Iva Greenwald

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Notch and the awesome power of genetics
    Iva Greenwald
    Department of Biochemistry and Molecular Biophysics, Department of Genetics and Development, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genetics 191:655-69. 2012
  2. pmc Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans
    Xinyong Zhang
    Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 188:847-58. 2011
  3. ncbi request reprint Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis
    Xantha Karp
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 272:460-9. 2004
  4. ncbi request reprint lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans
    Toshia R Myers
    Department of Biological Sciences, Columbia University, New York, NY 10032, USA
    Dev Cell 8:117-23. 2005
  5. pmc LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans
    Andrew S Yoo
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Science 310:1330-3. 2005
  6. pmc LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning
    Ji Li
    Department of Biological Sciences, Columbia University, New York, NY 10032, USA
    Curr Biol 20:1875-9. 2010
  7. pmc EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans
    Iskra Katic
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 174:1907-15. 2006
  8. ncbi request reprint Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development
    Andrew S Yoo
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Science 303:663-6. 2004
  9. ncbi request reprint SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells
    Natalie de Souza
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, 701 W 168th Street, Hammer Health Sciences, New York, NY 10032, USA
    Development 134:691-702. 2007
  10. ncbi request reprint SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans
    Mingxue Cui
    Howard Hughes Medical Institute, Department of MCD Biology, University of Colorado, Boulder, Colorado 80309, USA
    Dev Cell 10:667-72. 2006

Collaborators

Detail Information

Publications23

  1. pmc Notch and the awesome power of genetics
    Iva Greenwald
    Department of Biochemistry and Molecular Biophysics, Department of Genetics and Development, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genetics 191:655-69. 2012
    ..As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery...
  2. pmc Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans
    Xinyong Zhang
    Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 188:847-58. 2011
    ..Relief of repression of lag-2 in P6.p offers a plausible mechanistic basis for spatial restriction of lag-2 in generating the precise spatial pattern of VPC fates...
  3. ncbi request reprint Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis
    Xantha Karp
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 272:460-9. 2004
    ..hlh-2 also acts at an independent point in the gonadal lineage both to specify distal tip cells (DTCs) and in DTC differentiation and function...
  4. ncbi request reprint lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans
    Toshia R Myers
    Department of Biological Sciences, Columbia University, New York, NY 10032, USA
    Dev Cell 8:117-23. 2005
    ..LIN-35 Rb may inhibit vulval fates by regulating a signal from hyp7 to the VPCs or the physiological state of hyp7...
  5. pmc LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans
    Andrew S Yoo
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Science 310:1330-3. 2005
    ..Our results suggest that lin-12, mir-61, and vav-1 form a feedback loop that helps maximize lin-12 activity in the presumptive 2 degrees VPCs...
  6. pmc LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning
    Ji Li
    Department of Biological Sciences, Columbia University, New York, NY 10032, USA
    Curr Biol 20:1875-9. 2010
    ....
  7. pmc EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans
    Iskra Katic
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 174:1907-15. 2006
    ..emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain and has apparent orthologs in fission yeast, plants, and animals...
  8. ncbi request reprint Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development
    Andrew S Yoo
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Science 303:663-6. 2004
    ..Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal...
  9. ncbi request reprint SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells
    Natalie de Souza
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, 701 W 168th Street, Hammer Health Sciences, New York, NY 10032, USA
    Development 134:691-702. 2007
    ..Our results also suggest that sel-2 activity may contribute to the appropriate steady-state level of LIN-12 or to trafficking events that affect receptor activation...
  10. ncbi request reprint SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans
    Mingxue Cui
    Howard Hughes Medical Institute, Department of MCD Biology, University of Colorado, Boulder, Colorado 80309, USA
    Dev Cell 10:667-72. 2006
    ....
  11. ncbi request reprint The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins
    Ning Chen
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Dev Cell 6:183-92. 2004
    ..In addition, we show that DSL-1, which lacks a predicted transmembrane domain, is a natural secreted ligand and can substitute for the transmembrane ligand LAG-2 in different functional assays...
  12. pmc A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells
    Cory D Dunn
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Institute for Cancer Genetics, USA
    Proc Natl Acad Sci U S A 107:5907-12. 2010
    ..We also acquired evidence for functional redundancy among tetraspanins in both C. elegans and human cells. Selective inhibition of tetraspanins may constitute an anti-NOTCH therapeutic approach to reduce gamma-secretase activity...
  13. pmc Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans
    Xantha Karp
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 110:2181-6. 2013
    ....
  14. pmc sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans
    Min Sung Choi
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 5:e11885. 2010
    ..Loss of negative regulators of lin-12/Notch activity has the potential for influencing cell fate decisions during development and the genesis or aggressiveness of cancer...
  15. pmc New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme
    Iskra Katic
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    Genetics 171:1605-15. 2005
    ..Genetic analysis and cell ablation experiments suggest that bre-5 functions prior to ligand-induced ectodomain shedding that activates LIN-12 for signal transduction...
  16. ncbi request reprint LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans
    Daniel D Shaye
    Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
    Development 132:5081-92. 2005
    ....
  17. pmc Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans
    Toshia R Myers
    Departments of Biological Sciences and Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, Room 720, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:20368-73. 2007
    ..We propose that Wnt signaling plays a permissive role in preventing VPCs from fusing with hyp7 and reevaluate the roles of Wnt and LIN-3/EGF signaling in competence and induction...
  18. ncbi request reprint Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans
    Daniel D Shaye
    Department of Genetics and Development, and Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 420:686-90. 2002
    ..We also show that if LIN-12 is stabilized in P6.p, lateral signalling is compromised, indicating that LIN-12 downregulation is important in the appropriate specification of cell fates in vivo...
  19. pmc Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE
    Sophie Jarriault
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Biol 287:1-10. 2005
    ..Our results are consistent with the possibility that sup-17 and adm-4 are functionally redundant for at least a subset of LIN-12/Notch-mediated decisions in C. elegans...
  20. pmc sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans
    Jiabin Chen
    Department of Biochemistry and Molecular Biophysics, Molecular and Biophysical Studies, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 166:151-60. 2004
    ..8, that also interacts with SEL-8, a known component of the nuclear complex that forms upon LIN-12 activation. Our data suggest potential roles for SEL-7 in the assembly or function of this nuclear complex...
  21. pmc Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans
    Xantha Karp
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 17:3100-11. 2003
    ..We propose models to suggest how birth order, HLH-2 accumulation, and transcription of lag-2 may be linked during the AC/VU decision...
  22. pmc OrthoList: a compendium of C. elegans genes with human orthologs
    Daniel D Shaye
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 6:e20085. 2011
    ..We sought to assess the orthology between C. elegans and human genes to understand better the relationship between their genomes and to generate a compelling list of candidates to streamline RNAi-based screens in this model...
  23. pmc Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans
    Sophie Jarriault
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 16:2713-28. 2002
    ....