Andreas H Hielscher

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Optical tomographic imaging of small animals
    Andreas H Hielscher
    Department of Biomedical Engineering, Columbia University, ET351 Mudd Building, 500 West 120th Street, MC8904, New York, NY 10027, USA
    Curr Opin Biotechnol 16:79-88. 2005
  2. pmc Computer-aided diagnosis of rheumatoid arthritis with optical tomography, Part 1: feature extraction
    Ludguier D Montejo
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Biomed Opt 18:076001. 2013
  3. pmc Parametric image reconstruction using the discrete cosine transform for optical tomography
    Xuejun Gu
    Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, MC8904, 1210 Amsterdam Avenue, New York, New York 10027, USA
    J Biomed Opt 14:064003. 2009
  4. pmc Computer-aided interpretation approach for optical tomographic images
    Christian D Klose
    Columbia University, Department of Biomedical Engineering, New York, NY 10027, USA
    J Biomed Opt 15:066020. 2010
  5. doi request reprint Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography
    Molly L Flexman
    Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027
    J Biomed Opt 18:096012. 2013
  6. doi request reprint Multiparameter classifications of optical tomographic images
    Christian D Klose
    Columbia University, Department of Biomedical Engineering, New York, New York 10027, USA
    J Biomed Opt 13:050503. 2008
  7. pmc Computer-aided diagnosis of rheumatoid arthritis with optical tomography, Part 2: image classification
    Ludguier D Montejo
    Department of Biomedical Engineering, Columbia University, New York, New York 10025, USA
    J Biomed Opt 18:076002. 2013
  8. pmc Digital optical tomography system for dynamic breast imaging
    Molly L Flexman
    Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027, USA
    J Biomed Opt 16:076014. 2011
  9. ncbi request reprint Parametric reconstruction method in optical tomography
    Xuejun Gu
    Dept of Biomed Eng, Columbia Univ, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2667-70. 2006
  10. doi request reprint The design and characterization of a digital optical breast cancer imaging system
    Molly L Flexman
    Biomedical Engineering Department, Columbia University, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:3735-8. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Optical tomographic imaging of small animals
    Andreas H Hielscher
    Department of Biomedical Engineering, Columbia University, ET351 Mudd Building, 500 West 120th Street, MC8904, New York, NY 10027, USA
    Curr Opin Biotechnol 16:79-88. 2005
    ..The past three years have seen an array of novel technological developments that have led to the first optical tomographic studies of small animals in the areas of cerebral ischemia and cancer...
  2. pmc Computer-aided diagnosis of rheumatoid arthritis with optical tomography, Part 1: feature extraction
    Ludguier D Montejo
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Biomed Opt 18:076001. 2013
    ..8. These findings suggest that DOT may be capable of distinguishing between PIP joints that are healthy and those affected by RA with or without effusion, erosion, or synovitis...
  3. pmc Parametric image reconstruction using the discrete cosine transform for optical tomography
    Xuejun Gu
    Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, MC8904, 1210 Amsterdam Avenue, New York, New York 10027, USA
    J Biomed Opt 14:064003. 2009
    ..We especially focus on the influence of initial guesses and noise levels on the reconstruction results...
  4. pmc Computer-aided interpretation approach for optical tomographic images
    Christian D Klose
    Columbia University, Department of Biomedical Engineering, New York, NY 10027, USA
    J Biomed Opt 15:066020. 2010
    ..9 can be achieved. These values are much higher than values obtained when only single parameter classifications were used, where sensitivities and specificities remained well below 0.8...
  5. doi request reprint Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography
    Molly L Flexman
    Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027
    J Biomed Opt 18:096012. 2013
    ..These features provide a physiologic method for identifying breast cancer without the need for ionizing radiation...
  6. doi request reprint Multiparameter classifications of optical tomographic images
    Christian D Klose
    Columbia University, Department of Biomedical Engineering, New York, New York 10027, USA
    J Biomed Opt 13:050503. 2008
    ..54, and an area under the curve (AUC) of 0.72. These values are higher than for previously reported single parameter classifications with a best sensitivity and specificity of 0.71, a Youden index of 0.41, and an AUC of 0.66...
  7. pmc Computer-aided diagnosis of rheumatoid arthritis with optical tomography, Part 2: image classification
    Ludguier D Montejo
    Department of Biomedical Engineering, Columbia University, New York, New York 10025, USA
    J Biomed Opt 18:076002. 2013
    ..These results underscore the high potential for DOT to become a clinically useful diagnostic tool and warrant larger prospective clinical trials to conclusively demonstrate the ultimate clinical utility of this approach...
  8. pmc Digital optical tomography system for dynamic breast imaging
    Molly L Flexman
    Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027, USA
    J Biomed Opt 16:076014. 2011
    ..Included is a preliminary study of one healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the hemodynamic response to a breath hold...
  9. ncbi request reprint Parametric reconstruction method in optical tomography
    Xuejun Gu
    Dept of Biomed Eng, Columbia Univ, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2667-70. 2006
    ..In this way the amount of measured data is equal or larger than the number of unknowns. Using synthetic data, we show examples that demonstrate how this approach leads to improvements in imaging quality...
  10. doi request reprint The design and characterization of a digital optical breast cancer imaging system
    Molly L Flexman
    Biomedical Engineering Department, Columbia University, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:3735-8. 2008
    ..Here we present a digital optical tomography system designed specifically for dynamic breast imaging. The instrument uses laser diodes at 4 different near-infrared wavelengths with 32 sources and 128 silicon photodiode detectors...
  11. ncbi request reprint Transport- and diffusion-based optical tomography in small domains: a comparative study
    Kui Ren
    Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, USA
    Appl Opt 46:6669-79. 2007
    ..However, transport-based reconstructions are considerably slower than diffusion-based reconstructions...
  12. ncbi request reprint Digital-signal-processor-based dynamic imaging system for optical tomography
    Joseph M Lasker
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace MC8904, New York, NY 10027, USA
    Rev Sci Instrum 78:083706. 2007
    ..First experiments on tissue phantoms show that dynamic behavior is accurately captured and spatial location can be correctly tracked using this system...
  13. doi request reprint Frequency-domain optical tomographic imaging of arthritic finger joints
    Andreas H Hielscher
    Department of Biomedical Engineering, Columbia University, New York 10027, USA
    IEEE Trans Med Imaging 30:1725-36. 2011
    ..Parameters derived from the scattering coefficient perform slightly better than absorption derived parameters. Furthermore we found that data obtained at 600 MHz leads to better classification results than data obtained at 0 or 300 MHz...
  14. ncbi request reprint Frequency-domain sensitivity analysis for small imaging domains using the equation of radiative transfer
    Xuejun Gu
    Columbia University, New York, New York 10027, USA
    Appl Opt 46:1624-32. 2007
    ..These results will be useful in the design of experiments and optical tomographic imaging systems that probe small tissue volumes...
  15. ncbi request reprint Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid joints
    Joseph M Lasker
    Columbia University, Department of Biomedical Engineering, 500 West 120th Street, ET351 Mudd Building, MC8904, New York, New York 10027, USA
    J Biomed Opt 12:052001. 2007
    ..Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints...
  16. ncbi request reprint Fluorescence tomography with simulated data based on the equation of radiative transfer
    Alexander D Klose
    Department of Biomedical Engineering and Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street, New York, New York 10027, USA
    Opt Lett 28:1019-21. 2003
    ..We obtain images of either the quantum yield or the fluorophore absorption...
  17. ncbi request reprint Parallel programming of gradient-based iterative image reconstruction schemes for optical tomography
    Andreas H Hielscher
    Departments of Biomedical Engineering and Radiology, Columbia University, 500 West 120th Street, MC 8904, New York, NY 10027, USA
    Comput Methods Programs Biomed 73:101-13. 2004
    ..The resulting algorithms are shown to accelerate the reconstruction process to various degrees, substantially reducing the computation times for clinically relevant problems...
  18. ncbi request reprint Optimal source-modulation frequencies for transport-theory-based optical tomography of small-tissue volumes
    Hyun Keol Kim
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Opt Express 16:18082-101. 2008
    ..We present numerical and experimental studies with a focus on small tissue volumes, as encountered in small animal and human finger imaging. Best reconstruction results were achieved in the 600-800 MHz frequency range...
  19. ncbi request reprint Algorithm for solving the equation of radiative transfer in the frequency domain
    Kui Ren
    Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, USA
    Opt Lett 29:578-80. 2004
    ..In this work the ERT is discretized by a combination of discrete-ordinate and finite-volume methods. Two numerical simulations are presented...
  20. pmc Dynamic diffuse optical tomography imaging of peripheral arterial disease
    Michael A Khalil
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biomed Opt Express 3:2288-98. 2012
    ..These preliminary results show significant differences in DDOT time-traces and images between all three cases, underscoring the potential of DDOT as a new diagnostic tool...
  21. pmc Monitoring early tumor response to drug therapy with diffuse optical tomography
    Molly L Flexman
    Columbia University, New York, Department of Biomedical Engineering, New York, New York 10027, USA
    J Biomed Opt 17:016014. 2012
    ..These results are confirmed by magnetic resonance imaging T2 relaxometry and lectin perfusion studies. Noninvasive DOT imaging may allow for earlier and more effective control of anti-angiogenic therapy...
  22. pmc Quantitative modeling of Cerenkov light production efficiency from medical radionuclides
    Bradley J Beattie
    Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e31402. 2012
    ..We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use...
  23. ncbi request reprint Sagittal laser optical tomography for imaging of rheumatoid finger joints
    Andreas H Hielscher
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Phys Med Biol 49:1147-63. 2004
    ..We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images...
  24. ncbi request reprint Development of a finger joint phantom for evaluation of frequency domain measurement systems
    Uwe J Netz
    Inst fur Medizinische Phys and Lasermedizin, Charite Universitatsmedizin Berlin
    Conf Proc IEEE Eng Med Biol Soc 1:1937-40. 2006
    ..Reliability of the phantom measurement was investigated by repeated assembling. The results show clear discrimination between different stages of joints within the signal deviation due to reassembling of the phantom...
  25. ncbi request reprint Comparison of two and three-dimensional optical tomographic image reconstructions of human finger joints
    Rong Song
    Depts of Biomedical Engineering and Radiology at Columbia University, New York, NY 10027 USA
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ..In particular we examined how these different approaches affect the discrimination between healthy and RA joints...
  26. doi request reprint Multipixel system for gigahertz frequency-domain optical imaging of finger joints
    Uwe J Netz
    Institut für Medizinische Physik und Lasermedizin, Charite Universitatsmedizin Berlin, 14195 Berlin, Germany
    Rev Sci Instrum 79:034301. 2008
    ....