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Genomes and Genes | Oliver HobertSummaryAffiliation: Columbia University Country: USA Publications
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Functions of LIM-homeobox genesO Hobert
Columbia University, College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics, 701 W 168th Street, New York, NY 10032, USA
Trends Genet 16:75-83. 2000..Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements...
The impact of whole genome sequencing on model system genetics: get ready for the rideOliver Hobert
Columbia University Medical Center, Howard Hughes Medical Institute, New York, New York 10032, USA
Genetics 184:317-9. 2010....- MicroRNAs: all gone and then what?Oliver Hobert
Department of Biochemistry and Molecular Physics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Curr Biol 15:R387-9. 2005..A new study reports the genetic elimination of miRNA function on a full genomic scale and identifies a subfamily of miRNAs involved in brain morphogenesis... - The molecular and gene regulatory signature of a neuronOliver Hobert
Columbia University Medical Center, Howard Hughes Medical Institute, New York, NY, USA
Trends Neurosci 33:435-45. 2010..The theoretical concepts discussed here provide testable hypotheses for future experimental analysis of the exact gene-regulatory mechanisms employed in the generation of neuronal diversity and identity... 
Gene regulation: enhancers stepping out of the shadowOliver Hobert
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Curr Biol 20:R697-9. 2010..Such enhancer redundancy ensures robustness of gene expression under adverse environmental or genetic conditions...- Regulatory logic of neuronal diversity: terminal selector genes and selector motifsOliver Hobert
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Proc Natl Acad Sci U S A 105:20067-71. 2008..The simplicity of the cis-regulatory logic on which the terminal selector gene concept is based may contribute to the evolvability of neuronal diversity... - Development and maintenance of neuronal architecture at the ventral midline of C. elegansOliver Hobert
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Curr Opin Neurobiol 13:70-8. 2003..Furthermore, a conceptually new mechanism that regulates the maintenance of axon positioning at the midline has been described in C. elegans... - Maintaining a memory by transcriptional autoregulationOliver Hobert
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Curr Biol 21:R146-7. 2011..Maintaining gene expression patterns in the nervous system is a particular challenge given the non-renewing nature and therefore extensive life span of many neuronal cell types... - Common logic of transcription factor and microRNA actionOliver Hobert
Columbia University Medical Center, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, New York, NY 10032, USA
Trends Biochem Sci 29:462-8. 2004..Just as the set of TFs in a given cell type has been proposed to constitute a 'code' that specifies cellular differentiation, so 'miRNA codes' are likely to have conceptually similar roles in the specification of cell types... - miRNAs play a tuneOliver Hobert
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Cell 131:22-4. 2007..2007; Karres et al., 2007). Furthermore, these studies illustrate the involvement of miRNAs in tuning the expression of target genes to physiologically relevant levels... - PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegansOliver Hobert
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Biotechniques 32:728-30. 2002 - Regulation of terminal differentiation programs in the nervous systemOliver Hobert
Howard Hughes Medical Institute, New York, NY 10032, USA
Annu Rev Cell Dev Biol 27:681-96. 2011.... - Gene regulation by transcription factors and microRNAsOliver Hobert
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Science 319:1785-6. 2008..Here, I review common principles of transcription factor- and microRNA-mediated gene regulatory events and discuss conceptual differences in how these factors control gene expression... - Behavioral plasticity in C. elegans: paradigms, circuits, genesOliver Hobert
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Neurobiol 54:203-23. 2003..Lastly, the review outlines how reverse genetics and genomic approaches can guide the analysis of the role of genes in behavior and why and how they will complement the forward genetic analysis of behavior... - Genetic screens for Caenorhabditis elegans mutants defective in left/right asymmetric neuronal fate specificationSumeet Sarin
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 W 168th Street, New York, NY 10032, USA
Genetics 176:2109-30. 2007..Taken together, our mutant screens identified a broad catalog of genes whose molecular characterization is expected to provide more insight into the complex genetic architecture of a left/right asymmetric neuronal cell fate decision... - An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C. elegansRobert J Johnston
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 W 168th Street, New York, NY 10032, USA
Development 133:3317-28. 2006..These network motifs endow the system with properties that provide insights into how cells adopt their stable terminally differentiated states... - Neuron-type specific regulation of a 3'UTR through redundant and combinatorially acting cis-regulatory elementsDominic Didiano
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
RNA 16:349-63. 2010..The features of 3'UTR regulation we describe here may apply to some of the vast number of genes in animal genomes whose expression is predicted to be regulated through their 3'UTR... - Cis-regulatory mechanisms of left/right asymmetric neuron-subtype specification in C. elegansJohn F Etchberger
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032, USA
Development 136:147-60. 2009..It also suggests that feed-forward loop motifs may be a prominent feature of neuronal diversification events... - Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclasesChristopher O Ortiz
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Genetics 173:131-49. 2006..In sum, our results indicate the existence of a surprising multitude of putative chemoreceptors in the gustatory ASE neurons and suggest the existence of a substantial degree of laterality in gustatory signaling mechanisms in nematodes... - Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal developmentM Maggie O'Meara
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Genetics 181:1679-86. 2009..The multiplicity of cis-regulatory elements may ensure the robustness of gene expression... - Direct conversion of C. elegans germ cells into specific neuron typesBaris Tursun
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Science 331:304-8. 2011..Our findings illustrate the ability of germ cells to be directly converted into individual, terminally differentiated neuron types and demonstrate that a specific chromatin factor provides a barrier for cellular reprogramming... - Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cordOscar Aurelio
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Development 130:599-610. 2003..Our findings illustrate the importance of spatial and temporal control of gene expression in the nervous system and, furthermore, implicate heterochronic genes in postmitotic neural patterning events... - The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegansEileen B Flowers
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, Columbia University, New York, NY 10032, USA
Development 137:1799-805. 2010..We propose that Groucho-mediated gene regulatory events involve heteromeric complexes of distinct Groucho-like proteins... - The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversificationSumeet Sarin
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 W 168th Street, New York, NY 10032, USA
Development 136:2933-44. 2009.... - The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegansClaire Bénard
Department of Biochemistry, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
Genetics 183:917-27. 2009..elegans ortholog of the human L1 protein. Our studies shed further light on the use of dedicated factors to maintain nervous system architecture and corroborate the complexity of the mechanisms involved... - A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23Nehal Mehta
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Genetics 166:1253-67. 2004..We have thus defined separable activities of LIN-23 in two distinct processes, cell cycle control and axon patterning. We propose that LIN-23 targets distinct substrates for ubiquitination within each process... - Hypoxia activates a latent circuit for processing gustatory information in C. elegansRoger Pocock
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York, USA
Nat Neurosci 13:610-4. 2010..Thus, physiological detection of hypoxia results in the activation of an additional, previously unrecognized circuit for processing sensory information that is not required for sensory processing under normoxic conditions... - Gene regulatory logic of dopamine neuron differentiationNuria Flames
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Nature 458:885-9. 2009..Our studies reveal a simple and apparently conserved regulatory logic of dopamine neuron terminal differentiation and may provide new entry points into the diagnosis or therapy of conditions in which dopamine neurons are defective... - Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegansRoger Pocock
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
Nat Neurosci 11:894-900. 2008..Similar genetic pathways may cause aberrant human brain development under hypoxic conditions... - A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegansSarah Chang
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Genes Dev 17:2123-37. 2003..Our studies have thus identified transcriptional mediators of a putative L/R-asymmetric signaling event and suggest that vertebrate homologs of these proteins may have similar functions in regulating vertebrate brain asymmetries... - Analysis of multiple ethyl methanesulfonate-mutagenized Caenorhabditis elegans strains by whole-genome sequencingSumeet Sarin
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
Genetics 185:417-30. 2010..elegans community to study gene function... - Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegansAdam S Wenick
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032, USA
Dev Cell 6:757-70. 2004..The identity of these homeodomain targets provides novel insights into the biology of the AIY interneuron... - A C. elegans CLIC-like protein required for intracellular tube formation and maintenanceKatherine L Berry
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Science 302:2134-7. 2003..A conserved 55-amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance... - A left/right asymmetric neuronal differentiation program is controlled by the Caenorhabditis elegans lsy-27 zinc-finger transcription factorFeifan Zhang
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Genetics 188:753-9. 2011..lsy-27 is broadly and exclusively expressed in the embryo and acts during the initiation, but not during the maintenance phase of ASE asymmetry control to assist in the initiation of lim-6 expression... - MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematodeSarah Chang
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University Medical Center, 701 W 168th Street, New York 10032, USA
Nature 430:785-9. 2004..Thus, an inverse distribution of two sequentially acting miRNAs in two bilaterally symmetric neurons controls laterality of the nematode chemosensory system... - A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegansRichard J Poole
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York, USA
PLoS Genet 7:e1002109. 2011..The results of this analysis provide a starting point for future studies that will eventually lead to a more complete understanding of how individual neuronal cell types are generated from a single-cell embryo... - The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuronJohn F Etchberger
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Genes Dev 21:1653-74. 2007..Taken together, our results provide a unique view of the molecular landscape of a single neuron type and reveal an important aspect of the regulatory logic for gustatory neuron specification in C. elegans... - A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegansPaula M Loria
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Neurosci 24:2191-201. 2004.... - Mapping functional domains of chloride intracellular channel (CLIC) proteins in vivoKatherine L Berry
Department of Biochemistry and Molecular Biophysics Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
J Mol Biol 359:1316-33. 2006..The PTM region thus provides both targeting information and CLIC functional specificity, possibly adapting GST-type proteins to function as ion channels... - A novel C. elegans zinc finger transcription factor, lsy-2, required for the cell type-specific expression of the lsy-6 microRNARobert J Johnston
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032, USA
Development 132:5451-60. 2005.... - LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous systemEphraim L Tsalik
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Dev Biol 263:81-102. 2003..Lastly, we analyze a mutant allele of the ser-2 tyramine receptor, a target of the ttx-3 Lhx gene in the AIY interneuron class. ser-2 mutants display none of the defects previously shown to be associated with loss of AIY function... - Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1Roger Pocock
Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Mol Cell Neurosci 37:56-68. 2008..Lastly, we show that of the several protein binding motifs present in the intracellular region of SAX-7, only its ankyrin binding motif is required and also solely sufficient to confer the adhesive functions of SAX-7... - Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector genePaschalis Kratsios
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York, USA
Nat Neurosci 15:205-14. 2012..Thus, UNC-3 is a terminal selector for cholinergic motor neuron differentiation whose function is conserved across phylogeny... - Molecular architecture of a miRNA-regulated 3' UTRDominic Didiano
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
RNA 14:1297-317. 2008..The large number of 3' UTRs that we analyzed in this study will also be useful to computational biologists in designing the next generation of miRNA/target prediction algorithms... - C. elegans mutant identification with a one-step whole-genome-sequencing and SNP mapping strategyMaria Doitsidou
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York, United States of America
PLoS ONE 5:e15435. 2010..We find that the molecular lesion resides in the Pax-6/Eyeless ortholog vab-3. The strategy described here will further reduce the time between mutant isolation and identification of the molecular lesion... - A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost functionThomas Boulin
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Curr Biol 16:1871-83. 2006..Their function during development, if any, is not known... - Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene kal-1Hannes E Bülow
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 99:6346-51. 2002..We hypothesize that KAL-1 binds by means of a heparan sulfate proteoglycan to its cognate receptor or other extracellular cues to induce axonal branching and axon misrouting... - Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegansEphraim L Tsalik
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurobiol 56:178-97. 2003..AIY, AIZ, and RIB are the first interneurons directly implicated in chemosensory signaling. Our neuronal mapping studies provide the framework for further genetic and functional dissections of neuronal circuits in C. elegans... - A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegansRobert J Johnston
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 701 W 168th Street, New York, New York 10032, USA
Nature 426:845-9. 2003..lsy-6 is the first microRNA to our knowledge with a role in neuronal patterning, providing new insights into left/right axis formation... - MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decisionRobert J Johnston
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:12449-54. 2005..The interaction of miRNAs in double-negative feedback loops may not only be a means for miRNAs to regulate their own expression but may also represent a general paradigm for how terminal cell fates are selected and stabilized... - Embryonic priming of a miRNA locus predetermines postmitotic neuronal left/right asymmetry in C. elegansLuisa Cochella
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Cell 151:1229-42. 2012..This study shows how cells can become committed during early developmental stages to execute a specific fate much later in development and provides a conceptual framework for understanding the generation of neuronal diversity... - Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclasesChristopher O Ortiz
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Curr Biol 19:996-1004. 2009..The extent of functional lateralization of the ASE neurons and genes responsible for the left/right asymmetric activity of ASEL and ASER is unknown... - Lineage programming: navigating through transient regulatory states via binary decisionsVincent Bertrand
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Curr Opin Genet Dev 20:362-8. 2010..A similar cell fate specification system seems to play a role in generating cellular diversity in the nervous system of more complex organisms such as Drosophila and vertebrates... - Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon positionHannes E Bülow
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Neuron 42:367-74. 2004..An engineered, secreted form of EGL-15(5A) containing only its ectodomain is sufficient for maintenance of axon position, thus providing novel insights into receptor tyrosine kinase function and the process of maintaining axon position... - Looking beyond development: maintaining nervous system architectureClaire Bénard
Department of Biochemistry, Howard Hughes Medical Institute, Columbia University Medical Center, New York, USA
Curr Top Dev Biol 87:175-94. 2009..Here, we discuss different molecules underlying these neuronal maintenance mechanisms, with a focus on lessons learned from the nematode Caenorhabditis elegans... - Developmental control of lateralized neuron size in the nematode Caenorhabditis elegansAndrew D Goldsmith
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Neural Dev 5:33. 2010.... - A toolkit and robust pipeline for the generation of fosmid-based reporter genes in C. elegansBaris Tursun
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York, United States of America
PLoS ONE 4:e4625. 2009..We describe other applications of fosmid recombineering as well. The simplicity, speed and robustness of the recombineering pipeline described here should prompt the routine use of this strategy for expression studies in C. elegans... - Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneuronsVincent Bertrand
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Curr Biol 21:1225-31. 2011.... - Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegansVincent Bertrand
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
Dev Cell 16:563-75. 2009..Our study establishes how transient lineage and asymmetric division inputs are integrated and suggests that the Wnt/beta-catenin pathway is widely used to control the identity of neuronal lineages... - Differential sulfations and epimerization define heparan sulfate specificity in nervous system developmentHannes E Bülow
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032 USA
Neuron 41:723-36. 2004..Our results demonstrate that the molecular diversity in HS encodes information that is crucial for different aspects of neuronal development... 
CisOrtho: a program pipeline for genome-wide identification of transcription factor target genes using phylogenetic footprintingHenry R Bigelow
Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
BMC Bioinformatics 5:27. 2004..It is important to develop methods that will reveal how these transcription factors act on a genome wide level, that is, through what target genes they exert their function...- Uses of GFP in Caenorhabditis elegansOliver Hobert
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Methods Biochem Anal 47:203-26. 2006 - Comparing platforms for C. elegans mutant identification using high-throughput whole-genome sequencingYufeng Shen
Department of Computer Science, Columbia University, New York, New York, United States of America
PLoS ONE 3:e4012. 2008..Whole-genome sequencing represents a promising approach to pinpoint chemically induced mutations in genetic model organisms, thereby short-cutting time-consuming genetic mapping efforts... - Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organizationOscar Aurelio
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Science 295:686-90. 2002..Dedicated axon maintenance mechanisms may be widely used to ensure the preservation of functional neuronal circuitries... - DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architectureClaire Y Benard
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Development 133:3329-40. 2006..We propose that DIG-1 is a component of the basement membrane that mediates specific contacts between cellular surfaces and their environment through the interaction with a cell-type specific set of other maintenance factors... - Caenorhabditis elegans mutant allele identification by whole-genome sequencingSumeet Sarin
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
Nat Methods 5:865-7. 2008..elegans genome and thus pinpointed a single-nucleotide mutation in the genome that affects a neuronal cell fate decision. This constitutes a proof-of-principle for using whole-genome sequencing to analyze C. elegans mutants... - Transcriptional control of the terminal fate of monoaminergic neuronsNuria Flames
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
Annu Rev Neurosci 34:153-84. 2011.... - Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmissionPaula M Loria
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
Curr Biol 13:1317-23. 2003..elegans homolog of ELAV, is required for the fine tuning of synaptic transmission. These findings thus provide a novel molecular link between pre-mRNA splicing and presynaptic function... - Left-right asymmetry in the nervous system: the Caenorhabditis elegans modelOliver Hobert
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Nat Rev Neurosci 3:629-40. 2002 - Automated screening for mutants affecting dopaminergic-neuron specification in C. elegansMaria Doitsidou
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Nat Methods 5:869-72. 2008..This methodology is considerably more efficient than comparable manual screens and enabled us to isolate mutants in which dopamine neurons do not differentiate appropriately... - Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiationXinzhu Deng
Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Nat Genet 36:906-12. 2004..These studies indicate that ABL-1 distinguishes proapoptotic signals triggered by two different DNA-damaging agents and suggest that C. elegans might provide tissue models for development of anticancer drugs... - Ezh2 controls B cell development through histone H3 methylation and Igh rearrangementI Hsin Su
Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
Nat Immunol 4:124-31. 2003..Our data suggest Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development... - Early embryonic programming of neuronal left/right asymmetry in C. elegansRichard J Poole
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
Curr Biol 16:2279-92. 2006.... - Perfect seed pairing is not a generally reliable predictor for miRNA-target interactionsDominic Didiano
Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, Howard Hughes Medical Institute, 701 W. 168th Street, New York, New York 10032, USA
Nat Struct Mol Biol 13:849-51. 2006..Rather, lsy-6 can functionally interact with its target site only in specific 3' UTR contexts. Our findings illustrate the difficulty of establishing generalizable rules of miRNA-target interactions... - Vector-free DNA constructs improve transgene expression in C. elegansJohn F Etchberger
Nat Methods 5:3. 2008 - An interneuronal chemoreceptor required for olfactory imprinting in C. elegansJean Jacques Remy
Laboratoire NMDA CNRS UMR 6156, Institut de Biologie du Developpement IBDM, 13288 Marseille Cedex 9, France
Science 309:787-90. 2005..Our study provides insights into the cellular and molecular basis of olfactory imprinting and reveals a function for a chemosensory receptor family member in interneurons... - Oliver HobertOliver Hobert
Curr Biol 16:R233-4. 2006 - Developmental regulation of whole cell capacitance and membrane current in identified interneurons in C. elegansSerge Faumont
Institute of Neuroscience, University of Oregon, Eugene, USA
J Neurophysiol 95:3665-73. 2006..We conclude that AIY interneurons contain distinct pathways for regulating capacitance and membrane current... - New insights into the diversity and function of neuronal immunoglobulin superfamily moleculesGenevieve Rougon
Laboratoire NMDA CNRS UMR 6156, Universite de la Mediterranee, Institut de Biologie du Developpement IBDM, Marseille Cedex 9, 13288 France
Annu Rev Neurosci 26:207-38. 2003..We illustrate that the complexity of IgSF protein function results from various different levels of regulation including regulation of gene expression, protein localization, and protein interactions... - Introduction: behavioral genetics--the third centuryOliver Hobert
J Neurobiol 54:1-3. 2003 - Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1AWilliam B Raich
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Genetics 163:571-80. 2003..Our results suggest that increased gene dosage of human DYRK1A in trisomy 21 may disrupt the function of fully differentiated neurons and that this disruption is reversible... - The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogasterOliver Hobert
Development 131:2237-8; author reply 2238-40. 2004
Research Grants
- Stem Cells and Cell Lineage SpecificationOliver Hobert; Fiscal Year: 2007....
- De-coding Cis-regulatory information on a Genome-Wide Level with Single Neuron ReOliver Hobert; Fiscal Year: 2009..We propose here to systematically decode cis-regulatory information on a genome-wide level and to determine the identity of a single neuron-specific gene expression program. ..
- De-coding Cis-regulatory information on a Genome-Wide Level with Single Neuron ReOliver Hobert; Fiscal Year: 2009..We propose here to systematically decode cis-regulatory information on a genome-wide level and to determine the identity of a single neuron-specific gene expression program. ..
- Diversity Along the Left/Right Axis in Nervous SystemOliver Hobert; Fiscal Year: 2007..Future genetic studies will determine how the asymmetric activity of these gene regulatory factors is triggered. Our studies may provide novel insights into the creation of cellular diversity in the nervous system. ..
- Genetic analysis of dopaminergic neuron specification in C.elegansOliver Hobert; Fiscal Year: 2010..We use genetic approaches in the simple model organism C.elegans to address how the expression of genes that are normally expressed in dopaminergic neurons is regulated. ..
- Function and development of a C. elegans GABAergic interneuronOliver Hobert; Fiscal Year: 2010..elegans (Aim #2). PUBLIC HEALTH RELEVANCE: We propose to study development and function of a single GABAergic interneuron in the nematode C. elegans using a combination of genetic, molecular and physiological approaches. ..
- Genome-wide expression profiling of miRNAs with single cell resolutionOliver Hobert; Fiscal Year: 2006..Moreover, it will (4) validate the "sensor strategy" to determine miRNA expression profiles in C. elegans, and (5) build a toolkit of potentially useful gfp cell fate markers. ..
- LIM HOMEOBOX GENE LIM-6 IN MOTOR NEURON DIFFERENTIATIONOliver Hobert; Fiscal Year: 2004..These studies may give important insights into the function of the vertebrate homologs of lim-6 as well and may reveal common themes of Lhx gene action. ..
- Left/right asymmetric neuronal cell fate specificationOliver Hobert; Fiscal Year: 2006..These studies may reveal fundamental principles of neuronal development and may shed light onto the elusive mechanisms of generating L/R asymmetry in the nervous system...
- Genetic analysis of dopaminergic neuron specification in C.elegansOliver Hobert; Fiscal Year: 2009..We use genetic approaches in the simple model organism C.elegans to address how the expression of genes that are normally expressed in dopaminergic neurons is regulated. ..