CLARK HUNG

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Intrinsically superparamagnetic Fe-hydroxyapatite nanoparticles positively influence osteoblast-like cell behaviour
    Silvia Panseri
    Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Nanobiotechnology 10:32. 2012
  2. ncbi request reprint Anatomically shaped osteochondral constructs for articular cartilage repair
    Clark T Hung
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
    J Biomech 36:1853-64. 2003
  3. ncbi request reprint Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture
    Clark T Hung
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 40:61-72. 2003
  4. pmc Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage
    K W Ng
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Osteoarthritis Cartilage 17:220-7. 2009
  5. doi request reprint One breath closer to making engineered tissues a clinical reality
    Clark T Hung
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Cell Stem Cell 4:5-6. 2009
  6. ncbi request reprint A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading
    Clark T Hung
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ann Biomed Eng 32:35-49. 2004
  7. ncbi request reprint Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels
    Robert L Mauck
    Department of Biomedical Engineering, Columbia University, 351J Engineering Terrace, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ann Biomed Eng 30:1046-56. 2002
  8. ncbi request reprint Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading
    Pen Hsiu Grace Chao
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Am J Physiol Cell Physiol 291:C718-25. 2006
  9. pmc Anisotropic strain-dependent material properties of bovine articular cartilage in the transitional range from tension to compression
    Nadeen O Chahine
    Musculoskeletal Biomechanics Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 37:1251-61. 2004
  10. pmc Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering
    Robert L Mauck
    Department of Biomedical Engineering, Columbia University, 500 West 120th St, MC4703, New York, NY 10027, USA
    J Biomech Eng 125:602-14. 2003

Collaborators

Detail Information

Publications63

  1. pmc Intrinsically superparamagnetic Fe-hydroxyapatite nanoparticles positively influence osteoblast-like cell behaviour
    Silvia Panseri
    Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Nanobiotechnology 10:32. 2012
    ....
  2. ncbi request reprint Anatomically shaped osteochondral constructs for articular cartilage repair
    Clark T Hung
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
    J Biomech 36:1853-64. 2003
    ..Anatomically shaped constructs on a bony substrate may represent a new paradigm in the design of a functional articular cartilage tissue replacement...
  3. ncbi request reprint Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture
    Clark T Hung
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 40:61-72. 2003
    ....
  4. pmc Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage
    K W Ng
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Osteoarthritis Cartilage 17:220-7. 2009
    ..It was hypothesized that controlled, scaffold removal in engineered cartilage constructs would improve their collagen content and mechanical properties over time in culture...
  5. doi request reprint One breath closer to making engineered tissues a clinical reality
    Clark T Hung
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Cell Stem Cell 4:5-6. 2009
    ..The restoration of the patient's quality of life testifies to this successful translation of benchtop to bedside studies and provides promise for the application of regenerative medicine strategies to other clinical disorders...
  6. ncbi request reprint A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading
    Clark T Hung
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ann Biomed Eng 32:35-49. 2004
    ....
  7. ncbi request reprint Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels
    Robert L Mauck
    Department of Biomedical Engineering, Columbia University, 351J Engineering Terrace, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ann Biomed Eng 30:1046-56. 2002
    ..Our findings provide evidence for initial cell seeding density and nutrient accessibility as important parameters in modulating tissue development of engineered constructs, and their ability to respond to a defined mechanical stimulus...
  8. ncbi request reprint Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading
    Pen Hsiu Grace Chao
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Am J Physiol Cell Physiol 291:C718-25. 2006
    ..These studies illustrate the utility of the microfluidic device in cell signaling investigations, and their potential role in helping to elucidate mechanisms that mediate chondrocyte mechanotransduction to dynamic stimuli...
  9. pmc Anisotropic strain-dependent material properties of bovine articular cartilage in the transitional range from tension to compression
    Nadeen O Chahine
    Musculoskeletal Biomechanics Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 37:1251-61. 2004
    ..The strain-softening behavior of cartilage (the initial decrease in EYi with increasing compressive strain) can be interpreted in the context of osmotic swelling and tension-compression nonlinearity...
  10. pmc Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering
    Robert L Mauck
    Department of Biomedical Engineering, Columbia University, 500 West 120th St, MC4703, New York, NY 10027, USA
    J Biomech Eng 125:602-14. 2003
    ..The results of this study apply to any porous hydrated tissue or material, and it is therefore plausible to hypothesize that dynamic loading may serve to enhance solute transport in a variety of physiological processes...
  11. ncbi request reprint The effect of applied compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3
    Eric G Lima
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    Conf Proc IEEE Eng Med Biol Soc 1:779-82. 2006
    ..The present study extends the work on the mechanical preconditioning of engineered cartilage constructs to include transient supplementation with TGF-beta3 in a clinically-relevant, chemically-defined, serum-free media formulation...
  12. pmc Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: a canine model
    Kenneth W Ng
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Tissue Eng Part A 16:1041-51. 2010
    ..The encouraging findings of this work highlight the potential for tissue engineering strategies using adult chondrocytes in the clinical treatment of cartilage defects...
  13. doi request reprint Low-serum media and dynamic deformational loading in tissue engineering of articular cartilage
    Terri Ann N Kelly
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ann Biomed Eng 36:769-79. 2008
    ..By priming the chondrocytes in 20%FBS prior to exposure to low-serum/ITS media, we observed that low-serum/ITS media produced significant enhancement in tissue properties compared to constructs grown continuously in 20%FBS...
  14. ncbi request reprint Spatial and temporal development of chondrocyte-seeded agarose constructs in free-swelling and dynamically loaded cultures
    Terri Ann N Kelly
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 39:1489-97. 2006
    ....
  15. pmc Genipin enhances the mechanical properties of tissue-engineered cartilage and protects against inflammatory degradation when used as a medium supplement
    Eric G Lima
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Biomed Mater Res A 91:692-700. 2009
    ..These studies demonstrate a potential use of genipin as a medium supplement to develop enhanced engineered cartilage...
  16. pmc Frictional response of bovine articular cartilage under creep loading following proteoglycan digestion with chondroitinase ABC
    Ines M Basalo
    Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 128:131-4. 2006
    ..These findings strengthen the motivation for developing chondroprotective strategies by increasing cartilage chondroitin sulfate content in osteoarthritic joints...
  17. ncbi request reprint Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered cartilage construct
    Kenneth W Ng
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 43:497-507. 2006
    ..Our study underscores the importance of other physical properties of the scaffold that may have a greater influence on interconnected tissue formation than intrinsic scaffold stiffness...
  18. pmc Optical determination of anisotropic material properties of bovine articular cartilage in compression
    Christopher C B Wang
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 36:339-53. 2003
    ....
  19. ncbi request reprint Dynamic osmotic loading of chondrocytes using a novel microfluidic device
    P Grace Chao
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
    J Biomech 38:1273-81. 2005
    ....
  20. ncbi request reprint In-situ measurements of chondrocyte deformation under transient loading
    Nadeen O Chahine
    Musculoskeletal Biomechanics Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Eur Cell Mater 13:100-11; discussion 111. 2007
    ..The results of this study suggest that mechanotransduction of chondrocytes may be significantly mediated by this strain amplification mechanism during loading...
  21. pmc Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs
    Eric G Lima
    Materials Characterization Laboratory, Cooper Union, 51 Astor Place, New York, NY 10003, USA
    J Biomech 41:3253-9. 2008
    ..Physiologic loading was unable to counteract the long-term catabolic effects of IL-1 under any of the conditions tested, and in some cases led to further degeneration over unloaded controls...
  22. pmc Dynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes
    Liming Bian
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, Engineering Terrace 351, 1210 Amsteram Ave, New York, NY 10027, USA
    Tissue Eng Part A 16:1781-90. 2010
    ..The objective of this study was to assess the efficacy of a modified FTE protocol using adult canine chondrocytes seeded in agarose hydrogel and subjected to dynamic loading...
  23. ncbi request reprint The functional environment of chondrocytes within cartilage subjected to compressive loading: a theoretical and experimental approach
    Christopher C B Wang
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 39:11-25. 2002
    ..Coupled with biological assays of cell-scale biosynthesis, there is also a great potential in the future to study chondrocyte mechanotransduction in situ with a new level of specificity...
  24. pmc Electrostatic and non-electrostatic contributions of proteoglycans to the compressive equilibrium modulus of bovine articular cartilage
    Clare Canal Guterl
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 43:1343-50. 2010
    ..These increased insights on the structure-function relationships of cartilage can lead to improved constitutive models and a better understanding of the response of cartilage to physiological loading conditions...
  25. pmc Direct measurement of osmotic pressure of glycosaminoglycan solutions by membrane osmometry at room temperature
    Nadeen O Chahine
    Musculoskeletal Biomechanics Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Biophys J 89:1543-50. 2005
    ..A strong dependence of this intrinsic modulus on salt concentration was found; therefore, it appears that proteoglycans contribute structurally to the magnitude of H(A), in a manner independent of osmotic pressure...
  26. pmc Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media
    Michael B Albro
    Department of Biomedical Engineering, Columbia University, New York, NY, USA
    J Biomech 43:2267-73. 2010
    ....
  27. pmc Cartilage interstitial fluid load support in unconfined compression following enzymatic digestion
    Ines M Basalo
    Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 126:779-86. 2004
    ..0001). The drop in interstitial fluid load support following enzymatic treatment is believed to result from a decrease in the ratio of tensile to compressive moduli of the solid matrix...
  28. pmc Two-dimensional strain fields on the cross-section of the bovine humeral head under contact loading
    Clare E Canal
    Department of Biomedical Engineering, Columbia University, NY 10027, USA
    J Biomech 41:3145-51. 2008
    ..These experimental results yield new insights into the local mechanical environment of the tissue and cells, and suggest that further refinements are needed in the modeling of contacting articular layers...
  29. pmc The effect of devitalized trabecular bone on the formation of osteochondral tissue-engineered constructs
    Eric G Lima
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace MC8904, 1210 Amsterdam Avenue, New York, NY 10027, United States
    Biomaterials 29:4292-9. 2008
    ..2+/-0.9%ww) were achieved when a porous tantalum metal base material was adopted instead of bone. This work suggests that devitalized bone may not be a suitable substrate for long-term cultivation of osteochondral grafts...
  30. ncbi request reprint Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering
    Robert L Mauck
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Tissue Eng 9:597-611. 2003
    ..These results support the hypothesis that the combination of chemical and mechanical promoters of matrix biosynthesis can optimize the growth of tissue-engineered cartilage constructs...
  31. pmc Modeling of active transmembrane transport in a mixture theory framework
    Gerard A Ateshian
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ann Biomed Eng 38:1801-14. 2010
    ..The resulting relations are simple and easy to use, and address an important need in the membrane transport literature...
  32. pmc Two-dimensional strain fields on the cross-section of the human patellofemoral joint under physiological loading
    Clare Canal Guterl
    Department of Biomedical Engineering, Columbia University, 500W 120th Street, New York, NY, USA
    J Biomech 42:1275-81. 2009
    ..090+/-0.030 and -0.072+/-0.038 (p<0.005). These experimental results provide a detailed description of the manner by which human PFJ articular layers deform in situ under physiological load conditions...
  33. doi request reprint Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair
    Jie Jiang
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ann Biomed Eng 38:2183-96. 2010
    ..These results demonstrate the potential of the stratified scaffold for integrative cartilage repair and future studies will focus on scaffold optimization and in vivo evaluations...
  34. pmc Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density
    Gerard A Ateshian
    Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 131:101001. 2009
    ..Applications of this growth model are illustrated in several examples...
  35. pmc The correspondence between equilibrium biphasic and triphasic material properties in mixture models of articular cartilage
    Gerard A Ateshian
    Departments of Mechanical Engineering and Biomedical Engineering, Columbia University, New York, NY10027, USA
    J Biomech 37:391-400. 2004
    ....
  36. ncbi request reprint Culture duration modulates collagen hydrolysate-induced tissue remodeling in chondrocyte-seeded agarose hydrogels
    Kenneth W Ng
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, MC8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ann Biomed Eng 35:1914-23. 2007
    ..Therefore, collagen hydrolysate as a media supplement is not a viable long-term method to improve the collagen content of engineered cartilage tissue...
  37. pmc Effects of enzymatic degradation on the frictional response of articular cartilage in stress relaxation
    Ines M Basalo
    Department of Mechanical Engineering, Columbia University, SW Mudd, Mail Code 4703, 500 West 120th Street, New York, NY 10027, USA
    J Biomech 38:1343-9. 2005
    ..Based on earlier findings, the increase in the ratio micro(min)/micro(eq) may be attributed to the decrease in fluid load support...
  38. ncbi request reprint Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent
    Erica Takai
    Bone Bioengineering Laboratory, Columbia University, New York, NY 10027, USA
    Ann Biomed Eng 33:963-71. 2005
    ..Modulation of cell stiffness upon adhesion to various substrates may influence mechanosignal transduction in osteoblasts...
  39. pmc Osmotic loading of spherical gels: a biomimetic study of hindered transport in the cell protoplasm
    Michael B Albro
    Department of Mechanical Engineering, Columbia University, 500 West 120th Street, MC 4703, New York, NY 10027, USA
    J Biomech Eng 129:503-10. 2007
    ..The validation of this theoretical framework facilitates future investigations of the role of the protoplasm in the response of cells to osmotic loading...
  40. pmc Modeling the matrix of articular cartilage using a continuous fiber angular distribution predicts many observed phenomena
    Gerard A Ateshian
    Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 131:061003. 2009
    ..Biomech. Eng., 129(2), pp. 240-249)...
  41. pmc A mixture theory analysis for passive transport in osmotic loading of cells
    Gerard A Ateshian
    Departments of Mechanical Engineering and Biomedical Engineering, Columbia University, 500 West 120th St, MC4703 New York, NY 10027, USA
    J Biomech 39:464-75. 2006
    ..Deviations of the Boyle-van't Hoff response from a straight line under hypo-osmotic loading may be indicative of cell membrane tension...
  42. ncbi request reprint Intracellular calcium waves in bone cell networks under single cell nanoindentation
    X Edward Guo
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Mol Cell Biomech 3:95-107. 2006
    ..Thus, this study provides new experimental data that support the idea of osteocyte network memory of mechanical loading similar to memory in neural networks...
  43. pmc Influence of temporary chondroitinase ABC-induced glycosaminoglycan suppression on maturation of tissue-engineered cartilage
    Liming Bian
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Tissue Eng Part A 15:2065-72. 2009
    ..In this study, this hypothesis is tested by inducing enzymatic GAG loss in the early culture period of cartilage tissue constructs, and monitoring collagen content at various time points after cessation of enzymatic treatment...
  44. pmc Zonal chondrocytes seeded in a layered agarose hydrogel create engineered cartilage with depth-dependent cellular and mechanical inhomogeneity
    Kenneth W Ng
    Department of Biomedical Engineering, Cellular Engineering Laboratory, Columbia University, New York 10027, USA
    Tissue Eng Part A 15:2315-24. 2009
    ..Future studies will determine if replicating inhomogeneity is advantageous in clinical applications of tissue engineered cartilage...
  45. ncbi request reprint A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs
    Kenneth W Ng
    Cellular Engineering Laboratory, 351 Engineering Terrace, MC8904, 1210 Amsterdam Avenue, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Orthop Res 23:134-41. 2005
    ....
  46. pmc Influence of the partitioning of osmolytes by the cytoplasm on the passive response of cells to osmotic loading
    Michael B Albro
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Biophys J 97:2886-93. 2009
    ..Furthermore, a positive correlation is observed, suggesting that a solute's cytoplasmic partition coefficient increases with increasing hydrophobicity...
  47. ncbi request reprint Functional tissue engineering of chondral and osteochondral constructs
    Eric G Lima
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 41:577-90. 2004
    ....
  48. ncbi request reprint An automated approach for direct measurement of two-dimensional strain distributions within articular cartilage under unconfined compression
    Christopher C B Wang
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 124:557-67. 2002
    ..The variation of the apparent Poisson's ratio with depth is found to be consistent with a theoretical model of cartilage which accounts for the disparity in its tensile and compressive moduli...
  49. ncbi request reprint Characterization of the mechanical properties and mineral distribution of the anterior cruciate ligament-to-bone insertion site
    Kristen L Moffat
    Biomaterials and Interface Tissue Engineering Laboratory, Columbia University, New York, NY 10021, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2366-9. 2006
    ..The findings of this study suggest that a structure-function relationship exists at the ACL-to-bone interface...
  50. doi request reprint Differences in interleukin-1 response between engineered and native cartilage
    Eric G Lima
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Tissue Eng Part A 14:1721-30. 2008
    ....
  51. ncbi request reprint Role of cell-associated matrix in the development of free-swelling and dynamically loaded chondrocyte-seeded agarose gels
    Terri Ann N Kelly
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 41:223-37. 2004
    ..In further support of these findings, culturing chondrocytes in agarose for two weeks prior to the application of deformational loading also did not exhibit expedited construct development...
  52. ncbi request reprint Chondrocyte nuclear response to osmotic loading
    Elizabeth S Oswald
    Dept of Biomed Eng, Columbia Univ, New York, NY, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3659-61. 2006
    ..In the current study, we focus on the potential role of the actin cytoskeleton in mediating the transmission of osmotic loading-induced cell size changes to the nucleus...
  53. ncbi request reprint Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure
    Erica Takai
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Bone Miner Res 19:1403-10. 2004
    ..However, live osteocytes were necessary for osteoblasts to form osteoids in response to DHP, which directly show osteoblast-osteocyte interactions in this in vitro culture...
  54. ncbi request reprint Chondroitin sulfate reduces the friction coefficient of articular cartilage
    Ines M Basalo
    Department of Mechanical Engineering, Columbia University, 500 West 120th Street, 220 SW Mudd, MC 4703, New York, NY 10027, USA
    J Biomech 40:1847-54. 2007
    ..These results suggest that direct injection of CS into the joint may provide beneficial tribological effects...
  55. pmc Effect of dynamic loading on the transport of solutes into agarose hydrogels
    Nadeen O Chahine
    Biomechanics and Bioengineering Research Laboratory, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    Biophys J 97:968-75. 2009
    ....
  56. pmc Dynamic loading of deformable porous media can induce active solute transport
    Michael B Albro
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 41:3152-7. 2008
    ..Upon cessation of loading, the concentration reverts back to that achieved under passive diffusion. Thus, active solute transport in porous media can indeed be mediated by cyclical mechanical loading...
  57. pmc Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term culture
    Liming Bian
    Cellular Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 42:286-90. 2009
    ..Based on this adverse outcome the hypothesis of this study is rejected, dampening our enthusiasm for the use of intra-articular CS injections as a prophylactic treatment in osteoarthritis...
  58. ncbi request reprint Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral disc
    Yoshimasa Ishii
    Department of Orthopaedic Surgery, Columbia University, New York, NY, USA
    Spine (Phila Pa 1976) 31:1539-46. 2006
    ....
  59. ncbi request reprint Spatially varying material properties of the rat caudal intervertebral disc
    Mandy M Ho
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Spine (Phila Pa 1976) 31:E486-93. 2006
    ..The use of a microscopy based material testing technique to assess the local material properties of rat caudal intervertebral discs under uniaxial compression...
  60. pmc Characterization of the structure-function relationship at the ligament-to-bone interface
    Kristen L Moffat
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 105:7947-52. 2008
    ..The interface structure-function relationship elucidated in this study provides critical insight for interface regeneration and the formation of complex tissue systems...
  61. ncbi request reprint Effects of applied DC electric field on ligament fibroblast migration and wound healing
    Pen Hsiu Grace Chao
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Connect Tissue Res 48:188-97. 2007
    ..Our results demonstrate that applied EFs augment ACL fibroblast migration and biosynthesis and provide potential mechanisms by which EFs may be used for enhancing ligament healing and repair...
  62. ncbi request reprint Optimization of Schwann cell adhesion in response to shear stress in an in vitro model for peripheral nerve tissue engineering
    Dara Chafik
    Department of Orthopedic Surgery, University of California, Irvine, Irvine, California 92657, USA
    Tissue Eng 9:233-41. 2003
    ..As mechanical stress is an integral part of the host environment, our study is the first to incorporate this factor into an in vitro model for peripheral nerve tissue engineering...
  63. ncbi request reprint Shear stress alters the expression of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in Schwann cells
    Ranjan Gupta
    Peripheral Nerve Research Lab, Department of Orthopedic Surgery, University of California, Irvine, CA 92697, USA
    J Orthop Res 23:1232-9. 2005
    ..035) and 35% (p<.02), respectively. This study provides novel information regarding Schwann cell direct response to this physical stimulus that is not secondary to an axonal injury...

Research Grants26

  1. Intervertebral Disc Response to Cyclic Loading in Vivo
    CLARK HUNG; Fiscal Year: 2005
    ..abstract_text> ..
  2. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2007
    ..4) Deformational loading will promote less construct surface roughness and better frictional properties than free-swelling constructs. ..
  3. Chondrocyte Mechanotransduction Using Microfluidics
    CLARK HUNG; Fiscal Year: 2007
    ....
  4. Chondrocyte Mechanotransduction Using Microfluidics
    CLARK HUNG; Fiscal Year: 2009
    ....
  5. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    Clark T Hung; Fiscal Year: 2010
    ..A clinically relevant algorithm derived from translational evidence for guiding decisions regarding indications for current and future cartilage repair strategies would be invaluable to surgeons. ..
  6. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    Clark T Hung; Fiscal Year: 2010
    ....
  7. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    CLARK HUNG; Fiscal Year: 2003
    ..Currently, OA affects 5 percent of the general population and 70 percent of the population over age 65 and costs nearly 8 billion dollars annually in health care. ..
  8. Novel Determination Of Chondrocyte Material Properties
    CLARK HUNG; Fiscal Year: 2004
    ..Successful implementation of the aforementioned will permit new research questions regarding the role of biomechanical influences in the development and progression of OA to be addressed. ..
  9. PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERING
    Clark T Hung; Fiscal Year: 2010
    ..A clinically relevant algorithm derived from translational evidence for guiding decisions regarding indications for current and future cartilage repair strategies would be invaluable to surgeons. ..