Research Topics
Genomes and Genes | X Edward GuoSummaryAffiliation: Columbia University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Quantification of a rat tail vertebra model for trabecular bone adaptation studiesX Edward Guo
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 238 SW Mudd, MC 4703, New York, NY 10027, USA
J Biomech 35:363-8. 2002....
Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal womenX Sherry Liu
Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
J Bone Miner Res 25:2229-38. 2010..78) and vBMD by cQCT (r = 0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton...- Individual trabeculae segmentation (ITS)-based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosisX Sherry Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Bone Miner Res 25:1496-505. 2010..The results suggest that ITS-based morphological analysis of HR-pQCT images is a sensitive and promising clinical tool for the investigation of trabecular bone microstructure in human studies of osteoporosis... 
In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integrationJeffrey P Spalazzi
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
J Biomed Mater Res A 86:1-12. 2008....- Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white womenX Sherry Liu
Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Bone Miner Res 26:1783-92. 2011..The observation that Chinese-American women have a major microstructural advantage over white women may help to explain why their risk of fracture is lower despite their lower BMD... - Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture historyAdi Cohen
Department of Medicine, PH8 864, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA
J Clin Endocrinol Metab 97:4244-52. 2012..The extent to which low bone mineral density (BMD) by dual-energy x-ray absorptiometry (DXA) reflects low volumetric BMD, bone microstructure, and strength is uncertain in the absence of low trauma fracture... - Microarchitectural abnormalities are more severe in postmenopausal women with vertebral compared to nonvertebral fracturesEmily M Stein
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH8 West 864, New York, New York 10032, USA
J Clin Endocrinol Metab 97:E1918-26. 2012..Abnormal bone microarchitecture predisposes postmenopausal women to fragility fractures. Whether women with vertebral fractures have worse microarchitecture than those with nonvertebral fractures is unknown... - Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurementsX Sherry Liu
Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Bone Miner Res 27:263-72. 2012..We conclude that HR-pQCT-based ITS and µFEA measurements increase our understanding of the microstructural pathogenesis of fragility fracture in postmenopausal women... - A linearized formulation of triphasic mixture theory for articular cartilage, and its application to indentation analysisXin L Lu
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace 500 West 120 th Street, New York, NY 10027, USA
J Biomech 43:673-9. 2010..These results have implications for studying chondrocyte mechanotransduction in different cartilage zones and for tissue engineering designs or in vivo cartilage repair... - Efficacy of serotonin inhibition in mouse models of bone lossHiroyuki Inose
Departments of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
J Bone Miner Res 26:2002-11. 2011..This study provides a more comprehensive view of the anabolic efficacy of Tph1 inhibitors and further establishes the spectrum of their therapeutic potential in the treatment of bone-loss disorders... - CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neuronsFranck Oury
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Genes Dev 24:2330-42. 2010.... - Abnormal microarchitecture and stiffness in postmenopausal women with ankle fracturesEmily M Stein
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Endocrinol Metab 96:2041-8. 2011..Ankle fractures are not typically considered osteoporotic fractures. However, bone quality in patients with low trauma ankle fractures has not been explored... - Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repairJie Jiang
Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace Building, MC 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
Ann Biomed Eng 38:2183-96. 2010..These results demonstrate the potential of the stratified scaffold for integrative cartilage repair and future studies will focus on scaffold optimization and in vivo evaluations... - Differences in bone microarchitecture between postmenopausal Chinese-American and white womenMARCELLA D WALKER
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Bone Miner Res 26:1392-8. 2011..Whole-bone finite-element analysis may indicate that the thicker, more dense cortical bone and thicker trabeculae in postmenopausal Chinese-American women compensate for fewer trabeculae and smaller bone size... - Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrualDaisuke Kajimura
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA
J Exp Med 208:841-51. 2011..As such, it suggests that inhibiting sympathetic signaling could be beneficial in the treatment of low bone mass conditions... - Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fracturesEmily M Stein
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Bone Miner Res 25:2572-81. 2010..2010 American Society for Bone and Mineral Research... - Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivoYu Shi
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 105:20529-33. 2008..This work establishes that in vivo leptin regulates bone mass accrual by acting through neuronal means and provides a direct demonstration that this function of leptin can occur independently of its regulation of energy metabolism... - Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular boneX Sherry Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Bone Miner Res 23:223-35. 2008..The ITS-based morphological analyses better characterize microarchitecture and help predict anisotropic mechanical properties of trabecular bone... - The generalized triphasic correspondence principle for simultaneous determination of the mechanical properties and proteoglycan content of articular cartilage by indentationX Lux Lu
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 500 West 120th Street, New York, NY 10027, USA
J Biomech 40:2434-41. 2007.... - Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activityYu Shi
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Cell Metab 11:231-8. 2010..By showing that both arms of the autonomic nervous system affect bone remodeling, this study further underscores the importance of neuronal regulation of bone... - Matrix deposition modulates the viscoelastic shear properties of hydrogel-based cartilage graftsLeo Q Wan
Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
Tissue Eng Part A 17:1111-22. 2011..The findings of this study provide new insights into the structure-function relationship of engineered cartilage and design of functional grafts for cartilage repair... - Prediction of cortical bone elastic constants by a two-level micromechanical model using a generalized self-consistent methodX Neil Dong
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Biomech Eng 128:309-16. 2006..The present micromechanical model of cortical bone will be useful in understanding the contribution of cortical bone porosity to femoral neck fractures... - In vitro model of vascularized bone: synergizing vascular development and osteogenesisCristina Correia
Department of Biomedical Engineering, Columbia University, New York, New York, United States of America
PLoS ONE 6:e28352. 2011.... - A triphasic orthotropic laminate model for cartilage curling behavior: fixed charge density versus mechanical properties inhomogeneityLeo Q Wan
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Biomech Eng 132:024504. 2010..g., relatively dense and with high stiffness at the articular surface, play the dominate role in determining curling behaviors of such tissues... - Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosisAdi Cohen
Department of Medicine, Columbia University, New York, New York 10032, USA
J Clin Endocrinol Metab 94:4351-60. 2009..Idiopathic osteoporosis (IOP) is an uncommon disorder in which low areal bone mineral density (aBMD) and/or fractures occur in otherwise healthy premenopausal women... - Micromechanical analyses of vertebral trabecular bone based on individual trabeculae segmentation of plates and rodsX Sherry Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
J Biomech 42:249-56. 2009..The relative failed number and tissue fraction at apparent yield point indicate homogeneous local failure in plates and rods of different orientations... - Accuracy of high-resolution in vivo micro magnetic resonance imaging for measurements of microstructural and mechanical properties of human distal tibial boneX Sherry Liu
Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
J Bone Miner Res 25:2039-50. 2010..40 to 0.58). We conclude that most microstructural and mechanical properties of the distal tibia can be derived efficiently from µMR images and can provide additional information regarding bone quality... - FOXO1 orchestrates the bone-suppressing function of gut-derived serotoninAruna Kode
Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 122:3490-503. 2012..These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation... - Calcium response in osteocytic networks under steady and oscillatory fluid flowX Lucas Lu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Bone 51:466-73. 2012..Our findings support the hypothesis that the [Ca(2+)](i) responses of osteocytic networks are significantly dependent on the profiles of fluid flow... - The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerinSonglin Peng
Department of Spine Surgery, Shenzhen People s Hospital, Jinan University School of Medicine, Shenzhen, China
Bone 49:1290-8. 2011..We hypothesize that OPG plays an important role in the cross-talk between osteoclasts and osteoblasts in response to Sr treatment... - miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2Jianwen Wei
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Cell Biol 197:509-21. 2012..These results are the first to identify a family of microRNAs involved in bone formation in vivo and to identify a specific genetic pathway by which these microRNAs regulate osteoblast differentiation... - An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentationBo Huo
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Cell Calcium 47:234-41. 2010..No [Ca2+](i) response was detected in the cell network when the extracellular calcium source was removed. These findings identified the biochemical pathways involved in the calcium signaling propagation in bone cell networks... - Intercellular calcium wave propagation in linear and circuit-like bone cell networksBo Huo
Bone Bioengineering Laboratory, Department of Biomedical Engineering, University of Columbia, 351 Engineering Terrace, PO Box 8904, 1210 Amsterdan Avenue, New York, NY 10027, USA
Philos Trans A Math Phys Eng Sci 368:617-33. 2010.... - High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial boneX Sherry Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Bone Miner Res 25:746-56. 2010..We conclude that microstructural measurements and mechanical parameters of distal tibia can be efficiently derived from HR-pQCT images and provide additional information regarding bone fragility... - Geometric control of human stem cell morphology and differentiationLeo Q Wan
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY 10027, USA
Integr Biol (Camb) 2:346-53. 2010..This study confirms the role of substrate geometry on stem cell differentiation, through associated physical forces, and provides a simple and controllable system for studying biophysical regulation of cell function... - Optimizing the medium perfusion rate in bone tissue engineering bioreactorsWarren L Grayson
Department of Biomedical Engineering, Columbia University, New York, New York 10032, USA
Biotechnol Bioeng 108:1159-70. 2011..The complexity of the cellular responses found at different flow velocities underscores the need to use a range of evaluation parameters to determine the quality of engineered bone... - Dynamic simulation of three dimensional architectural and mechanical alterations in human trabecular bone during menopauseX Sherry Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, New York 10027, USA
Bone 43:292-301. 2008..The combined effect of trabeculae perforation, breakage, and isolated fragments resulted in fewer and smaller trabecular plates and more but thinner trabecular rods... - Quasi-3D cytoskeletal dynamics of osteocytes under fluid flowAndrew D Baik
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York, USA
Biophys J 99:2812-20. 2010..Disruption of MT networks caused actin normal strains to decrease, whereas actin disruption had little effect on the MT network strains, highlighting the networks' mechanical interactions in osteocytes... - Spatially varying material properties of the rat caudal intervertebral discMandy M Ho
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Spine 31:E486-93. 2006..At equilibrium, the anulus fibrosus also appears to have a shielding effect independent of the material filling up the nucleus pulposus space... - In vivo microMRI-based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatmentX Henry Zhang
Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
J Bone Miner Res 23:1426-34. 2008..These results suggest that 24 mo of testosterone treatment of hypogonadal men improves estimated elastic moduli of tibial trabecular bone by increased trabecular plate thickness... - Bariatric surgery results in cortical bone lossEmily M Stein
MD, MS, AssistantColumbia University College of Physicians and Surgeons, 630 West 168th Street, PH8 West 864, New York, New York 10032
J Clin Endocrinol Metab 98:541-9. 2013..This study highlights deterioration of cortical bone loss as a novel mechanism for bone loss after bariatric surgery... - Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flowX Lucas Lu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Bone Miner Res 27:563-74. 2012..The findings in this study proved that osteocytic networks possess unique characteristics in sensing and processing mechanical signals... - Intracellular calcium waves in bone cell networks under single cell nanoindentationX Edward Guo
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Mol Cell Biomech 3:95-107. 2006..Thus, this study provides new experimental data that support the idea of osteocyte network memory of mechanical loading similar to memory in neural networks... - Fixed electrical charges and mobile ions affect the measurable mechano-electrochemical properties of charged-hydrated biological tissues: the articular cartilage paradigmLeo Q Wan
The Liu Ping Laboratory for Functional Tissue Engineering Research, Columbia University, New York, NY, USA
Mech Chem Biosyst 1:81-99. 2004..These results provide a better understanding of the manner in which fixed electric charges and mobile ions within the tissue contribute to the observed material responses... - Contributions of trabecular rods of various orientations in determining the elastic properties of human vertebral trabecular boneX Sherry Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY 10027, USA
Bone 45:158-63. 2009..The predictive ability of bone mineral density, a surrogate of BV/TV in clinical measurements, may reduce more quickly for transverse mechanical properties than for the axial mechanical properties... - Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flowAndrew D Baik
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, NY 10027, USA
Biochem Biophys Res Commun 431:718-23. 2013..Taken together, the actin networks are the more responsive cytoskeletal networks in osteocytes under oscillatory flow and may play a bigger role in mechanotransduction pathway activation and regulation... - Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosisVijay K Yadav
Department of Genetics and Development, Columbia University Medical Center, New York, New York, USA
Nat Med 16:308-12. 2010..These results provide a proof of principle that inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis... - Osteoblast elastic modulus measured by atomic force microscopy is substrate dependentErica Takai
Bone Bioengineering Laboratory, Columbia University, New York, NY 10027, USA
Ann Biomed Eng 33:963-71. 2005..Modulation of cell stiffness upon adhesion to various substrates may influence mechanosignal transduction in osteoblasts... - Individual trabecula segmentation (ITS)-based morphological analysis of microscale images of human tibial trabecular bone at limited spatial resolutionX Sherry Liu
Division of Endocrinology, Department of Medicine, Columbia University, New York, NY 10027, USA
J Bone Miner Res 26:2184-93. 2011..59-0.95). We conclude that ITS measurements of HR-pQCT images are highly reflective of trabecular bone microarchitecture from a biomechanical perspective... - Engineering anatomically shaped human bone graftsWarren L Grayson
Department of Biomedical Engineering, Columbia University, VC 12 234, New York, NY 10032, USA
Proc Natl Acad Sci U S A 107:3299-304. 2010..This approach has potential to overcome a critical hurdle-in vitro cultivation of viable bone grafts of complex geometries-to provide patient-specific bone grafts for craniofacial and orthopedic reconstructions... - The effect of matrix tension-compression nonlinearity and fixed negative charges on chondrocyte responses in cartilageMorakot Likhitpanichkul
Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace 500 West 120th Street, New York, NY 10027, USA
Mol Cell Biomech 2:191-204. 2005.... - Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral discYoshimasa Ishii
Department of Orthopaedic Surgery, Columbia University, New York, NY, USA
Spine (Phila Pa 1976) 31:1539-46. 2006.... - Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular boneXiaowei S Liu
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
J Bone Miner Res 21:1608-17. 2006..42). CONCLUSIONS: These results quantitatively show that the microarchitecture alone affects elastic moduli of trabecular bone and trabecular plates make a far greater contribution than rods to the bone's elastic behavior... - Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropiesVan C Mow
Department of Biomedical Engineering, Columbia University New York, New York 10027, USA
Annu Rev Biomed Eng 4:175-209. 2002..Future directions in cartilage biomechanics and mechano-biology research are proposed... - The functional environment of chondrocytes within cartilage subjected to compressive loading: a theoretical and experimental approachChristopher C-B Wang
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Biorheology 39:11-25. 2002..Coupled with biological assays of cell-scale biosynthesis, there is also a great potential in the future to study chondrocyte mechanotransduction in situ with a new level of specificity... - Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db miceStreamson C Chua
Department of Pediatrics, Columbia University, New York, New York 10032, USA
Am J Physiol Endocrinol Metab 286:E384-92. 2004..Finally, the slightly increased adiposity and mild insulin resistance of transgenic db/db dams were not a contributory factor to the increased fat content of transgenic db/db male progeny... - Anatomically shaped osteochondral constructs for articular cartilage repairClark T Hung
Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY 10027, USA
J Biomech 36:1853-64. 2003..Anatomically shaped constructs on a bony substrate may represent a new paradigm in the design of a functional articular cartilage tissue replacement... - Interfacial strength of cement lines in human cortical boneX Neil Dong
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Mech Chem Biosyst 2:63-8. 2005..71 +/- 15.06 MPa, ranging from 45.97 MPa to 93.74 MPa. Therefore, our results suggest that the cement line interface between osteon and interstitial bone tissue is weaker than that between bone tissue lamellae... - Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironmentChi Hyun Kim
Department of Biomedical Engineering, Bone Bioengineering Laboratory, Columbia University, New York, New York 10027, USA
J Bone Miner Res 18:2116-25. 2003..PTH enhances and sustains increased bone formation rate, which directly correlates to mechanical microenvironment, suggesting beneficial effects of combined PTH treatment and exercise in preventing osteoporosis... - The dependence of transversely isotropic elasticity of human femoral cortical bone on porosityX Neil Dong
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
J Biomech 37:1281-7. 2004..These results may help a number of researchers develop more accurate micromechanics models of cortical bone... - Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone lossMone Zaidi
The Mount Sinai Bone Program, Box 1055, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Curr Osteoporos Rep 7:118-26. 2009.... - Spatiotemporal properties of intracellular calcium signaling in osteocytic and osteoblastic cell networks under fluid flowDa Jing
Department of Biomedical Engineering, Fourth Military Medical University, Xi an, Shaanxi 710032, China
Bone 53:531-40. 2013..The higher intracellular Ca(2+) oscillatory behaviors and intercellular coordination of MLO-Y4 cells provided further evidences that osteocytes may behave as the major mechanical sensor in bone modeling and remodeling processes... - Indentation determined mechanoelectrochemical properties and fixed charge density of articular cartilageX Lux Lu
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Ann Biomed Eng 32:370-9. 2004..Current study represents a first step toward developing a valid and effective method for the study of structure-function relationship in cartilage and possibly for future early stage OA detection in vivo... - Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressureErica Takai
Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
J Bone Miner Res 19:1403-10. 2004..Furthermore, osteocytes play a critical role in the transmission of signals from DHP loading to modulate osteoblast function. This explant culture model may be used for mechanotransduction studies in long-term cultures... - In vivo evaluation of a tri-phasic composite scaffold for anterior cruciate ligament-to-bone integrationJeffrey P Spalazzi
Dept. of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 1:525-8. 2006..The results of this study demonstrate the feasibility of multi-tissue regeneration on a single graft, as well as th- e potential of interface tissue engineering to enable the biological fixation of soft tissue grafts to bone... - A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditureVijay K Yadav
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Cell 138:976-89. 2009..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online... - An application of nanoindentation technique to measure bone tissue Lamellae propertiesC Edward Hoffler
Orthopaedic Research Laboratories, Orthopaedic Surgery, The University of Michigan, Ann Arbor, MI 48109-0486, USA
J Biomech Eng 127:1046-53. 2005..The preliminary results indicated that interstitial bone tissue has significantly higher modulus and hardness than osteonal bone tissue. In addition, a significant correlation between hardness and elastic modulus was observed... - Geometric determinants to cement line debonding and osteonal lamellae failure in osteon pushout testsX Neil Dong
Bone and Joint Center, Department of Orthopaedic Surgery, Henry Ford Health System, Detroit, MI 48202, USA
J Biomech Eng 126:387-90. 2004..Furthermore, the finite-element results suggest that a smoothly curved punch would most likely cause debonding at the cement line instead of osteonal lamellae... - Effects of thresholding techniques on microCT-based finite element models of trabecular boneChi Hyun Kim
Department of Biomedical Engineering, Institute of Medical Engineering, Yonsei University, 234 Maejiri, Wonju, Kangwon Do, Korea
J Biomech Eng 129:481-6. 2007..Our findings suggest that predictions of apparent mechanical properties and structural properties agree well with experimental measurements regardless of the choice of thresholding methods or the format of micro-CT images... - Advanced tools for tissue engineering: scaffolds, bioreactors, and signalingLisa E Freed
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Tissue Eng 12:3285-305. 2006.... - Immune response and effect of adenovirus-mediated human BMP-2 gene transfer on the repair of segmental tibial bone defects in goatsX Leon Xu
Department of Orthopaedic Surgery, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, P. R. China
Acta Orthop 76:637-46. 2005..INTERPRETATION: We found that Adv-hBMP-2 genetransduced BMSCs had superior osteoinductivity in the repair of tibial bone defects in goats, but it could cause temporary cellular and persistent humoral immune responses against adenovirus...