Research Topics
| Andreas H HielscherSummaryAffiliation: Columbia University Country: USA Publications
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Detail Information
Publications
Optical tomographic imaging of small animalsAndreas H Hielscher
Department of Biomedical Engineering, Columbia University, ET351 Mudd Building, 500 West 120th Street, MC8904, New York, NY 10027, USA
Curr Opin Biotechnol 16:79-88. 2005..The past three years have seen an array of novel technological developments that have led to the first optical tomographic studies of small animals in the areas of cerebral ischemia and cancer...- Computer-aided interpretation approach for optical tomographic imagesChristian D Klose
Columbia University, Department of Biomedical Engineering, New York, NY 10027, USA
J Biomed Opt 15:066020. 2010..9 can be achieved. These values are much higher than values obtained when only single parameter classifications were used, where sensitivities and specificities remained well below 0.8... - Parametric image reconstruction using the discrete cosine transform for optical tomographyXuejun Gu
Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, MC8904, 1210 Amsterdam Avenue, New York, New York 10027, USA
J Biomed Opt 14:064003. 2009..We especially focus on the influence of initial guesses and noise levels on the reconstruction results... - Multiparameter classifications of optical tomographic imagesChristian D Klose
Columbia University, Department of Biomedical Engineering, New York, New York 10027, USA
J Biomed Opt 13:050503. 2008..54, and an area under the curve (AUC) of 0.72. These values are higher than for previously reported single parameter classifications with a best sensitivity and specificity of 0.71, a Youden index of 0.41, and an AUC of 0.66... - The design and characterization of a digital optical breast cancer imaging systemMolly L Flexman
Biomedical Engineering Department, Columbia University, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 2008:3735-8. 2008..Here we present a digital optical tomography system designed specifically for dynamic breast imaging. The instrument uses laser diodes at 4 different near-infrared wavelengths with 32 sources and 128 silicon photodiode detectors... - Digital optical tomography system for dynamic breast imagingMolly L Flexman
Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027, USA
J Biomed Opt 16:076014. 2011..Included is a preliminary study of one healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the hemodynamic response to a breath hold... - Parametric reconstruction method in optical tomographyXuejun Gu
Dept of Biomed Eng, Columbia Univ, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 1:2667-70. 2006..In this way the amount of measured data is equal or larger than the number of unknowns. Using synthetic data, we show examples that demonstrate how this approach leads to improvements in imaging quality... - Transport- and diffusion-based optical tomography in small domains: a comparative studyKui Ren
Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, USA
Appl Opt 46:6669-79. 2007..However, transport-based reconstructions are considerably slower than diffusion-based reconstructions... - Digital-signal-processor-based dynamic imaging system for optical tomographyJoseph M Lasker
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace MC8904, New York, NY 10027, USA
Rev Sci Instrum 78:083706. 2007..First experiments on tissue phantoms show that dynamic behavior is accurately captured and spatial location can be correctly tracked using this system... - Frequency-domain optical tomographic imaging of arthritic finger jointsAndreas H Hielscher
Department of Biomedical Engineering, Columbia University, New York 10027, USA
IEEE Trans Med Imaging 30:1725-36. 2011..Parameters derived from the scattering coefficient perform slightly better than absorption derived parameters. Furthermore we found that data obtained at 600 MHz leads to better classification results than data obtained at 0 or 300 MHz... - Frequency-domain sensitivity analysis for small imaging domains using the equation of radiative transferXuejun Gu
Columbia University, New York, New York 10027, USA
Appl Opt 46:1624-32. 2007..These results will be useful in the design of experiments and optical tomographic imaging systems that probe small tissue volumes... - Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid jointsJoseph M Lasker
Columbia University, Department of Biomedical Engineering, 500 West 120th Street, ET351 Mudd Building, MC8904, New York, New York 10027, USA
J Biomed Opt 12:052001. 2007..Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints... - Fluorescence tomography with simulated data based on the equation of radiative transferAlexander D Klose
Department of Biomedical Engineering and Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street, New York, New York 10027, USA
Opt Lett 28:1019-21. 2003..We obtain images of either the quantum yield or the fluorophore absorption... - Parallel programming of gradient-based iterative image reconstruction schemes for optical tomographyAndreas H Hielscher
Departments of Biomedical Engineering and Radiology, Columbia University, 500 West 120th Street, MC 8904, New York, NY 10027, USA
Comput Methods Programs Biomed 73:101-13. 2004..The resulting algorithms are shown to accelerate the reconstruction process to various degrees, substantially reducing the computation times for clinically relevant problems... - Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumesHyun Keol Kim
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Opt Express 16:18082-101. 2008..We present numerical and experimental studies with a focus on small tissue volumes, as encountered in small animal and human finger imaging. Best reconstruction results were achieved in the 600-800 MHz frequency range... - Algorithm for solving the equation of radiative transfer in the frequency domainKui Ren
Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, USA
Opt Lett 29:578-80. 2004..In this work the ERT is discretized by a combination of discrete-ordinate and finite-volume methods. Two numerical simulations are presented... - Monitoring early tumor response to drug therapy with diffuse optical tomographyMolly L Flexman
Columbia University, New York, Department of Biomedical Engineering, New York, New York 10027, USA
J Biomed Opt 17:016014. 2012..These results are confirmed by magnetic resonance imaging T2 relaxometry and lectin perfusion studies. Noninvasive DOT imaging may allow for earlier and more effective control of anti-angiogenic therapy... - Quantitative modeling of Cerenkov light production efficiency from medical radionuclidesBradley J Beattie
Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
PLoS ONE 7:e31402. 2012..We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use... - Sagittal laser optical tomography for imaging of rheumatoid finger jointsAndreas H Hielscher
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Phys Med Biol 49:1147-63. 2004..We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images... - Development of a finger joint phantom for evaluation of frequency domain measurement systemsUwe J Netz
Inst fur Medizinische Phys and Lasermedizin, Charite Universitatsmedizin Berlin
Conf Proc IEEE Eng Med Biol Soc 1:1937-40. 2006..Reliability of the phantom measurement was investigated by repeated assembling. The results show clear discrimination between different stages of joints within the signal deviation due to reassembling of the phantom... - Comparison of two and three-dimensional optical tomographic image reconstructions of human finger jointsRong Song
Depts. of Biomedical Engineering and Radiology at Columbia University, New York, NY 10027 USA
Conf Proc IEEE Eng Med Biol Soc . 2006..In particular we examined how these different approaches affect the discrimination between healthy and RA joints... - Multipixel system for gigahertz frequency-domain optical imaging of finger jointsUwe J Netz
Institut für Medizinische Physik und Lasermedizin, Charite Universitatsmedizin Berlin, 14195 Berlin, Germany
Rev Sci Instrum 79:034301. 2008....