W Ian Lipkin

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Comprehensive viral oligonucleotide probe design using conserved protein regions
    Omar J Jabado
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 1801, New York, NY 10032, USA
    Nucleic Acids Res 36:e3. 2008
  2. pmc Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway
    Kavitha Yaddanapudi
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e26766. 2011
  3. pmc Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances
    Brent L Williams
    Center for Infection and Immunity, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e24585. 2011
  4. pmc Lack of evidence for an association between Iridovirus and colony collapse disorder
    Rafal Tokarz
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e21844. 2011
  5. pmc Panmicrobial oligonucleotide array for diagnosis of infectious diseases
    Gustavo Palacios
    Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 13:73-81. 2007
  6. pmc Diagnostic system for rapid and sensitive differential detection of pathogens
    Thomas Briese
    Columbia University, New York, NY 10032, USA
    Emerg Infect Dis 11:310-3. 2005
  7. pmc Greene SCPrimer: a rapid comprehensive tool for designing degenerate primers from multiple sequence alignments
    Omar J Jabado
    Jerome L and Dawn Greene Laboratory for Infectious Diseases, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Nucleic Acids Res 34:6605-11. 2006
  8. pmc Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae
    Gustavo Palacios
    Center for Genomic Sciences, United States Army Medical Research Institute for Infectious Diseases, Frederick, MD 10032, USA
    Virol J 10:219. 2013
  9. pmc Human blood RNA stabilization in samples collected and transported for a large biobank
    Nur Duale
    The Norwegian Institute of Public Health, Oslo, Norway
    BMC Res Notes 5:510. 2012
  10. doi request reprint Viral surveillance and discovery
    WALTER IAN LIPKIN
    Center for Infection and Immunity, Mailman School of Public Health of Columbia University, 722 West 168th Street, New York, NY 10025, USA
    Curr Opin Virol 3:199-204. 2013

Collaborators

Detail Information

Publications32

  1. pmc Comprehensive viral oligonucleotide probe design using conserved protein regions
    Omar J Jabado
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 1801, New York, NY 10032, USA
    Nucleic Acids Res 36:e3. 2008
    ..In silico testing using an experimentally derived thermodynamic model indicated near complete coverage of the viral sequence database...
  2. pmc Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway
    Kavitha Yaddanapudi
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e26766. 2011
    ....
  3. pmc Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances
    Brent L Williams
    Center for Infection and Immunity, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e24585. 2011
    ..These results indicate a relationship between human intestinal gene expression and bacterial community structure and may provide insights into the pathophysiology of gastrointestinal disturbances in children with autism...
  4. pmc Lack of evidence for an association between Iridovirus and colony collapse disorder
    Rafal Tokarz
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e21844. 2011
    ..Neither analysis revealed any evidence to suggest the presence of an Iridovirus in healthy or CCD colonies...
  5. pmc Panmicrobial oligonucleotide array for diagnosis of infectious diseases
    Gustavo Palacios
    Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 13:73-81. 2007
    ....
  6. pmc Diagnostic system for rapid and sensitive differential detection of pathogens
    Thomas Briese
    Columbia University, New York, NY 10032, USA
    Emerg Infect Dis 11:310-3. 2005
    ..We describe a diagnostic system for rapid, sensitive, multiplex discrimination of microbial gene sequences and report its application for detecting 22 respiratory pathogens in clinical samples...
  7. pmc Greene SCPrimer: a rapid comprehensive tool for designing degenerate primers from multiple sequence alignments
    Omar J Jabado
    Jerome L and Dawn Greene Laboratory for Infectious Diseases, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Nucleic Acids Res 34:6605-11. 2006
    ....
  8. pmc Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae
    Gustavo Palacios
    Center for Genomic Sciences, United States Army Medical Research Institute for Infectious Diseases, Frederick, MD 10032, USA
    Virol J 10:219. 2013
    ..Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA...
  9. pmc Human blood RNA stabilization in samples collected and transported for a large biobank
    Nur Duale
    The Norwegian Institute of Public Health, Oslo, Norway
    BMC Res Notes 5:510. 2012
    ..Endpoints to characterize the samples were RNA quality and yield, and the RNA transcript stability of selected genes...
  10. doi request reprint Viral surveillance and discovery
    WALTER IAN LIPKIN
    Center for Infection and Immunity, Mailman School of Public Health of Columbia University, 722 West 168th Street, New York, NY 10025, USA
    Curr Opin Virol 3:199-204. 2013
    ....
  11. pmc The changing face of pathogen discovery and surveillance
    W Ian Lipkin
    Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Nat Rev Microbiol 11:133-41. 2013
    ..Here, I review the factors that contribute to infectious-disease emergence, as well as strategies for addressing the challenges of pathogen surveillance and discovery...
  12. doi request reprint Borna disease virus - fact and fantasy
    W Ian Lipkin
    Center for Infection and Immunity, Columbia University Mailman School of Public Health, 722 W 168th St, 17th Floor, New York, NY 10032, United States
    Virus Res 162:162-72. 2011
    ..This article reviews the history, molecular biology, epidemiology, and pathobiology of bornaviruses...
  13. pmc Longitudinal molecular microbial analysis of influenza-like illness in New York City, May 2009 through May 2010
    Rafal Tokarz
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, USA
    Virol J 8:288. 2011
    ....
  14. pmc Nonparametric methods for the analysis of single-color pathogen microarrays
    Omar J Jabado
    Center for Infection and Immunity Mailman School of Public Health Columbia University New York, NY, USA
    BMC Bioinformatics 11:354. 2010
    ..Exploratory analysis of fluorescent signal distribution in clinical samples has revealed deviations from normality, suggesting that distribution-free approaches should be applied...
  15. pmc Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus
    B L Williams
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Virol 80:8613-26. 2006
    ..These results implicate an imbalance between ER stress-mediated apoptosis and survival signaling as a critical determinant of neural cell fate in NBD...
  16. pmc Microbe hunting
    W Ian Lipkin
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Microbiol Mol Biol Rev 74:363-77. 2010
    ..These refinements are working constructs that will continue to evolve in light of new technologies, new models, and new insights. What will endure is the excitement of the chase. Happy hunting!..
  17. pmc Diagnostics and discovery in viral hemorrhagic fevers
    W Ian Lipkin
    Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York, USA
    Ann N Y Acad Sci 1171:E6-11. 2009
    ..This chapter reviews recent progress in the field of pathogen surveillance and discovery with a focus on viral hemorrhagic fevers...
  18. pmc Pathogen discovery
    W Ian Lipkin
    Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, New York, United States of America
    PLoS Pathog 4:e1000002. 2008
  19. pmc Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection
    Brent L Williams
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 1801, New York, NY 10032, USA
    J Virol 82:1748-58. 2008
    ..These results implicate aberrant zinc homeostasis, PARP-1, and caspase 3 activation as contributing factors in hippocampal neurodegeneration in NBD...
  20. ncbi request reprint Rapid sequence-based diagnosis of viral infection
    Phenix lan Quan
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Antiviral Res 79:1-5. 2008
    ..Here we review the current status of viral diagnostics and the utility of various sequence-based diagnostic platforms for applications in clinical microbiology, surveillance and pathogen discovery...
  21. pmc Molecular identification of mumps virus genotypes from clinical samples: standardized method of analysis
    G Palacios
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, 722 W 168th Street, Fl 18, New York, NY 10032, USA
    J Clin Microbiol 43:1869-78. 2005
    ..This PCR assay for characterization of mumps infections coupled to a web-based analytical program provides a rapid method for identification of known and novel strains...
  22. pmc Genetic analysis of Israel acute paralysis virus: distinct clusters are circulating in the United States
    G Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 1801, New York, NY 10032, USA
    J Virol 82:6209-17. 2008
    ..Analysis of representatives from each proposed lineage suggested the possibility of recombination events and revealed differences in coding sequences that may have implications for virulence...
  23. ncbi request reprint Neurotoxic effects of postnatal thimerosal are mouse strain dependent
    M Hornig
    Jerome L and Dawn Greene Infectious Disease Laboratory, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Mol Psychiatry 9:833-45. 2004
    ..Strains resistant to autoimmunity, C57BL/6J and BALB/cJ, were not susceptible. These findings implicate genetic influences and provide a model for investigating thimerosal-related neurotoxicity...
  24. ncbi request reprint Natural M-segment reassortment in Potosi and Main Drain viruses: implications for the evolution of orthobunyaviruses
    T Briese
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Arch Virol 152:2237-47. 2007
    ..Our findings indicate M-segment reassortment in Potosi and Main Drain viruses and demonstrate natural genome reassortment as a driving force in the evolution of viruses of the Bunyamwera serogroup...
  25. ncbi request reprint Infectious and immune factors in neurodevelopmental damage
    M Hornig
    Center for Immunopathogenesis and Infectious Diseases, Dept of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Mol Psychiatry 7:S34-5. 2002
  26. doi request reprint Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection
    K Yaddanapudi
    Center for Infection and Immunity and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Mol Psychiatry 15:712-26. 2010
    ..This work provides insights into PANDAS pathogenesis and may lead to new strategies for identification and treatment of children at risk for autoimmune brain disorders...
  27. pmc Molecular identification of adenoviruses in clinical samples by analyzing a partial hexon genomic region
    I Casas
    Jerome L and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, 772 W 168th Street, Floor 18, New York, NY 10032, USA
    J Clin Microbiol 43:6176-82. 2005
    ..Known associations between specific serotypes and clinical syndromes are verified. Possible new associations are described to allow further independent testing...
  28. pmc Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction
    Lina Fan
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    J Virol 84:1785-91. 2010
    ....

Research Grants37

  1. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  2. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  3. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  4. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2001
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  5. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  6. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2001
    ....
  7. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2002
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  8. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2002
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  9. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  10. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2000
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  11. Northeast Biodefense Center
    W Ian Lipkin; Fiscal Year: 2007
    ..An emergency response plan has been developed to rapidly realign the NBC's activities and provide facilities, including cores and scientific support, to first line responders in the event of a biodefense emergency. ..
  12. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1993
    ..to continue our studies in the molecular biology of the BD agent; 2. to use our molecular probes for the BD agent to ask whether BD can be implicated in selected human neuropsychiatric diseases...
  13. Gene-Environment Interactions in an Autism Birth Cohort
    W Ian Lipkin; Fiscal Year: 2007
    ..abstract_text> ..
  14. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1991
    ..to continue our studies in the molecular biology of the BD agent; 2. to use our molecular probes for the BD agent to ask whether BD can be implicated in selected human neuropsychiatric diseases...
  15. Viral Arrays for Biodefense
    W Ian Lipkin; Fiscal Year: 2007
    ....
  16. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  17. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  18. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  19. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2007
    ....
  20. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    WALTER LIPKIN; Fiscal Year: 2006
    ....
  21. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2003
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  22. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1999
    ....
  23. MOLECULAR ANALYIS OF A NEUROTROPIC AGENT, BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1992
    ..to continue our studies in the molecular biology of the BD agent; 2. to use our molecular probes for the BD agent to ask whether BD can be implicated in selected human neuropsychiatric diseases...
  24. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 1999
    ....
  25. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2000
    ....
  26. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2000
    ....
  27. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  28. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2003
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..