Research Topics
Species | Eric HallSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosisFengtao Su
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China
Radiat Oncol 5:15. 2010..To understand some of the mechanisms involved, we examined the role of monoallelic loss or Atm and Brca1 on cell transformation and apoptosis induced by radiation...- The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM geneEric J Hall
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Radiat Environ Biophys 45:99-104. 2006..Haploinsufficiency for ATM results in an enhanced sensitivity to X-rays compared with the wild type, and this enhancement appears even larger after exposure to high-LET heavy ions... - Genomic instability and bystander effects induced by high-LET radiationEric J Hall
Center for Radiological Research, and The Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Oncogene 22:7034-42. 2003.... - Introduction to session I: Helical CT and cancer riskEric J Hall
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Pediatr Radiol 32:225-7. 2002 - Lessons we have learned from our children: cancer risks from diagnostic radiologyEric J Hall
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Pediatr Radiol 32:700-6. 2002..7 million of such procedures performed annually. Every effort is needed to minimize doses by an appropriate choice of peak kilovoltage (kVp) and milliampere-seconds (mAs), and at the same time to urge a more selective use of pediatric CT... - Cancer risks from diagnostic radiologyE J Hall
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Br J Radiol 81:362-78. 2008..A further issue is the increasing use of CT scans as a screening procedure in asymptomatic patients; at this time, the benefit/risk balance for any of the commonly suggested CT screening techniques has yet to be established... - The weight of evidence does not support the suggestion that exposure to low doses of X rays increases longevityEric J Hall
Center for Radiological Research, Columbia University, 630 W 168th Street, New York, NY 10024, USA
Radiology 229:18-9. 2003 - The impact of protons on the incidence of second malignancies in radiotherapyEric J Hall
Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
Technol Cancer Res Treat 6:31-4. 2007..Neutrons are highly effective at inducing second cancers and so, for the full potential of protons to be realized, spot scanning is essential... - Radiation-induced second cancers: the impact of 3D-CRT and IMRTEric J Hall
Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Int J Radiat Oncol Biol Phys 56:83-8. 2003..75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same... - The bystander effectEric J Hall
Columbia University, Center for Radiological Research, 630 West 168th Street, New York, NY 10032, USA
Health Phys 85:31-5. 2003..Bystander studies imply that the target for the biological effects of radiation is larger than the cell and this could make a simple linear extrapolation of radiation risks from high to low doses of questionable validity... - The inaugural Frank Ellis Lecture--latrogenic cancer: the impact of intensity-modulated radiotherapyE J Hall
Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
Clin Oncol (R Coll Radiol) 18:277-82. 2006..This is an advantage only if the proton machine uses a pencil scanning beam, as passive modulation of a scattering foil produces neutrons, which results in an effective dose to the patient higher than that characteristic of IMRT... - Dose-painting by numbers: a feasible approach?Eric J Hall
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Lancet Oncol 6:66. 2005 - Henry S. Kaplan Distinguished Scientist Award 2003. The crooked shall be made straight; dose-response relationships for carcinogenesisE J Hall
Columbia University Center for Radiological Research 630 West 168th Street, P and S 11 230 New York NY 10032 USA
Int J Radiat Biol 80:327-37. 2004.... - Intensity-modulated radiation therapy, protons, and the risk of second cancersEric J Hall
Center for Radiological Research, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
Int J Radiat Oncol Biol Phys 65:1-7. 2006..The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT... - Radiation biology for pediatric radiologistsEric J Hall
Columbia University Medical Center, New York, NY 10032, USA
Pediatr Radiol 39:S57-64. 2009..It is for this reason that every effort should be made to reduce the doses associated with procedures such as CT scans, particularly in children, in the spirit of ALARA... - Genetic susceptibility to radiationE J Hall
Columbia University Medical Center, College of Physicians and Surgeons, Center for Radiological Research, New York, NY 10032 3795, USA
Adv Space Res 35:249-53. 2005..An exciting possibility is the creation of double heterozygotes for pairs of mutated genes that function in the same signal transduction pathway, and consequently confer even greater radiosensitivity... - Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterpartsBasil V Worgul
Eye Radiation and Environmental Research Laboratory and Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 99:9836-9. 2002.... - Genomic instability, bystander effect, cytoplasmic irradiation and other phenomena that may achieve fame without fortuneE J Hall
Center for Radiological Research and Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
Phys Med 17:21-5. 2001.... - A microbeam study of DNA double-strand breaks in bystander primary human fibroblastsL B Smilenov
Center for Radiological Research, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Radiat Prot Dosimetry 122:256-9. 2006..The delay and persistence of the bystander response suggests a different mechanism of DSB induction in bystander cells than in directly irradiated cells... - Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypesB V Worgul
Eye Radiation and Environmental Research Laboratory, Columbia University, New York, NY 10032, USA
Adv Space Res 35:254-9. 2005..This may have to be considered in the selection of individuals who will be exposed to both HZE particles and low-LET radiation as they may be predisposed to increased late normal tissue damage... - The bystander response in C3H 10T1/2 cells: the influence of cell-to-cell contactS A Mitchell
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 161:397-401. 2004.... - Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamicsLubomir B Smilenov
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Cancer Res 65:933-8. 2005.... - Microbeams: a potent mix of physics and biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation ResponseD J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Radiat Prot Dosimetry 99:283-6. 2002.... - Neutron-energy-dependent cell survival and oncogenic transformationR C Miller
Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
J Radiat Res 40:53-9. 1999..Based on calculations of dose-averaged LET, 0.35 MeV neutrons have the greatest LET and therefore would be expected to be more biologically effective than neutrons of greater or lesser energies... - Do no harm--normal tissue effectsE J Hall
Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York 10032, USA
Acta Oncol 40:913-6. 2001..Radiation-induced sarcomas appear only in the heavily irradiated areas. These are small in number but appear with a very high relative risk... - Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiationT K Hei
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Adv Space Res 27:411-9. 2001..The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process... - Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cellsL B Smilenov
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Cancer Res 61:5710-3. 2001..From these data we suggest that Ataxia Telangiectasia heterozygotes could indeed represent a societally-significant radiosensitive human subpopulation... - Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ionsC Q Piao
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Radiat Res 155:263-267. 2001..No significant difference in either PALA resistance or microsatellite instability was found in tumor cell lines that were induced by alpha particles compared to those induced by (56)Fe ions... - Adaptive response and the bystander effect induced by radiation in C3H 10T(1/2) cells in cultureS G Sawant
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 156:177-80. 2001..The magnitude of this bystander effect increased with the number of particles per cell. An adaptive dose of 2 cGy of gamma rays, delivered 6 h beforehand, canceled out about half of the bystander effect produced by the alpha particles... - The radiation-induced bystander effect for clonogenic survivalS G Sawant
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 157:361-4. 2002..The biological effect was studied in the neomycin-resistant V79 cells after selective removal of the hit cells with geneticin treatment... - Bystander effect and adaptive response in C3H 10T(1/2) cellsS A Mitchell
Center for Radiological Research, Columbia University, New York, NY 10032, USA
Int J Radiat Biol 80:465-72. 2004..For oncogenic transformation, but not cell survival, radioadaption can occur in unirradiated cells via a transmissible factor(s)... - The oncogenic potential of a combination of hyperthermia and chemotherapy agentsK Komatsu
Department of Radiation Oncology, College of Physicians and Surgeons of Columbia University, New York, NY 10032
Br J Cancer 57:59-63. 1988..The modulating effects of heat on drug-induced transformation incidence appeared to be independent of whether application of heat and drug was concurrent or sequential... - The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cellsS G Sawant
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 155:397-401. 2001..e., that unirradiated cells are responding to damage induced in irradiated cells. This bystander effect in a biological system of relevance to carcinogenesis could have significant implications for risk estimation for low-dose radiation... - Scientific view of low-level radiation risksE J Hall
Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY 10032
Radiographics 11:509-18. 1991..The balance of risk versus benefit in diagnostic radiology is heavily weighted toward benefit, but the risks are there, and constant efforts are needed to reduce radiation doses to the minimum necessary... - Mortality patterns in British and US radiologists: what can we really conclude?D J Brenner
Center for Radiological Research, Columbia University, 630 West 168th St, New York, NY 10032, USA
Br J Radiol 76:1-2. 2003 - Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cellsY L Zhao
Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Radiat Res 155:230-234. 2001.... - Failla Memorial Lecture. From beans to genes--back to the futureE J Hall
Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, New York 10032
Radiat Res 129:235-49. 1992..Radiation-induced oncogenic transformation in C3H 10T1/2 cells has been shown to be due to a dominant acting transforming gene, which has been isolated and is in the process of being characterized and sequenced by Greg Freyer... - Telomere stability correlates with longevity of human beings exposed to ionizing radiationsGirdhar G Sharma
Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
Oncol Rep 10:1733-6. 2003.... - Cancer caused by x-rays--a random event?Eric J Hall
Lancet Oncol 8:369-70. 2007 - Demonstration of a radiation-induced bystander effect for low dose low LET beta-particlesRudranath Persaud
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Radiat Environ Biophys 46:395-400. 2007..The results of this study will address the relevant issues of actual target size and radiation quality, and are likely to have a significant impact on our current understanding of radiation risk assessment... - Biological responses in known bystander cells relative to known microbeam-irradiated cellsBrian Ponnaiya
Center for Radiological Research, Columbia University, New York, New York 10032, USA
Radiat Res 162:426-32. 2004..They indicate that the phenomenon has a quantitative basis and imply that the target for radiation effects cannot be considered to be the individual cell... - Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in miceNorman J Kleiman
Center for Radiological Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Radiat Res 168:567-73. 2007..These findings demonstrate that Mrad9 and Atm are important determinants of lens opacification and, given the roles of Atm and Rad9 in maintaining genomic stability, are consistent with a genotoxic basis for radiation cataractogenesis... - Computed tomography--an increasing source of radiation exposureDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
N Engl J Med 357:2277-84. 2007 - Secondary neutrons in clinical proton radiotherapy: a charged issueDavid J Brenner
Center for Radiological Research, Columbia University Medical Center, NY 10032, USA
Radiother Oncol 86:165-70. 2008..We discuss here the neutron doses involved, and the associated potential second cancer risks, with an emphasis on the uncertainties involved... - Antiprotons for radiotherapy?Eric J Hall
Radiother Oncol 81:231-2. 2006 - Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cellsHongning Zhou
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Radiat Res 160:512-6. 2003..Results from the present study address some of the pressing issues regarding both the actual target size and the radiation dose response and can improve on our current understanding of radiation risk assessment... - Radiation oncology: a century of achievementsJacques Bernier
Department of Radio Oncology, Oncology Institute of Southern Switzerland, CH 6504 Bellinzona, Switzerland
Nat Rev Cancer 4:737-47. 2004.... - Multiple gene effects in radiation oncogenesisEric J Hall
Center for Radiological Research, Columbia University Medical Center, New York, USA
Radiat Res 163:697-8. 2005 - Prostate radiotherapy is associated with second cancers in many organs, not just the colorectumDavid J Brenner
Gastroenterology 129:773-4; author reply 774-5. 2005 - Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblastsMykyta V Sokolov
Department of Nuclear Medicine, Clinical Center, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
Oncogene 24:7257-65. 2005..These studies show that H2AX phosphorylation is an early step in the bystander effect and that the DNA DSBs underlying gamma-H2AX focus formation may be responsible for its downstream manifestations... - Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture modelRudranath Persaud
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Cancer Res 65:9876-82. 2005..The results of this study will address the relevant issues of actual target size and radiation quality and are likely to have a significant effect on our current understanding of radiation risk assessment... - Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendationsLois B Travis
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Natl Cancer Inst 98:15-25. 2006..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer... - Risk of cancer from diagnostic X-raysDavid J Brenner
Lancet 363:2192; author reply 2192-3. 2004 - Cancer risks attributable to low doses of ionizing radiation: assessing what we really knowDavid J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:13761-6. 2003..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others... - Toward a consensus on radiobiology teaching to radiation oncology residentsJoseph R Dynlacht
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Radiat Res 157:599-606. 2002.... - Re: Bladder cancer risk following primary and adjuvant external beam radiation for prostate cancerDavid J Brenner
J Urol 175:788-9; author reply 789. 2006
Research Grants
- HIGH ENERGY IONS AND GENOMIC INSTABILITYEric Hall; Fiscal Year: 2001....