Oliver Hobert

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. Serrano Saiz E, Pereira L, Gendrel M, Aghayeva U, Bhattacharya A, Howell K, et al. A Neurotransmitter Atlas of the Caenorhabditis elegans Male Nervous System Reveals Sexually Dimorphic Neurotransmitter Usage. Genetics. 2017;206:1251-1269 pubmed publisher
    ..Taken together, the male neurotransmitter atlas provides an entry point for future functional and developmental analysis of the male nervous system. ..
  2. Hobert O. Regulation of terminal differentiation programs in the nervous system. Annu Rev Cell Dev Biol. 2011;27:681-96 pubmed publisher
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    Hobert O. Behavioral plasticity in C. elegans: paradigms, circuits, genes. J Neurobiol. 2003;54:203-23 pubmed
    ..Lastly, the review outlines how reverse genetics and genomic approaches can guide the analysis of the role of genes in behavior and why and how they will complement the forward genetic analysis of behavior. ..
  4. Bhattacharya A, Aghayeva U, Berghoff E, Hobert O. Plasticity of the Electrical Connectome of C. elegans. Cell. 2019;176:1174-1189.e16 pubmed publisher
    ..We describe an intersectional gene regulatory mechanism involving terminal selector and FoxO transcription factors mediating dynamic innexin expression plasticity in a neuron-type- and environment-specific manner. ..
  5. Hobert O, Kratsios P. Neuronal identity control by terminal selectors in worms, flies, and chordates. Curr Opin Neurobiol. 2019;56:97-105 pubmed publisher
    ..We will also describe how the terminal selector concept has been expanded by recent work in C. elegans to explain neuronal subtype diversification and plasticity of neuronal identity. ..
  6. Kratsios P, Hobert O. Nervous System Development: Flies and Worms Converging on Neuron Identity Control. Curr Biol. 2018;28:R1154-R1157 pubmed publisher
    ..Studies in worms and flies have revealed that this phenotypic convergence can be brought about by distinct transcription factors regulating the same effector genes in different neuron types. ..
  7. Bayer E, Hobert O. Past experience shapes sexually dimorphic neuronal wiring through monoaminergic signalling. Nature. 2018;561:117-121 pubmed publisher
    ..Our studies demonstrate how life history shapes neurotransmitter production, synaptic connectivity and behavioural output in a sexually dimorphic circuit. ..
  8. Serrano Saiz E, Leyva Díaz E, De La Cruz E, Hobert O. BRN3-type POU Homeobox Genes Maintain the Identity of Mature Postmitotic Neurons in Nematodes and Mice. Curr Biol. 2018;28:2813-2823.e2 pubmed publisher
    ..We conclude that the continuous expression of transcription factors is essential for the active maintenance of the differentiated state of a neuron across phylogeny. ..
  9. Stefanakis N, Carrera I, Hobert O. Regulatory Logic of Pan-Neuronal Gene Expression in C. elegans. Neuron. 2015;87:733-50 pubmed publisher
    ..Neuron-type-specific genes are generally controlled by discrete and non-redundantly acting regulatory inputs, while pan-neuronal gene expression is controlled by diverse, coincident and seemingly redundant regulatory inputs. ..

More Information

Publications23

  1. Arlotta P, Hobert O. Homeotic Transformations of Neuronal Cell Identities. Trends Neurosci. 2015;38:751-62 pubmed publisher
    ..The concept of homeosis provides a framework for the evolution of cell type diversity in the brain. ..
  2. Howell K, Hobert O. Morphological Diversity of C. elegans Sensory Cilia Instructed by the Differential Expression of an Immunoglobulin Domain Protein. Curr Biol. 2017;27:1782-1790.e5 pubmed publisher
    ..Levels of OIG-8 expression are controlled by the specific combination of a terminal selector type of transcription factors that also specify other identity features of distinct olfactory neuron types. ..
  3. Serrano Saiz E, Oren Suissa M, Bayer E, Hobert O. Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor. Curr Biol. 2017;27:199-209 pubmed publisher
    ..Taken together, our studies provide mechanistic insights into how neurons are specified in a sexually dimorphic manner. ..
  4. Kerk S, Kratsios P, Hart M, Mourao R, Hobert O. Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression. Neuron. 2017;93:80-98 pubmed publisher
    ..The strategy of antagonizing the activity of broadly acting terminal selectors of neuron identity in a subtype-specific fashion may constitute a general principle of neuron subtype diversification. ..
  5. Hobert O. Terminal Selectors of Neuronal Identity. Curr Top Dev Biol. 2016;116:455-75 pubmed publisher
    ..elegans system such as coregulation of terminal effector batteries, combinatorial control mechanisms, and the coupling of initiation and maintenance of neuronal identity. ..
  6. Howell K, Hobert O. Small Immunoglobulin Domain Proteins at Synapses and the Maintenance of Neuronal Features. Neuron. 2016;89:239-41 pubmed publisher
    ..In this issue of Neuron, Cherra and Jin (2016) characterize a small, two-Ig domain protein, ZIG-10, and its role in maintaining synaptic density in a specific set of C. elegans neurons. ..
  7. Hart M, Hobert O. Sexual Dimorphism: Mystery Neurons Control Sex-Specific Behavioral Plasticity. Curr Biol. 2015;25:R1170-2 pubmed publisher
    ..A recent study describes a pair of newly discovered, male-specific neurons in C. elegans that control a sex-specific learning behavior termed sexual conditioning. ..
  8. Weinberg P, Berkseth M, Zarkower D, Hobert O. Sexually Dimorphic unc-6/Netrin Expression Controls Sex-Specific Maintenance of Synaptic Connectivity. Curr Biol. 2018;28:623-629.e3 pubmed publisher
    ..Taken together, intersectional transcriptional regulation of unc-6/Netrin is required and sufficient to cell autonomously pattern sexually dimorphic synapses. ..
  9. Gordon P, Hobert O. A competition mechanism for a homeotic neuron identity transformation in C. elegans. Dev Cell. 2015;34:206-19 pubmed publisher
    ..Homeotic control of neuronal identity programs has implications for the evolution of neuronal cell types. ..
  10. Kratsios P, Pinan Lucarré B, Kerk S, Weinreb A, Bessereau J, Hobert O. Transcriptional coordination of synaptogenesis and neurotransmitter signaling. Curr Biol. 2015;25:1282-95 pubmed publisher
    ..Our study shows how synaptogenesis and distinct, function-defining signaling features of a postmitotic neuron are hardwired together through coordinated transcriptional control. ..
  11. Hobert O, Glenwinkel L, White J. Revisiting Neuronal Cell Type Classification in Caenorhabditis elegans. Curr Biol. 2016;26:R1197-R1203 pubmed publisher
    ..elegans nervous system. Neuron classification in C. elegans may be paradigmatic for neuron classification schemes in vertebrate nervous systems. ..
  12. Murgan S, Kari W, Rothbächer U, Iché Torres M, Mélénec P, Hobert O, et al. Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors. Dev Cell. 2015;33:737-45 pubmed publisher
    ..This mechanism is later reinforced by specific bHLH factors. This study reveals an atypical mode of action for TCF that may apply to other binary decisions mediated by Wnt signaling. ..
  13. Vogt M, Hobert O. Olfactory Imprinting: A Worm's Memory of Things Past. Curr Biol. 2017;27:R1108-R1110 pubmed publisher
    ..A new study in Caenorhabditis elegans demonstrates that changes in neuronal activity of one synaptic connection following early-life pheromone exposure are sufficient to permanently enhance specific avoidance responses...
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    Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000;16:75-83 pubmed
    ..Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements. ..