Lawrence S Honig

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Association of shorter leukocyte telomere repeat length with dementia and mortality
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 69:1332-9. 2012
  2. ncbi request reprint Natural history of Alzheimer's disease
    L S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, and Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032 3795, USA
    Aging (Milano) 13:171-82. 2001
  3. pmc Translational research in neurology: dementia
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, New York, New York, USA
    Arch Neurol 69:969-77. 2012
  4. ncbi request reprint Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain and the Gertrude H Sergievsky Center, New York, NY, USA
    Ann Neurol 60:181-7. 2006
  5. ncbi request reprint Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 64:494-500. 2005
  6. ncbi request reprint Alzheimer's disease
    L S Honig
    Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Alzheimer s Disease Research Center, Department of Neurology, New York, NY 10032, USA
    Sci Aging Knowledge Environ 2001:dn2. 2001
  7. ncbi request reprint Frontotemporal dementia
    Lawrence S Honig
    Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, and the Department of Neurology, New York, NY 10032, USA
    Sci Aging Knowledge Environ 2003:DN1. 2003
  8. pmc Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 24:1600-5. 2009
  9. pmc Reduced Purkinje cell number in essential tremor: a postmortem study
    Jordan E Axelrad
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Arch Neurol 65:101-7. 2008
  10. pmc Relation between leukocyte telomere length and incident coronary heart disease events (from the 1995 Canadian Nova Scotia Health Survey)
    Siqin Ye
    Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University, New York, NY, USA
    Am J Cardiol 111:962-7. 2013

Detail Information

Publications38

  1. pmc Association of shorter leukocyte telomere repeat length with dementia and mortality
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 69:1332-9. 2012
    ..Shortening of chromosomal telomeres is a consequence of cell division and is a biological factor related to cellular aging and potentially to more rapid organismal biological aging...
  2. ncbi request reprint Natural history of Alzheimer's disease
    L S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, and Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032 3795, USA
    Aging (Milano) 13:171-82. 2001
    ..We also discuss the more advanced stages of AD, and address factors that may influence disease course. Understanding the natural history of AD will allow better targeting of the disease-modifying treatments that are on the horizon...
  3. pmc Translational research in neurology: dementia
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, New York, New York, USA
    Arch Neurol 69:969-77. 2012
    ....
  4. ncbi request reprint Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain and the Gertrude H Sergievsky Center, New York, NY, USA
    Ann Neurol 60:181-7. 2006
    ..Reduced telomere length may be a marker of biological aging. We hypothesized that telomere length might thus relate to increased risk for dementia and mortality...
  5. ncbi request reprint Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 64:494-500. 2005
    ..This investigation examined the association between cerebrovascular disease and the pathologic manifestations of AD in an autopsy series...
  6. ncbi request reprint Alzheimer's disease
    L S Honig
    Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Alzheimer s Disease Research Center, Department of Neurology, New York, NY 10032, USA
    Sci Aging Knowledge Environ 2001:dn2. 2001
    ..Throughout the limbic system and neocortex of the patient were large numbers of senile plaques and neurofibrillary tangles, the pathological hallmarks of AD...
  7. ncbi request reprint Frontotemporal dementia
    Lawrence S Honig
    Columbia University College of Physicians and Surgeons, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, and the Department of Neurology, New York, NY 10032, USA
    Sci Aging Knowledge Environ 2003:DN1. 2003
    ....
  8. pmc Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 24:1600-5. 2009
    ..Although torpedoes are increased in AD and PD, as well as cerebellar ET, the magnitude of increase in cerebellar ET is greater, and cannot be accounted for by concomitant AD or PD pathology...
  9. pmc Reduced Purkinje cell number in essential tremor: a postmortem study
    Jordan E Axelrad
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Arch Neurol 65:101-7. 2008
    ..In recent postmortem studies, we documented increased numbers of torpedoes (Purkinje cell axonal swellings) in ET patients without Lewy bodies. Purkinje cell loss, however, has never been rigorously assessed...
  10. pmc Relation between leukocyte telomere length and incident coronary heart disease events (from the 1995 Canadian Nova Scotia Health Survey)
    Siqin Ye
    Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University, New York, NY, USA
    Am J Cardiol 111:962-7. 2013
    ..25, 95% confidence interval 0.82 to 1.90, p = 0.30). In conclusion, these findings do not support a linear association between leukocyte telomere length and incident CHD risk in the general population...
  11. pmc Seizures in Alzheimer disease: who, when, and how common?
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, 622 W 168 St, PH Bldg, 19th Floor, New York, NY 10032, USA
    Arch Neurol 66:992-7. 2009
    ..The incidence of seizures in AD and predictors of which patients with AD might be more predisposed to them is based primarily on retrospective studies and is not well established...
  12. pmc Older onset essential tremor: More rapid progression and more degenerative pathology
    Elan D Louis
    GH Sergievsky Center, Columbia University, New York, New York, USA
    Mov Disord 24:1606-12. 2009
    ..In a brain bank, older age of onset was associated with more degenerative pathology in the cerebellum. As in several neurodegenerative disorders, in older onset cases, it is possible that the disease advances more rapidly...
  13. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  14. pmc Clinical and pathological characteristics of LRRK2 G2019S patients with PD
    Markos Poulopoulos
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Mol Neurosci 47:139-43. 2012
    ..However, the extent of cortical involvement is variable. Larger longitudinal follow-up of LRRK2 G2019S mutation carriers is required to assess for risk factors for cortical involvement and dementia...
  15. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  16. pmc RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
    David A MacLeod
    Department of Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USA
    Neuron 77:425-39. 2013
    ..Expression of wild-type VPS35, but not a familial PD-associated mutant form, rescued these defects. Taken together, these studies implicate retromer and lysosomal pathway alterations in PD risk...
  17. pmc Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performance
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuroimage 23:35-45. 2004
    ..Expression of covariance patterns correlates with cognitive and functional performance measures, holding promise for meaningful associations with underlying biopathological processes...
  18. pmc Seizures and epilepsy in Alzheimer's disease
    Daniel Friedman
    New York University Comprehensive Epilepsy Center, New York, NY 10016, USA
    CNS Neurosci Ther 18:285-94. 2012
    ..We conclude that the literature on seizures and epilepsy in AD, including diagnosis, risk factors, and response to treatment suffers from methodological limitations and gaps...
  19. pmc Depressive symptoms, vascular risk factors, and Alzheimer's disease
    Jose A Luchsinger
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, USA
    Int J Geriatr Psychiatry 23:922-8. 2008
    ..We sought to determine whether the association between depressive symptoms and AD is explained by a history of vascular risk factors and stroke...
  20. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008
    ..To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD)...
  21. pmc "Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor
    Cordelia R Erickson-Davis
    GH Sergievsky Center, Columbia University, New York, New York, USA
    J Neuropathol Exp Neurol 69:262-71. 2010
    ..These data indicate that structural changes are not restricted to PCs in ET, and that other neurons within their functional network may be involved in its pathogenesis...
  22. doi request reprint Early neuropsychological discriminants for Lewy body disease: an autopsy series
    Hiroshi Yoshizawa
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Neurol Neurosurg Psychiatry 84:1326-30. 2013
    ..To determine which neuropsychological test measures and which symptoms at presentation might best differentiate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD)...
  23. pmc Depressive symptoms are not associated with leukocyte telomere length: findings from the Nova Scotia Health Survey (NSHS95), a population-based study
    Jonathan A Shaffer
    Center for Behavioral Cardiovascular Health, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e48318. 2012
    ....
  24. pmc Association of glucocerebrosidase mutations with dementia with lewy bodies
    Lorraine N Clark
    Taub Institute for Research onAlzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:578-83. 2009
    ..Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders...
  25. ncbi request reprint Dementia with cerebrovascular disease
    Clinton B Wright
    Columbia University College of Physicians and Surgeons, Department of Neurology, New York, NY 10032, USA
    Sci Aging Knowledge Environ 2006:dn1. 2006
    ..In some cases of mixed dementia, the pathological involvement of AD may be the principal contributory cause of the cognitive symptoms, and in others, the vascular changes may give the greater contribution...
  26. ncbi request reprint A case of progressive apraxia of speech in pathologically verified Alzheimer disease
    Elizabeth Gerstner
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    Cogn Behav Neurol 20:15-20. 2007
    ..To present the case of a man with progressive speech loss and other clinical features and diagnostic tests consistent with fronto-temporal dementia but whose postmortem neuropathologic findings revealed Alzheimer disease (AD)...
  27. ncbi request reprint Neuropathological changes in essential tremor: 33 cases compared with 21 controls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA
    Brain 130:3297-307. 2007
    ..The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study...
  28. ncbi request reprint Laboratory biomarkers in Alzheimer's disease
    Joshua R Steinerman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University College of Physician and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 7:381-7. 2007
    ..In this review, we focus on biomarkers in cerebrospinal fluid and plasma, including measurements of the proteins tau and beta-amyloid...
  29. pmc Cognitive reserve-mediated modulation of positron emission tomographic activations during memory tasks in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Arch Neurol 61:73-8. 2004
    ..Epidemiological data and evidence from positron emission tomography suggest that it may be mediated through education or IQ...
  30. pmc Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
    Alim Muhammad
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7327-32. 2008
    ..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis...
  31. doi request reprint Presenting neuropsychological testing profile of autopsy-confirmed frontotemporal lobar degeneration
    Hiroshi Yoshizawa
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, N Y, USA
    Dement Geriatr Cogn Disord 36:279-89. 2013
    ..However, test measures did not discriminate between FTLD-tau and FTLD-ubiquitin. Conclusion: We confirm that memory and language function tests discriminate between FTLD and AD. © 2013 S. Karger AG, Basel. ..
  32. pmc Interplay of LRRK2 with chaperone-mediated autophagy
    Samantha J Orenstein
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 16:394-406. 2013
    ..This newly described LRRK2 self-perpetuating inhibitory effect on CMA could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson's disease-related protein degraded by this pathway...
  33. pmc Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
    Robin B Chan
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 287:2678-88. 2012
    ..Overall, our study highlights the hypothesis generating potential of lipidomics and identifies novel region-specific lipid anomalies potentially linked to AD pathogenesis...
  34. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  35. ncbi request reprint Intention tremor of the head in patients with essential tremor
    Julie Leegwater-Kim
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 21:2001-5. 2006
    ..These patients trended toward having more severe kinetic arm tremor and they had more severe intention tremor of the arms. These observations provide further support for the evolving view that the cerebellum may be involved in ET...
  36. ncbi request reprint Essential tremor associated with pathologic changes in the cerebellum
    Elan D Louis
    Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 W 168th Street, New York, NY 10032, USA
    Arch Neurol 63:1189-93. 2006
    ..Although essential tremor (ET) is one of the most common neurologic disorders, there have been few postmortem studies. We recently reported postmortem changes (torpedoes and Bergmann gliosis) in the cerebellar cortex in a few ET cases...
  37. ncbi request reprint Brain tumor-associated dementia
    James McC Noble
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Sci Aging Knowledge Environ 2005:dn2. 2005
    ..Unlike more common degenerative dementias, however, there was no marked memory involvement. In addition, the onset of illness was rapid and associated with headaches, incontinence, and some gait and motor dysfunction...
  38. ncbi request reprint Stroke and the risk of Alzheimer disease
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, Columbia University, New York
    Arch Neurol 60:1707-12. 2003
    ..Alzheimer disease (AD) and stroke are common in elderly individuals, but the relation between these 2 disorders remains uncertain...