Research Topics
Genomes and Genes
| Antonio IavaroneSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastomaAnna Lasorella
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 62:301-6. 2002..We suggest that Id2 overexpression may be a better prognostic indicator than N-myc gene amplification in neuroblastoma. Thus, disrupting Id2 function may lead to new and useful therapeutic strategies for cancer patients...- Id proteins in neural cancerAntonio Iavarone
Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, 10032 New York, USA
Cancer Lett 204:189-96. 2004..Future work will be required to fully elucidate the molecular networks engaged by Id proteins to contribute to the essential hallmarks of neural cancer... - Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophagesAntonio Iavarone
Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nature 432:1040-5. 2004..1, a master regulator of macrophage differentiation. Thus, Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythropoiesis... 
Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellumDomenico D'Arca
Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
Proc Natl Acad Sci U S A 107:5875-80. 2010....- The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brainXudong Zhao
Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 17:210-21. 2009..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors... 
The transcriptional network for mesenchymal transformation of brain tumoursMaria Stella Carro
Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
Nature 463:318-25. 2010..These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells...- E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cellsGerson Rothschild
Institute for Cancer Genetics, 1150 St Nicholas Ave, Columbia University, New York, NY 10032, USA
Mol Cell Biol 26:4351-61. 2006.... - Transforming fusions of FGFR and TACC genes in human glioblastomaDevendra Singh
Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
Science 337:1231-5. 2012..FGFR-TACC fusions could potentially identify a subset of GBM patients who would benefit from targeted FGFR kinase inhibition... - The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoproteinXudong Zhao
Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
Nat Cell Biol 10:643-53. 2008..These findings indicate that Huwe1 links destruction of N-Myc to the quiescent state that complements differentiation in the neural tissue... - Control of chromosome stability by the beta-TrCP-REST-Mad2 axisDaniele Guardavaccaro
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA
Nature 452:365-9. 2008..The high levels of REST or its truncated variants found in certain human tumours may contribute to cellular transformation by promoting genomic instability... - Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growthAnna Lasorella
Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Nature 442:471-4. 2006..These findings indicate that deregulated Id activity might be useful to reprogramme quiescent neurons into the axonal growth mode... - Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant miceAnna Lasorella
Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
Mol Cell Biol 25:3563-74. 2005..In human neuroblastoma, the N-Myc-driven expression of Id2 is sufficient and necessary for expression of VEGF. These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer... - The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous systemAnna Lasorella
Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA
Proc Natl Acad Sci U S A 103:4976-81. 2006..These data indicate that ENH contributes to differentiation of the nervous system through cytoplasmic sequestration of Id2. They also suggest that ENH is a restraining factor of the oncogenic activity of Id proteins in neural tumors... - ID proteins as targets in cancer and tools in neurobiologyAntonio Iavarone
Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Trends Mol Med 12:588-94. 2006..Here, we discuss how unique properties of ID proteins in cancer cells and neurons pave the way to unexpected therapeutic opportunities... - Id proteins synchronize stemness and anchorage to the niche of neural stem cellsFrancesco Niola
Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
Nat Cell Biol 14:477-87. 2012..Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche... - Self-renewal does not predict tumor growth potential in mouse models of high-grade gliomaLindy E Barrett
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Cell 21:11-24. 2012.... - Id2 drives differentiation and suppresses tumor formation in the intestinal epitheliumRobert G Russell
Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, D C, USA
Cancer Res 64:7220-5. 2004..Thus, our data are the first to establish a direct requirement of basic helix-loop-helix inhibitors in driving differentiation and define an unexpected role for the retinoblastoma-binding protein Id2 in preventing tumor formation... - Id family of helix-loop-helix proteins in cancerJonathan Perk
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue Box 241, New York 10021, USA
Nat Rev Cancer 5:603-14. 2005.... - Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cellsWilliam Light
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Development 132:1831-41. 2005..These results shed new light on the mechanisms governing the formation and maintenance of a developmentally and clinically important cell population...
Research Grants
- Computational analysis of Human High Grade GliomasAntonio Iavarone; Fiscal Year: 2010..We anticipate that the identification of the master genetic programs directing the most aggressive features of malignant gliomas will offer the best possible targets for therapeutic intervention. ..
- ID2 IN CELL CYCLE REGULATION AND CANCERAntonio Iavarone; Fiscal Year: 2010..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
- Computational analysis of Human High Grade GliomasAntonio Iavarone; Fiscal Year: 2009..We anticipate that the identification of the master genetic programs directing the most aggressive features of malignant gliomas will offer the best possible targets for therapeutic intervention. ..
- Mechanisms and regulation of post-translational modifications of Id proteinsAntonio Iavarone; Fiscal Year: 2010..Through the proposed work, we aim to provide a better understanding of the post-translational regulatory machinery for Id proteins and unravel new layers of intervention targeting the alteration of this machinery in human cancer. ..
- ID2 IN CELL CYCLE REGULATION AND CANCERAntonio Iavarone; Fiscal Year: 2007..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
- ID2 IN CELL CYCLE REGULATION AND CANCERAntonio Iavarone; Fiscal Year: 2004..abstract_text> ..
- Mechanisms and regulation of post-translational modifications of Id proteinsAntonio Iavarone; Fiscal Year: 2011..Through the proposed work, we aim to provide a better understanding of the post-translational regulatory machinery for Id proteins and unravel new layers of intervention targeting the alteration of this machinery in human cancer. ..