S B Heymsfield

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    S B Heymsfield
    Weight Control Unit, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    JAMA 282:1568-75. 1999
  2. ncbi Body composition modeling. Application to exploration of the resting energy expenditure fat-free mass relationship
    S B Heymsfield
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025, USA
    Ann N Y Acad Sci 904:290-7. 2000
  3. ncbi Effect of calcium supplementation on weight and fat loss in women
    Sue A Shapses
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Clin Endocrinol Metab 89:632-7. 2004
  4. ncbi Anthropometry and methods of body composition measurement for research and field application in the elderly
    S B Heymsfield
    Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Eur J Clin Nutr 54:S26-32. 2000
  5. ncbi Measurements of energy balance
    S B Heymsfield
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA
    Acta Diabetol 40:S117-21. 2003
  6. ncbi Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial
    S B Heymsfield
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    JAMA 280:1596-600. 1998
  7. ncbi Rhoads Lecture. Heat and life: the ongoing scientific odyssey
    Steven B Heymsfield
    St Luke s Roosevelt Hospital, Columbia University, Institute of Human Nutrition, College of Physicians and Surgeons, New York, New York 10025, USA
    JPEN J Parenter Enteral Nutr 26:319-32, vii. 2002
  8. ncbi Weight management using a meal replacement strategy: meta and pooling analysis from six studies
    S B Heymsfield
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Obes Relat Metab Disord 27:537-49. 2003
  9. ncbi Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass
    Steven B Heymsfield
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 282:E132-8. 2002
  10. ncbi Human body composition: advances in models and methods
    S B Heymsfield
    Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Annu Rev Nutr 17:527-58. 1997

Research Grants

  1. MRI Visceral Adipose Tissue Partitioning:Advanced Models
    Steven Heymsfield; Fiscal Year: 2005

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. ncbi Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    S B Heymsfield
    Weight Control Unit, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    JAMA 282:1568-75. 1999
    ..The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may affect weight loss...
  2. ncbi Body composition modeling. Application to exploration of the resting energy expenditure fat-free mass relationship
    S B Heymsfield
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025, USA
    Ann N Y Acad Sci 904:290-7. 2000
    ....
  3. ncbi Effect of calcium supplementation on weight and fat loss in women
    Sue A Shapses
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Clin Endocrinol Metab 89:632-7. 2004
    ..Nevertheless, the magnitude and direction of the differences for group means are consistent with a hypothesized small effect...
  4. ncbi Anthropometry and methods of body composition measurement for research and field application in the elderly
    S B Heymsfield
    Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Eur J Clin Nutr 54:S26-32. 2000
    ....
  5. ncbi Measurements of energy balance
    S B Heymsfield
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA
    Acta Diabetol 40:S117-21. 2003
    ....
  6. ncbi Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial
    S B Heymsfield
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    JAMA 280:1596-600. 1998
    ..As a citrate cleavage enzyme that may play an essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body weight and reduce fat mass in humans...
  7. ncbi Rhoads Lecture. Heat and life: the ongoing scientific odyssey
    Steven B Heymsfield
    St Luke s Roosevelt Hospital, Columbia University, Institute of Human Nutrition, College of Physicians and Surgeons, New York, New York 10025, USA
    JPEN J Parenter Enteral Nutr 26:319-32, vii. 2002
    ..Far from being fully understood, the study of heat production is an area of intense research interest bridging the gap between modern biology and physics...
  8. ncbi Weight management using a meal replacement strategy: meta and pooling analysis from six studies
    S B Heymsfield
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Obes Relat Metab Disord 27:537-49. 2003
    ....
  9. ncbi Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass
    Steven B Heymsfield
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 282:E132-8. 2002
    ..These observations have important implications for the interpretation of between-individual differences in REE expressed relative to metabolically active tissue mass...
  10. ncbi Human body composition: advances in models and methods
    S B Heymsfield
    Obesity Research Center, Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Annu Rev Nutr 17:527-58. 1997
    ..This review summarizes main body composition research concepts, examines new component-measurement methodologies, and identifies potential areas of future research...
  11. ncbi Techniques used in the measurement of body composition: an overview with emphasis on bioelectrical impedance analysis
    S B Heymsfield
    Department of Medicine, St Luke s Roosevel Hospital Center, New York, USA
    Am J Clin Nutr 64:478S-484S. 1996
    ..Body-composition research is a rapidly expanding area and in-depth systematic evaluation of new methods is a vital aspect of the field's growth...
  12. ncbi Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults
    S B Heymsfield
    Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York, NY, USA
    Arch Intern Med 160:1321-6. 2000
    ..Orlistat is a gastrointestinal lipase inhibitor that reduces dietary fat absorption by approximately 30%, promotes weight loss, and may reduce the risk of developing impaired glucose tolerance and type 2 diabetes in obese subjects...
  13. ncbi MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, NY 10025, USA
    Eur J Clin Nutr 66:983-8. 2012
    ..This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years)...
  14. ncbi Is there an association between skeletal muscle mass and bone mineral density among African-American, Asian-American, and European-American women?
    A J Sun
    Obesity Research Center, St Luke s Roosevelt Hospital Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
    Acta Diabetol 40:S309-13. 2003
    ..Body weight and age were positively and negatively associated with TBBMD, respectively, and the relationship was stronger in POM. In all race groups the variability in TBBMD was significantly greater in POM women...
  15. ncbi Truncal fat in relation to total body fat: influences of age, sex, ethnicity and fatness
    C H Wu
    Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY, USA
    Int J Obes (Lond) 31:1384-91. 2007
    ..To investigate the influence of age, sex, ethnicity and total fatness on central obesity in four ethnic populations...
  16. ncbi Evaluation of between-methods agreement of extracellular water measurements in adults and children
    Analiza M Silva
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University Institute of Human Nutrition, College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 88:315-23. 2008
    ..Extracellular water (ECW), a relevant molecular level component for clinical assessment, is commonly obtained by 2 methods that rely on assumptions that may not be possible to test at the time the measurements are made...
  17. ncbi Resting metabolic rate in obese, premenopausal black women
    J Albu
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 66:531-8. 1997
    ..This could contribute to the difference in the prevalence of obesity in the populations represented by these groups...
  18. ncbi Bone turnover and density in obese premenopausal women during moderate weight loss and calcium supplementation
    S A Shapses
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901-8525, USA
    J Bone Miner Res 16:1329-36. 2001
    ..In contrast to our previous findings in postmenopausal women, premenopausal obese women who consume a low calcium diet do not lose bone over a 6-month period, whether their weight is stable or decreasing moderately...
  19. ncbi Smaller organ tissue mass in the elderly fails to explain lower resting metabolic rate
    D Gallagher
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Ann N Y Acad Sci 904:449-55. 2000
    ..Further studies are required to investigate whether there is a reduction in the oxidative capacity of individual organs and tissues...
  20. ncbi Hydration of fat-free body mass: review and critique of a classic body-composition constant
    Z Wang
    St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 69:833-41. 1999
    ..These are important issues because water dilution is the only method currently available for estimating body fat in all mammals, which range in body mass by a factor of 10(4)...
  21. ncbi Correlations between skeletal muscle mass and bone mass in children 6-18 years: influences of sex, ethnicity, and pubertal status
    J Wang
    Department of Medicine, St Lukes Roosevelt Hospital Center, Columbia University, New York, NY, USA
    Growth Dev Aging 63:99-109. 1999
    ..Thus TBK/TBCa can be used as an index of relative growth in skeletal muscle mass and bone mass in white, black, and Asian children according to sex, age and pubertal status...
  22. ncbi Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism
    D Gallagher
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, New York 10025, USA
    Am J Physiol Endocrinol Metab 279:E124-31. 2000
    ....
  23. ncbi MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women
    W Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, NY 10025, USA
    Osteoporos Int 18:641-7. 2007
    ..Previous research using regional magnetic resonance spectroscopy methods to measure BMAT has reported inconsistent findings on the relationship between BMAT and dual-energy absorptiometry (DXA)-measured bone mineral density (BMD)...
  24. ncbi Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Osteoporos Int 23:2293-301. 2012
    ..This suggests that the mechanisms that regulate the differentiation and proliferation of bone marrow stromal cells may differ in these populations...
  25. ncbi Fat distribution in HIV-infected patients reporting truncal enlargement quantified by whole-body magnetic resonance imaging
    E S Engelson
    Gastrointestinal Division, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 69:1162-9. 1999
    ..Antiretroviral therapy has improved the prospects for people infected with HIV, but some develop a syndrome of profound body habitus and metabolic alterations that include truncal enlargement...
  26. ncbi Weight loss increases and fat loss decreases all-cause mortality rate: results from two independent cohort studies
    D B Allison
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes Relat Metab Disord 23:603-11. 1999
    ..No study has considered the independent effects of weight loss and fat loss on mortality rate. We studied mortality rate as a function of weight loss and fat loss...
  27. ncbi Sexual dimorphism in circulating leptin concentrations is not accounted for by differences in adipose tissue distribution
    M Rosenbaum
    Division of Molecular Genetics, Columbia University College of Physicians and Surgeons, New York, USA
    Int J Obes Relat Metab Disord 25:1365-71. 2001
    ..Gender-related differences in the relative amounts of SAT and VAT may account for the greater circulating leptin concentration relative to fat-mass in females than males...
  28. ncbi Muscularity in adult humans: proportion of adipose tissue-free body mass as skeletal muscle
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Hum Biol 13:612-9. 2001
    ..In addition, the SM/ATFM ratio was significantly lower in AIDS patients than corresponding values in healthy subjects...
  29. ncbi Comparison of visceral adipose tissue mass in adult African Americans and whites
    Daniel J Hoffman
    Department of Nutritional Sciences, Rutgers University, Room 230 Davison Hall, 26 Nichol Avenue, Room 228B, New Brunswick, NJ 08901, USA
    Obes Res 13:66-74. 2005
    ..This study was designed to measure the extent to which race is associated with VAT, controlling for total adipose tissue (TAT) mass and testosterone...
  30. ncbi DXA: potential for creating a metabolic map of organ-tissue resting energy expenditure components
    Matthew Hayes
    Department of Medicine, Obesity Research Center, St. Luke's/Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025, USA
    Obes Res 10:969-77. 2002
    ..DISCUSSION: This approach offers a new practical and educational opportunity to examine REE in subject groups using modeling strategies that reveal the magnitude and distribution of fundamental somatic heat-producing units...
  31. ncbi Assessment of body composition in dialysis patients by arm bioimpedance compared to MRI and 40K measurements
    M Carter
    Renal Research Institute, Yorkville Dialysis Center, 1555 3rd Avenue 218, New York, NY 10128, USA
    Blood Purif 27:330-7. 2009
    ..86, SEE = 2.28 kg). Total body MM and SAT can be accurately predicted by arm BIS models with advantages of convenience and portability, and it should be useful to assess nutritional status in HD patients...
  32. ncbi Sexual dimorphism in the energy content of weight change
    A Pietrobelli
    New York Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University Institute of Human Nutrition, College of Physicians and Surgeons, New York, USA
    Int J Obes Relat Metab Disord 26:1339-48. 2002
    ..CONCLUSIONS: Sexual dimorphism and age-dependency appears to exist in the estimated energy content of weight change and these observations have important clinical and research implications...
  33. ncbi Relative overhydration of fat-free mass in postobese versus never-obese subjects
    P A Leone
    Department of Medicine, St Luke s Roosevelt Hospital, Columbia University, New York, New York 10025, USA
    Ann N Y Acad Sci 904:514-9. 2000
    ..05). These observations are important for interpreting body weight, body composition, and metabolic data of obese subjects who lost weight and maintained their weight loss over the long term...
  34. ncbi Resting energy expenditure-fat-free mass relationship: new insights provided by body composition modeling
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, New York 10025, USA
    Am J Physiol Endocrinol Metab 279:E539-45. 2000
    ....
  35. ncbi Magnitude and variation of ratio of total body potassium to fat-free mass: a cellular level modeling study
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Am J Physiol Endocrinol Metab 281:E1-7. 2001
    ..The present study provides a conceptual framework for examining the separate TBK/FFM determinants and suggests important limitations of the TBK/FFM method used in estimating total body fat in humans and other mammals...
  36. ncbi Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds
    Shankuan Zhu
    New York Obesity Research Center, St Luke's-Roosevelt Hospital Center, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Am J Clin Nutr 76:743-9. 2002
    ..CONCLUSION: WC is more closely linked to cardiovascular disease risk factors than is BMI...
  37. ncbi Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy
    George A Kaysen
    Renal Research Institute, New York, NY, USA
    Am J Clin Nutr 82:988-95. 2005
    ..Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive...
  38. ncbi Cellular-level body composition model. A new approach to studying fat-free mass hydration
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025, USA
    Ann N Y Acad Sci 904:306-11. 2000
    ..73, and a variation range 0.69-0.77. The suggested modeling approach provides a conceptual framework for TBW-fat estimation method and identifies important areas that remain to be studied...
  39. ncbi Hydration of fat-free body mass: new physiological modeling approach
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Am J Physiol 276:E995-E1003. 1999
    ..The present study, the first to advance a physiological hydration model, provides a conceptual framework for the TBW-fat estimation method and identifies important areas that remain to be studied...
  40. ncbi Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection
    Ellen S Engelson
    Gastrointestinal Division, Obesity Research Center, New York 10025, USA
    J Acquir Immune Defic Syndr 30:379-91. 2002
    ..However, frequent adverse effects warrant controlled studies and careful patient monitoring, especially regarding glucose tolerance...
  41. ncbi Dual-energy X-ray absorptiometry lean soft tissue hydration: independent contributions of intra- and extracellular water
    Marie-Pierre St-Onge
    St. Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New Youk, NY 10025, USA
    Am J Physiol Endocrinol Metab 287:E842-7. 2004
    ..This observation has implications for the accuracy of body fat measurements by DEXA and the use of TBW as a means of checking DEXA system calibration...
  42. ncbi Body-composition differences between African American and white women: relation to resting energy requirements
    Alfredo Jones
    Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Am J Clin Nutr 79:780-6. 2004
    ....
  43. ncbi Total body potassium differs by sex and race across the adult age span
    Qing He
    Obesity Research Center, St Luke's-Roosevelt Hospital, and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 1025, USA
    Am J Clin Nutr 78:72-7. 2003
    ..CONCLUSION: Significant sex and racial differences exist in the rate of change in TBK with age. Further studies are needed to explore the associations of declining TBK with health risks...
  44. ncbi Assessment of body composition in long-term hemodialysis patients: rationale and methodology
    Shubho R Sarkar
    Renal Research Institute, New York, NY 10128, USA
    J Ren Nutr 15:152-8. 2005
    ..Preliminary results based on up to 40 hemodialysis patients are reported...
  45. ncbi Body fat and water changes during pregnancy in women with different body weight and weight gain
    S A Lederman
    Columbia University School of Public Health, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York, USA
    Obstet Gynecol 90:483-8. 1997
    ....
  46. ncbi Visceral adipose tissue: relationships between single slice areas at different locations and obesity-related health risks
    W Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes (Lond) 31:763-9. 2007
    ..At present, it is unknown whether the area with the highest correlation is also the most strongly associated with obesity-related health risk...
  47. ncbi Metabolic consequences of body size and body composition in hemodialysis patients
    S R Sarkar
    Renal Research Institute and Beth Israel Medical Center, New York, USA
    Kidney Int 70:1832-9. 2006
    ..The poorer survival observed in smaller dialysis patients may be related to these relative differences...
  48. ncbi Estimation of adipose pools in hemodialysis patients from anthropometric measures
    George A Kaysen
    Renal Research Institute, New York, New York, USA
    J Ren Nutr 18:473-8. 2008
    ..We measured total adipose tissue, subcutaneous adipose tissue, and VAT in 48 prevalent HD patients, using magnetic resonance imaging...
  49. ncbi Validation of an elliptical anthropometric model to estimate visceral compartment area
    Qing He
    Division of Gastroenterology, St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York 10025, USA
    Obes Res 12:250-7. 2004
    ..0001). DISCUSSION: An elliptical anthropometric model might be superior to a circular model to estimate abdominal SAT and VCA...
  50. ncbi Techniques used in measuring human body composition
    A Pietrobelli
    Obesity Research Centre, Saint Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, USA
    Curr Opin Clin Nutr Metab Care 1:439-48. 1998
    ..As the dual-energy X-ray absorptiometry is now gaining acceptance, both clinically and in the research laboratory, as a useful body composition method, particular emphasis is placed on this important approach...
  51. ncbi An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial
    C N Boozer
    Obesity Research Center, St Luke s Roosevelt Hospital Center and Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10025, USA
    Int J Obes Relat Metab Disord 25:316-24. 2001
    ..To examine in overweight humans the short-term safety and efficacy for weight loss of an herbal supplement containing Ma Huang, Guarana and other ingredients...
  52. ncbi Alternative treatments for weight loss: a critical review
    D B Allison
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Crit Rev Food Sci Nutr 41:1-28; discussion 39-40. 2001
    ..Nevertheless, some have plausible mechanisms of action and encouraging preliminary data that are sufficiently provocative to merit further research...
  53. ncbi The relationship between body mass index and body cell mass in African-American, Asian, and Caucasian adults
    J Wang
    Body Composition Unit, St Luke s Roosevelt Hospital Columbia University, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Acta Diabetol 40:S305-8. 2003
    ..The fraction, BCM/FFM decreased with BMI in all subgroups by race, sex, and age, and males decreased more per age and AA decrease more than A and C. Not only the BCM-BMI relationship but also BCM/FFM vs. BMI is important to health...
  54. ncbi Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue
    Dympna Gallagher
    Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, New York, NY, USA
    Am J Clin Nutr 81:903-10. 2005
    ..CONCLUSION: Race differences in AT distribution extend to IMAT, a depot that may influence race-ethnicity differences in dysglycemia...
  55. ncbi Association of lean tissue and fat mass with bone mineral content in children and adolescents
    Angelo Pietrobelli
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Obes Res 10:56-60. 2002
    ..Based on suggested skeletal muscle-bone relationships, this study tested the hypothesis that in children and adolescents lean tissue mass (LTM) is a better predictor of total bone mineral content (TBMC) than is FM...
  56. ncbi Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual
    Marie Pierre St-Onge
    Institute of Human Nutrition, Obesity Research Center, Columbia University, New York, New York, USA
    Diabetes Care 27:2222-8. 2004
    ..To determine the prevalence rates and likelihood of the metabolic syndrome and its individual components in normal-weight and slightly overweight individuals (BMI 18.5-26.9 kg/m(2))...
  57. ncbi Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults
    Jaehee Kim
    Obesity Research Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    J Appl Physiol 97:655-60. 2004
    ..The DXA-based models are accurate for predicting IMAT-free SM in selected populations and thus provide a new opportunity for quantifying SM in physiological and epidemiological investigations...
  58. ncbi Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction
    Gerald B Phillips
    Department of Medicine, Columbia University College of Physicians and Surgeons, St. Luke's-Roosevelt Hospital Center, New York, NY 10019, USA
    Metabolism 52:784-90. 2003
    ....
  59. ncbi Resting energy expenditure: systematic organization and critique of prediction methods
    Z Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Obes Res 9:331-6. 2001
    ....
  60. ncbi Multi-component body composition models: recent advances and future directions
    A Pietrobelli
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Eur J Clin Nutr 55:69-75. 2001
    ..We summarize the rationale for, applications, and types of multi-component models along with sources of error. Our review presents the strengths and limitations of available models and identifies important future research directions...
  61. ncbi Low physical activity levels of modern Homo sapiens among free-ranging mammals
    M Hayes
    Department of Medicine, Obesity Research Center, St Luke's/Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes (Lond) 29:151-6. 2005
    ..Our observations lend support to the hypothesis that low activity-related energy expenditure levels contribute to the rising worldwide prevalence of obesity...
  62. ncbi Assessment by bioimpedance of forearm cell mass: a new approach to calibration
    A Pietrobelli
    Obesity Research Center, St. Luke's/Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York 10025, USA
    Eur J Clin Nutr 56:723-8. 2002
    ..This simple and practical approach should facilitate the development of BIA-based regional cell mass prediction formulas..
  63. ncbi Effects of whey protein and resistance exercise on body cell mass, muscle strength, and quality of life in women with HIV
    D Agin
    Gastrointestinal Division, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    AIDS 15:2431-40. 2001
    ..To determine the effects of whey protein, resistance exercise, and combined protein and exercise treatment on body cell mass (BCM), muscle strength, and quality of life (QOL) in HIV-infected women with reduced BCM...
  64. ncbi A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study
    L J Aronne
    Weill Cornell Medical College, New York, NY 10021 7917, USA
    Int J Obes (Lond) 34:919-35. 2010
    ..To evaluate the efficacy, safety and tolerability of taranabant in obese and overweight patients.Design:Double-blind, randomized, placebo-controlled study...
  65. ncbi Bioimpedance for severe obesity: comparing research methods for total body water and resting energy expenditure
    Gladys W Strain
    Department of Surgery, Weill Medical College of Cornell University, New York, New York, USA
    Obesity (Silver Spring) 16:1953-6. 2008
    ..Research methods such as deuterium (D(2)O) dilution and metabolic carts are problematic in the clinical setting. We compared bioimpedance analysis (BIA) predicted (Tanita TBF-310) and measured TBW and REE...
  66. ncbi Evolving concepts on adjusting human resting energy expenditure measurements for body size
    S B Heymsfield
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Rev 13:1001-14. 2012
    ....
  67. ncbi Effects of strength or aerobic training on body composition, resting metabolic rate, and peak oxygen consumption in obese dieting subjects
    A Geliebter
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 66:557-63. 1997
    ..Peak oxygen consumption increased the most for the aerobic group (P = 0.03). In conclusion, strength training significantly reduced the loss of FFM during dieting but did not prevent the decline in RMR...
  68. ncbi Body fat redistribution after weight gain in women with anorexia nervosa
    Laurel Mayer
    Department of Psychiatry, Columbia University, New York, NY, USA
    Am J Clin Nutr 81:1286-91. 2005
    ..Increasing evidence suggests that the fat distribution immediately after weight restoration in patients with AN differs from the distribution typical of healthy adult women...
  69. ncbi Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 92:1369-77. 2010
    ..5 for adipose tissue, and 12 for residual organs and tissues. However, Elia's K(i) values have never been fully evaluated...
  70. ncbi Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey
    James E Gangwisch
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Hypertension 47:833-9. 2006
    ..Short sleep duration could, therefore, be a significant risk factor for hypertension...
  71. ncbi Total body protein mass: validation of total body potassium prediction model in children and adolescents
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nutr 136:1032-6. 2006
    ..032, P > 0.05). The TBK-Mo model can thus be used to estimate TBPro in healthy adults, adolescents, and children > 5 y old...
  72. ncbi Evaluation of specific metabolic rates of major organs and tissues: comparison between men and women
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Hum Biol 23:333-8. 2011
    ..However, it is unknown whether gender influences the K(i) values. The aim of the present study was to compare the K(i) values observed in nonelderly nonobese men to the corresponding values in women...
  73. ncbi Inadequate sleep as a risk factor for obesity: analyses of the NHANES I
    James E Gangwisch
    Mailman School of Public Health, Department of Epidemiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Sleep 28:1289-96. 2005
    ..This study examines cross-sectional and longitudinal data from a large United States sample to determine whether sleep duration is associated with obesity and weight gain...
  74. ncbi A new total body potassium method to estimate total body skeletal muscle mass in children
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    J Nutr 137:1988-91. 2007
    ..Because the adult TBK SM prediction model is not applicable for pediatric use, this study provides new empirical TBK SM prediction equations that should prove useful for studies on nutrition, growth, and development in children...
  75. ncbi Pediatric obesity phenotyping by magnetic resonance methods
    Wei Shen
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Curr Opin Clin Nutr Metab Care 8:595-601. 2005
    ..The aim is to provide an investigator-focused overview of magnetic resonance methods for use in the study of pediatric body composition and metabolism...
  76. ncbi Air displacement plethysmography: validation in overweight and obese subjects
    Samir R Ginde
    Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Obes Res 13:1232-7. 2005
    ..DISCUSSION: Body density, an important physical property used in human body composition models, can be accurately measured by ADP in overweight and obese subjects...
  77. ncbi Waist circumference correlates with metabolic syndrome indicators better than percentage fat
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Obesity (Silver Spring) 14:727-36. 2006
    ....
  78. ncbi Metabolically active portion of fat-free mass: a cellular body composition level modeling analysis
    ZiMian Wang
    Obesity Research Center, 1090 Amsterdam Ave, 14th Floor, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 292:E49-53. 2007
    ..584 +/- 0.041 and 0.529 +/- 0.041 for adult men and women (P < 0.001), respectively. A multiple linear regression model showed that there are independent significant associations of sex, age, and fat mass with BCM/FFM...
  79. ncbi Greater resting energy expenditure and lower respiratory quotient after 1 week of supplementation with milk relative to supplementation with a sugar-only beverage in children
    Marie Pierre St-Onge
    Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10032, USA
    Metabolism 56:1699-707. 2007
    ..Over the longer term, consumption of milk beverages may have more favorable effects on energy balance in children than consumption of fruit-flavored beverages...
  80. ncbi Sleep duration associated with mortality in elderly, but not middle-aged, adults in a large US sample
    James E Gangwisch
    Columbia University, College of Physicians and Surgeons, Department of Psychiatry, Division of Medical Genetics, New York, NY 10032, USA
    Sleep 31:1087-96. 2008
    ..No epidemiologic studies have published multivariate analyses stratified by age, even though life expectancy is 75 years and the majority of deaths occur in the elderly...
  81. ncbi Does percent body fat predict outcome in anorexia nervosa?
    Laurel E S Mayer
    Eating Disorders Research Unit, New York State Psychiatric Institute, Columbia College of Physicians and Surgeons, Columbia University, and New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10032, USA
    Am J Psychiatry 164:970-2. 2007
    ..The goal of this study was to investigate the relationship of body composition and neuroendocrine levels with clinical outcome in women with anorexia nervosa in a relapse-prevention trial...
  82. ncbi Supplementation with soy-protein-rich foods does not enhance weight loss
    Marie Pierre St-Onge
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10026, USA
    J Am Diet Assoc 107:500-5. 2007
    ..Our results do not lend support to the emerging notion that soy-protein-rich foods could be considered potential functional foods for weight management, in the quantities consumed in this study...
  83. ncbi Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study
    Wei Shen
    Obesity Research Center, St, Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Nutr Metab (Lond) 6:17. 2009
    ..abstract:..
  84. ncbi Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents
    Jaehee Kim
    Obesity Research Center, St Luke's-Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1014-20. 2006
    ..A new DXA SM prediction model was developed for prepubertal and pubertal subjects (Tanner stage </=4) aged >/=5 y. DXA thus provides an important opportunity for quantifying total-body SM mass across most of the human life span...
  85. ncbi Skeletal muscle mass in acromegaly assessed by magnetic resonance imaging and dual-photon x-ray absorptiometry
    Pamela U Freda
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Endocrinol Metab 94:2880-6. 2009
    ..GH and IGF-I are nitrogen retaining and anabolic, but the impact of long-term exposure to supraphysiological GH and IGF-I, either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle (SM) mass is not clear...
  86. ncbi Use of a Durnin-Womersley formula to estimate change in subcutaneous fat content in HIV-infected subjects
    Shireen Andrade
    Gastrointestinal Division, the Weight Control Unit, The Department of Medicine, St Luke's--Roosevelt Hospital Center, Columbia University of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 75:587-92. 2002
    ..The limits of agreement and the SEE for predicting change in SAT by MRI are approximately twice as great as the error of repeated Durnin-Womersley measures in control subjects...
  87. ncbi Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa
    Laurel E S Mayer
    Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York, NY, USA
    Am J Clin Nutr 90:1132-7. 2009
    ..Whether these abnormalities persist over time remains unknown...
  88. ncbi Insomnia and sleep duration as mediators of the relationship between depression and hypertension incidence
    James E Gangwisch
    Division of Cognitive Neuroscience, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Hypertens 23:62-9. 2010
    ..No previous published population studies have examined whether insomnia and sleep duration mediate the relationship between depression and hypertension incidence...
  89. ncbi Estimation of percentage body fat by dual-energy x-ray absorptiometry: evaluation by in vivo human elemental composition
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Phys Med Biol 55:2619-35. 2010
    ..4 +/- 12.0% versus 24.9 +/- 11.1%, r = 0.983, P < 0.001). DXA R(ST) is evaluated by in vivo elemental composition, and the present study supports the underlying physical concept and accuracy of the DXA method for estimating %fat...
  90. ncbi Quantitative magnetic resonance fat measurements in humans correlate with established methods but are biased
    Dympna Gallagher
    New York Obesity Nutrition Research Center, Department of Medicine, St Luke s Roosevelt Hospital, New York, New York, USA
    Obesity (Silver Spring) 18:2047-54. 2010
    ..Should the latter be accomplished, QMR holds promise as a highly precise, rapid, and safe, noninvasive method for estimating the amount of and changes in TBF in overweight and severely obese persons...
  91. ncbi Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women
    Gerald B Phillips
    Department of Medicine, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Metabolism 57:838-44. 2008
    ....
  92. ncbi Four commonly used dual-energy X-ray absorptiometry scanners do not identically classify subjects for osteopenia or osteoporosis by T-score in four bone regions BIz11.5
    Jack Wang
    Body Composition Unit, Obesity Research Center, St Luke s Roosevelt Hospital Columbia University, New York, NY 10025, USA
    J Clin Densitom 8:191-8. 2005
    ..These results indicate that classification of bone density in individual subjects using T-scores varies by different DXA scanners, even the scanners were made by the same manufacturer...
  93. ncbi Total body protein: a new cellular level mass and distribution prediction model
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 78:979-84. 2003
    ....
  94. ncbi Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice
    Streamson C Chua
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Am J Physiol Endocrinol Metab 286:E384-92. 2004
    ..Finally, the slightly increased adiposity and mild insulin resistance of transgenic db/db dams were not a contributory factor to the increased fat content of transgenic db/db male progeny...
  95. ncbi Preferential loss of omental-mesenteric fat during growth hormone therapy of HIV-associated lipodystrophy
    Qing He
    Division of Gastroenterology, Obesity Research Center, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA
    J Appl Physiol 94:2051-7. 2003
    ..37%, P < 0.001). There is preferential loss and regain of OMAT, compared with RPAT, in subjects with HIV-associated lipodystrophy undergoing growth hormone treatment...
  96. ncbi Percentage body fat ranges associated with metabolic syndrome risk: results based on the third National Health and Nutrition Examination Survey (1988-1994)
    Shankuan Zhu
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
    Am J Clin Nutr 78:228-35. 2003
    ..Increasing attention has focused on the association between body fatness and related metabolic risk factors. The quantitative link between percentage body fat (%BF) and the risk of metabolic syndrome is unknown...
  97. ncbi Comparisons of waist circumferences measured at 4 sites
    Jack Wang
    Body Composition Unit and New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York 10025, USA
    Am J Clin Nutr 77:379-84. 2003
    ....
  98. ncbi Volume estimates by imaging methods: model comparisons with visible woman as the reference
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, USA
    Obes Res 11:217-25. 2003
    ..To compare the accuracy of four volume estimation models to actual tissue and organ volumes measured in the visible woman...
  99. ncbi Multicomponent methods: evaluation of new and traditional soft tissue mineral models by in vivo neutron activation analysis
    ZiMian Wang
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 76:968-74. 2002
    ..Practical and accurate methods for quantifying the soft tissue mineral component of multicomponent fat-estimation models are needed...
  100. ncbi Magnitude and variation of fat-free mass density: a cellular-level body composition modeling study
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York 10025, USA
    Am J Physiol Endocrinol Metab 284:E267-73. 2003
    ..The difference in FFM density across sex, race, and age groups was examined with the developed model. The present study thus provides a conceptual framework for the systematic study of FFM density in humans...
  101. ncbi Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY, USA
    J Appl Physiol 97:2333-8. 2004
    ..Measurement of a single abdominal image can thus provide estimates of total body SM and AT for group studies of healthy adults...

Research Grants1

  1. MRI Visceral Adipose Tissue Partitioning:Advanced Models
    Steven Heymsfield; Fiscal Year: 2005
    ..Our findings could help to set new standards for VAT and adipose tissue subcompartment measurement, lower the cost of MRI body composition studies, and improve study power. ..