Research Topics
Species | Michael F GrunebaumSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Pilot randomized clinical trial of an SSRI vs bupropion: effects on suicidal behavior, ideation, and mood in major depressionMichael F Grunebaum
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 37:697-706. 2012..Given the lack of evidence-based pharmacotherapy guidelines for suicidal, depressed patients-an important public health population-this preliminary finding merits further study...
Symptom components of standard depression scales and past suicidal behaviorMichael F Grunebaum
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, United States
J Affect Disord 87:73-82. 2005..Global severity on depression scales may obscure associations between specific symptoms and suicidal behavior...- Correlates of suicide attempt history in bipolar disorder: a stress-diathesis perspectiveMichael F Grunebaum
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
Bipolar Disord 8:551-7. 2006..We sought to identify such factors and to consider them within a stress-diathesis model of suicidal behavior... - Aggression and substance abuse in bipolar disorderMichael F Grunebaum
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
Bipolar Disord 8:496-502. 2006..We also explored the chronology of onset of mood and SUD... 
Association of X-box binding protein 1 ( XBP1) genotype with morning cortisol and 1-year clinical course after a major depressive episodeMichael F Grunebaum
Department of Psychiatry, Columbia University, New York, NY 10032, USA
Int J Neuropsychopharmacol 12:281-3. 2009..The results suggest that hypothalamic-pituitary-adrenocortical and cellular stress pathways involving the XBP1 gene may be involved in the pathophysiology of major depressive disorder. These relationships merit further study...- Attachment and social adjustment: relationships to suicide attempt and major depressive episode in a prospective studyMichael F Grunebaum
Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, USA
J Affect Disord 123:123-30. 2010..To study two aspects of interpersonal function - attachment security and social adjustment - in relation to suicide attempt and major depressive episode (MDE) during naturalistic follow-up of up to one year after presentation with MDE... - Antidepressants and suicide risk in the United States, 1985-1999Michael F Grunebaum
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
J Clin Psychiatry 65:1456-62. 2004..An association was hypothesized between the increase in the use of non-tricyclic antidepressant medications in the United States and the decline in the suicide rate during the years 1985-1999... - Melancholia and the probability and lethality of suicide attemptsMichael F Grunebaum
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA
Br J Psychiatry 184:534-5. 2004..Controlling for depression severity and other covariates, melancholia at baseline assessment was associated with more serious past suicide attempts and with the probability of suicide attempt during follow-up... - Protective factors against suicidal behavior in depressed adults reporting childhood abuseKanita Dervic
Department of Neuroscience, New York State Psychiatric Institute, and Columbia University, New York, New York 10032, USA
J Nerv Ment Dis 194:971-4. 2006..The results of this clinical study add support to previous reports that religious/spiritual coping could serve as an additional resource in prevention of suicidal behavior for subjects with reported childhood abuse... - Moral objections to suicide: Can they counteract suicidality in patients with cluster B psychopathology?Kanita Dervic
Department of Neuroscience, Columbia University, New York, NY, USA
J Clin Psychiatry 67:620-5. 2006..The effect of MOS was then examined in relation to other mechanisms affecting suicide risk including trait aggressivity and the presence of effective coping strategies... - Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorderMaria A Oquendo
Department of Neuroscience, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
Am J Psychiatry 161:1433-41. 2004..The predictive potential of the diathesis was tested by determining whether clinical correlates of past suicidal behavior predict suicidal acts during a 2-year follow-up of patients with a major depressive episode... - Clinical correlates of planned, more lethal suicide attempts in major depressive disorderAtsuo Nakagawa
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, USA
J Affect Disord 112:237-42. 2009..The purpose of this study was to investigate clinical correlates of suicide planning in depressed patients... - Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?Juan J Carballo
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, United States
J Affect Disord 109:57-63. 2008..Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects... - A prospective study of the association of cerebrospinal fluid monoamine metabolite levels with lethality of suicide attempts in patients with bipolar disorderLeo Sher
Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
Bipolar Disord 8:543-50. 2006.... - Sex differences in clinical predictors of suicidal acts after major depression: a prospective studyMaria A Oquendo
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Dr, New York, NY 10032, USA
Am J Psychiatry 164:134-41. 2007.... - Treatment of depressed bipolar patients with alcohol use disorders: plenty of room for improvementEnrique Baca-Garcia
Molecular Imaging and Neuropathology Division, NYS Psychiatric Institute and Columbia University, New York 10032, USA
J Affect Disord 115:262-8. 2009..We hypothesize that the adequacy of antidepressant treatment and the compliance with treatment for those with AUD are lower than for those without AUD... - Clinical predictors of suicidal acts after major depression in bipolar disorder: a prospective studyHanga Galfalvy
Department of Neuroscience, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
Bipolar Disord 8:586-95. 2006..This study determined the clinical predictors of suicidal behavior during a 2-year follow-up of patients with bipolar disorder presenting with a major depressive episode (MDE)... - A comparison of the medical lethality of suicide attempts in bipolar and major depressive disordersGil Zalsman
Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
Bipolar Disord 8:558-65. 2006.... - Association of comorbid posttraumatic stress disorder and major depression with greater risk for suicidal behaviorMaria A Oquendo
New York State Psychiatric Institute, Columbia University, New York, 10032, USA
Am J Psychiatry 160:580-2. 2003..The authors' goal was to examine the effect of comorbid PTSD and major depressive episode on suicidal behavior... - The role of moral objections to suicide in the assessment of suicidal patientsDana Lizardi
School of Social Work, Columbia University, New York, NY 10027, USA
J Psychiatr Res 42:815-21. 2008..It is unclear whether MOS are a protective factor against suicide attempt per se, or if this effect is mediated through other variables... - Suicidal behavior and mild traumatic brain injury in major depressionMaria A Oquendo
Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
J Nerv Ment Dis 192:430-4. 2004..Our data suggest that suicidal behavior and TBI share antecedent risk factors: hostility and aggression. Future studies may yield confirmation using a prospective design... - Are high-lethality suicide attempters with bipolar disorder a distinct phenotype?Maria A Oquendo
Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
Arch Suicide Res 13:247-56. 2009..A subset of high-lethality attempters make only high-lethality attempts. However, presence of previous low-lethality attempts does not indicate that risk for more lethal, possibly successful, attempts is reduced... - Higher cerebrospinal fluid homovanillic acid levels in depressed patients with comorbid posttraumatic stress disorderLeo Sher
Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
Eur Neuropsychopharmacol 15:203-9. 2005..Higher dopaminergic activity may contribute to alterations in memory and other cognitive functions, anhedonia, and hypervigilance observed in PTSD... - The relationship of aggression to suicidal behavior in depressed patients with a history of alcoholismLeo Sher
Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
Addict Behav 30:1144-53. 2005..The reason for higher rate of suicide and suicide attempts in comorbid subjects is uncertain. We explored clinical characteristics that may be associated with this increased suicidality... - Does first episode polarity predict risk for suicide attempt in bipolar disorder?Sadia R Chaudhury
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, United States
J Affect Disord 104:245-50. 2007..We tested the hypothesis that the polarity of a patient's first mood episode would be a marker for BD subtypes with differential risk for suicidality... - CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependenceLeo Sher
Division of Neuroscience, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Eur Neuropsychopharmacol 17:12-5. 2007..We sought to study the relationship of CSF monoamine metabolites to lethality of suicidal acts in depressed subjects with comorbid alcoholism... - Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behaviorMaria A Oquendo
Columbia University, New York State Psychiatric Institute, New York, USA
Am J Psychiatry 168:1050-6. 2011..The authors tested the hypothesis that lithium offers bipolar patients with a history of suicide attempt greater protection against suicidal behavior compared to valproate... - Testosterone levels in suicide attempters with bipolar disorderLeo Sher
New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York, NY 10468, USA
J Psychiatr Res 46:1267-71. 2012..This is the first study to examine whether there is a relation between testosterone levels and clinical parameters in bipolar suicide attempters... - Lower CSF homovanillic acid levels in depressed patients with a history of alcoholismLeo Sher
Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 28:1712-9. 2003..Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE... - Religious affiliation and suicide attemptKanita Dervic
Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Dr, Unit Number 42, New York, NY 10032, USA
Am J Psychiatry 161:2303-8. 2004..Further study about the influence of religious affiliation on aggressive behavior and how moral objections can reduce the probability of acting on suicidal thoughts may offer new therapeutic strategies in suicide prevention... - Neuropsychological characteristics as predictors of SSRI treatment response in depressed subjectsMarianne Gorlyn
Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
J Neural Transm 115:1213-9. 2008..Cognitive slowing may mediate the working memory and executive function deficits found in nonresponders. These findings can inform exploration for pharmacogenetic endophenotypes... - Protective factors against suicidal behavior in LatinosMaria A Oquendo
Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY, USA
J Nerv Ment Dis 193:438-43. 2005..Further studies to elucidate the impact of these factors on suicidal behavior and their relationship to specific cultural constructs would be of interest... - Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: an open studyLeo Sher
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Psychiatry Res 196:261-6. 2012..Our finding has not supported the hypothesis that a response to treatment is poorer in the PTSD-MDD group which may indicate that sicker patients benefit more from the treatment... - Association of suicide and antidepressant prescription rates in Japan, 1999-2003Atsuo Nakagawa
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
J Clin Psychiatry 68:908-16. 2007..We examined the relationship of increasing prescription volume of newer antidepressants, introduced in Japan in 1999, to national rates of suicide... - Clinical impact of a 2-week psychotropic medication washout in unipolar depressed inpatientsMichael F Grunebaum
The Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
J Affect Disord 75:291-6. 2003..We studied the impact of a short-term medication washout in unipolar depressed patients consecutively admitted to hospital for neuroimaging and cerebrospinal fluid (CSF) studies... - Adequacy of antidepressant treatment after discharge and the occurrence of suicidal acts in major depression: a prospective studyMaria A Oquendo
New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Am J Psychiatry 159:1746-51. 2002..The authors prospectively studied the adequacy of antidepressant treatment and its impact on suicidal acts in the 2 years after hospitalization for major depression... - Are BPI and BPII suicide attempters distinct neuropsychologically?Jill M Harkavy-Friedman
New York State Psychiatric Institute and Columbia University, USA
J Affect Disord 94:255-9. 2006..Neuropsychological functioning is a means of understanding similarities and differences between diagnostic groups... - Plasma kynurenine levels are elevated in suicide attempters with major depressive disorderM Elizabeth Sublette
Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY 10032, United States
Brain Behav Immun 25:1272-8. 2011..We hypothesized that patients with major depressive disorder (MDD) and a history of suicide attempt would have higher levels of KYN than depressed nonattempters, who in turn would have higher levels than healthy volunteers... - Suicidal ideation and the subjective aspects of depressionJohn G Keilp
Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, NY 10032, United States
J Affect Disord 140:75-81. 2012.... - Depressive symptoms and antidepressant use in a random community sample of ethnically diverse, urban elder personsMichael F Grunebaum
Department of Psychiatry, The College of Physicians and Surgeons, Columbia University, United States
J Affect Disord 105:273-7. 2008..There are limited data on depressive symptoms and antidepressant use in ethnically diverse, urban elderly... - Cluster C personality disorders in major depressive episodes: the relationship between hostility and suicidal behaviorKanita Dervic
Department of Child and Adolescent Neuropsychiatry University Hospital, Medical University of Vienna, Austria
Arch Suicide Res 11:83-90. 2007..1990)... - Prospective study of falls in long-term inpatients with chronic psychotic disordersAtsuo Nakagawa
Schizophr Res 88:283-5. 2006 - Comorbid anxiety in bipolar disorder: does it have an independent effect on suicidality?Atsuo Nakagawa
Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan
Bipolar Disord 10:530-8. 2008..This study examined the impact of comorbid Cluster B personality disorder and anxiety disorder on suicidality in bipolar disorder...
Research Grants
- Fluoxetine Versus Bupropion in Suicide Attempters With Major Depressive DisorderMichael Grunebaum; Fiscal Year: 2007..The long-term goal of this award is for the candidate to become an expert and independent clinical researcher on the treatment of depression with a special focus on suicide prevention. ..