Dawn L Hershman

..Future interventions should determine the most efficient and effective method for delivering survivorship care plans...

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..Public policy should ensure that access to reconstructive surgery is universally available...

..We examined first-cycle colony-stimulating factor use (FC-CSF) before and after 2002 and estimated US expenditures for dose-dense chemotherapy...

..We investigated the association of surgeon-related factors with receipt of adjuvant radiotherapy after BCS...

..Acupuncture is an effective and well-tolerated strategy for managing this common treatment-related side effect...

..Although these growth factors support chemotherapy, their long-term safety has not been evaluated. We studied the association between G-CSF use and incidence of leukemia in a population-based sample of breast cancer patients...

..We investigated the rates and predictors of early discontinuation and nonadherence to hormonal therapy in patients enrolled in Kaiser Permanente of Northern California health system...

..We investigated factors that influence the time interval between lumpectomy and RT, and the association between that interval and survival...

..Both early discontinuation and non-adherence to HT were common and associated with increased mortality. Interventions to improve continuation of and adherence to HT may be critical to improve BC survival...

..However, to the authors' knowledge, the effect of the interval between surgery and the initiation of chemotherapy on survival has not been investigated...

..The FACT/GOG-Ntx is an appropriate outcome measure for clinical trials evaluating ways to prevent long-term neurotoxicity in BC survivors...

..BMD remained stable 1 yr after completion of ZA. Serum CTX increased significantly by 12 and 24 months. More frequent administration may be required to suppress bone resorption in this patient population...

..We analyzed the association of race and survival with duration of treatment and number of treatment cycles among women receiving chemotherapy for early-stage breast cancer...

..Erythropoiesis-stimulating agents (erythropoietin and darbepoietin) have been approved to reduce the number of blood transfusions required during chemotherapy; however, concerns about the risks of venous thromboembolism and mortality exist...

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..The purpose of this study was to assess the patterns of use of chemotherapy in women with stage II ovarian cancer, and to compare the survival of treated and untreated patients aged 65+ years in a population-based sample...

..Aside from clinical factors, this decision may be associated with surgeon and patient characteristics. We investigated the effect of surgeon characteristics on the BCS rate...

..This review summarizes the prevention and management of osteoporosis and osteopenia resulting from cancer treatment in survivors of breast and prostate cancer...

..We previously showed that only about half of women over the age of 65 years with this disease received platinum-based chemotherapy, and that the likelihood of receiving it decreases with age...

..We examined whether zoledronic acid (ZA) prevents bone loss in premenopausal women receiving chemotherapy for early-stage BC...

..In the current study, the association between oncologist characteristics and the receipt of chemotherapy in elderly women with BC was evaluated...

..We studied the cardiac effects of doxorubicin in a population-based sample of older patients with diffuse large B-cell lymphoma (DLBCL)...

..To determine if granulocyte-colony-stimulating factor (G-CSF) primary prophylaxis is associated with a lower risk of febrile neutropenia (FN) than non-primary prophylaxis...

..We analyzed race and other predictors of treatment and survival among men with stage I-III breast cancer...

..Cytoreductive surgery is associated with extensive morbidity and may delay chemotherapy. We examined the associations among cytoreduction, perioperative complications, and delay or omission of chemotherapy...

..However, little is known about the predictors of, or the survival associated with, duration of chemotherapy in the community...

..Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG)...

..For some women, adjuvant chemotherapy for nonmetastatic breast cancer decreases recurrences and increases survival; however, patient-physician decisions regarding chemotherapy receipt can be influenced by medical and nonmedical factors...

..To perform a population-based analysis to determine possible factors associated with use of laparoscopy and ovarian-conserving cystectomy...

..We performed a population-based analysis to compare laparoscopic hysterectomy and robotic hysterectomy for endometrial cancer...

..We performed a population-based analysis to determine the effect of histology on survival for women with invasive cervical cancer...

..As the number of long-term survivors grows, identifying and minimizing the late effects of treatment will become increasingly important...

..Whether this reflects the medical impact of the delay of chemotherapy or factors associated with delay is unclear, but until this is clarified, patients should be encouraged to initiate treatment without significant delay...

..We examined the use, safety, and economic impact of same-day discharge for women undergoing laparoscopic hysterectomy...

..We examined the role of complications, failure to rescue from complications, and mortality based on hospital volume for ovarian cancer...

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..Educational interventions to women about the benefits of hormonal therapy may decrease negative beliefs and increase hormone therapy initiation...

..For many cancers, features of the metabolic syndrome, such as diabetes and obesity, have been associated with both increased risk of cancer development and poor outcomes...

..However, once approved, these treatments are often used differently than as tested in trials. We performed an analysis to determine the patterns of use of erythropoiesis-stimulating agents (ESAs)...

..A better understanding of these associations may help to improve cancer outcomes among individuals of African ancestry...

..We examined the outcomes of cytoreductive surgery to determine if there are groups of patients in which the morbidity is so substantial that alternate treatment strategies are warranted...

..However, patients receiving AIs may experience joint symptoms, which may lead to early discontinuation of this effective therapy. We hypothesize that acupuncture is a safe and effective treatment for AI-induced arthralgias...

..The authors of this report analyzed the prevalence of and factors associated with antioxidant supplement use during breast cancer (BC) treatment among women who participated in the Long Island Breast Cancer Study Project...

..Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention...

..We analyzed the uptake, morbidity, and cost of laparoscopic and robotic radical hysterectomies for cervical cancer...

..To estimate the influence of surgical volume on outcome and resource utilization for laparoscopic hysterectomy for benign indications...

..The authors investigated factors associated with the receipt of liver transplant among patients with HCC and evaluated the effects of these differences on survival...

..We examined the influence of surgeon and hospital case volume on morbidity, mortality, and resource utilization for women with endometrial cancer undergoing laparoscopic hysterectomy...

..This information may be useful in planning interventions to improve quality of care...

..The objective of this study was to assess, in a randomized, double-blind, placebo-controlled trial, whether administration of alendronate (70 mg weekly) would prevent bone loss associated with tamoxifen discontinuation...

..Noncompliance with adjuvant hormonal therapy among women with breast cancer is common. Little is known about the impact of financial factors, such as co-payments, on noncompliance...

..Relatively few studies of breast cancer survivors have included nonwhite women or women who do not speak English...

..The authors of this report compared outcomes of esophagectomy versus chemoradiation in a population-based sample of elderly patients with early stage esophageal cancer...

..We investigated the effectiveness of adjuvant chemoRT after gastric cancer resection in an elderly general population and its effects by stage...

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..Further research is needed to elucidate to what degree this represents appropriate clinical judgment and to what degree other factors, such as patient choice, play a role...

..Many women with hormone receptor-positive breast cancer discontinue effective aromatase inhibitor (AI) treatment due to joint symptoms...

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..We analyzed the content, quality, and accuracy of information provided on hospital web sites about robotic gynecologic surgery...

..Cervical cancer is common in the elderly. The authors examined the patterns of care, treatment, and outcomes of elderly women with cervical cancer...

..The purpose of the current study was to evaluate the prevalence of and identify risk factors for AI-related joint symptoms...

..We investigated whether this new standard of care was differentially adopted across racial and socioeconomic lines...

..We hypothesized that hepatocellular carcinoma (HCC) patients with higher Body Mass Index (BMI) might have more microvascular invasion (MVI) in their tumors...

..It was hypothesized that differences in the tumor size and number of positive lymph nodes within each disease stage contribute to the survival disparity...

..Prior studies have found that postmastectomy radiotherapy (PMRT) for breast cancer (BC) increases the risk of lung cancer (LC). We explored the joint effects of cigarette smoking and PMRT on LC risk...

..We assessed the association between race and treatment discontinuation/delay, WBC counts, and survival in women enrolled onto breast cancer clinical trials...

..Observational studies and clinical trials are needed to verify the results of this analysis of the long-term benefits of preventive strategies among BRCA1/2-positive women...

..Our findings may also be relevant to the well-known association of breast cancer stage at diagnosis with low income and minority race/ethnicity...

..Annual screening with MRI and mammography was the most effective strategy because it was associated with the longest quality-adjusted survival, but it was also very expensive...

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..Findings need to be confirmed in other insured populations and the reasons for under-initiation among these groups need to be explored...

..If replicated, women with these genotypes should be closely monitored for toxicities and could be targeted for preventive measures or alternative therapeutic approaches...

..We assessed recent predictors of use of liver transplantation and its effect on survival for those with nonmetastatic HCC...

..We conducted a comprehensive review of literature on the associations between antioxidant supplement use during breast cancer treatment and patient outcomes...

..CONCLUSION: On the basis of this model, the most cost-effective strategies for BRCA mutation carriers, with and without quality adjustment, were oophorectomy alone and oophorectomy and mastectomy, respectively...

..The most promising agents act on the CNS and include selective serotonin reuptake inhibitors, as well as venlafaxine and gabapentin...

..Future studies should control for the independent effects of slowed motor functioning when looking to study possible chemotherapy related cognitive processing deficits...

..CONCLUSION: This case illustrates the benefits of cytoreductive surgery for the management of recurrent disease, the use of serum tumor markers to help guide therapy, and the importance of extended follow-up...

..Although effort should be made to initiate radiotherapy as soon as possible after surgical resection/biopsy, a brief delay similar to that experienced by our cohort does not have a significant impact on survival...

..In the past 25 years, clinical trials have demonstrated the benefits of chemotherapy for patients with aggressive non-Hodgkin lymphoma. The authors analyzed the predictors and outcomes of chemotherapy among elderly patients with lymphoma...

..The objective of this study was to assess hormone receptor status as an independent predictor of survival in a population-based cohort of women with breast carcinoma who were followed for up to 11 years...

..Less than 4% of participants in the previously conducted P1 (tamoxifen vs. placebo) trial were minority women. We, therefore, studied barriers to minority participation in STAR among black, white, and Hispanic women who completed an RAF...

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..To report use of breast cancer treatment (surgery, radiation, and chemotherapy) by patients with Alzheimer's disease (AD)...

..Our findings support the use of average-risk individuals' time trade-off preference ratings for health care policy development...

..The objective of the current study was to assess levels of mullerian inhibitory substance (MIS), estradiol (E2), follicle-stimulating hormone (FSH), and menstrual status, in women undergoing chemotherapy...

..To estimate the use of venous thromboembolism prophylaxis in women undergoing gynecologic surgery and to estimate the patient, physician, and hospital characteristics associated with guideline-based prophylaxis...

..Finally, we review monitoring and preventive practices that may reduce the long-term risk of anthracycline-related cardiotoxicity...

..We studied the cardiac effects of RT and the impact of pre-existing cardiac risk factors (CRFs) in a population-based sample of older patients with breast cancer...

..Included is a preliminary study of one healthy patient and two breast cancer patients showing the ability to identify an invasive carcinoma based on the hemodynamic response to a breath hold...

..This trial investigated the safety and efficacy of paclitaxel and topotecan combination chemotherapy for patients with advanced cervical cancer (ACC)...

..We have assessed whether immune sensitization to the HER-2/neu tumor antigen occurs during treatment with the anti-HER-2/neu monoclonal antibody trastuzumab...

..The present study investigated relations between reported childhood abuse and recent traumatic stress symptoms in women newly diagnosed with breast cancer (n=330)...

..For women with a very high risk of invasive breast cancer, chemoprevention with tamoxifen seems to be cost-effective...

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..We propose to use the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database to evaluate several important new costly therapies for their patterns of "appropriate use", "over-use", benefits and toxicities ..

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..We propose to use the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database to evaluate several important new costly therapies for their patterns of "appropriate use", "over-use", benefits and toxicities ..