:318-25. 2010
    ..These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells...
  9. pmc Transforming fusions of FGFR and TACC genes in human glioblastoma
    Devendra Singh
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    Science 337:1231-5. 2012
    ..FGFR-TACC fusions could potentially identify a subset of GBM patients who would benefit from targeted FGFR kinase inhibition...
  10. pmc The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Cell Biol 10:643-53. 2008
    ..These findings indicate that Huwe1 links destruction of N-Myc to the quiescent state that complements differentiation in the neural tissue...
  11. ncbi request reprint Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
    Anna Lasorella
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 442:471-4. 2006
    ..These findings indicate that deregulated Id activity might be useful to reprogramme quiescent neurons into the axonal growth mode...
  12. pmc Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
    Daniele Guardavaccaro
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA
    Nature 452:365-9. 2008
    ..The high levels of REST or its truncated variants found in certain human tumours may contribute to cellular transformation by promoting genomic instability...
  13. pmc Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
    Anna Lasorella
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell Biol 25:3563-74. 2005
    ..In human neuroblastoma, the N-Myc-driven expression of Id2 is sufficient and necessary for expression of VEGF. These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer...
  14. pmc The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system
    Anna Lasorella
    Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:4976-81. 2006
    ..These data indicate that ENH contributes to differentiation of the nervous system through cytoplasmic sequestration of Id2. They also suggest that ENH is a restraining factor of the oncogenic activity of Id proteins in neural tumors...
  15. ncbi request reprint ID proteins as targets in cancer and tools in neurobiology
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Trends Mol Med 12:588-94. 2006
    ..Here, we discuss how unique properties of ID proteins in cancer cells and neurons pave the way to unexpected therapeutic opportunities...
  16. pmc RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation
    Carla Danussi
    Authors Affiliations Institute for Cancer Genetics, Department of Systems Biology, Department of Pediatrics, Pathology, Neurology, Columbia University Medical Center, and Department of Biological Sciences, Columbia University, New York, New York
    Cancer Res 73:5140-50. 2013
    ..Our results define RHPN2 amplification as a central genetic determinant of a highly aggressive phenotype that directs the worst clinical outcomes in patients with GBM. Cancer Res; 73(16); 5140-50. ©2013 AACR. ..
  17. pmc Id proteins synchronize stemness and anchorage to the niche of neural stem cells
    Francesco Niola
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Cell Biol 14:477-87. 2012
    ..Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche...
  18. doi request reprint Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma
    Lindy E Barrett
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 21:11-24. 2012
    ....
  19. ncbi request reprint Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium
    Robert G Russell
    Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, D C, USA
    Cancer Res 64:7220-5. 2004
    ..Thus, our data are the first to establish a direct requirement of basic helix-loop-helix inhibitors in driving differentiation and define an unexpected role for the retinoblastoma-binding protein Id2 in preventing tumor formation...
  20. ncbi request reprint Id family of helix-loop-helix proteins in cancer
    Jonathan Perk
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 241, New York 10021, USA
    Nat Rev Cancer 5:603-14. 2005
    ....
  21. ncbi request reprint Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells
    William Light
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Development 132:1831-41. 2005
    ..These results shed new light on the mechanisms governing the formation and maintenance of a developmentally and clinically important cell population...

Research Grants17

  1. Computational analysis of Human High Grade Gliomas
    Antonio Iavarone; Fiscal Year: 2010
    ..We anticipate that the identification of the master genetic programs directing the most aggressive features of malignant gliomas will offer the best possible targets for therapeutic intervention. ..
  2. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
    ..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
  3. Computational analysis of Human High Grade Gliomas
    Antonio Iavarone; Fiscal Year: 2009
    ..We anticipate that the identification of the master genetic programs directing the most aggressive features of malignant gliomas will offer the best possible targets for therapeutic intervention. ..
  4. Mechanisms and regulation of post-translational modifications of Id proteins
    Antonio Iavarone; Fiscal Year: 2010
    ..Through the proposed work, we aim to provide a better understanding of the post-translational regulatory machinery for Id proteins and unravel new layers of intervention targeting the alteration of this machinery in human cancer. ..
  5. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2007
    ..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
  6. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2004
    ..abstract_text> ..
  7. Mechanisms and regulation of post-translational modifications of Id proteins
    Antonio Iavarone; Fiscal Year: 2011
    ..Through the proposed work, we aim to provide a better understanding of the post-translational regulatory machinery for Id proteins and unravel new layers of intervention targeting the alteration of this machinery in human cancer. ..