G A Heiman

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, NY, USA
    Biol Psychiatry 51:591-601. 2002
  2. ncbi request reprint Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study)
    Gary A Heiman
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Hum Hered 58:30-9. 2004
  3. ncbi request reprint Increased risk for recurrent major depression in DYT1 dystonia mutation carriers
    G A Heiman
    Department of Epidemiology of Joseph L Mailman School of Public Health, Columbia University, New York 10032, USA
    Neurology 63:631-7. 2004
  4. pmc Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene
    Gary A Heiman
    Department of Epidemiology of Joseph L Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 144:361-4. 2007
  5. ncbi request reprint Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers
    C W Hess
    Department of Neurology, PACC, Beth Israel Medical Center, Suite 5J, 10 Union Square East, New York, NY 10003, USA
    Neurology 68:522-4. 2007
  6. ncbi request reprint A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci
    Abby J Fyer
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 60:388-401. 2006
  7. pmc Seizure remission in adults with long-standing intractable epilepsy: an extended follow-up
    Hyunmi Choi
    Department of Neurology, Columbia University, New York, NY, United States
    Epilepsy Res 93:115-9. 2011
  8. pmc A unified approach for quantifying, testing and correcting population stratification in case-control association studies
    Prakash Gorroochurn
    Division of Statistical Genetics, Department of Biostatistics, Columbia University, New York, NY 10032, USA
    Hum Hered 64:149-59. 2007
  9. ncbi request reprint Non-replication of association studies: "pseudo-failures" to replicate?
    Prakash Gorroochurn
    Division of Statistical Genetics, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Genet Med 9:325-31. 2007
  10. pmc Mutations in THAP1 (DYT6) in early-onset dystonia: a genetic screening study
    Susan B Bressman
    Department of Neurology, Beth Israel Medical Center, New York, NY 10003, USA
    Lancet Neurol 8:441-6. 2009

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University, New York, NY, USA
    Biol Psychiatry 51:591-601. 2002
    ....
  2. ncbi request reprint Effect of population stratification on case-control association studies. I. Elevation in false positive rates and comparison to confounding risk ratios (a simulation study)
    Gary A Heiman
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Hum Hered 58:30-9. 2004
    ....
  3. ncbi request reprint Increased risk for recurrent major depression in DYT1 dystonia mutation carriers
    G A Heiman
    Department of Epidemiology of Joseph L Mailman School of Public Health, Columbia University, New York 10032, USA
    Neurology 63:631-7. 2004
    ..This comorbidity could be a reaction to a chronic debilitating disorder or expression of a predisposing gene. The authors took advantage of the identification of a gene for dystonia, DYT1, to test these alternative explanations...
  4. pmc Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene
    Gary A Heiman
    Department of Epidemiology of Joseph L Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 144:361-4. 2007
    ..We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia...
  5. ncbi request reprint Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers
    C W Hess
    Department of Neurology, PACC, Beth Israel Medical Center, Suite 5J, 10 Union Square East, New York, NY 10003, USA
    Neurology 68:522-4. 2007
    ....
  6. ncbi request reprint A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci
    Abby J Fyer
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 60:388-401. 2006
    ..Panic disorder (PD) is a common illness with a definite but "complex" genetic contribution and estimated heritability of 30-46%...
  7. pmc Seizure remission in adults with long-standing intractable epilepsy: an extended follow-up
    Hyunmi Choi
    Department of Neurology, Columbia University, New York, NY, United States
    Epilepsy Res 93:115-9. 2011
    ..By year 5 since the start of seizure remission, the cumulative probability of seizure relapse was 81%, although only half of the patients with seizure relapse went on to experience their previous seizure frequency...
  8. pmc A unified approach for quantifying, testing and correcting population stratification in case-control association studies
    Prakash Gorroochurn
    Division of Statistical Genetics, Department of Biostatistics, Columbia University, New York, NY 10032, USA
    Hum Hered 64:149-59. 2007
    ..We also performed simulations to compare our correction procedure with Genomic Control (GC). Our results show that, unlike GC, it maintains good Type I error rates and power across all levels of PS...
  9. ncbi request reprint Non-replication of association studies: "pseudo-failures" to replicate?
    Prakash Gorroochurn
    Division of Statistical Genetics, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Genet Med 9:325-31. 2007
    ..We refer to replication failures for which the replication power is low as "pseudo-failures."..
  10. pmc Mutations in THAP1 (DYT6) in early-onset dystonia: a genetic screening study
    Susan B Bressman
    Department of Neurology, Beth Israel Medical Center, New York, NY 10003, USA
    Lancet Neurol 8:441-6. 2009
    ..To assess more broadly the role of this gene, we screened for mutations in families that included one family member who had early-onset, non-focal primary dystonia...
  11. pmc Numeracy and framing bias in epilepsy
    Hyunmi Choi
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Epilepsy Behav 20:29-33. 2011
    ..631, P<0.0001), suggesting a relationship between aspects of executive functioning and framing bias. Poor numeracy and susceptibility framing bias place patients with epilepsy at risk for uninformed decisions...
  12. ncbi request reprint Centralizing the non-central chi-square: A new method to correct for population stratification in genetic case-control association studies
    Prakash Gorroochurn
    Division of Statistical Genetics, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Genet Epidemiol 30:277-89. 2006
    ..5) We compare DC with genomic control and show that where as the latter becomes overconservative when there is considerable confounding due to PS (i.e. when delta is large), DC performs well for all values of delta...
  13. ncbi request reprint New simple tests for age-at-onset anticipation: application to panic disorder
    W Y Tsai
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA
    Genet Epidemiol 28:256-60. 2005
    ..We illustrate the approaches with an example of panic disorder...
  14. ncbi request reprint Interstitial cystitis and panic disorder: a potential genetic syndrome
    Myrna M Weissman
    Departments of Psychiatry and Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Gen Psychiatry 61:273-9. 2004
    ..Whereas PD had been well characterized by direct interview, the urologic problems had been found only via medical history checklists and records. A case review by a board-certified urologist suggested they could be IC...
  15. ncbi request reprint Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design
    Habibul Ahsan
    Department of Epidemiology, Joseph L Mailman School of Public Health, New York, NY, USA
    Int J Epidemiol 31:669-78. 2002
    ..Also, by allowing the potential sources of selection bias to be revealed more easily the design is made more accessible both conceptually and practically to epidemiologists...
  16. pmc Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:2550-5. 2003
    ....
  17. ncbi request reprint Investigation of polymorphisms in the CREM gene in panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 126:111-5. 2004
    ..These findings provide little additional evidence for a susceptibility locus for panic disorder either within the CREM gene or in a nearby region of chromosome 10p11 in our sample...
  18. doi request reprint Phenotypic spectrum and sex effects in eleven myoclonus-dystonia families with epsilon-sarcoglycan mutations
    Deborah Raymond
    The Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, New York 10003, USA
    Mov Disord 23:588-92. 2008
    ..0097). We found no association between mutation type and phenotype...
  19. ncbi request reprint Results of a genome-wide genetic screen for panic disorder
    J A Knowles
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and New York State Psychiatric Institute, New York 10032, USA
    Am J Med Genet 81:139-47. 1998
    ..Analysis with SIBPAIR yielded P values equivalent to a lod score of 1.0 or greater (i.e., P < .016, one-sided, uncorrected for multiple tests) for 11 marker loci (2, 7p, 8p, 8q, 9p, 11q, 12q, 16p, 20p and 20q)...
  20. ncbi request reprint Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder
    Steven P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, New York City, NY 10032, USA
    Neuropsychopharmacology 29:558-65. 2004
    ....
  21. pmc Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies
    Gary A Heiman
    Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA
    Drug Alcohol Depend 92:258-66. 2008
    ....
  22. ncbi request reprint Robustness of case-control studies to population stratification
    Gary A Heiman
    Cancer Epidemiol Biomarkers Prev 14:1579-80; author reply 1580-1. 2005

Research Grants1

  1. Shared Genetic Risk for Epilepsy and Depression
    Gary Heiman; Fiscal Year: 2007
    ....