Anna Katerina Hadjantonakis

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint The color of mice: in the light of GFP-variant reporters
    A K Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Histochem Cell Biol 115:49-58. 2001
  2. pmc Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal
    Anna Katerina Hadjantonakis
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    BMC Biotechnol 2:11. 2002
  3. pmc The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 27:997-1002. 2013
  4. ncbi request reprint Live imaging and morphometric analysis of embryonic development in the ascidian Ciona intestinalis
    Jerry M Rhee
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 43:136-47. 2005
  5. pmc FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse
    Minjung Kang
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Development 140:267-79. 2013
  6. pmc Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice
    Stuart T Fraser
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genesis 42:162-71. 2005
  7. pmc The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Dev Biol 350:393-404. 2011
  8. pmc Genetic and spectrally distinct in vivo imaging: embryonic stem cells and mice with widespread expression of a monomeric red fluorescent protein
    Jonathan Z Long
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    BMC Biotechnol 5:20. 2005
  9. pmc Role of the gut endoderm in relaying left-right patterning in mice
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 10:e1001276. 2012
  10. pmc BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Dev Biol 361:245-62. 2012

Collaborators

Detail Information

Publications64

  1. ncbi request reprint The color of mice: in the light of GFP-variant reporters
    A K Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Histochem Cell Biol 115:49-58. 2001
    ....
  2. pmc Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal
    Anna Katerina Hadjantonakis
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    BMC Biotechnol 2:11. 2002
    ..We have previously demonstrated the utility and developmental neutrality of enhanced green fluorescent protein (EGFP) in embryonic stem (ES) cells and mice 2...
  3. pmc The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 27:997-1002. 2013
    ..Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity...
  4. ncbi request reprint Live imaging and morphometric analysis of embryonic development in the ascidian Ciona intestinalis
    Jerry M Rhee
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 43:136-47. 2005
    ..The approach we describe can be used to document morphogenetic cell and tissue rearrangements in living embryos and paves the way for a live digitized anatomical atlas of Ciona...
  5. pmc FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse
    Minjung Kang
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Development 140:267-79. 2013
    ..Instead, depending on concentration, we noted no effect or conversion of all ICM cells to GATA6-positive PrE. We propose that heterogeneities in the availability of FGF produce the salt-and-pepper distribution of lineage-biased cells...
  6. pmc Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice
    Stuart T Fraser
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genesis 42:162-71. 2005
    ..These transgenic lines permit real-time imaging in normal and pathological vasculogenesis and angiogenesis to track individual cells and mitotic events at a level of detail that is unprecedented in the mouse...
  7. pmc The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Dev Biol 350:393-404. 2011
    ..However, analysis of implantation-delayed blastocysts, revealed a role for SOX17 in the maintenance of PrE epithelial integrity, with the absence of SOX17 leading to premature delamination and migration of parietal endoderm...
  8. pmc Genetic and spectrally distinct in vivo imaging: embryonic stem cells and mice with widespread expression of a monomeric red fluorescent protein
    Jonathan Z Long
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    BMC Biotechnol 5:20. 2005
    ..A mutagenesis approach directing the stepwise evolution of DsRed has produced mRFP1, the first true monomer. mRFP1 currently represents an attractive autofluorescent reporter for use in heterologous systems...
  9. pmc Role of the gut endoderm in relaying left-right patterning in mice
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 10:e1001276. 2012
    ....
  10. pmc BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Dev Biol 361:245-62. 2012
    ..Taken together, our data suggest that XEN cells can be differentiated towards an exVE identity upon BMP4 stimulation and therefore represent a valuable tool for investigating PrE lineage differentiation...
  11. pmc PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA Institut Pasteur, CNRS URA 2578, Mouse Functional Genetics, Paris, France
    Stem Cells 31:1932-41. 2013
    ..Taken together, these data uncover an early role of PDGF signaling in PrE cell survival at the time when PrE and EPI cells are segregated...
  12. pmc Live imaging, identifying, and tracking single cells in complex populations in vivo and ex vivo
    Minjung Kang
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 1052:109-23. 2013
    ....
  13. ncbi request reprint Technicolour transgenics: imaging tools for functional genomics in the mouse
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Nat Rev Genet 4:613-25. 2003
    ..Importantly, these technologies allow direct visual access to complex events as they happen in their native environment, which provides greater insights into mammalian biology than ever before...
  14. pmc Dual transgene strategy for live visualization of chromatin and plasma membrane dynamics in murine embryonic stem cells and embryonic tissues
    Sonja Nowotschin
    Sloan Kettering Institute, New York, New York, USA
    Genesis 47:330-6. 2009
    ....
  15. pmc Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Dyn 235:2549-58. 2006
    ..These mice represent a valuable resource for live imaging as well as identification, quantitation, and isolation of cells from the primitive and definitive endoderm lineages of the developing mouse embryo...
  16. pmc GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst
    Nadine Schrode
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Dev Cell 29:454-67. 2014
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
  17. pmc Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th St, New York, NY 10032, USA
    BMC Biotechnol 4:33. 2004
    ..As a result, imaging using autofluorescent protein reporters is gaining popularity in mouse transgenic and targeted mutagenesis applications...
  18. pmc Afp::mCherry, a red fluorescent transgenic reporter of the mouse visceral endoderm
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA
    Genesis 49:124-33. 2011
    ..The Afp::mCherry reporter was also noted to be expressed in other documented sites of Afp expression including hepatocytes as well as in pancreas, digestive tract, and brain of postnatal mice...
  19. pmc Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo
    Joan Isern
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Blood 117:4924-34. 2011
    ..This is the first transcriptome assembled for a single hematopoietic lineage of the embryo over the course of its differentiation...
  20. pmc A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Development 137:3361-72. 2010
    ..Taken together, our data suggest a role for PDGF signaling in the expansion of the ExEn lineage. Our observations also uncover a possible role for the PrE in regulating the size of the pluripotent EPI compartment...
  21. pmc Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud
    Adam Packard
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Dev Cell 27:319-30. 2013
    ..Given the high rate of cell division in ureteric tips, this cellular behavior causes extensive epithelial cell rearrangements that may contribute to renal branching morphogenesis. ..
  22. pmc Anatomy of a blastocyst: cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo
    Nadine Schrode
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Genesis 51:219-33. 2013
    ....
  23. ncbi request reprint Live imaging of fluorescent proteins in chordate embryos: from ascidians to mice
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Microsc Res Tech 69:160-7. 2006
    ....
  24. pmc The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 15:509-20. 2008
    ....
  25. pmc Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 45:208-17. 2007
    ..These features establish the Tg(Eomes::GFP) BAC transgenic strain as a novel reagent for both live imaging and the isolation of Eomes expressing cells from specific locations within the embryo...
  26. pmc Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA
    Dev Biol 367:1-14. 2012
    ....
  27. pmc Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
    Berenika Plusa
    Developmental Biology Program, Sloan Kettering Institute, New York, USA
    Development 135:3081-91. 2008
    ..Subsequently, a gradual progression towards a mutually exclusive expression of PrE- and EPI-specific markers occurs. Finally, cell sorting is achieved by a variety of cell behaviours and by selective apoptosis...
  28. pmc Troika of the mouse blastocyst: lineage segregation and stem cells
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Curr Stem Cell Res Ther 7:78-91. 2012
    ..In this review, we will discuss how the isolation and genetic manipulation of murine stem cells representing each of these three lineages has contributed to our understanding of the molecular basis of early developmental events...
  29. pmc Live imaging mouse embryonic development: seeing is believing and revealing
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 1092:405-20. 2014
    ..Here, we provide an overview of some recent advances in this rapidly evolving field. ..
  30. pmc A bright single-cell resolution live imaging reporter of Notch signaling in the mouse
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    BMC Dev Biol 13:15. 2013
    ..In this way, CBF1 binding sites represent a good target for the design of a Notch signaling reporter...
  31. ncbi request reprint The multidimensionality of cell behaviors underlying morphogenesis: a case study in ascidians
    Anna Di Gregorio
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Bioessays 28:874-9. 2006
    ..They convincingly illustrated the utility of their approach by applying it to the early ascidian embryo...
  32. pmc A comparative analysis of extra-embryonic endoderm cell lines
    Kemar Brown
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 5:e12016. 2010
    ..In addition, pathway analysis suggests that the ExEn may mediate some of its functions through a non-classical MAP Kinase signaling pathway downstream of TAK1...
  33. pmc Cellular dynamics in the early mouse embryo: from axis formation to gastrulation
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Curr Opin Genet Dev 20:420-7. 2010
    ..In situ visualization of these processes in living specimens is a major goal, as it provides unprecedented detail of the individual cellular behaviors, which translate into the large-scale tissue rearrangements that shape the embryo...
  34. pmc Oriented cell motility and division underlie early limb bud morphogenesis
    Laurie A Wyngaarden
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, M5G 1X8, Canada
    Development 137:2551-8. 2010
    ..Furthermore, we provide evidence that Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours...
  35. pmc A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching
    Xuan Chi
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Genesis 47:61-6. 2009
    ..This strain should be extremely useful for studies of cell behavior during ureteric bud branching morphogenesis in wild type and mutant mouse lines...
  36. pmc Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library
    Mark J Tomishima
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Stem Cells 25:39-45. 2007
    ..Our protocols provide a simple and efficient strategy to utilize the whole GENSAT BAC library to create hundreds of novel fluorescent cell lines for use in ES cell biology...
  37. pmc AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
    Ritu Kumar
    Department of Surgery, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 500:89-92. 2013
    ..AID regulates this late step, removing epigenetic memory to stabilize the pluripotent state. ..
  38. doi request reprint Live imaging fluorescent proteins in early mouse embryos
    Panagiotis Xenopoulos
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, USA
    Methods Enzymol 506:361-89. 2012
    ..Here, we review recent advances in the application of FPs for live imaging in the early mouse embryo, as well as some of the methods used for ex utero embryo development that facilitate on-stage time-lapse specimen visualization...
  39. pmc Use of KikGR a photoconvertible green-to-red fluorescent protein for cell labeling and lineage analysis in ES cells and mouse embryos
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    BMC Dev Biol 9:49. 2009
    ..Photomodulatable fluorescent proteins are one of the emerging classes of genetically-encoded fluorescent proteins...
  40. pmc Imaging mouse development with confocal time-lapse microscopy
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, USA
    Methods Enzymol 476:351-77. 2010
    ..Live imaging using genetically encoded fluorescent protein reporters is pushing the envelope of our understanding by uncovering unprecedented insights into mouse development and leading to the formulation of quantitative accurate models...
  41. pmc Production of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos
    Guy S Eakin
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nat Protoc 1:1145-53. 2006
    ..Using this protocol, mouse chimeras can be generated and transferred to pseudopregnant surrogate mothers in a 5-d period...
  42. pmc Cell lineage allocation within the inner cell mass of the mouse blastocyst
    Panagiotis Xenopoulos
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Results Probl Cell Differ 55:185-202. 2012
    ..We discuss recent advances that have focused on elucidating how the salt-and-pepper pattern is established and then resolved within the ICM, leading to the correct apposition of cell lineages in preparation for implantation...
  43. pmc Dynamic and polarized muscle cell behaviors accompany tail morphogenesis in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 2:e714. 2007
    ..Investigating the cell behaviors underlying the morphogenesis of muscle in ascidians may therefore reveal the evolutionarily conserved mechanisms operating during this process...
  44. pmc A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse
    Anna Ferrer-Vaquer
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    BMC Dev Biol 10:121. 2010
    ..However, even though several transgenic Wnt/β-catenin reporter strains have been generated, to date, none provides the single-cell resolution favored for live imaging studies...
  45. pmc Birth defects associated with perturbations in preimplantation, gastrulation, and axis extension: from conjoined twinning to caudal dysgenesis
    Anna Ferrer-Vaquer
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Wiley Interdiscip Rev Dev Biol 2:427-42. 2013
    ..We will also review some of the rare birth defects occurring at these stages, in particular those resulting in conjoined twinning or caudal dysgenesis...
  46. pmc A conditional mutant allele for analysis of Mixl1 function in the mouse
    Maria V Pulina
    Developmental Biology Program, Sloan Kettering Institute, New York, New York
    Genesis 52:417-23. 2014
    ..Mixl1(KO/KO) embryos resembled the previously reported Mixl1(-/-) mutant phenotype. Therefore, the Mixl1 cKO allele provides a tool for investigating the temporal and tissue-specific requirements for Mixl1 in the mouse...
  47. pmc Sex-specific gene expression in preimplantation mouse embryos
    Guy S Eakin
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Genome Biol 7:205. 2006
    ..This tiny structure has now been observed to express nearly 600 genes in a sex-specific fashion, including at least one gene (Rhox/Pem) expressed only in females from their paternal X chromosome...
  48. pmc Can mammalian cloning combined with embryonic stem cell technologies be used to treat human diseases?
    Anna Katerina Hadjantonakis
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Genome Biol 3:REVIEWS1023. 2002
    ..A recent report offers the first 'proof of principle' of such cloning for therapeutic purposes, referred to as nuclear transplantation to produce stem cells for autologous transplantation...
  49. pmc eXtraembryonic ENdoderm (XEN) stem cells produce factors that activate heart formation
    Kemar Brown
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 5:e13446. 2010
    ..The recent development of protocols to isolate eXtraembryonic ENdoderm (XEN) stem cells, representing the extraembryonic endoderm lineage, from blastocyst stage mouse embryos offers new tools for the genetic dissection of cardiogenesis...
  50. pmc Aggregation chimeras: combining ES cells, diploid, and tetraploid embryos
    Mika Tanaka
    Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Methods Mol Biol 530:287-309. 2009
    ..Finally, detailed protocols and trouble-shooting suggestions will be presented for each of the steps involved...
  51. ncbi request reprint Generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos
    Jérôme Artus
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 693:37-56. 2011
    ..This chapter describes a simple and economical technique used to generate mouse chimeras by embryo aggregation. Multiple aggregation combinations are described each of which can be tailored to answer particular biological questions...
  52. pmc Ex utero culture and live imaging of mouse embryos
    Anna Piliszek
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 770:243-57. 2011
    ....
  53. pmc Nap1-mediated actin remodeling is essential for mammalian myoblast fusion
    Scott J Nowak
    Program in Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA
    J Cell Sci 122:3282-93. 2009
    ....
  54. pmc In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice
    Jerry M Rhee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Genesis 44:202-18. 2006
    ..Furthermore, combining these reporters with the study of mouse mutants will be a step forward in understanding the inter- and intracellular behaviors underlying morphogenesis in both normal and mutant contexts...
  55. pmc Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endoderm
    Gloria S Kwon
    Sloan Kettering Institute, New York, New York 10065, USA
    Genesis 47:447-55. 2009
    ..The Ttr::Cre strain can therefore be used as a tool for genetic modifications within the visceral endoderm lineage...
  56. ncbi request reprint Afp::mCherry, a red fluorescent transgenic reporter of the mouse visceral endoderm
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York Biochemistry, Cell and Molecular Biology Graduate Program, Weill Medical College of Cornell University, New York, New York
    Genesis 49:spcone. 2011
    ..Red and green fluorescent reporter-expressing cells are located in the endoderm layer along villi, but excluded from the crypt stem cell zone. See the article by Viotti at al. in this issue...
  57. pmc Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo
    Anna Ferrer-Vaquer
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Cell Adh Migr 4:447-57. 2010
    ..The cell behaviors and molecular mechanisms promoting transitions between these two states in the early mouse embryo are discussed in this review...
  58. pmc Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair
    Deniz Simsek
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 471:245-8. 2011
    ..Lig3-null cells are not sensitive to several DNA-damaging agents that sensitize Xrcc1-deficient cells. Our results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1...
  59. pmc A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D
    Anthony Santella
    Developmental Biology, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10065, USA
    BMC Bioinformatics 11:580. 2010
    ..Variability in nuclear appearance and undersampled volumetric data make this a challenge...
  60. pmc Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling
    Anna Katerina Hadjantonakis
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS ONE 3:e2511. 2008
    ..Here we describe a novel role for the T-box transcription factor gene Tbx6 in left/right body axis determination in the mouse...
  61. pmc Live-imaging fluorescent proteins in mouse embryos: multi-dimensional, multi-spectral perspectives
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, NY10065, USA
    Trends Biotechnol 27:266-76. 2009
    ..Here, we review some recent advances in this rapidly evolving field as applied to live-imaging capabilities in the mouse, the most genetically tractable mammalian model organism for embryologists...
  62. ncbi request reprint Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endoderm
    Gloria S Kwon
    Developmental Biology Program, Sloan Kettering Institute, New York, New York
    Genesis 47:spcone. 2009
    ..3D reconstructions of confocal z-stacks reveal reporter localization throughout the visceral endoderm (righthand image of each pair). See the paper by Kwon and Hadjantonakis in this issue...
  63. ncbi request reprint Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles
    A Nagy
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Curr Biol 8:661-4. 1998
    ..This, and the possibility of subsequent lineage-specific or conditional allele repair in situ, represent new genome modification strategies that can be used to investigate multiple functions of a single gene...
  64. ncbi request reprint The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:4691-701. 1999
    ....