Stephen P Goff

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, et al. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015;112:15666-71 pubmed publisher
    ..These findings establish Aph2 as a critical in vivo regulator of cardiac function and reveal roles for protein palmitoylation in the development of other organs including eyes. ..
  2. Cingoz O, Goff S. HIV-1 Is a Poor Inducer of Innate Immune Responses. MBio. 2019;10: pubmed publisher
  3. Zhu Y, Wang G, Cingoz O, Goff S. NP220 mediates silencing of unintegrated retroviral DNA. Nature. 2018;564:278-282 pubmed publisher
    ..Knockout of NP220 accelerates the replication of retroviruses. These experiments identify the molecular machinery that silences extrachromosomal retroviral DNA. ..
  4. Metzger M, Paynter A, Siddall M, Goff S. Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla. Proc Natl Acad Sci U S A. 2018;115:E4227-E4235 pubmed publisher
    ..These data suggest that over both short- and long-term evolutionary timescales, Steamer-like retrotransposons, much like retroviruses, can move between organisms and integrate new copies into new host genomes. ..
  5. Griffin D, Goff S. Restriction of HIV-1-based lentiviral vectors in adult primary marrow-derived and peripheral mobilized human CD34+ hematopoietic stem and progenitor cells occurs prior to viral DNA integration. Retrovirology. 2016;13:14 pubmed publisher
    ..Murine restriction of MLV and human cellular restriction of HIV-1 are fundamentally different. While murine restriction of MLV occurs post integration, human restriction of HIV-1 occurs before integration. ..
  6. Lee A, Cingoz O, Sabo Y, Goff S. Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology. 2018;516:165-175 pubmed publisher
    ..Additionally, we found that residue K779 was critical for Trim28-mediated silencing of M-MLV in embryonic cells. ..
  7. Cingoz O, Goff S. Cyclin-dependent kinase activity is required for type I interferon production. Proc Natl Acad Sci U S A. 2018;115:E2950-E2959 pubmed publisher
    ..Our findings reveal a critical role for CDKs in the translation of IFN-?. ..
  8. Erazo A, Goff S. Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction. Retrovirology. 2015;12:57 pubmed publisher
    ..Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. This study suggests that this ZAP regulatory mechanism is shared with additional nuclear matrix proteins. ..
  9. Wang G, Goff S. Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells. J Virol. 2017;91: pubmed publisher
    ..The findings reveal novel features of human EC gene regulation not present in their murine counterparts. ..

More Information

Publications11

  1. Wang G, Wang Y, Goff S. Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry. Cell Host Microbe. 2016;20:798-809 pubmed publisher
    ..The data show that histone loading onto unintegrated DNAs occurs very rapidly after nuclear entry and does not require prior establishment of an integrated provirus. ..
  2. Wang C, Goff S. Differential control of retrovirus silencing in embryonic cells by proteasomal regulation of the ZFP809 retroviral repressor. Proc Natl Acad Sci U S A. 2017;114:E922-E930 pubmed publisher
    ..These findings suggest that the stem cell state is established not only by an unusual transcriptional profile but also by unusual regulation of protein levels through the proteasomal degradation pathway. ..