Affiliation: Columbia University
- Arlotta P, Hobert O. Homeotic Transformations of Neuronal Cell Identities. Trends Neurosci. 2015;38:751-62 pubmed publisher..The concept of homeosis provides a framework for the evolution of cell type diversity in the brain. ..
- Howell K, Hobert O. Morphological Diversity of C. elegans Sensory Cilia Instructed by the Differential Expression of an Immunoglobulin Domain Protein. Curr Biol. 2017;27:1782-1790.e5 pubmed publisher..Levels of OIG-8 expression are controlled by the specific combination of a terminal selector type of transcription factors that also specify other identity features of distinct olfactory neuron types. ..
- Serrano Saiz E, Oren Suissa M, Bayer E, Hobert O. Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor. Curr Biol. 2017;27:199-209 pubmed publisher..Taken together, our studies provide mechanistic insights into how neurons are specified in a sexually dimorphic manner. ..
- Kerk S, Kratsios P, Hart M, Mourao R, Hobert O. Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression. Neuron. 2017;93:80-98 pubmed publisher..The strategy of antagonizing the activity of broadly acting terminal selectors of neuron identity in a subtype-specific fashion may constitute a general principle of neuron subtype diversification. ..
- Hobert O. Terminal Selectors of Neuronal Identity. Curr Top Dev Biol. 2016;116:455-75 pubmed publisher..elegans system such as coregulation of terminal effector batteries, combinatorial control mechanisms, and the coupling of initiation and maintenance of neuronal identity. ..
- Howell K, Hobert O. Small Immunoglobulin Domain Proteins at Synapses and the Maintenance of Neuronal Features. Neuron. 2016;89:239-41 pubmed publisher..In this issue of Neuron, Cherra and Jin (2016) characterize a small, two-Ig domain protein, ZIG-10, and its role in maintaining synaptic density in a specific set of C.Â elegans neurons. ..
- Hart M, Hobert O. Sexual Dimorphism: Mystery Neurons Control Sex-Specific Behavioral Plasticity. Curr Biol. 2015;25:R1170-2 pubmed publisher..A recent study describes a pair of newly discovered, male-specific neurons in C. elegans that control a sex-specific learning behavior termed sexual conditioning. ..
- Weinberg P, Berkseth M, Zarkower D, Hobert O. Sexually Dimorphic unc-6/Netrin Expression Controls Sex-Specific Maintenance of Synaptic Connectivity. Curr Biol. 2018;28:623-629.e3 pubmed publisher..Taken together, intersectional transcriptional regulation of unc-6/Netrin is required and sufficient to cell autonomously pattern sexually dimorphic synapses. ..
- Gordon P, Hobert O. A competition mechanism for a homeotic neuron identity transformation in C. elegans. Dev Cell. 2015;34:206-19 pubmed publisher..Homeotic control of neuronal identity programs has implications for the evolution of neuronal cell types. ..
- Kratsios P, Pinan LucarrÃ© B, Kerk S, Weinreb A, Bessereau J, Hobert O. Transcriptional coordination of synaptogenesis and neurotransmitter signaling. Curr Biol. 2015;25:1282-95 pubmed publisher..Our study shows how synaptogenesis and distinct, function-defining signaling features of a postmitotic neuron are hardwired together through coordinated transcriptional control. ..
- Hobert O, Glenwinkel L, White J. Revisiting Neuronal Cell Type Classification in Caenorhabditis elegans. Curr Biol. 2016;26:R1197-R1203 pubmed publisher..elegans nervous system. Neuron classification in C. elegans may be paradigmatic for neuron classification schemes in vertebrate nervous systems. ..
- Murgan S, Kari W, RothbÃ¤cher U, IchÃ© Torres M, MÃ©lÃ©nec P, Hobert O, et al. Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C.Â elegans Neuronal Precursors. Dev Cell. 2015;33:737-45 pubmed publisher..This mechanism is later reinforced by specific bHLH factors. This study reveals an atypical mode of action for TCF that may apply to other binary decisions mediated by Wnt signaling. ..
- Vogt M, Hobert O. Olfactory Imprinting: A Worm's Memory of Things Past. Curr Biol. 2017;27:R1108-R1110 pubmed publisher..A new study in Caenorhabditis elegans demonstrates that changes in neuronal activity of one synaptic connection following early-life pheromone exposure are sufficient to permanently enhance specific avoidance responses...
- Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000;16:75-83 pubmed..Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements. ..