TOM HEI

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression
    Bingyan Li
    School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    BMC Cancer 12:239. 2012
  2. pmc Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts
    Shanaz A Ghandhi
    Center for Radiological Research, Columbia University, VC11 215, 630 West 168th Street, New York, NY 10032, USA
    BMC Med Genomics 3:31. 2010
  3. pmc Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR
    Jinesh N Shah
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    BMC Cancer 8:284. 2008
  4. ncbi request reprint Mechanism of fiber carcinogenesis: from reactive radical species to silencing of the beta igH3 gene
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Inhal Toxicol 18:985-90. 2006
  5. doi request reprint Mechanism of radiation-induced bystander effects: a unifying model
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Pharm Pharmacol 60:943-50. 2008
  6. ncbi request reprint Advances in radiobiological studies using a microbeam
    Tom K Hei
    Center for Radiological Research, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Radiat Res 50:A7-A12. 2009
  7. pmc Mutagenic effects of a single and an exact number of alpha particles in mammalian cells
    T K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 94:3765-70. 1997
  8. pmc Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells
    An Xu
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Part Fibre Toxicol 6:3. 2009
  9. pmc Radiation induced non-targeted response: mechanism and potential clinical implications
    Tom K Hei
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, Vanderbilt Clinic, New York, USA
    Curr Mol Pharmacol 4:96-105. 2011
  10. doi request reprint Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade
    Tom K Hei
    Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Adv Exp Med Biol 720:163-70. 2011

Research Grants

  1. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
  2. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
  3. Cytoplasmic Damage and Genotoxicity
    TOM HEI; Fiscal Year: 2007
  4. MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2001
  5. MECHANISMS OF FIBER CARCINOGENESIS
    TOM HEI; Fiscal Year: 2001
  6. Cytoplasmic Damage and Genotoxicity
    TOM HEI; Fiscal Year: 2009

Collaborators

Detail Information

Publications77

  1. pmc The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression
    Bingyan Li
    School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    BMC Cancer 12:239. 2012
    ..In this study, ectopic expression of TGFBI was used to ascertain its role as a tumor suppressor and to determine the underlying mechanism of mesothelioma and breast cancer...
  2. pmc Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts
    Shanaz A Ghandhi
    Center for Radiological Research, Columbia University, VC11 215, 630 West 168th Street, New York, NY 10032, USA
    BMC Med Genomics 3:31. 2010
    ....
  3. pmc Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR
    Jinesh N Shah
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    BMC Cancer 8:284. 2008
    ..In this study, we optimized a methylation-specific polymerase chain reaction (MSP) method and investigated the methylation status of the TGFBI promoter in human lung and prostate cancer specimens...
  4. ncbi request reprint Mechanism of fiber carcinogenesis: from reactive radical species to silencing of the beta igH3 gene
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Inhal Toxicol 18:985-90. 2006
    ....
  5. doi request reprint Mechanism of radiation-induced bystander effects: a unifying model
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Pharm Pharmacol 60:943-50. 2008
    ....
  6. ncbi request reprint Advances in radiobiological studies using a microbeam
    Tom K Hei
    Center for Radiological Research, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Radiat Res 50:A7-A12. 2009
    ..The identification of specific signaling pathways provides mechanistic insight on the nature of the bystander process...
  7. pmc Mutagenic effects of a single and an exact number of alpha particles in mammalian cells
    T K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 94:3765-70. 1997
    ..These data provide direct evidence that a single a particle traversing a nucleus will have a high probability of resulting in a mutation and highlight the need for radiation protection at low doses...
  8. pmc Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells
    An Xu
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Part Fibre Toxicol 6:3. 2009
    ..abstract:..
  9. pmc Radiation induced non-targeted response: mechanism and potential clinical implications
    Tom K Hei
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, Vanderbilt Clinic, New York, USA
    Curr Mol Pharmacol 4:96-105. 2011
    ..A better understanding of the mechanism of the non-targeted effects will be invaluable to assess its clinical relevance and ways in which the bystander phenomenon can be manipulated to increase therapeutic gain in radiotherapy...
  10. doi request reprint Mechanism of radiation carcinogenesis: role of the TGFBI gene and the inflammatory signaling cascade
    Tom K Hei
    Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Adv Exp Med Biol 720:163-70. 2011
    ..The involvement of NFκB-dependent cytokines and the resultant inflammatory response works in concert with in modulating radiation-induced bronchial carcinogenesis...
  11. pmc Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species
    T K Hei
    Center for Radiological Research, College of Physicians and Surgeons, School of Public Health, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:8103-7. 1998
    ..Thus, the carcinogenicity of arsenite can be explained at least in part by it being a mutagen that depends on reactive oxygen species for its activity...
  12. pmc Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers
    T K Hei
    Center for Radiological Research, Vanderbilt Clinic, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Environ Health Perspect 105:1085-8. 1997
    ..This model provides a unique opportunity to study the cellular and molecular changes at the various stages in fiber-mediated neoplastic transformation of human bronchial epithelial cells...
  13. ncbi request reprint Genotoxicity in the eyes of bystander cells
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, Vanderbilt Clinic 11 205, 630 West 168th Street, New York, NY 10032, USA
    Mutat Res 568:111-20. 2004
    ....
  14. doi request reprint Environmental mutagens induced transversions but not transitions in regulatory region of mitochondrial DNA
    Michael A Partridge
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    J Toxicol Environ Health A 72:301-4. 2009
    ..Data suggest that only a change in the number of rare transversions would be indicative of an increase in point mutations in mtDNA after exposure to mutagens...
  15. doi request reprint Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
    Geoffrey E Johnson
    Center for Radiological Research, Columbia University, VC11 236, 630 West 168th Street, New York, NY 10032, USA
    Apoptosis 13:790-802. 2008
    ..Hence, surface expression of TRAIL induced by resveratrol appears to be a decisive event, one which determines an apoptotic versus a necrotic response of melanoma cells to sequential treatment...
  16. pmc Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:14641-6. 2005
    ..These results provide evidence that the COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon...
  17. ncbi request reprint Epigenetic inactivation of Betaig-h3 gene in human cancer cells
    Genze Shao
    Center for Radiological Research and Department of Pathology, Columbia University, New York, New York 10032, USA
    Cancer Res 66:4566-73. 2006
    ..These results suggest that promoter methylation plays a critical role in promoter silencing of the Betaig-h3 gene in human tumor cells...
  18. ncbi request reprint Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model
    Rudranath Persaud
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 65:9876-82. 2005
    ..The results of this study will address the relevant issues of actual target size and radiation quality and are likely to have a significant effect on our current understanding of radiation risk assessment...
  19. pmc The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage
    Haiyang Li
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Cell Biol 183:253-65. 2008
    ..Our findings suggest that the tumor suppressor function of HINT1 is caused by, at least in part, its normal role in enhancing cellular responses to DNA damage by regulating the functions of both gamma-H2AX and ATM...
  20. ncbi request reprint Loss of Betaig-h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cells
    Yongliang Zhao
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mol Carcinog 45:84-92. 2006
    ..These observations demonstrate that downregulation of Betaig-h3 gene is a frequent event and related to the tumor progression in human lung cancer...
  21. ncbi request reprint Role of Vitamin D receptor gene in radiation-induced neoplastic transformation of human breast epithelial cell
    Debasish Roy
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Steroids 68:621-7. 2003
    ..Considering all these evidence, it is likely that VDR can be used as a prognostic marker of tumor progression in radiation- and estrogen-induced breast carcinogenesis...
  22. ncbi request reprint Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells
    Su Xian Liu
    Center for Radiological Research, Department of Neurology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 65:3236-42. 2005
    ....
  23. pmc Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Res 68:2233-40. 2008
    ....
  24. ncbi request reprint Effect of medium on chromatin damage in bystander mammalian cells
    Masao Suzuki
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Radiat Res 162:264-9. 2004
    ..These results suggest that certain unidentified modulating factors secreted from the irradiated cells on the bottom Mylar layer into the medium induce chromatin damage in the unirradiated bystander cells...
  25. ncbi request reprint Genotoxic mechanisms of asbestos fibers: role of extranuclear targets
    An Xu
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NewYork 10032, USA
    Chem Res Toxicol 20:724-33. 2007
    ..These data showed that extranuclear targets play an essential role in the initiation of oxidative damage that mediates fiber mutagenesis in mammalian cells...
  26. ncbi request reprint Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells
    Masao Suzuki
    ISRL, NIRS
    Biol Sci Space 17:251-2. 2003
    ..These findings provide clear evidence that single He-ion irradiated cells can induce bystander chromosomal alterations in neighboring cells not directly hit by He ion...
  27. ncbi request reprint Effects of irradiated medium on chromatid aberrations in mammalian cells using double mylar dishes
    Masao Suzuki
    ISRL, NIRS
    Biol Sci Space 18:110-1. 2004
    ..These results suggest that certain modulating factors secreted from the irradiated cells on the bottom mylar layer into the medium, induce chromatin damage in the un-irradiated, bystander cells...
  28. doi request reprint p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase
    Genze Shao
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Pennsylvania, USA
    Mol Carcinog 47:775-83. 2008
    ..They are anchorage dependent and do not form tumors in immunosuppressed host animals. Therefore, premalignantly transformed human PrECs provide a valuable model for prostate cancer research...
  29. ncbi request reprint Demonstration of a radiation-induced bystander effect for low dose low LET beta-particles
    Rudranath Persaud
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 46:395-400. 2007
    ..The results of this study will address the relevant issues of actual target size and radiation quality, and are likely to have a significant impact on our current understanding of radiation risk assessment...
  30. ncbi request reprint Arsenic induces oxidative DNA damage in mammalian cells
    Maris Kessel
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, NY 10032, USA
    Mol Cell Biochem 234:301-8. 2002
    ..Taken together, our data provide clear evidence that reactive oxygen species play an important causal role in the genotoxicity of arsenic in mammalian cells...
  31. pmc Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species
    An Xu
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 110:1003-8. 2002
    ..These results provide direct evidence that the mutagenicity of asbestos is mediated by ROS in mammalian cells...
  32. ncbi request reprint Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: implications for genotoxic mechanisms in mammalian cells
    Michael A Partridge
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 67:5239-47. 2007
    ..These data support the theory that the mitochondria, and particularly mtDNA, are important targets of the mutagenic effects of arsenic in mammalian cells...
  33. ncbi request reprint A novel mechanism for p53 to regulate its target gene ECK in signaling apoptosis
    Y Jenny Jin
    Department of Radiation Oncology College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Cancer Res 4:769-78. 2006
    ..Our findings show that p53 is a transcriptional regulator of ECK in mediating apoptosis. The discovery of the novel p53-binding motif in the promoter may lead to the identification of a new class of p53 target genes...
  34. ncbi request reprint Mutagenicity of diesel exhaust particles mediated by cell-particle interaction in mammalian cells
    Lingzhi Bao
    Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Hefei, PR China
    Toxicology 229:91-100. 2007
    ..05). These results provided direct evidence that DEPs was mutagenic in mammalian cells and that cell-particle interaction played an essential role in the process...
  35. ncbi request reprint The time and spatial effects of bystander response in mammalian cells induced by low dose radiation
    Burong Hu
    Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, People s Republic of China
    Carcinogenesis 27:245-51. 2006
    ....
  36. ncbi request reprint BigH3 protein expression as a marker for breast cancer
    Gloria M Calaf
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Int J Mol Med 21:561-8. 2008
    ..We conclude that this protein can be used as a marker for breast cancer progression...
  37. pmc Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression
    Vladimir N Ivanov
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Cell Res 312:4120-38. 2006
    ..Finally, AKT overactivation increased melanoma survival in cell culture and dramatically accelerated growth of melanoma transplant in vivo, highlighting a role of AKT suppression for effective anticancer treatment...
  38. pmc Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression
    Vladimir N Ivanov
    Center for Radiological Research, Columbia University, New York, NY 10032, USA
    Exp Cell Res 314:1163-76. 2008
    ..Taken together, these results suggest that resveratrol, in combination with TRAIL, may have a significant efficacy in the treatment of human melanomas...
  39. ncbi request reprint Effects of irradiated medium with or without cells on bystander cell responses
    Hongning Zhou
    Center for Radiological Research, Vanderbilt Clinic 11 201, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mutat Res 499:135-41. 2002
    ..However, such factor(s) had little effect on mutation induction. Our results suggest that different bystander end points may involve different mechanisms with different cell types...
  40. ncbi request reprint Genomic instability and bystander effects induced by high-LET radiation
    Eric J Hall
    Center for Radiological Research, and The Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Oncogene 22:7034-42. 2003
    ....
  41. doi request reprint Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis
    Vladimir N Ivanov
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Cell Biochem 112:463-75. 2011
    ..The present study provides new understanding of the regulation of TRAIL-mediated apoptosis in melanoma and will serve as the foundation for the potential development of a novel approach for a therapy of resistant melanomas...
  42. pmc Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission
    Vladimir N Ivanov
    Center for Radiological Research, Department of Radiation Oncology, Columbia University, New York, NY 10032, USA
    Cell Signal 22:1076-87. 2010
    ....
  43. doi request reprint Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells
    Vladimir N Ivanov
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 69:3510-9. 2009
    ..Taken together, our data show the existence of an ATM-dependent STAT3-mediated antiapoptotic pathway, which on suppression sensitizes human melanoma cells to TRAIL-mediated apoptosis...
  44. pmc Consequences of cytoplasmic irradiation: studies from microbeam
    Hongning Zhou
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    J Radiat Res 50:A59-65. 2009
    ..This review will summarize the biological responses after cytoplasm irradiated by microbeam, and the possible mechanisms involved in cytoplasmic irradiation...
  45. ncbi request reprint Downregulation of Betaig-h3 gene is causally linked to tumorigenic phenotype in asbestos treated immortalized human bronchial epithelial cells
    Yong L Zhao
    Center for Radiological Research, College of Physicians and Surgeons, Joseph Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Oncogene 21:7471-7. 2002
    ..The result strongly suggests that loss of Betaig-h3 expression is a frequent event in human cancer and causally related to acquisition of tumorigenic phenotype in asbestos-treated BEP2D cells...
  46. ncbi request reprint Allelic imbalance at 11p15.5-15.4 correlated with c-Ha-ras mutation during radiation-induced neoplastic transformation of human breast epithelial cells
    Debasish Roy
    Center for Radiological Research, Vanderbilt Clinic, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Int J Cancer 103:730-7. 2003
    ....
  47. doi request reprint Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment
    Gengyun Wen
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, United States
    Sci Total Environ 407:1174-81. 2009
    ..To confirm the involvement of p38 in the regulation of apoptosis we pretreated cells with the p38 kinase inhibitor, SB 203580 and observed a significant decrease in apoptosis...
  48. pmc Critical role of oxidative stress in estrogen-induced carcinogenesis
    Hari K Bhat
    Department of Environmental Health Sciences, Mailman School of Public Health, 60 Haven Avenue B1, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:3913-8. 2003
    ..Thus, these data provide evidence that oxidant stress plays a crucial role in estrogen-induced carcinogenesis...
  49. ncbi request reprint Malignant transformation of human bronchial epithelial cells with the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Int J Cancer 106:821-6. 2003
    ..These data suggested that NNK can induce malignant transformation of human bronchial epithelial cells, and the tumor cell lines established are useful models in investigating the carcinogenic mechanism(s) of NNK...
  50. pmc Neoplastic transformation of human small airway epithelial cells induced by arsenic
    Gengyun Wen
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Mol Med 14:2-10. 2008
    ..Taken together, these results strongly suggest that h-TERT immortalized human small airway epithelial cells underwent step-wise transformation after inorganic arsenic treatment...
  51. ncbi request reprint Immortalization of human small airway epithelial cells by ectopic expression of telomerase
    Chang Q Piao
    Center for Radiological Research, College of Physicians and Surgens, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Carcinogenesis 26:725-31. 2005
    ....
  52. ncbi request reprint Beta catenin is associated with breast cancer progression in vitro
    Gloria M Calaf
    Department of Biology and Health, Faculty of Science, Tarapaca University, Arica, Chile
    Int J Oncol 26:913-21. 2005
    ..It can be concluded that malignant progression is a stepwise process and tumor growth occurs after a series of molecular events that parallel morphological changes indicative of cell transformation...
  53. ncbi request reprint Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation
    Gloria M Calaf
    Center for Radiological Research, Columbia University Medical Center, P and S 11 230, 630 West 168th Street, New York, NY 10032, USA
    Histochem Cell Biol 124:261-74. 2005
    ..These results provide evidence that multiple steps with consecutive changes are involved when normal cells become tumorigenic cells as a result of alpha particle irradiation and estrogen treatments...
  54. ncbi request reprint Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway
    Vladimir N Ivanov
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, 630 West 168 th St, VC11 218, New York, NY 10032, USA
    Oncogene 24:616-26. 2005
    ..Taken together, these data provide additional approaches in sensitizing melanomas to the cytotoxic effects of specific inhibitors of survival pathways...
  55. ncbi request reprint Differential impact of mouse Rad9 deletion on ionizing radiation-induced bystander effects
    Aiping Zhu
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Radiat Res 164:655-61. 2005
    ..Results are presented in the context of defining the function of Rad9 in the cellular response to radiation and its differential effects on individual bystander end points...
  56. ncbi request reprint Quantification of CD59- mutants in human-hamster hybrid (AL) cells by flow cytometry
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Vanderbilt Clinic 11 201, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Mutat Res 594:113-9. 2006
    ....
  57. ncbi request reprint Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis
    Vladimir N Ivanov
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 281:1840-52. 2006
    ....
  58. ncbi request reprint Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells
    Vladimir N Ivanov
    Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Exp Cell Res 312:1401-17. 2006
    ..Data obtained demonstrate that the combination of arsenite with inhibitors of COX-2 may affect the target cancer cells via induction of FasL-mediated death signaling...
  59. ncbi request reprint Role of oxidative damage in the genotoxicity of arsenic
    Tom K Hei
    Center for Radiological Research, College of Physician and Surgeons, Columbia University, New York, NY 10032, USA
    Free Radic Biol Med 37:574-81. 2004
    ..The data suggest that antioxidants may be a useful interventional treatment in reducing the deleterious effects of arsenic...
  60. ncbi request reprint Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Radiat Res 160:512-6. 2003
    ..Results from the present study address some of the pressing issues regarding both the actual target size and the radiation dose response and can improve on our current understanding of radiation risk assessment...
  61. ncbi request reprint Down-regulation of Betaig-h3 gene is involved in the tumorigenesis in human bronchial epithelial cells induced by heavy-ion radiation
    Yongliang Zhao
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Radiat Res 162:655-9. 2004
    ..Our data strongly suggest that down-regulation of Betaig-h3 expression results from the defect in the TGFB1 signaling pathway and plays a pivotal role in the tumorigenic process induced by (56)Fe heavy-ion radiation...
  62. ncbi request reprint Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway
    Vladimir N Ivanov
    Center for Radiological Research, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:22747-58. 2004
    ..Taken together, these data could provide potential approaches to sensitize melanomas to the cytotoxic effects of arsenite through modulating the signaling pathways...
  63. ncbi request reprint Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells
    Dae Won Kim
    Department of Orthopaedic Surgery, Center for Orthopaedic Research, Columbia University, 630 West 168th Street BB14 1412, New York, NY 10032, USA
    J Orthop Res 25:820-8. 2007
    ..3-fold increase in cell death after radiation (p < 0.05). Our findings support a novel therapeutic concept that gene silencing may be used as a molecular adjuvant therapy for radioresistant sarcomas...
  64. ncbi request reprint The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA
    Michael A Partridge
    College of Physicians and Surgeons, Center for Radiological Research, Columbia University, New York, NY 10032, USA
    DNA Seq 18:341-6. 2007
    ..We have obtained here the entire 16,284 bp sequence of the Chinese hamster mitochondrial genome, which will enable detailed analysis of mtDNA mutations caused by exposure to mutagens in hamster-derived cell lines...
  65. ncbi request reprint Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells
    Vladimir N Ivanov
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 67:5397-407. 2007
    ..These data highlight the efficacy of combined modality treatment involving radiation and arsenite in clinical management of this often fatal form of skin cancer...
  66. ncbi request reprint Mutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage
    Metka Filipic
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, 1000 Ljubljana, Slovenia
    Mutat Res 546:81-91. 2004
    ..Thus, the carcinogenicity of cadmium can, in part, be explained by its mutagenic activity, which is mediated by reactive oxygen species induced DNA damage and by its interference with the repair of oxidative DNA damage...
  67. ncbi request reprint Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles
    Hongzhen Li
    Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Oncol 31:537-44. 2007
    ..This model provides an opportunity to study the cellular and molecular alterations that occur in radiation carcinogenesis in human prostate cells...
  68. pmc High-throughput antibody-based assays to identify and quantify radiation-responsive protein biomarkers
    Michael A Partridge
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Int J Radiat Biol 86:321-8. 2010
    ..However, only a fraction of those individuals will need urgent medical attention. Consequently, a rapid screening test is needed to identify those people who require immediate treatment...
  69. pmc Estrogen-induced breast cancer: alterations in breast morphology and oxidative stress as a function of estrogen exposure
    Sarah M Mense
    Department of Environmental Health Science Mailman School of Public Health Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 232:78-85. 2008
    ..These oxidative changes appear to be a function of E(2) exposure and occur prior to tumor development...
  70. ncbi request reprint Survival of mammalian cells under high vacuum condition for ion bombardment
    Huiyun Feng
    Key Laboratory of Ion Beam Bioengineering of Chinese Academy of Sciences, Institute of Plasma Physics, P O Box 1126, Hefei 230031, Anhui Province, People s Republic of China
    Cryobiology 49:241-9. 2004
    ..In addition to the improvements made in this study, other factors are discussed that may increase the survival of mammalian cells exposed to a vacuum in future studies...
  71. pmc Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma
    Thomas B Karasic
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Cell Res 316:1994-2007. 2010
    ..The ultimate goal of this direction of research is the discovery of a new treatment method for highly resistant human metastatic melanomas. Our findings provide the rationale for further preclinical evaluation of this novel treatment...
  72. pmc Phytoestrogens and breast cancer prevention: possible mechanisms of action
    Sarah M Mense
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 116:426-33. 2008
    ..In this article we review the published literature related to phytoestrogens and breast cancer as well as suggest the possible mechanisms that may underlie the relationship between phytoestrogens and breast cancer...
  73. pmc New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay
    An Xu
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:87-92. 2007
    ..However, there is less evidence to demonstrate the contribution of deletions to the mutagenicity of asbestos fibers in vivo...
  74. ncbi request reprint Induction of germline cell cycle arrest and apoptosis by sodium arsenite in Caenorhabditis elegans
    Shunchang Wang
    Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031, People s Republic of China
    Chem Res Toxicol 20:181-6. 2007
    ..The present study also indicated that C. elegans might be used as an in vivo model system to study the mechanisms of arsenic-induced genotoxic effects...
  75. ncbi request reprint Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect
    Tom K Hei
    Center for Radiological Research, College of Physicians and Surgeons, and Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Mol Carcinog 45:455-60. 2006
    ....
  76. ncbi request reprint Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington 05405, USA
    Free Radic Biol Med 34:1117-29. 2003
    ..There is strong evidence supporting the premise that oxidants contribute to asbestos-induced lung injury; thus, strategies for reducing oxidant stress to pulmonary cells may attenuate the deleterious effects of asbestos...
  77. pmc TGFBI deficiency predisposes mice to spontaneous tumor development
    Ye Zhang
    Center for Radiological Research, Herbert Irving Comprehensive Cancer Center, and Department of Clinical Pathology, Columbia University, New York, NY 10032, USA
    Cancer Res 69:37-44. 2009
    ..Cyclin D1 up-regulation was also identified in most of the tumors arising from TGFBI(-/-) mice. Our studies provide the first evidence that TGFBI functions as a tumor suppressor in vivo...

Research Grants27

  1. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
    ..abstract_text> ..
  2. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
  3. Cytoplasmic Damage and Genotoxicity
    TOM HEI; Fiscal Year: 2007
    ..Together with the bystander mutagenic effect, the study will address some of the fundamental issues regarding extranuclear target and how cytoplasmic damages are being processed in mammalian cells. ..
  4. MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2001
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by chrysotile fibers and oxyradicals will be compared. ..
  5. MECHANISMS OF FIBER CARCINOGENESIS
    TOM HEI; Fiscal Year: 2001
    ..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
  6. Cytoplasmic Damage and Genotoxicity
    TOM HEI; Fiscal Year: 2009
    ..The study will address some of the fundamental issues regarding extranuclear target and how cytoplasmic damages are being processed in mammalian cells. ..