Margaret Haney

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 38:1557-65. 2013
  2. pmc Predictors of marijuana relapse in the human laboratory: robust impact of tobacco cigarette smoking status
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Biol Psychiatry 73:242-8. 2013
  3. ncbi Smoked cocaine discrimination in humans: effects of gabapentin
    Margaret Haney
    Division on Substance Abuse, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Drug Alcohol Depend 80:53-61. 2005
  4. ncbi Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans
    M Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, 120, New York, NY 10032, USA
    Drug Alcohol Depend 64:63-73. 2001
  5. pmc Self-administration of cocaine, cannabis and heroin in the human laboratory: benefits and pitfalls
    Margaret Haney
    College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, Department of Psychiatry, New York, 10032, USA
    Addict Biol 14:9-21. 2009
  6. pmc Controversies in translational research: drug self-administration
    Margaret Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 199:403-19. 2008
  7. pmc Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA
    Psychopharmacology (Berl) 197:157-68. 2008
  8. ncbi Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 45:545-54. 2007
  9. ncbi Nefazodone decreases anxiety during marijuana withdrawal in humans
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 165:157-65. 2003
  10. ncbi Interaction between naltrexone and oral THC in heavy marijuana smokers
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 166:77-85. 2003

Detail Information

Publications86

  1. pmc Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 38:1557-65. 2013
    ..Thus, nabilone maintenance produced a robust attenuation of marijuana withdrawal symptoms and a laboratory measure of relapse even with once per day dosing. These data support testing of nabilone for patients seeking marijuana treatment...
  2. pmc Predictors of marijuana relapse in the human laboratory: robust impact of tobacco cigarette smoking status
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Biol Psychiatry 73:242-8. 2013
    ..Few marijuana smokers in treatment achieve sustained abstinence, yet factors contributing to high relapse rates are unknown...
  3. ncbi Smoked cocaine discrimination in humans: effects of gabapentin
    Margaret Haney
    Division on Substance Abuse, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Drug Alcohol Depend 80:53-61. 2005
    ..The results suggest gabapentin may not produce effects sufficiently robust to be clinically useful, at least at this dose regimen...
  4. ncbi Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans
    M Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, 120, New York, NY 10032, USA
    Drug Alcohol Depend 64:63-73. 2001
    ..The long-lasting and selective disruptions in serotonin pathways following chronic cocaine use may provide a neurochemical basis for changes in mood commonly reported during cocaine withdrawal...
  5. pmc Self-administration of cocaine, cannabis and heroin in the human laboratory: benefits and pitfalls
    Margaret Haney
    College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, Department of Psychiatry, New York, 10032, USA
    Addict Biol 14:9-21. 2009
    ..These studies contribute to our understanding of the variables maintaining cocaine, marijuana and heroin intake, and are important in guiding the development of more effective drug treatment programs...
  6. pmc Controversies in translational research: drug self-administration
    Margaret Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 199:403-19. 2008
    ..Laboratory animal and human models of drug self-administration are used to evaluate potential pharmacotherapies for drug abuse, yet the utility of these models in predicting clinically useful medications is variable...
  7. pmc Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA
    Psychopharmacology (Berl) 197:157-68. 2008
    ..Individuals seeking treatment for their marijuana use rarely achieve sustained abstinence...
  8. ncbi Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 45:545-54. 2007
    ..This placebo-controlled within-subjects study evaluated marijuana and dronabinol across a range of behaviors: eating topography, mood, cognitive performance, physiologic measures, and sleep...
  9. ncbi Nefazodone decreases anxiety during marijuana withdrawal in humans
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 165:157-65. 2003
    ..Symptoms of marijuana withdrawal include increased irritability, depression and anxiety, and decreased sleep quality. Nefazodone, which is an antidepressant with sedative properties, may attenuate symptoms of marijuana withdrawal...
  10. ncbi Interaction between naltrexone and oral THC in heavy marijuana smokers
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 166:77-85. 2003
    ..Studies in non-human animals suggest that opioid antagonists block the reinforcing effects of cannabinoids...
  11. ncbi Opioid antagonism of cannabinoid effects: differences between marijuana smokers and nonmarijuana smokers
    Margaret Haney
    Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 32:1391-403. 2007
    ..These data demonstrate that the interaction between opioid antagonists and cannabinoid agonists varies as a function of marijuana use history...
  12. ncbi Marijuana withdrawal in humans: effects of oral THC or divalproex
    Margaret Haney
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:158-70. 2004
    ..Divalproex worsened mood and cognitive performance during marijuana abstinence. These data suggest that oral THC, but not divalproex, may be useful in the treatment of marijuana dependence...
  13. ncbi The marijuana withdrawal syndrome: diagnosis and treatment
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Curr Psychiatry Rep 7:360-6. 2005
    ..The objective of this review is to update clinicians on the current state of marijuana research and to describe features of marijuana withdrawal to facilitate the diagnosis and treatment of cannabis use disorders...
  14. ncbi Therapeutic vaccines for substance dependence
    Margaret Haney
    College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, Department of Psychiatry, New York, NY 10032, USA
    Expert Rev Vaccines 3:11-8. 2004
    ..Overall, immunotherapy offers a range of potential treatment options: drug treatment, as well as the treatment of overdose, prevention of brain or cardiac toxicity and fetal protection in pregnant drug abusers...
  15. ncbi Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers
    Margaret Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and the Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:1814-21. 2006
    ..The distinct pattern of effects in methadone-maintained participants suggests baclofen may not be effective in opioid-dependent cocaine users...
  16. ncbi Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 181:170-8. 2005
    ..No studies to date have directly compared the tolerability and efficacy of smoked marijuana and oral dronabinol in HIV(+) marijuana smokers...
  17. ncbi Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans
    M Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 155:330-7. 2001
    ..Data obtained in laboratory animals and humans suggest that dopamine D1 receptor antagonists decrease cocaine self-administration and block cocaine's discriminative stimulus and subjective effects...
  18. ncbi Bupropion SR worsens mood during marijuana withdrawal in humans
    M Haney
    Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Psychopharmacology (Berl) 155:171-9. 2001
    ..Symptoms of withdrawal after daily marijuana smoking include increased ratings of irritability and depression. Similar mood symptoms are reported by cigarette smokers during nicotine abstinence...
  19. ncbi Effects of pergolide on intravenous cocaine self-administration in men and women
    M Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Psychopharmacology (Berl) 137:15-24. 1998
    ....
  20. ncbi Abstinence symptoms following smoked marijuana in humans
    M Haney
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 141:395-404. 1999
    ..This empirical demonstration of withdrawal from smoked marijuana may suggest that daily marijuana use may be maintained, at least in part, by the alleviation of abstinence symptoms...
  21. pmc Aripiprazole maintenance increases smoked cocaine self-administration in humans
    Margaret Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Psychopharmacology (Berl) 216:379-87. 2011
    ..Partial dopamine receptor agonists have been proposed as candidate pharmacotherapies for cocaine dependence...
  22. pmc Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 211:233-44. 2010
    ..Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed...
  23. ncbi Abstinence symptoms following oral THC administration to humans
    M Haney
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 141:385-94. 1999
    ....
  24. ncbi Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humans
    M Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Psychopharmacology (Berl) 143:102-10. 1999
    ..Data in laboratory animals suggest that D1 receptor agonists may have potential utility for the treatment of cocaine abuse...
  25. ncbi Alprazolam increases food intake in humans
    M Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, and New York State Psychiatric Institute, New York 10032, USA
    Psychopharmacology (Berl) 132:311-4. 1997
    ..These data demonstrate alprazolam's robust effects on food intake in humans...
  26. pmc Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans
    Margaret Haney
    College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Biol Psychiatry 67:59-65. 2010
    ..The objective of this human laboratory study was to measure the relationship between antibody titers and the effects of smoked cocaine on ratings of intoxication, craving, and cardiovascular effects...
  27. pmc Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study
    Gillinder Bedi
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Psychopharmacology (Berl) 212:675-86. 2010
    ..HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects...
  28. ncbi Gabapentin does not reduce smoked cocaine self-administration: employment of a novel self-administration procedure
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, Columbia University, Columbia, New York 10032, USA
    Behav Pharmacol 18:71-5. 2007
    ..Together, the data indicate that gabapentin does not show promise as a treatment medication for cocaine dependence...
  29. ncbi Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 73:279-87. 2004
    ....
  30. ncbi Smoked cocaine self-administration is decreased by modafinil
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:761-8. 2008
    ..Thus, our data support the potential of modafinil as a pharmacotherapy for cocaine dependence...
  31. pmc Modafinil does not serve as a reinforcer in cocaine abusers
    Suzanne K Vosburg
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States
    Drug Alcohol Depend 106:233-6. 2010
    ..Results suggest that modafinil does not have abuse liability in cocaine abusers...
  32. ncbi Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 86:274-7. 2007
    ....
  33. ncbi Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:407-15. 2002
    ..Yet, there has been no systematic comparison of repeated doses of oral delta(9)-THC with repeated doses of smoked marijuana in the same individuals...
  34. ncbi Modafinil attenuates disruptions in cognitive performance during simulated night-shift work
    Carl L Hart
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 31:1526-36. 2006
    ..Therapeutic doses of modafinil attenuated night-shift-associated disruptions, but the larger dose produced some sleep impairments when administered during day-shift work...
  35. ncbi Memantine increases cardiovascular but not behavioral effects of cocaine in methadone-maintained humans
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 83:47-55. 2006
    ..Taken together, these findings corroborate earlier data suggesting that this dose of memantine will not be helpful in the pharmacotherapy of cocaine abuse...
  36. ncbi Reinforcing effects of oral Delta9-THC in male marijuana smokers in a laboratory choice procedure
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians, Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 181:237-43. 2005
    ..Oral Delta-9-tetrahydrocannabinol (Delta(9)-THC; Marinol) is medically available for the treatment of nausea associated with cancer chemotherapy and for wasting syndromes related to HIV/AIDS. Little is known about its reinforcing effects...
  37. doi Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes
    Matthew G Kirkpatrick
    Department of Psychology, Columbia University, New York, USA
    Psychopharmacology (Berl) 203:771-80. 2009
    ..Methamphetamine attenuates disruptions that occur after changes in work shifts. The reinforcing effects of the drug during shift work have yet to be characterized...
  38. pmc Cardiovascular and subjective effects of repeated smoked cocaine administration in experienced cocaine users
    Stephanie Collins Reed
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 102:102-7. 2009
    ..These data indicate modest tolerance rather than sensitization to the positive subjective effects of cocaine with repeated exposure...
  39. pmc Decision-making in long-term cocaine users: Effects of a cash monetary contingency on Gambling task performance
    Nehal P Vadhan
    Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive 120, New York, NY 10032, USA
    Drug Alcohol Depend 102:95-101. 2009
    ..We examined the effects of a cash monetary contingency on Gambling task performance in cocaine abusers and control participants...
  40. pmc Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers
    Sandra D Comer
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, and College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neuropsychopharmacology 38:2427-38. 2013
    ..Future studies should continue to evaluate NTX as a potential anti-craving medication for COC dependence. ..
  41. pmc Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers
    Gillinder Bedi
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Addict Biol 18:872-81. 2013
    ..Nabilone was well tolerated by marijuana smokers, supporting further testing as a potential medication for marijuana dependence...
  42. pmc Intranasal cocaine in humans: effects of sex and menstrual cycle
    Stephanie L Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 86:117-24. 2007
    ....
  43. ncbi Zolpidem-related effects on performance and mood during simulated night-shift work
    Carl L Hart
    Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Exp Clin Psychopharmacol 11:259-68. 2003
    ..Food intake was unaffected by zolpidem. These data indicate that shift changes produce performance impairments, mood alterations, and decreases in food intake, and that zolpidem attenuates some shift-change-related disruptions...
  44. ncbi The effects of escalating doses of smoked cocaine in humans
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
    Drug Alcohol Depend 70:149-57. 2003
    ..e., "binge", of cocaine use can increment the effects of cocaine, but administering the same cocaine dose maintains, but does not increment the effects of cocaine...
  45. doi Marijuana's dose-dependent effects in daily marijuana smokers
    Divya Ramesh
    Division on Substance Abuse, New York Psychiatric Institute, New York, NY, USA
    Exp Clin Psychopharmacol 21:287-93. 2013
    ....
  46. ncbi An evaluation of the reinforcing effects of memantine in cocaine-dependent humans
    Suzanne K Vosburg
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Drug Alcohol Depend 79:257-60. 2005
    ..Memantine was not reinforcing and subjective-effects ratings were not altered as a function of dose. Results suggest that these doses of memantine do not have abuse liability in cocaine-dependent individuals...
  47. ncbi The effects of acute pretreatment with high-dose memantine on the cardiovascular and behavioral effects of cocaine in humans
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Exp Clin Psychopharmacol 15:228-37. 2007
    ..However, memantine pretreatment did not alter the choice to self-administer cocaine. These data suggest that memantine pretreatment may not be helpful in the treatment of cocaine dependence...
  48. ncbi Effects of oral THC maintenance on smoked marijuana self-administration
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 67:301-9. 2002
    ..These data indicate that participants' choice to self-administer marijuana was unaltered by the oral Delta(9)-THC dosing regimen used in the present investigation...
  49. pmc Opioid antagonism enhances marijuana's effects in heavy marijuana smokers
    Ziva D Cooper
    Division on Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 211:141-8. 2010
    ..This study sought to clarify this interaction by assessing how a range of naltrexone doses altered the subjective, cognitive, and cardiovascular effects of marijuana...
  50. ncbi Combined effects of methamphetamine and zolpidem on performance and mood during simulated night shift work
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Pharmacol Biochem Behav 81:559-68. 2005
    ..Zolpidem, given alone or in combination with methamphetamine, did not alleviate most shift-change mood and performance effects...
  51. ncbi Effects of alternative reinforcer and craving on the choice to smoke cigarettes in the laboratory
    Adam Bisaga
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Hum Psychopharmacol 22:41-7. 2007
    ..This paradigm models the motivational component associated with choice to smoke and could be used to evaluate the effects of pharmacological and behavioral interventions to decrease cigarette smoking...
  52. doi A direct comparison of the behavioral and physiological effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Matthew G Kirkpatrick
    Department of Psychology, Columbia University, New York, NY, USA
    Psychopharmacology (Berl) 219:109-22. 2012
    ..In humans, individual studies of methamphetamine and MDMA indicate that the drugs engender overlapping and divergent effects; there are only limited data comparing the two drugs in the same individuals...
  53. ncbi Methamphetamine attenuates disruptions in performance and mood during simulated night-shift work
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 169:42-51. 2003
    ..Increased sleepiness while working and sleep disruptions are common complaints among shift workers. Consequently, shift workers may be more susceptible to diminished performance and work-related accidents...
  54. pmc Using a novel alternative to drug choice in a human laboratory model of a cocaine binge: a game of chance
    Suzanne K Vosburg
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States
    Drug Alcohol Depend 110:144-50. 2010
    ..The current model could be used to evaluate whether behavioral and pharmacological manipulations shift choice from cocaine to a non-drug alternative...
  55. ncbi Effects of the NMDA antagonist memantine on human methamphetamine discrimination
    Carl L Hart
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:376-84. 2002
    ..To date, no published study has assessed their ability to alter methamphetamine-related discriminative stimulus effects in humans...
  56. ncbi Acute effects of smoked marijuana on decision making, as assessed by a modified gambling task, in experienced marijuana users
    Nehal P Vadhan
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 29:357-64. 2007
    ..These data are consistent with previous findings that indicated that speed of performance on tests of executive function, but not accuracy, is disrupted in experienced marijuana users during marijuana intoxication...
  57. pmc Effects of repeated oxycodone administration on its analgesic and subjective effects in normal, healthy volunteers
    Ziva D Cooper
    Department of Psychiatry, Division on Substance Abuse, New York Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Behav Pharmacol 23:271-9. 2012
    ..These data also suggest that intermittent administration may enhance the analgesic effects of oxycodone, while also increasing some of the drug's positive subjective effects related to abuse liability...
  58. pmc Substance use after participation in laboratory studies involving smoked cocaine self-administration
    Raj K Kalapatapu
    Substance Use Research Center, Columbia University, New York, NY 10032, United States
    Drug Alcohol Depend 120:162-7. 2012
    ..This paper analyzed follow-up data from six smoked cocaine self-administration laboratory studies, in order to determine whether changes in substance use occurred 1 and 3 months after study participation compared to pre-study baseline...
  59. ncbi Substance use and psychosocial outcomes following participation in residential laboratory studies of marijuana, methamphetamine and zolpidem
    Nehal P Vadhan
    Columbia University, New York, New York, USA
    Am J Drug Alcohol Abuse 32:589-97. 2006
    ..However, the administration of substances from drug classes with abuse potential to human volunteers raises ethical questions regarding potential risk to study volunteers...
  60. ncbi Intranasal cocaine in humans: acute tolerance, cardiovascular and subjective effects
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032 USA
    Pharmacol Biochem Behav 78:93-101. 2004
    ..These data demonstrate that, as observed with smoked and intravenous cocaine, acute within-session tolerance develops during repeated intranasal cocaine administration...
  61. ncbi The effects of venlafaxine on the subjective, reinforcing, and cardiovascular effects of cocaine in opioid-dependent and non-opioid-dependent humans
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Exp Clin Psychopharmacol 11:123-30. 2003
    ..Although the reduction in cocaine's effects was small, further studies using a longer venlafaxine maintenance period or a larger venlafaxine dose are warranted...
  62. pmc The subjective effects of cocaine: relationship to years of cocaine use and current age
    Raj K Kalapatapu
    Substance Use Research Center, New York State Psychiatric Institute and Columbia University, 1051Riverside Drive, New York, NY 10032, USA
    Am J Drug Alcohol Abuse 38:530-4. 2012
    ..Little is known about whether the duration of cocaine use or an individual's age may influence the acute effects of cocaine, patterns of use, and specific treatment needs...
  63. ncbi Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
    Pharmacol Biochem Behav 76:401-7. 2003
    ..These findings, taken together with the decidedly mixed literature, suggest that amantadine (100 mg bid) will not have a role in the treatment of cocaine dependence...
  64. ncbi Effects of smoked marijuana in healthy and HIV + marijuana smokers
    Margaret Haney
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    J Clin Pharmacol 42:34S-40S. 2002
    ..Preliminary data (n = 9) suggest that oral THC was more effective at increasing food intake, but the volunteers "liked" the effects of smoked marijuana more than the effects of oral THC...
  65. doi Modafinil decreases food intake in humans subjected to simulated shift work
    Gydmer A Perez
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Pharmacol Biochem Behav 90:717-22. 2008
    ..These findings show that modafinil produced clear reductions in food intake and suggest that future prospective studies should examine the drug in obese participants...
  66. ncbi The effects of smoked cocaine during the follicular and luteal phases of the menstrual cycle in women
    Suzette M Evans
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Psychopharmacology (Berl) 159:397-406. 2002
    ..Few studies have systematically determined whether the response to cocaine in human females is related to hormonal fluctuations at different phases of the menstrual cycle...
  67. pmc Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts
    Ziva D Cooper
    Division on Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Drug Alcohol Depend 103:107-13. 2009
    ..These findings demonstrate that smoking marijuana in a tobacco leaf may increase the risks of marijuana use by enhancing carbon monoxide exposure and increasing heart rate compared to joints...
  68. pmc Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor
    Ziva D Cooper
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Addict Biol 13:188-95. 2008
    ..Lastly, treatment options that may alleviate withdrawal symptoms and promote marijuana abstinence will be considered...
  69. ncbi Binge cocaine self-administration by humans: smoked cocaine
    A S Ward
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Behav Pharmacol 8:736-44. 1997
    ....
  70. pmc Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Pharmacol Biochem Behav 86:766-73. 2007
    ..Thus, although effective in decreasing food intake, there was no evidence of a specific effect of CB(1) receptor antagonism on consumption of a large meal or a palatable food...
  71. pmc Quantification and comparison of marijuana smoking practices: blunts, joints, and pipes
    John J Mariani
    New York State Psychiatric Institute, Division on Substance Abuse, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Drug Alcohol Depend 113:249-51. 2011
    ..Individual variability in use practices limits the utility of this method to estimating within-subject comparisons, rather than between subject comparisons...
  72. pmc Actions of delta-9-tetrahydrocannabinol in cannabis: relation to use, abuse, dependence
    Ziva D Cooper
    Division on Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Int Rev Psychiatry 21:104-12. 2009
    ..Opioidergic modulation of these effects is also discussed...
  73. pmc Effects of research setting on observed depressive symptoms in marijuana users
    John J Mariani
    Division on Substance Abuse, New York State Psychiatric Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Subst Abuse Treat 37:431-4. 2009
    ..e., treatment-seekers are more likely to be experiencing some degree of clinical distress), it is notable that treatment-seeking, and not marijuana use per se, is associated with significantly higher rates of depression...
  74. ncbi Ketoconazole attenuates the cortisol response but not the subjective effects of smoked cocaine in humans
    A S Ward
    Division on Substance Abuse, New York State Psychiatric Institute, NY 10032, USA
    Behav Pharmacol 9:577-86. 1998
    ..To the extent that self-administration can be predicted by subjective effects, these results further argue that the HPA axis does not play a critical role in cocaine self-administration by humans...
  75. ncbi Effects of caffeine withdrawal on humans living in a residential laboratory
    S D Comer
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Exp Clin Psychopharmacol 5:399-403. 1997
    ..Furthermore, the effects of caffeine on food intake were enhanced after 2 days of caffeine abstinence...
  76. ncbi Mood and performance changes in women with premenstrual dysphoric disorder: acute effects of alprazolam
    S M Evans
    New York State Psychiatric Institute, NY 10032, USA
    Neuropsychopharmacology 19:499-516. 1998
    ..Taken together, these data suggest that acute administration of alprazolam doses are not clinically useful for the treatment of PMS...
  77. ncbi Conditioned effects of environmental stimuli paired with smoked cocaine in humans
    R W Foltin
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Psychopharmacology (Berl) 149:24-33. 2000
    ..Clinical data suggest that stimuli paired with cocaine use acquire emergent stimulus effects, such as the ability to elicit cocaine craving...
  78. ncbi Effects of repeated oral methamphetamine administration in humans
    S D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 155:397-404. 2001
    ..Although methamphetamine use has increased over the past several years, few studies have evaluated the effects of repeated methamphetamine administration in humans...
  79. ncbi Alternative reinforcers differentially modify cocaine self-administration by humans
    C L Hart
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, USA
    Behav Pharmacol 11:87-91. 2000
    ..These data demonstrate that money vouchers are a more effective alternative reinforcer than merchandise vouchers in cocaine abusers...
  80. ncbi Fluoxetine-maintained obese humans: effect on food intake and body weight
    A S Ward
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Physiol Behav 66:815-21. 1999
    ..Therefore, fluoxetine maintenance does not appear promising as a sole long-term therapy for obesity...
  81. ncbi Methamphetamine self-administration by humans
    C L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 157:75-81. 2001
    ..Methamphetamine abuse has become increasingly problematic. Yet, the reinforcing effects of methamphetamine in humans have not been systematically evaluated...
  82. ncbi Effects of acute smoked marijuana on complex cognitive performance
    C L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Neuropsychopharmacology 25:757-65. 2001
    ..These data demonstrate that acute marijuana smoking produced minimal effects on complex cognitive task performance in experienced marijuana users...
  83. ncbi Behavioral contingencies modulate alprazolam self-administration by humans
    M Haney
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Behav Pharmacol 8:82-90. 1997
    ..Thus, the self-administration of either a stimulant or a minor tranquilizer is significantly reduced when it is associated with a consequent loss of an alternative reinforcer, in this case money...
  84. ncbi Blockade of cocaine-induced increases in adrenocorticotrophic hormone and cortisol does not attenuate the subjective effects of smoked cocaine in humans
    A S Ward
    Division on Substance Abuse, New York State Psychiatric Institute, NY 10032, USA
    Behav Pharmacol 10:523-9. 1999
    ..These data are concordant with findings in non-human primates, but contrast with findings in laboratory rodents, thus underscoring the importance of validation of rodent models with laboratory studies in humans...
  85. ncbi Factors influencing marijuana self-administration by humans
    M Haney
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Behav Pharmacol 8:101-12. 1997
    ....
  86. ncbi The effects of a monetary alternative on marijuana self-administration
    A S Ward
    Division on Substance Abuse, New York State Psychiatric Institute, NY 10032, USA
    Behav Pharmacol 8:275-86. 1997
    ..The results further indicate that contingency manipulations may override the performance-impairing effects of marijuana observed in other studies...

Research Grants16

  1. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2000
    ....
  2. Modafinil and DRD4 Genotype in a Human Laboratory Model of Cocaine Relapse
    Margaret Haney; Fiscal Year: 2010
    ....
  3. Modafinil and DRD4 Genotype in a Human Laboratory Model of Cocaine Relapse
    Margaret Haney; Fiscal Year: 2009
    ....
  4. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2007
    ..abstract_text> ..
  5. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2006
    ..abstract_text> ..
  6. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2005
    ..abstract_text> ..
  7. Medication Development for Marijuana Relapse
    Margaret Haney; Fiscal Year: 2004
    ..abstract_text> ..
  8. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2003
    ....
  9. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2002
    ....
  10. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2002
    ....
  11. THC AND MARIJUANA--EFFECTS IN INDIVIDUALS WITH HIV/AIDS
    Margaret Haney; Fiscal Year: 2001
    ....
  12. NOVEL COCAINE PHARMACOTHERAPIES: LAB STUDIES
    Margaret Haney; Fiscal Year: 2001
    ....
  13. Marijuana Relapse: Influence of Tobacco Cessation and Varenicline
    Margaret Haney; Fiscal Year: 2010
    ..We will directly assess how cigarette smoking and medication maintenance influence marijuana withdrawal and relapse, with the aim of using these data to improve marijuana treatment outcome. ..