Robert D Hawkins

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization
    Robert D Hawkins
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Learn Mem 13:397-403. 2006
  2. ncbi request reprint Molecular mechanisms of memory storage in Aplysia
    Robert D Hawkins
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Bull 210:174-91. 2006
  3. ncbi request reprint Operant conditioning of gill withdrawal in Aplysia
    Robert D Hawkins
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 26:2443-8. 2006
  4. doi request reprint Nonlinear temporal integration of brain stimulation reward
    Robert D Hawkins
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Behav Neurosci 125:892-9. 2011
  5. pmc Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia
    Iksung Jin
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 109:9137-42. 2012
  6. pmc Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation
    Hsiu Ling Li
    Howard Hughes Medical Institute, Department of Neuroscience, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 61:527-40. 2009
  7. ncbi request reprint Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons
    Hiroshi Udo
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neuron 45:887-901. 2005
  8. pmc Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia
    Iksung Jin
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:11656-61. 2011
  9. ncbi request reprint Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins
    Hong Gang Wang
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 45:389-403. 2005
  10. pmc Rapid and long-lasting increase in sites for synapse assembly during late-phase potentiation in rat hippocampal neurons
    Irina Antonova
    Department of Neuroscience, Columbia University, New York, NY, USA
    PLoS ONE 4:e7690. 2009

Collaborators

Detail Information

Publications21

  1. pmc Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization
    Robert D Hawkins
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Learn Mem 13:397-403. 2006
    ..5 min after the shock, dishabituation is due to superimposed sensitization. These results thus suggest that dishabituation may involve either process in the same preparation, and begin to define the conditions that favor one or the other...
  2. ncbi request reprint Molecular mechanisms of memory storage in Aplysia
    Robert D Hawkins
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Bull 210:174-91. 2006
    ....
  3. ncbi request reprint Operant conditioning of gill withdrawal in Aplysia
    Robert D Hawkins
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 26:2443-8. 2006
    ....
  4. doi request reprint Nonlinear temporal integration of brain stimulation reward
    Robert D Hawkins
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Behav Neurosci 125:892-9. 2011
    ..These results suggest that integration in the brain stimulation reward system is nonlinear, and involves either adaptation or temporal discounting of reward value...
  5. pmc Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia
    Iksung Jin
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 109:9137-42. 2012
    ..These results suggest that the different stages of facilitation involve a cascade of pre- and postsynaptic mechanisms, which is initiated by spontaneous release and may culminate in synaptic growth...
  6. pmc Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation
    Hsiu Ling Li
    Howard Hughes Medical Institute, Department of Neuroscience, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 61:527-40. 2009
    ..Taken together, these findings suggest that learning-induced synapse formation recapitulates, at least in part, aspects of the mechanisms that govern de novo synaptogenesis...
  7. ncbi request reprint Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons
    Hiroshi Udo
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neuron 45:887-901. 2005
    ....
  8. pmc Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia
    Iksung Jin
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:11656-61. 2011
    ....
  9. ncbi request reprint Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins
    Hong Gang Wang
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 45:389-403. 2005
    ..cGK phosphorylates synaptic VASP during the potentiation, whereas Rho GTPases act both in parallel and upstream of cGMP, in part by maintaining the synaptic localization of soluble guanylyl cyclase...
  10. pmc Rapid and long-lasting increase in sites for synapse assembly during late-phase potentiation in rat hippocampal neurons
    Irina Antonova
    Department of Neuroscience, Columbia University, New York, NY, USA
    PLoS ONE 4:e7690. 2009
    ....
  11. pmc Spontaneous transmitter release is critical for the induction of long-term and intermediate-term facilitation in Aplysia
    Iksung Jin
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 109:9131-6. 2012
    ..Spontaneous release could make a similar contribution to learning-related synaptic plasticity in mammals...
  12. pmc Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis
    Iksung Jin
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Learn Mem 18:96-102. 2011
    ....
  13. doi request reprint Presynaptic and postsynaptic mechanisms of synaptic plasticity and metaplasticity during intermediate-term memory formation in Aplysia
    Igor Antonov
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    J Neurosci 30:5781-91. 2010
    ..These results demonstrate that not only the mechanisms but also the site of plasticity depend on both the stage of plasticity and metaplasticity during memory formation...
  14. ncbi request reprint Role of nitric oxide in classical conditioning of siphon withdrawal in Aplysia
    Igor Antonov
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 27:10993-1002. 2007
    ..In addition, they suggest that NO does not come from either the sensory or motor neurons but rather comes from another source, perhaps the L29 interneurons...
  15. pmc alpha-Synuclein produces a long-lasting increase in neurotransmitter release
    Shumin Liu
    Department of Pathology, Columbia University, New York, NY, USA
    EMBO J 23:4506-16. 2004
    ..Thus, alpha-synuclein is involved in synaptic plasticity by augmenting transmitter release from the presynaptic terminal...
  16. pmc Presynaptic and postsynaptic Ca(2+) and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons
    Fang Min Lu
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:4264-9. 2006
    ..CA3-CA3 LTP with the 1-Hz-paired protocol also partially depends on presynaptic Ca(2+), suggesting that it may involve presynaptic mechanisms as well...
  17. ncbi request reprint Presynaptic and postsynaptic mechanisms of a novel form of homosynaptic potentiation at aplysia sensory-motor neuron synapses
    Iksung Jin
    Center for Neurobiology and Behavior, Columbia University, and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 23:7288-97. 2003
    ..These results are consistent with the more general idea that there is a molecular alphabet of basic components that can be combined in various ways to create novel as well as known types of plasticity...
  18. pmc The long-term stability of new hippocampal place fields requires new protein synthesis
    Naveen T Agnihotri
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:3656-61. 2004
    ..Our results indicate that place fields parallel both behavioral memories and the late phase of long-term potentiation in requiring the synthesis of new proteins for consolidation...
  19. ncbi request reprint Increased attention to spatial context increases both place field stability and spatial memory
    Clifford G Kentros
    Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:283-95. 2004
    ..We propose a model whereby attention provides the requisite neuromodulatation to switch short-term homosynaptic plasticity to long-term heterosynaptic plasticity, and we implicate dopamine in this process...
  20. ncbi request reprint Activity-dependent presynaptic facilitation and hebbian LTP are both required and interact during classical conditioning in Aplysia
    Igor Antonov
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 37:135-47. 2003
    ..In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling...
  21. ncbi request reprint Ryanodine receptors contribute to cGMP-induced late-phase LTP and CREB phosphorylation in the hippocampus
    Yun fei Lu
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurophysiol 88:1270-8. 2002
    ..These results suggest that NO, cGMP, and PKG cause release of Ca(2+) from ryanodine-sensitive stores, which in turn causes phosphorylation of CREB in parallel with PKA during the induction of L-LTP...