Ningning Guo

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia
    Ningning Guo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 28:1703-11. 2003
  2. ncbi request reprint The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    Zhihong Zhu
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:983-94. 2004
  3. ncbi request reprint A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:727-38. 2004
  4. ncbi request reprint A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:543-56. 2004
  5. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
  6. ncbi request reprint Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents
    Yiyun Huang
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Med Chem 48:2559-70. 2005
  7. ncbi request reprint A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone
    Yiyun Huang
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Med Chem 48:5096-9. 2005
  8. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
  9. pmc Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers
    Ningning Guo
    Department of Psychiatry, Columbia University, New York, NY10032, USA
    Neuropsychopharmacology 35:806-17. 2010
  10. ncbi request reprint In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman primates
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Psychopharmacology (Berl) 175:274-86. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia
    Ningning Guo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 28:1703-11. 2003
    ....
  2. ncbi request reprint The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics
    Zhihong Zhu
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 31:983-94. 2004
    ..In summary, [(11)C]AFE appears to be a PET radioligand with fast brain uptake kinetics and can be used for the visualization and quantification of SERT in vivo...
  3. ncbi request reprint A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:727-38. 2004
    ..In summary, [11C]AFA appears to be an appropriate PET radioligand with a fast brain uptake kinetics:..
  4. ncbi request reprint A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Box 31, New York, NY 10032, USA
    Nucl Med Biol 31:543-56. 2004
    ..In summary, [(11)C]AFM appears to be an excellent PET radioligand for the visualization and reliable quantification of SERT in vivo...
  5. doi request reprint Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Synapse 66:1002-14. 2012
    ..Radioligands with higher affinity and/or lower lipophilicity are needed to successfully image the mGlu1 receptor in humans...
  6. ncbi request reprint Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents
    Yiyun Huang
    Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Med Chem 48:2559-70. 2005
    ..Among these four ligands, three appear to be promising radioligands suitable for the labeling of SERT in vivo, with 18a providing a higher specific binding in vivo than 16 or 18b...
  7. ncbi request reprint A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone
    Yiyun Huang
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Med Chem 48:5096-9. 2005
    ..Results from animal experiments demonstrate that the radioligand [11C]2 is the first PET tracer capable of labeling the rat mGlu1 receptor in vivo...
  8. ncbi request reprint Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography
    Bart N M van Berckel
    Department of Psychiatry, Columbia University, New York, NY, USA
    Neuropsychopharmacology 31:967-77. 2006
    ....
  9. pmc Impact of D2 receptor internalization on binding affinity of neuroimaging radiotracers
    Ningning Guo
    Department of Psychiatry, Columbia University, New York, NY10032, USA
    Neuropsychopharmacology 35:806-17. 2010
    ....
  10. ncbi request reprint In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman primates
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Psychopharmacology (Berl) 175:274-86. 2004
    ..The high signal to noise ratio of [18F]fallypride has been attributed to its high affinity for D2 receptors (K(D) of 0.03 nM, measured in vitro at room temperature)...
  11. ncbi request reprint Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA)
    Yiyun Huang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucl Med Biol 29:741-51. 2002
    ..In summary, [11C]DAPA appears to be a promising radioligand suitable for the visualization of SERT in vivo using PET...
  12. ncbi request reprint Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT(2A/2C) serotonin agonist
    Yolanda Zea-Ponce
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Nucl Med Biol 29:575-83. 2002
    ....
  13. ncbi request reprint A method based on multispectral imaging technique for white blood cell segmentation
    Ningning Guo
    Electronic Information School, Wuhan University, Wuhan, PR China
    Comput Biol Med 37:70-6. 2007
    ..Mass of experiments showed that the method is robust, effective and insensitive to smear staining and illumination condition...