Joseph A Gogos
Affiliation: Columbia University
Sun Z, Williams D, Xu B, Gogos J. Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophrenia. Transl Psychiatry. 2018;8:85 pubmed publisher
..2 deletion mouse model at different culture times and provide valuable insights towards revealing disease mechanisms and discovery of new therapeutic compounds. ..
Tamura M, Mukai J, Gordon J, Gogos J. Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition. Neuron. 2016;89:1100-9 pubmed publisher
..Taken together, these results provide mechanistic insight into how the microdeletion results in cognitive deficits, and they suggest possible targets for novel therapies. ..
Piskorowski R, Nasrallah K, Diamantopoulou A, Mukai J, Hassan S, Siegelbaum S, et al
. Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome. Neuron. 2016;89:163-76 pubmed publisher
..Finally, we show that Df(16)A(+/-) mice display impaired social cognition, providing a potential mechanism and a neural substrate for this impairment in psychiatric disorders. ..
Crabtree G, Park A, Gordon J, Gogos J. Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade. Cell Rep. 2016;17:570-582 pubmed publisher
..These findings indicate that accumulation of a neuroactive metabolite can lead to molecular and synaptic dysfunction and help to understand mechanisms underlying neuropsychiatric disease. ..
Crabtree G, Sun Z, Kvajo M, Broek J, Fenelon K, McKellar H, et al
. Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness. J Neurosci. 2017;37:4158-4180 pubmed publisher
Tamura M, Spellman T, Rosen A, Gogos J, Gordon J. Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task. Nat Commun. 2017;8:2182 pubmed publisher
..These findings suggest that enhancement of theta-slow gamma coupling reflects a compensatory mechanism to maintain spatial working memory performance in the setting of increased difficulty. ..