X Edward Guo

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Quantification of a rat tail vertebra model for trabecular bone adaptation studies
    X Edward Guo
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 238 SW Mudd, MC 4703, New York, NY 10027, USA
    J Biomech 35:363-8. 2002
  2. pmc Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1
    Daisuke Kajimura
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 17:901-15. 2013
  3. pmc Premenopausal and postmenopausal differences in bone microstructure and mechanical competence in Chinese-American and white women
    MARCELLA D WALKER
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Bone Miner Res 28:1308-18. 2013
  4. pmc Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 25:2229-38. 2010
  5. pmc Individual trabeculae segmentation (ITS)-based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 25:1496-505. 2010
  6. doi request reprint In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration
    Jeffrey P Spalazzi
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Biomed Mater Res A 86:1-12. 2008
  7. pmc Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women
    X Sherry Liu
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Bone Miner Res 26:1783-92. 2011
  8. pmc Fast trabecular bone strength predictions of HR-pQCT and individual trabeculae segmentation-based plate and rod finite element model discriminate postmenopausal vertebral fractures
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA
    J Bone Miner Res 28:1666-78. 2013
  9. pmc Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study
    Adi Cohen
    Department of Medicine, Columbia University, College of Physicians and Surgeons, PH8 864 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:2562-72. 2013
  10. pmc Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history
    Adi Cohen
    Department of Medicine, PH8 864, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 97:4244-52. 2012

Detail Information

Publications80

  1. ncbi request reprint Quantification of a rat tail vertebra model for trabecular bone adaptation studies
    X Edward Guo
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 238 SW Mudd, MC 4703, New York, NY 10027, USA
    J Biomech 35:363-8. 2002
    ....
  2. pmc Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1
    Daisuke Kajimura
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell Metab 17:901-15. 2013
    ..It also proposes that adiponectin regulation of bone mass occurs through a PI3-kinase-FoxO1 pathway...
  3. pmc Premenopausal and postmenopausal differences in bone microstructure and mechanical competence in Chinese-American and white women
    MARCELLA D WALKER
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Bone Miner Res 28:1308-18. 2013
    ..Within-race cross-sectional differences between premenopausal and postmenopausal women suggest greater loss of plate-like Tb bone with aging in Chinese-Americans, though thicker cortices and more plate-like Tb bone persists...
  4. pmc Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 25:2229-38. 2010
    ..78) and vBMD by cQCT (r = 0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton...
  5. pmc Individual trabeculae segmentation (ITS)-based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 25:1496-505. 2010
    ..The results suggest that ITS-based morphological analysis of HR-pQCT images is a sensitive and promising clinical tool for the investigation of trabecular bone microstructure in human studies of osteoporosis...
  6. doi request reprint In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration
    Jeffrey P Spalazzi
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Biomed Mater Res A 86:1-12. 2008
    ....
  7. pmc Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women
    X Sherry Liu
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Bone Miner Res 26:1783-92. 2011
    ..The observation that Chinese-American women have a major microstructural advantage over white women may help to explain why their risk of fracture is lower despite their lower BMD...
  8. pmc Fast trabecular bone strength predictions of HR-pQCT and individual trabeculae segmentation-based plate and rod finite element model discriminate postmenopausal vertebral fractures
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA
    J Bone Miner Res 28:1666-78. 2013
    ..This accurate nonlinear µFE prediction of the HR-pQCT PR model, which requires only seconds of desktop computer time, has tremendous promise for clinical assessment of bone strength...
  9. pmc Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study
    Adi Cohen
    Department of Medicine, Columbia University, College of Physicians and Surgeons, PH8 864 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:2562-72. 2013
    ..It is controversial whether effects of obesity on bone are mediated by increased bone resorption or decreased bone formation...
  10. pmc Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history
    Adi Cohen
    Department of Medicine, PH8 864, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 97:4244-52. 2012
    ..The extent to which low bone mineral density (BMD) by dual-energy x-ray absorptiometry (DXA) reflects low volumetric BMD, bone microstructure, and strength is uncertain in the absence of low trauma fracture...
  11. pmc Microarchitectural abnormalities are more severe in postmenopausal women with vertebral compared to nonvertebral fractures
    Emily M Stein
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH8 West 864, New York, New York 10032, USA
    J Clin Endocrinol Metab 97:E1918-26. 2012
    ..Abnormal bone microarchitecture predisposes postmenopausal women to fragility fractures. Whether women with vertebral fractures have worse microarchitecture than those with nonvertebral fractures is unknown...
  12. pmc Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Bone Miner Res 27:263-72. 2012
    ..We conclude that HR-pQCT-based ITS and µFEA measurements increase our understanding of the microstructural pathogenesis of fragility fracture in postmenopausal women...
  13. doi request reprint A linearized formulation of triphasic mixture theory for articular cartilage, and its application to indentation analysis
    Xin L Lu
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace 500 West 120 th Street, New York, NY 10027, USA
    J Biomech 43:673-9. 2010
    ..These results have implications for studying chondrocyte mechanotransduction in different cartilage zones and for tissue engineering designs or in vivo cartilage repair...
  14. pmc CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons
    Franck Oury
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 24:2330-42. 2010
    ....
  15. doi request reprint Efficacy of serotonin inhibition in mouse models of bone loss
    Hiroyuki Inose
    Departments of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    J Bone Miner Res 26:2002-11. 2011
    ..This study provides a more comprehensive view of the anabolic efficacy of Tph1 inhibitors and further establishes the spectrum of their therapeutic potential in the treatment of bone-loss disorders...
  16. pmc Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women
    Emily M Stein
    Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Bone Miner Res 28:1029-40. 2013
    ..These results provide evidence that in PHPT, microstructural abnormalities are pervasive and not limited to the cortical compartment, which may help to account for increased global fracture risk in PHPT...
  17. pmc Abnormal microarchitecture and stiffness in postmenopausal women with ankle fractures
    Emily M Stein
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 96:2041-8. 2011
    ..Ankle fractures are not typically considered osteoporotic fractures. However, bone quality in patients with low trauma ankle fractures has not been explored...
  18. pmc Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual
    Daisuke Kajimura
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA
    J Exp Med 208:841-51. 2011
    ..As such, it suggests that inhibiting sympathetic signaling could be beneficial in the treatment of low bone mass conditions...
  19. pmc Differences in bone microarchitecture between postmenopausal Chinese-American and white women
    MARCELLA D WALKER
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Bone Miner Res 26:1392-8. 2011
    ..Whole-bone finite-element analysis may indicate that the thicker, more dense cortical bone and thicker trabeculae in postmenopausal Chinese-American women compensate for fewer trabeculae and smaller bone size...
  20. doi request reprint Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair
    Jie Jiang
    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Ann Biomed Eng 38:2183-96. 2010
    ..These results demonstrate the potential of the stratified scaffold for integrative cartilage repair and future studies will focus on scaffold optimization and in vivo evaluations...
  21. pmc In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading
    Da Jing
    1351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Ave, Columbia University, New York, NY 10027, USA
    FASEB J 28:1582-92. 2014
    ..This study develops a novel approach in skeletal mechanobiology and also advances our fundamental knowledge of bone mechanotransduction...
  22. pmc FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin
    Aruna Kode
    Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3490-503. 2012
    ..These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation...
  23. ncbi request reprint The generalized triphasic correspondence principle for simultaneous determination of the mechanical properties and proteoglycan content of articular cartilage by indentation
    X Lux Lu
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 500 West 120th Street, New York, NY 10027, USA
    J Biomech 40:2434-41. 2007
    ....
  24. ncbi request reprint Prediction of cortical bone elastic constants by a two-level micromechanical model using a generalized self-consistent method
    X Neil Dong
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 128:309-16. 2006
    ..The present micromechanical model of cortical bone will be useful in understanding the contribution of cortical bone porosity to femoral neck fractures...
  25. pmc Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity
    Yu Shi
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell Metab 11:231-8. 2010
    ..By showing that both arms of the autonomic nervous system affect bone remodeling, this study further underscores the importance of neuronal regulation of bone...
  26. pmc Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 23:223-35. 2008
    ..The ITS-based morphological analyses better characterize microarchitecture and help predict anisotropic mechanical properties of trabecular bone...
  27. pmc Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures
    Emily M Stein
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Bone Miner Res 25:2572-81. 2010
    ..2010 American Society for Bone and Mineral Research...
  28. pmc Matrix deposition modulates the viscoelastic shear properties of hydrogel-based cartilage grafts
    Leo Q Wan
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    Tissue Eng Part A 17:1111-22. 2011
    ..The findings of this study provide new insights into the structure-function relationship of engineered cartilage and design of functional grafts for cartilage repair...
  29. pmc Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo
    Yu Shi
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:20529-33. 2008
    ..This work establishes that in vivo leptin regulates bone mass accrual by acting through neuronal means and provides a direct demonstration that this function of leptin can occur independently of its regulation of energy metabolism...
  30. pmc Bariatric surgery results in cortical bone loss
    Emily M Stein
    Department of Medicine Endocrinology, Columbia University of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:541-9. 2013
    ..Bariatric surgery results in bone loss at weight-bearing sites, the mechanism of which is unknown...
  31. pmc In vitro model of vascularized bone: synergizing vascular development and osteogenesis
    Cristina Correia
    Department of Biomedical Engineering, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e28352. 2011
    ....
  32. pmc Micromechanical analyses of vertebral trabecular bone based on individual trabeculae segmentation of plates and rods
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    J Biomech 42:249-56. 2009
    ..The relative failed number and tissue fraction at apparent yield point indicate homogeneous local failure in plates and rods of different orientations...
  33. pmc A triphasic orthotropic laminate model for cartilage curling behavior: fixed charge density versus mechanical properties inhomogeneity
    Leo Q Wan
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech Eng 132:024504. 2010
    ..g., relatively dense and with high stiffness at the articular surface, play the dominate role in determining curling behaviors of such tissues...
  34. pmc Accuracy of high-resolution in vivo micro magnetic resonance imaging for measurements of microstructural and mechanical properties of human distal tibial bone
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 25:2039-50. 2010
    ..40 to 0.58). We conclude that most microstructural and mechanical properties of the distal tibia can be derived efficiently from µMR images and can provide additional information regarding bone quality...
  35. pmc Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis
    Adi Cohen
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 94:4351-60. 2009
    ..Idiopathic osteoporosis (IOP) is an uncommon disorder in which low areal bone mineral density (aBMD) and/or fractures occur in otherwise healthy premenopausal women...
  36. pmc Teriparatide Increases Strength of the Peripheral Skeleton in Premenopausal Women With Idiopathic Osteoporosis: A Pilot HR-pQCT Study
    Kyle K Nishiyama
    Division of Endocrinology K K N, A C, P Y, E S, Department of Medicine, and Department of Pathology D W D, College of Physicians and Surgeons, Columbia University, New York, New York 10032 Department of Biomedical Engineering J W, X E G, Columbia University, New York, New York 10027 and Division of Endocrinology J M L, R R R, Department of Medicine, Creighton University, Omaha, Nebraska 68131
    J Clin Endocrinol Metab 99:2418-25. 2014
    ..Conclusions: In premenopausal women with IOP, 18 months of teriparatide was associated with increases in trabecular volumetric BMD, improved trabecular microarchitecture, and estimated bone strength at both the radius and tibia. ..
  37. pmc Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow
    Andrew D Baik
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, NY 10027, USA
    Biochem Biophys Res Commun 431:718-23. 2013
    ..Taken together, the actin networks are the more responsive cytoskeletal networks in osteocytes under oscillatory flow and may play a bigger role in mechanotransduction pathway activation and regulation...
  38. pmc Calcium response in osteocytic networks under steady and oscillatory fluid flow
    X Lucas Lu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Bone 51:466-73. 2012
    ..Our findings support the hypothesis that the [Ca(2+)](i) responses of osteocytic networks are significantly dependent on the profiles of fluid flow...
  39. pmc miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2
    Jianwen Wei
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 197:509-21. 2012
    ..These results are the first to identify a family of microRNAs involved in bone formation in vivo and to identify a specific genetic pathway by which these microRNAs regulate osteoblast differentiation...
  40. doi request reprint The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin
    Songlin Peng
    Department of Spine Surgery, Shenzhen People s Hospital, Jinan University School of Medicine, Shenzhen, China
    Bone 49:1290-8. 2011
    ..We hypothesize that OPG plays an important role in the cross-talk between osteoclasts and osteoblasts in response to Sr treatment...
  41. pmc Optimizing the medium perfusion rate in bone tissue engineering bioreactors
    Warren L Grayson
    Department of Biomedical Engineering, Columbia University, New York, New York 10032, USA
    Biotechnol Bioeng 108:1159-70. 2011
    ..The complexity of the cellular responses found at different flow velocities underscores the need to use a range of evaluation parameters to determine the quality of engineered bone...
  42. pmc Dynamic simulation of three dimensional architectural and mechanical alterations in human trabecular bone during menopause
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, New York 10027, USA
    Bone 43:292-301. 2008
    ..The combined effect of trabeculae perforation, breakage, and isolated fragments resulted in fewer and smaller trabecular plates and more but thinner trabecular rods...
  43. doi request reprint Geometric control of human stem cell morphology and differentiation
    Leo Q Wan
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Integr Biol (Camb) 2:346-53. 2010
    ..This study confirms the role of substrate geometry on stem cell differentiation, through associated physical forces, and provides a simple and controllable system for studying biophysical regulation of cell function...
  44. pmc High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 25:746-56. 2010
    ..We conclude that microstructural measurements and mechanical parameters of distal tibia can be efficiently derived from HR-pQCT images and provide additional information regarding bone fragility...
  45. pmc An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation
    Bo Huo
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Cell Calcium 47:234-41. 2010
    ..No [Ca2+](i) response was detected in the cell network when the extracellular calcium source was removed. These findings identified the biochemical pathways involved in the calcium signaling propagation in bone cell networks...
  46. pmc Intercellular calcium wave propagation in linear and circuit-like bone cell networks
    Bo Huo
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, University of Columbia, 351 Engineering Terrace, PO Box 8904, 1210 Amsterdan Avenue, New York, NY 10027, USA
    Philos Trans A Math Phys Eng Sci 368:617-33. 2010
    ....
  47. doi request reprint Lower cortical porosity and higher tissue mineral density in Chinese American versus white women
    Stephanie Boutroy
    College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Bone Miner Res 29:551-61. 2014
    ..Po and greater Ct.TMD explain higher Ct.BMD in Chinese American versus white women. Thicker and preserved cortical bone structure in Chinese American women may contribute to greater resistance to fracture compared to white women...
  48. ncbi request reprint Spatially varying material properties of the rat caudal intervertebral disc
    Mandy M Ho
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Spine (Phila Pa 1976) 31:E486-93. 2006
    ..The use of a microscopy based material testing technique to assess the local material properties of rat caudal intervertebral discs under uniaxial compression...
  49. pmc Quasi-3D cytoskeletal dynamics of osteocytes under fluid flow
    Andrew D Baik
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA
    Biophys J 99:2812-20. 2010
    ..Disruption of MT networks caused actin normal strains to decrease, whereas actin disruption had little effect on the MT network strains, highlighting the networks' mechanical interactions in osteocytes...
  50. pmc In vivo microMRI-based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment
    X Henry Zhang
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Bone Miner Res 23:1426-34. 2008
    ..These results suggest that 24 mo of testosterone treatment of hypogonadal men improves estimated elastic moduli of tibial trabecular bone by increased trabecular plate thickness...
  51. pmc A noninvasive approach to determine viscoelastic properties of an individual adherent cell under fluid flow
    Jun Qiu
    School of Aerospace, Tsinghua University, Beijing, PR China Bone Bioengineering Laboratory, Columbia University, New York, NY 10027, USA
    J Biomech 47:1537-41. 2014
    ..23 kPas. This new quantitative approach not only provides an excellent means to measure cell mechanical properties, but also may help to elucidate the mechanotransduction mechanisms for a variety of cells under fluid flow stimulation...
  52. pmc Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow
    X Lucas Lu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 27:563-74. 2012
    ..The findings in this study proved that osteocytic networks possess unique characteristics in sensing and processing mechanical signals...
  53. pmc Contributions of trabecular rods of various orientations in determining the elastic properties of human vertebral trabecular bone
    X Sherry Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
    Bone 45:158-63. 2009
    ..The predictive ability of bone mineral density, a surrogate of BV/TV in clinical measurements, may reduce more quickly for transverse mechanical properties than for the axial mechanical properties...
  54. pmc Fixed electrical charges and mobile ions affect the measurable mechano-electrochemical properties of charged-hydrated biological tissues: the articular cartilage paradigm
    Leo Q Wan
    The Liu Ping Laboratory for Functional Tissue Engineering Research, Columbia University, New York, NY, USA
    Mech Chem Biosyst 1:81-99. 2004
    ..These results provide a better understanding of the manner in which fixed electric charges and mobile ions within the tissue contribute to the observed material responses...
  55. ncbi request reprint Intracellular calcium waves in bone cell networks under single cell nanoindentation
    X Edward Guo
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Mol Cell Biomech 3:95-107. 2006
    ..Thus, this study provides new experimental data that support the idea of osteocyte network memory of mechanical loading similar to memory in neural networks...
  56. pmc Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone
    Xiaowei S Liu
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Bone Miner Res 21:1608-17. 2006
    ..The results suggest that trabecular plates play an essential role in determining elastic properties of trabecular bone...
  57. ncbi request reprint Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral disc
    Yoshimasa Ishii
    Department of Orthopaedic Surgery, Columbia University, New York, NY, USA
    Spine (Phila Pa 1976) 31:1539-46. 2006
    ....
  58. ncbi request reprint The effect of matrix tension-compression nonlinearity and fixed negative charges on chondrocyte responses in cartilage
    Morakot Likhitpanichkul
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace 500 West 120th Street, New York, NY 10027, USA
    Mol Cell Biomech 2:191-204. 2005
    ....
  59. pmc Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis
    Vijay K Yadav
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, USA
    Nat Med 16:308-12. 2010
    ..These results provide a proof of principle that inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis...
  60. ncbi request reprint Individual trabecula segmentation (ITS)-based morphological analysis of microscale images of human tibial trabecular bone at limited spatial resolution
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
    J Bone Miner Res 26:2184-93. 2011
    ..59-0.95). We conclude that ITS measurements of HR-pQCT images are highly reflective of trabecular bone microarchitecture from a biomechanical perspective...
  61. ncbi request reprint Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent
    Erica Takai
    Bone Bioengineering Laboratory, Columbia University, New York, NY 10027, USA
    Ann Biomed Eng 33:963-71. 2005
    ..Modulation of cell stiffness upon adhesion to various substrates may influence mechanosignal transduction in osteoblasts...
  62. pmc Engineering anatomically shaped human bone grafts
    Warren L Grayson
    Department of Biomedical Engineering, Columbia University, VC 12 234, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:3299-304. 2010
    ..This approach has potential to overcome a critical hurdle-in vitro cultivation of viable bone grafts of complex geometries-to provide patient-specific bone grafts for craniofacial and orthopedic reconstructions...
  63. ncbi request reprint Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies
    Van C Mow
    Department of Biomedical Engineering, Columbia University New York, New York 10027, USA
    Annu Rev Biomed Eng 4:175-209. 2002
    ..Future directions in cartilage biomechanics and mechano-biology research are proposed...
  64. ncbi request reprint Anatomically shaped osteochondral constructs for articular cartilage repair
    Clark T Hung
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
    J Biomech 36:1853-64. 2003
    ..Anatomically shaped constructs on a bony substrate may represent a new paradigm in the design of a functional articular cartilage tissue replacement...
  65. ncbi request reprint The functional environment of chondrocytes within cartilage subjected to compressive loading: a theoretical and experimental approach
    Christopher C B Wang
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biorheology 39:11-25. 2002
    ..Coupled with biological assays of cell-scale biosynthesis, there is also a great potential in the future to study chondrocyte mechanotransduction in situ with a new level of specificity...
  66. ncbi request reprint Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice
    Streamson C Chua
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Am J Physiol Endocrinol Metab 286:E384-92. 2004
    ..Finally, the slightly increased adiposity and mild insulin resistance of transgenic db/db dams were not a contributory factor to the increased fat content of transgenic db/db male progeny...
  67. ncbi request reprint Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss
    Mone Zaidi
    The Mount Sinai Bone Program, Box 1055, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Curr Osteoporos Rep 7:118-26. 2009
    ....
  68. ncbi request reprint Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment
    Chi Hyun Kim
    Department of Biomedical Engineering, Bone Bioengineering Laboratory, Columbia University, New York, New York 10027, USA
    J Bone Miner Res 18:2116-25. 2003
    ..PTH enhances and sustains increased bone formation rate, which directly correlates to mechanical microenvironment, suggesting beneficial effects of combined PTH treatment and exercise in preventing osteoporosis...
  69. ncbi request reprint The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity
    X Neil Dong
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    J Biomech 37:1281-7. 2004
    ..These results may help a number of researchers develop more accurate micromechanics models of cortical bone...
  70. ncbi request reprint Interfacial strength of cement lines in human cortical bone
    X Neil Dong
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Mech Chem Biosyst 2:63-8. 2005
    ..71 +/- 15.06 MPa, ranging from 45.97 MPa to 93.74 MPa. Therefore, our results suggest that the cement line interface between osteon and interstitial bone tissue is weaker than that between bone tissue lamellae...
  71. pmc Spatiotemporal properties of intracellular calcium signaling in osteocytic and osteoblastic cell networks under fluid flow
    Da Jing
    Department of Biomedical Engineering, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Bone 53:531-40. 2013
    ..The higher intracellular Ca(2+) oscillatory behaviors and intercellular coordination of MLO-Y4 cells provided further evidences that osteocytes may behave as the major mechanical sensor in bone modeling and remodeling processes...
  72. ncbi request reprint Indentation determined mechanoelectrochemical properties and fixed charge density of articular cartilage
    X Lux Lu
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ann Biomed Eng 32:370-9. 2004
    ..Current study represents a first step toward developing a valid and effective method for the study of structure-function relationship in cartilage and possibly for future early stage OA detection in vivo...
  73. ncbi request reprint Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure
    Erica Takai
    Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Bone Miner Res 19:1403-10. 2004
    ..However, live osteocytes were necessary for osteoblasts to form osteoids in response to DHP, which directly show osteoblast-osteocyte interactions in this in vitro culture...
  74. ncbi request reprint In vivo evaluation of a tri-phasic composite scaffold for anterior cruciate ligament-to-bone integration
    Jeffrey P Spalazzi
    Dept of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 1:525-8. 2006
    ..The results of this study demonstrate the feasibility of multi-tissue regeneration on a single graft, as well as th- e potential of interface tissue engineering to enable the biological fixation of soft tissue grafts to bone...
  75. pmc A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
    Vijay K Yadav
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 138:976-89. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  76. ncbi request reprint Effects of thresholding techniques on microCT-based finite element models of trabecular bone
    Chi Hyun Kim
    Department of Biomedical Engineering, Institute of Medical Engineering, Yonsei University, 234 Maejiri, Wonju, Kangwon Do, Korea
    J Biomech Eng 129:481-6. 2007
    ..Our findings suggest that predictions of apparent mechanical properties and structural properties agree well with experimental measurements regardless of the choice of thresholding methods or the format of micro-CT images...
  77. ncbi request reprint An application of nanoindentation technique to measure bone tissue Lamellae properties
    C Edward Hoffler
    Orthopaedic Research Laboratories, Orthopaedic Surgery, The University of Michigan, Ann Arbor, MI 48109 0486, USA
    J Biomech Eng 127:1046-53. 2005
    ..The preliminary results indicated that interstitial bone tissue has significantly higher modulus and hardness than osteonal bone tissue. In addition, a significant correlation between hardness and elastic modulus was observed...
  78. ncbi request reprint Geometric determinants to cement line debonding and osteonal lamellae failure in osteon pushout tests
    X Neil Dong
    Bone and Joint Center, Department of Orthopaedic Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    J Biomech Eng 126:387-90. 2004
    ..Furthermore, the finite-element results suggest that a smoothly curved punch would most likely cause debonding at the cement line instead of osteonal lamellae...
  79. ncbi request reprint Immune response and effect of adenovirus-mediated human BMP-2 gene transfer on the repair of segmental tibial bone defects in goats
    X Leon Xu
    Department of Orthopaedic Surgery, Ninth People s Hospital, Shanghai Second Medical University, Shanghai 200011, P R China
    Acta Orthop 76:637-46. 2005
    ..Tissue-engineered bone may be used for filling bone defects. There are, however, no reports on this technique used in large animals...
  80. ncbi request reprint Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling
    Lisa E Freed
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Tissue Eng 12:3285-305. 2006
    ....