Research Topics
| Lawrence J HirschSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Predictors of Lamotrigine-associated rashLawrence J Hirsch
Comprehensive Epilepsy Center, Department of Neurology, Mailman School of Public Health, Columbia University, 710 W 168th Street, NI 1 35, New York, NY 10032, U S A
Epilepsia 47:318-22. 2006..To determine the predictors of lamotrigine-associated rash (LTG-rash) and the incidence of serious and benign LTG-rash to individualize risk assessment in a given patient...- Continuous EEG monitoring in the intensive care unit: an overviewLawrence J Hirsch
Comprehensive Epilepsy Center, Columbia University, 710 West 168th Street, New York, NY 10032, USA
J Clin Neurophysiol 21:332-40. 2004..Real-time detection of ischemia at a reversible stage is technologically feasible with CEEG and should be developed into a practical form for prevention of in-hospital infarction in the near future... 
Intracranial multimodal monitoring for acute brain injury: a single institution review of current practicesR Morgan Stuart
Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neurocrit Care 12:188-98. 2010..Here we review our experience in a consecutive series of acutely brain injured patients who underwent multimodality monitoring...- Intracortical electroencephalography in acute brain injuryAllen Waziri
Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
Ann Neurol 66:366-77. 2009..We hypothesized that bedside placement of an intracortical multicontact electrode would allow for improved monitoring of cortical potentials in critically ill neurological patients... - Intracortical EEG for the detection of vasospasm in patients with poor-grade subarachnoid hemorrhageR Morgan Stuart
Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neurocrit Care 13:355-8. 2010..To study the feasibility of utilizing intracortical electroencephalography (ICE) including quantitative EEG (qEEG) analysis for the detection of vasospasm in five consecutive poor-grade SAH patients... - Generalized convulsive status epilepticus after nontraumatic subarachnoid hemorrhage: the nationwide inpatient sampleJan Claassen
Division of Stroke and Critical Care Neurology and Comprehensive Epilepsy Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Neurosurgery 61:60-4; discussion 64-5. 2007..To identify the frequency of and impact on outcome of generalized convulsive status epilepticus (GCSE) among patients with nontraumatic subarachnoid hemorrhage (SAH)... 
Generalized periodic discharges in the critically ill: a case-control study of 200 patientsBrandon Foreman
Comprehensive Epilepsy Center, Neurological Institute of New York, Columbia University, New York, USA
Neurology 79:1951-60. 2012..Generalized periodic discharges are increasingly recognized on continuous EEG monitoring, but their relationship to seizures and prognosis remains unclear...- Effect of age and comedication on levetiracetam pharmacokinetics and tolerabilityLawrence J Hirsch
Comprehensive Epilepsy Center, Department of Neurology, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Epilepsia 48:1351-9. 2007..To compare pharmacokinetics and tolerability of levetiracetam (LEV) in older versus younger adults... - Continuous electroencephalographic monitoring in critically ill patients with central nervous system infectionsEmmanuel Carrera
Comprehensive Epilepsy Center, Columbia University Medical Center, 710 W 168th St, Box NI 135, New York, NY 10032, USA
Arch Neurol 65:1612-8. 2008..To determine the prevalence, predictors, and clinical significance of electrographic seizures (ESz) and other continuous electroencephalographic monitoring findings in critically ill patients with central nervous system infections... - Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsyHiba Arif
Comprehensive Epilepsy Center, Columbia University, Neurological Institute, 710 W 168th St, New York, NY 10032, USA
Arch Neurol 67:408-15. 2010..To compare the effectiveness of antiepileptic drugs (AEDs) for use in older adults with epilepsy... - Continuous electroencephalogram monitoring in the intensive care unitDaniel Friedman
Department of Neurology, Comprehensive Epilepsy Center, Columbia University, NewYork City, New York, USA
Anesth Analg 109:506-23. 2009..The exact role and cost-effectiveness of cEEG at the current time remains unclear, but we believe it has significant potential to improve neurologic outcomes in a variety of settings... - Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrhageJan Claassen
Division of Stroke and Critical Care Neurology, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Neurocrit Care 4:103-12. 2006..The objective of this study was to determine if continuous electroencephalogram (cEEG) monitoring results are predictive of 3-month outcome in critically ill patients with SAH... - Cyclic electrographic seizures in critically ill patientsDavid E Friedman
Comprehensive Epilepsy Center, Columbia University Medical Center, New York, New York, U S A
Epilepsia 49:281-7. 2008..Compressed displays of EEG frequency spectra (such as compressed spectral array, CSA) can facilitate interpretation of continuous EEG by allowing the reader to observe on a single screen patterns evolving over many minutes or hours... - Efficacy of clobazam as add-on therapy for refractory epilepsy: experience at a US epilepsy centerMaria A Montenegro
Department of Neurology, Comprehensive Epilepsy Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Clin Neuropharmacol 31:333-8. 2008..The objective of this study was to evaluate the usage patterns, efficacy, tolerability, and 1-year retention of CLB in patients with refractory epilepsy seen at a tertiary US epilepsy center... - Focal motor seizures induced by alerting stimuli in critically ill patientsLawrence J Hirsch
Department of Neurology, Comprehensive Epilepsy Center, Neurological Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Epilepsia 49:968-73. 2008.... - Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugsHiba Arif
Comprehensive Epilepsy Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Epilepsy Behav 14:202-9. 2009..They are least likely to be reported with gabapentin, valproate, lamotrigine, carbamazepine, and levetiracetam... - Updates in the management of seizures and status epilepticus in critically ill patientsKarine J Abou Khaled
Department of Neurology, Comprehensive Epilepsy Center, Columbia University, New York, NY 10032, USA
Neurol Clin 26:385-408, viii. 2008..This article discusses specific treatments and specific situations, such as hepatic and renal failure patients and organ transplant patients... - Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disordersSheetal Malik
Comprehensive Epilepsy Center, Columbia University Neurological Institute, Box NI 135, 710 West 168th Street, 7th Floor, New York, NY 10032, USA
Expert Rev Neurother 6:1609-27. 2006..Lamotrigine has demonstrated particular benefit in the treatment of women and elderly patients with epilepsy... - Continuous electroencephalogram monitoring in critically ill patientsNathalie Jette
Comprehensive Epilepsy Center, Columbia University, 710 West 168th Street, Box NI-135, New York, NY 10032, USA
Curr Neurol Neurosci Rep 5:312-21. 2005..This article reviews the indications and recent advances in cEEG in critically ill patients. Continuous brain monitoring with cEEG is rapidly becoming the standard of care in critically ill patients with neurologic impairment... - Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative datasetBrian T Bateman
Columbia Presbyterian Medical College for Physicians and Surgeons, Columbia University, New York, NY, USA
Neurocrit Care 7:187-93. 2007..We examined the occurrence of GCSE in acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) using a large discharge database... - The effect of age and comedication on lamotrigine clearance, tolerability, and efficacyHiba Arif
Columbia University Comprehensive Epilepsy Center, New York, New York, USA
Epilepsia 52:1905-13. 2011..To compare pharmacokinetics, tolerability, and efficacy of lamotrigine (LTG) in older versus younger adults... - Seizures and CNS hemorrhage: spontaneous intracerebral and aneurysmal subarachnoid hemorrhageEmily Gilmore
Division of Critical Care Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neurologist 16:165-75. 2010..The deleterious effects of seizures on brain recovering from a recent injury have to be weighed against the deleterious effects of antiepileptic medications when making decisions on prophylaxis and treatment... - How long does it take to make an accurate diagnosis in an epilepsy monitoring unit?David E Friedman
Neurological Institute, Comprehensive Epilepsy Center, Columbia University Medical Center, New York, New York, USA
J Clin Neurophysiol 26:213-7. 2009..Interictal electroencephalography alone cannot reliably distinguish between those with epileptic seizures and nonepileptic events... - Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhageJan Claassen
The Division of Stroke and Critical Care Neurology, Department of Neurology, Neurological Institute, Columbia University, New York, NY 10032, USA
Clin Neurophysiol 115:2699-710. 2004..The purpose of this study was to identify quantitative EEG (qEEG) parameters that are most sensitive and specific for the detection of DCI in stuporous or comatose SAH patients... - Continuous electroencephalography in the medical intensive care unitMauro Oddo
Department of Neurology, Division of Critical Care, Neurological Institute, Columbia University Medical Center, New York, New York, USA
Crit Care Med 37:2051-6. 2009..To examine predictors and the prognostic value of electrographic seizures (ESZs) and periodic epileptiform discharges (PEDs) in medical intensive care unit (MICU) patients without a primary acute neurologic condition... - Continuous EEG monitoring in the intensive care unitLawrence J Hirsch
Neurological Institute of New York, Comprehensive Epilepsy Center, Columbia University, New York, New York 10032, USA
Am J Electroneurodiagnostic Technol 44:137-58. 2004.... - Treatment of status epilepticusHiba Arif
Comprehensive Epilepsy Center, Columbia University, New York, New York, USA
Semin Neurol 28:342-54. 2008..In refractory SE, continuous EEG monitoring is required to recognize recurrence of seizure activity, as most seizures will be nonconvulsive... - Diagnostic utility of an epilepsy monitoring unitJanice L Smolowitz
Columbia University School of Nursing, Department of Neurology, New York, NY 10032, USA
Am J Med Qual 22:117-22. 2007..Admission resulted in change in treatment in 79%. This review documents the diagnostic utility of an epilepsy monitoring unit while highlighting that time since symptom onset to admission exceeded established guidelines... - The ACNS subcommittee on research terminology for continuous EEG monitoring: proposed standardized terminology for rhythmic and periodic EEG patterns encountered in critically ill patientsLawrence J Hirsch
Department of Neurology, Comprehensive Epilepsy Center, Columbia University, New York, New York, USA
J Clin Neurophysiol 22:128-35. 2005 - Continuous EEG monitoring in patients with subarachnoid hemorrhageJan Claassen
Comprehensive Epilepsy Center, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Neurophysiol 22:92-8. 2005..CEEG findings may lead to therapeutic (e.g., antiepileptic medication, hypertensive therapy, angioplasty) or additional diagnostic interventions such as angiography, CT or MRI... - Inadequacy of standard screen resolution for localization of seizures recorded from intracranial electrodesCatherine A Schevon
Comprehensive Epilepsy Center, Neurological Institute of New York, Columbia University, New York, New York 10016, USA
Epilepsia 45:1453-8. 2004..Alternatively, spectral analysis should be performed on recordings of neocortical seizures to detect high-frequency activity that may be missed on visual inspection... - Nonconvulsive status epilepticus after subarachnoid hemorrhageLyle J Dennis
Division of Critical Care Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
Neurosurgery 51:1136-43; discussion 1144. 2002..Routine postoperative cEEG monitoring of patients with SAH who are at high risk for NCSE, allowing earlier diagnosis and treatment, offers the best chance of improving the outcomes for patients with this disorder... - Epilepsy emergencies: diagnosis and managementBrandon Foreman
Comprehensive Epilepsy Center, Neurological Institute of New York, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA
Neurol Clin 30:11-41, vii. 2012..Refractory conditions can be quite complicated with limited evidence-based guidance, but treatment should not be restricted by nihilism even in the most prolonged cases, especially if there is not widespread irreversible brain injury... - Continuous electroencephalogram monitoring in the critically illJohn J Wittman
Comprehensive Epilepsy Center, Columbia University, New York, NY 10032, USA
Neurocrit Care 2:330-41. 2005..This article discusses findings with cEEG to date, pitfalls in performing and interpreting these studies, and where we should turn our attention with this underutilized brain monitoring technique... - Advances in the management of seizures and status epilepticus in critically ill patientsKarine J Abou Khaled
Comprehensive Epilepsy Center, Department of Neurology, Columbia University Neurological Institute, New York, NY 10032, USA
Crit Care Clin 22:637-59; abstract viii. 2006..This article discusses specific treatments and specific situations, such as hepatic and renal failure patients and organ transplant patients... - The current state of treatment of status epilepticusLawrence J Hirsch
Comprehensive Epilepsy Center, Columbia University Neurological Institute, Box NI 135, 710 West 168th Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 2:345-56. 2002..This article reviews these issues, concentrating on recent advances and practical issues related to the clinical care of patients with status epilepticus... - Levetiracetam may be more effective for late-onset partial epilepsyCarl W Bazil
Comprehensive Epilepsy Center, Department of Neurology, Columbia University, New York, NY 10032, USA
Arch Neurol 59:1905-8. 2002..Clinical experience suggests that certain individuals will respond to a given agent while others with the same seizure type will not... - Treatment of status epilepticus: a survey of neurologistsJan Claassen
Division of Critical Care Neurology, Department of Neurology, Neurological Institute, Columbia University College of Physicians and Surgeons, 710 West 168th Street, Unit 39, New York, NY 10032, USA
J Neurol Sci 211:37-41. 2003..There is no consensus for third-line or fourth-line treatment for RSE. The treatment of RSE needs to be studied in a large, prospective, randomized, multicenter trial... - Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs): a common EEG phenomenon in the critically illLawrence J Hirsch
Comprehensive Epilepsy Center Critical Care Division, Department of Neurology, Columbia University, New York, New York 10032, USA
Epilepsia 45:109-23. 2004..To describe an underrecognized EEG phenomenon in critically ill patients undergoing continuous EEG monitoring (cEEG). We named these EEG patterns stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs)... - Which EEG patterns warrant treatment in the critically ill? Reviewing the evidence for treatment of periodic epileptiform discharges and related patternsDerek J Chong
Columbia University Medical Center, New York, New York, USA
J Clin Neurophysiol 22:79-91. 2005..Recommendations for treatment are given, and a modification to current criteria for the diagnosis of nonconvulsive seizures is suggested... - Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic reviewJan Claassen
Department of Neurology, Division of Critical Care Neurology, and The Comprehensive Epilepsy Center, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Epilepsia 43:146-53. 2002..A prospective randomized trial comparing different agents and titration goals for RSE with obligatory continuous EEG monitoring is needed... - A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsyMarla J Hamberger
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Epilepsia 48:1283-91. 2007..To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints... - Heart rate and EKG changes in 102 seizures: analysis of influencing factorsChristian Opherk
The Columbia University Comprehensive Epilepsy Center, Department of Neurology, Columbia University, New York Presbyterian Hospital, New York, USA
Epilepsy Res 52:117-27. 2002..CONCLUSION: We conclude that ictal EKG abnormalities other than sinus tachycardia are not unusual, especially in generalized seizures. These findings may be relevant to the phenomenon of SUDEP... - Topiramate for the treatment of epilepsy and other nervous system disordersLeonie van Passel
Comprehensive Epilepsy Center, Neurological Institute, Columbia University, Box NI 135, New York, NY 10032, USA
Expert Rev Neurother 6:19-31. 2006..Paresthesias and cognitive side effects are the most common troublesome adverse effects. Recent trends towards lower doses may help achieve the best combination of efficacy and tolerability... - Can sudden unexplained death in epilepsy be prevented?Lawrence J Hirsch
Department of Neurology, College of Physicians and Surgeons, New York City, NY 10032, USA
Lancet 364:2157-8. 2004 - Tonic-absence seizures: an underrecognized seizure typeTina T Shih
Columbia Comprehensive Epilepsy Center, Department of Neurology, Columbia University, New York Presbyterian Hospital, New York, New York 10032, USA
Epilepsia 44:461-5. 2003..In addition, these descriptions were formulated in the pre-EMU (Epilepsy Monitoring Unit) era, without benefit of video/clinical correlation. We now characterize this underrecognized seizure type... - Effect of antiepileptic drug comedication on lamotrigine clearanceDavid Weintraub
Columbia Comprehensive Epilepsy Center and Department of Neurology, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Arch Neurol 62:1432-6. 2005..No newer AED, with the possible exception of oxcarbazepine, has a major impact on lamotrigine CL... - Video-EEG monitoring in the elderly: a review of 94 patientsAlexandra E McBride
Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY, USA
Epilepsia 43:165-9. 2002..Few studies have assessed the characteristics of epileptic and nonepileptic seizures in this age group. Diagnostic evaluation with video-EEG monitoring is a means to distinguish these different types of events... - Absence epilepsy with onset before age three years: could this be Glut-1 deficiency syndrome (De Vivo syndrome)?Lawrence J Hirsch
Epilepsia 45:92-3. 2004 - Ictal heart rate differentiates epileptic from non-epileptic seizuresChristian Opherk
Department of Medicine, University of Heidelberg, Heidelberg, Germany
Neurology 58:636-8. 2002..It was concluded that documenting an increase in HR during a spell of unresponsiveness usually can distinguish between epileptic and psychogenic causes... - Brain monitoring: the next frontier of ICU monitoringLawrence J Hirsch
J Clin Neurophysiol 21:305-6. 2004 - Facial emotion recognition after curative nondominant temporal lobectomy in patients with mesial temporal sclerosisShearwood McClelland
Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Epilepsia 47:1337-42. 2006..These results indicate that proper development of the right amygdala is necessary for optimal fear recognition, with other neural processes unable to compensate for early amygdalar damage... - In nonconvulsive status epilepticus (NCSE), treat to burst-suppression: pro and conKenneth G Jordan
Jordan NeuroScience, Inc, San Bernardino, California 92404, USA
Epilepsia 47:41-5. 2006..It remains unclear if nonconvulsive seizures cause permanent neuronal injury. Nonconvulsive seizures should be diagnosed and treated as quickly as possible,but with non-coma-inducing treatments in most cases [corrected].. - Frequency and predictors of nonconvulsive seizures during continuous electroencephalographic monitoring in critically ill childrenNathalie Jette
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Arch Neurol 63:1750-5. 2006..To determine the incidence, predictors, and timing of nonconvulsive seizures (NCSz) during continuous electroencephalographic monitoring (cEEG) in critically ill children... - Nonconvulsive status epilepticus in children: clinical and EEG characteristicsStacey K H Tay
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Epilepsia 47:1504-9. 2006..Prolonged EEG monitoring to exclude NCSE may be warranted in pediatric patients even after brief convulsive seizures. Prompt recognition and treatment may be necessary to improve neurological outcome...