Joseph Gogos

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Schizophrenia susceptibility genes: emergence of positional candidates and future directions
    Joseph A Gogos
    Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Pharmacol Sci 27:226-33. 2006
  2. pmc Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia
    Torfi Sigurdsson
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 464:763-7. 2010
  3. pmc Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice
    Hiroko Koike
    Human Neurogenetics Laboratory, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:3693-7. 2006
  4. ncbi request reprint Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
    Marta Paterlini
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 8:1586-94. 2005
  5. pmc Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion
    Jun Mukai
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Neurosci 11:1302-10. 2008
  6. pmc Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning
    Wen Sung Lai
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:16906-11. 2006
  7. pmc A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition
    Mirna Kvajo
    Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7076-81. 2008
  8. ncbi request reprint Molecules, signaling, and schizophrenia
    Mirna Kvajo
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Top Behav Neurosci 4:629-56. 2010
  9. pmc Cognition in mouse models of schizophrenia susceptibility genes
    P Alexander Arguello
    Department of Neuroscience, Columbia University Medical Center, New York, NY 10032, USA
    Schizophr Bull 36:289-300. 2010
  10. pmc 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
    Maria Karayiorgou
    Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, New York 10032, USA
    Nat Rev Neurosci 11:402-16. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Schizophrenia susceptibility genes: emergence of positional candidates and future directions
    Joseph A Gogos
    Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Pharmacol Sci 27:226-33. 2006
    ..A central goal of future research will be to use this genetic knowledge to generate specific animal models, characterize genetic interactions, investigate the disease pathophysiology and assist drug-discovery efforts...
  2. pmc Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia
    Torfi Sigurdsson
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 464:763-7. 2010
    ..Our findings further suggest that impaired long-range synchrony of neural activity is one consequence of the 22q11.2 deletion and may be a fundamental component of the pathophysiology underlying schizophrenia...
  3. pmc Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice
    Hiroko Koike
    Human Neurogenetics Laboratory, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:3693-7. 2006
    ....
  4. ncbi request reprint Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
    Marta Paterlini
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 8:1586-94. 2005
    ..This interaction modulates a number of schizophrenia-related phenotypes, providing a framework for understanding the high disease risk associated with this locus, the expression of the phenotype, or both...
  5. pmc Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion
    Jun Mukai
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Neurosci 11:1302-10. 2008
    ..Our analysis reveals that 22q11.2 microdeletion results in deficits in neuronal development and suggests that impaired neuronal protein palmitoylation contributes to many of these deficits...
  6. pmc Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning
    Wen Sung Lai
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:16906-11. 2006
    ....
  7. pmc A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition
    Mirna Kvajo
    Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7076-81. 2008
    ..Our results implicate malfunction of neural circuits within the hippocampus and medial prefrontal cortex and selective deficits in WM as contributing to the genetic risk conferred by this gene...
  8. ncbi request reprint Molecules, signaling, and schizophrenia
    Mirna Kvajo
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Top Behav Neurosci 4:629-56. 2010
    ..Finally, we discuss evidence supporting an impact of these susceptibility genes on common intracellular signaling pathways and the convergence of their effects on neuronal processes implicated in schizophrenia...
  9. pmc Cognition in mouse models of schizophrenia susceptibility genes
    P Alexander Arguello
    Department of Neuroscience, Columbia University Medical Center, New York, NY 10032, USA
    Schizophr Bull 36:289-300. 2010
    ....
  10. pmc 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
    Maria Karayiorgou
    Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, New York 10032, USA
    Nat Rev Neurosci 11:402-16. 2010
    ..In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders...
  11. doi request reprint Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model
    Kimberly L Stark
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Nat Genet 40:751-60. 2008
    ..2 microdeletion...
  12. pmc A signaling pathway AKTing up in schizophrenia
    P Alexander Arguello
    Department of Neuroscience and Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:2018-21. 2008
    ....
  13. ncbi request reprint Schizophrenia genetics: uncovering positional candidate genes
    Maria Karayiorgou
    The Rockefeller University, Laboratory of Human Neurogenetics, New York, NY 10021, USA
    Eur J Hum Genet 14:512-9. 2006
    ..Several of these findings hold considerable promise both for understanding the neuropathology of this brain disorder, the causes of which remain a mystery, but also for development of novel, mechanism-based treatments for the patients...
  14. ncbi request reprint Schizophrenia susceptibility genes: in search of a molecular logic and novel drug targets for a devastating disorder
    Joseph A Gogos
    Department of Physiology and Cellular Biophysics, and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Int Rev Neurobiol 78:397-422. 2007
    ....
  15. pmc Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia
    Hui Liu
    Human Neurogenetics Laboratory, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3717-22. 2002
    ..Our results have implications for understanding the genetic basis of the 22q11-associated psychiatric phenotypes and provide further insights into the genomic instability of this region...
  16. ncbi request reprint Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map
    C Ron Yu
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 42:553-66. 2004
    ..These studies suggest that spontaneous neural activity is required for the establishment and maintenance of the precise connectivity inherent in an olfactory sensory map...
  17. doi request reprint Strong association of de novo copy number mutations with sporadic schizophrenia
    Bin Xu
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Genet 40:880-5. 2008
    ....
  18. ncbi request reprint Modeling madness in mice: one piece at a time
    P Alexander Arguello
    Center for Neurobiology and Behavior, Columbia University Medical Center, New York, New York 10032, USA
    Neuron 52:179-96. 2006
    ..We also discuss accumulating empirical data and take an in-depth look at what we believe to be the future of animal models made possible by recent advances in psychiatric genetics...
  19. pmc Extended intermarker linkage disequilibrium in the Afrikaners
    Diana Hall
    The Rockefeller University, Human Neurogenetics Laboratory, New York, NY 10021, USA
    Genome Res 12:956-61. 2002
    ..This study strongly supports the appropriateness of the Afrikaner population for genome-wide scans that exploit LD to map common, multigenic disorders...
  20. pmc Development of animal models for schizophrenia
    P Alexander Arguello
    Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Dis Model Mech 3:22-6. 2010
    ..This has made it possible to engineer genetically faithful, and thus etiologically valid, animal models of this schizophrenia susceptibility locus...
  21. ncbi request reprint The molecular genetics of the 22q11-associated schizophrenia
    Maria Karayiorgou
    Laboratory of Human Neurogenetics, The Rockefeller University, New York, NY 10021, USA
    Brain Res Mol Brain Res 132:95-104. 2004
    ..In-depth human and animal model studies of 22q11DS promise to answer critical questions relating to the devastating illness of schizophrenia, whose causes remain largely unknown...
  22. ncbi request reprint Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia
    Jun Mukai
    Columbia University, College of Physicians and Surgeons, Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, New York, New York 10032, USA
    Nat Genet 36:725-31. 2004
    ..Our results indicate that there is an unexpected connection between impaired palmitate modification of neuronal proteins and the psychiatric phenotypes associated with microdeletions of chromosome 22q11...
  23. ncbi request reprint Phenotypic characterization and genealogical tracing in an Afrikaner schizophrenia database
    Maria Karayiorgou
    Human Neurogenetics Laboratory, The Rockefeller University, New York, New York 10021, USA
    Am J Med Genet B Neuropsychiatr Genet 124:20-8. 2004
    ....
  24. pmc Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder
    Diana Hall
    The Rockefeller University, Human Neurogenetics Laboratory, New York, NY, 10021, USA
    Am J Hum Genet 73:370-6. 2003
    ....
  25. pmc Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches
    Ruby Hsu
    Department of Neuroscience, Columbia University, New York, New York, United States of America
    PLoS ONE 2:e1234. 2007
    ..NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene...
  26. pmc Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo
    Luxiang Cao
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Curr Biol 17:911-21. 2007
    ..However, the molecular pathways that modulate axonal-branch stability or formation in competitive environments remain unknown...
  27. ncbi request reprint Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia
    Effat S Emamian
    The Rockefeller University, Laboratory of Human Neurogenetics, New York, New York 10021, USA
    J Neurosci 24:1561-4. 2004
    ....
  28. ncbi request reprint Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia
    Effat S Emamian
    The Rockefeller University, Laboratory of Human Neurogenetics, 1230 York Avenue, Box 313, New York, New York 10021, USA
    Nat Genet 36:131-7. 2004
    ....
  29. pmc Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans
    Bin Xu
    Departments of Psychiatry, Physiology and Cellular Biophysics, and Neuroscience, Columbia University Medical Center, New York, NY 10032
    Proc Natl Acad Sci U S A 106:16746-51. 2009
    ..They also highlight differences in the genetic architecture of the familial and sporadic forms of the disease...
  30. pmc Genetic variation in the 22q11 locus and susceptibility to schizophrenia
    Hui Liu
    The Rockefeller University, Human Neurogenetics Laboratory, New York, NY 10021 USA
    Proc Natl Acad Sci U S A 99:16859-64. 2002
    ..Finer-scale haplotype mapping has identified two subregions within the 1.5-Mb locus that are likely to harbor candidate schizophrenia susceptibility genes...
  31. ncbi request reprint Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
    Leonid Yavich
    In Vivo Voltammetry Contract Research Laboratory and Department of Pharmacology and Toxicology, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:10196-209. 2007
    ....
  32. ncbi request reprint Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice
    Teemu Helkamaa
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Hypertens 21:2365-74. 2003
    ..Previous studies have indicated that catechol-O-methyltransferase (COMT) can modulate renal dopaminergic tone...
  33. ncbi request reprint Genes for schizophrenia
    Maria Karayiorgou
    Lancet 361:1828-9; author reply 1829-30. 2003
  34. ncbi request reprint Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice
    Marko Huotari
    Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland
    J Pharmacol Exp Ther 303:1309-16. 2002
    ..Despite the possible interaction between DAT and extraneuronal uptake (and subsequently COMT), the role of COMT in dopamine elimination is still minimal in conditions when DAT is inhibited...
  35. pmc Reduced natriuretic response to acute sodium loading in COMT gene deleted mice
    Cecilia Odlind
    Dept of Medical Cell Biology, University of Uppsala, Biomedical Centre, Uppsala, Sweden
    BMC Physiol 2:14. 2002
    ..After acute intravenous isotonic sodium loading, renal function was followed...
  36. ncbi request reprint Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice
    Daniela Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Behav Brain Res 183:236-9. 2007
    ..Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1...
  37. pmc Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit
    David J Gerber
    Howard Hughes Medical Institute, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8993-8. 2003
    ..Our results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis...
  38. ncbi request reprint D-amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice
    Marko Huotari
    University of Kuopio, Department of Pharmacology and Toxicology, PO Box 1627, 70211, Kuopio, Finland
    Psychopharmacology (Berl) 172:1-10. 2004
    ..Further, when COMT knockout mice were challenged with l-dopa or a dopamine transporter (DAT) inhibitor, an accumulation of dopamine occurred and the neurochemical and locomotor effects of l-dopa and GBR 12909 were modified accordingly...
  39. ncbi request reprint Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice
    Marko Huotari
    University of Kuopio, Department of Pharmacology and Toxicology, PO Box 1627, FIN 70211 Kuopio, Finland
    Eur J Neurosci 15:246-56. 2002
    ..Our results may have implications for improving the treatment of Parkinson's disease and for understanding the contribution of the natural variation in COMT activity to psychiatric phenotypes...
  40. ncbi request reprint Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice
    Lefteris C Zacharia
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Circulation 108:2974-8. 2003
    ....
  41. ncbi request reprint Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice
    Markus M Forsberg
    Department of Pharmacology and Toxicology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Naunyn Schmiedebergs Arch Pharmacol 370:279-89. 2004
    ..In conclusion, we found no evidence of increased oxidative stress in the liver or brain of adult mice lacking COMT activity...
  42. pmc Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1
    Goncalo R Abecasis
    Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 74:403-17. 2004
    ..This is the first time a UPD has been described in a patient with schizophrenia, lending further support to involvement of chromosome 1 in schizophrenia susceptibility in the Afrikaners...