Henry Ginsberg

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying
    Gene P Ables
    Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 53:2364-79. 2012
  2. pmc Statins in cardiometabolic disease: what makes pitavastatin different?
    Henry Ginsberg
    Irving Institute for Clinical and Translational Research, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Cardiovasc Diabetol 12:S1. 2013
  3. pmc Effect of combination therapy with fenofibrate and simvastatin on postprandial lipemia in the ACCORD lipid trial
    Gissette Reyes-Soffer
    Department of Medicine, Columbia University Medical Center, New York, NY, USA
    Diabetes Care 36:422-8. 2013
  4. ncbi request reprint Niacin in the metabolic syndrome: more risk than benefit?
    Henry N Ginsberg
    Irving Center for Clinical Research, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Nat Clin Pract Endocrinol Metab 2:300-1. 2006
  5. ncbi request reprint Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue
    Yi Hao Yu
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circ Res 96:1042-52. 2005
  6. pmc The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
    Henry N Ginsberg
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 50:S162-6. 2009
  7. ncbi request reprint Metabolic syndrome: focus on dyslipidemia
    Henry N Ginsberg
    Department of Medicine, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 14:41S-49S. 2006
  8. pmc The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: II. Therapeutic management of atherogenic dyslipidemia
    Henry N Ginsberg
    Department of Medicine and the Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Clin Hypertens (Greenwich) 11:520-7. 2009
  9. pmc The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus
    Henry N Ginsberg
    Department of Medicine and the Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Cardiometab Syndr 4:113-9. 2009
  10. ncbi request reprint REVIEW: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia
    Henry N Ginsberg
    Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Endocrinol Metab 91:383-92. 2006

Research Grants

  1. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2007
  2. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry N Ginsberg; Fiscal Year: 2010
  3. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2006
  4. Clinical and Translational Science Award
    Henry Ginsberg; Fiscal Year: 2007
  5. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2004
  6. Assembly & Secretion Of Apo B Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2004
  7. Adapting the RAO Model to Four Types of Community-based Providers
    Henry Ginsberg; Fiscal Year: 2007
  8. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2003
  9. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2002
  10. ASSEMBLY AND SECRETION OF APO B CONTAINING LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 1999

Detail Information

Publications65

  1. pmc Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying
    Gene P Ables
    Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 53:2364-79. 2012
    ..Long-term hepatic retinoid metabolism was not impacted by DGAT1 inhibition...
  2. pmc Statins in cardiometabolic disease: what makes pitavastatin different?
    Henry Ginsberg
    Irving Institute for Clinical and Translational Research, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Cardiovasc Diabetol 12:S1. 2013
    ..Recent controversies surrounding the potentially diabetogenic effects of statins will also be discussed. ..
  3. pmc Effect of combination therapy with fenofibrate and simvastatin on postprandial lipemia in the ACCORD lipid trial
    Gissette Reyes-Soffer
    Department of Medicine, Columbia University Medical Center, New York, NY, USA
    Diabetes Care 36:422-8. 2013
    ..We examined the effects of FENO-S on postprandial (PP) lipid and lipoprotein levels in a subgroup of ACCORD Lipid subjects...
  4. ncbi request reprint Niacin in the metabolic syndrome: more risk than benefit?
    Henry N Ginsberg
    Irving Center for Clinical Research, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Nat Clin Pract Endocrinol Metab 2:300-1. 2006
  5. ncbi request reprint Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue
    Yi Hao Yu
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circ Res 96:1042-52. 2005
    ....
  6. pmc The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
    Henry N Ginsberg
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 50:S162-6. 2009
    ..In this review, we summarize both older and more recent findings on the pathways of apoB degradation, focusing on events in the liver...
  7. ncbi request reprint Metabolic syndrome: focus on dyslipidemia
    Henry N Ginsberg
    Department of Medicine, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 14:41S-49S. 2006
  8. pmc The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: II. Therapeutic management of atherogenic dyslipidemia
    Henry N Ginsberg
    Department of Medicine and the Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Clin Hypertens (Greenwich) 11:520-7. 2009
    ..Novel strategies currently in clinical development are also discussed...
  9. pmc The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus
    Henry N Ginsberg
    Department of Medicine and the Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Cardiometab Syndr 4:113-9. 2009
    ..In an accompanying article, current pharmacotherapies available for the management of atherogenic dyslipidemia in individuals with MS or T2DM are discussed...
  10. ncbi request reprint REVIEW: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia
    Henry N Ginsberg
    Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Endocrinol Metab 91:383-92. 2006
    ..This is based on the well-characterized efficacy and safety profiles of this class of agents as well as several clinical trials demonstrating that statin treatment reduces the risk of cardiovascular events...
  11. ncbi request reprint Regulation of plasma triglycerides in insulin resistance and diabetes
    Henry N Ginsberg
    College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Med Res 36:232-40. 2005
    ....
  12. ncbi request reprint Treatment for patients with the metabolic syndrome
    Henry N Ginsberg
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Am J Cardiol 91:29E-39E. 2003
    ....
  13. pmc Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling
    Byoung C Moon
    Irving Institute for Clinical and Translational Research, PH10 305, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 32:236-46. 2012
    ....
  14. ncbi request reprint New perspectives on atherogenesis: role of abnormal triglyceride-rich lipoprotein metabolism
    Henry N Ginsberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circulation 106:2137-42. 2002
  15. ncbi request reprint The metabolic syndrome: targeting dyslipidaemia to reduce coronary risk
    Henry N Ginsberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cardiovasc Risk 10:121-8. 2003
    ..This review discusses the diagnosis and management of the metabolic syndrome and examines the potential of future treatment options...
  16. ncbi request reprint Diabetic dyslipidemia
    Tina J Chahil
    Department of Medicine, College of Physicians and Surgeons of Columbia University, PH 10 305, 630 West 168th Street, New York, NY 10032, USA
    Endocrinol Metab Clin North Am 35:491-510, vii-viii. 2006
    ..A number of physiologic and pharmacologic approaches are available and should be used aggressively to treat diabetic dyslipidemia...
  17. pmc Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus
    Kazunori Nagashima
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 115:1323-32. 2005
    ..Thus, Pio, a PPARgamma agonist, reduced VLDL TG levels by increasing LPL mass and inhibiting apoC-III PR. These 2 changes were associated with an increased FCR of VLDL TGs, almost certainly due to increased LPL-mediated lipolysis...
  18. ncbi request reprint The conversion of apoB100 low density lipoprotein/high density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells
    Junji Yamaguchi
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Biol Chem 278:42643-51. 2003
    ..Similar results were obtained when ER were immuno-isolated with anti-calnexin antibodies. In conclusion, apoB100 bulk lipidation, resulting in conversion of LDL/HDL to VLDL, can occur in the ER, but not in the Golgi, in McA RH7777 cells...
  19. pmc Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    Tsuguhito Ota
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 118:316-32. 2008
    ..These results suggest that excessive ER stress in response to increased hepatic lipids may decrease the ability of the liver to secrete triglycerides by limiting apoB secretion, potentially worsening steatosis...
  20. ncbi request reprint Is the slippery slope from steatosis to steatohepatitis paved with triglyceride or cholesterol?
    Henry N Ginsberg
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell Metab 4:179-81. 2006
    ..In this issue of Cell Metabolism, Marí et al. (2006) provide evidence for excessive mitochondrial free cholesterol as a cause of the progession of steatosis to more severe liver disease...
  21. ncbi request reprint Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states
    Lars Berglund
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 86:1611-20. 2007
    ..In subjects with a high prevalence of metabolic risk abnormalities, the preferred replacement for saturated fat is unresolved...
  22. ncbi request reprint Effects of triacylglycerol and diacylglycerol oils on blood clearance, tissue uptake, and hepatic apolipoprotein B secretion in mice
    Koichi Yasunaga
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 48:1108-21. 2007
    ..DAG emulsions may by useful for intravenous nutrition in people with preexisting hypertriglyceridemia...
  23. ncbi request reprint Lipoprotein metabolism in chronic renal insufficiency
    Jeffrey M Saland
    Department of Pediatrics, The Mount Sinai School of Medicine, One Gustave L Levy Place, P O Box 1664, New York, NY 10029, USA
    Pediatr Nephrol 22:1095-112. 2007
    ..Therefore, it is not possible at this time to endorse general recommendations for the use of any agent to treat dyslipidemia in children with chronic kidney disease...
  24. ncbi request reprint Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver disease
    Ira J Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 130:1343-6. 2006
  25. ncbi request reprint Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis
    Yuan Li Zhang
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 281:37603-15. 2006
    ..The mechanism whereby hepatic Ppargamma2 gene expression is increased and how PPARgamma2 stimulates lipogenesis is under investigation...
  26. ncbi request reprint Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes
    Yi Hao Yu
    Department of Medicine, Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 277:50876-84. 2002
    ..These data suggest that dysregulation of DGAT1 may play a role in the development of obesity, and manipulation of the steady-state level of DGAT1 protein may offer a potential means to treat or prevent obesity...
  27. ncbi request reprint Ovariectomy leads to increased insulin resistance in human apolipoprotein B transgenic mice lacking brown adipose tissue
    Patty W Siri
    Institute of Human Nutrition and Division of Preventive Medicine and Nutrition, Columbia University, New York, NY 10032, USA
    Metabolism 52:659-61. 2003
    ..The apoB/BATless mouse should be a good model to delineate the molecular mechanisms whereby estrogen protects against insulin resistance...
  28. ncbi request reprint Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids. I. Differential response to the delivery of fatty acids via albumin or remnant-like emulsion particles
    Yuan Li Zhang
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:19362-74. 2004
    ....
  29. pmc C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    Amrom E Obstfeld
    Department of Medicine, Columbia University, New York, New York, USA
    Diabetes 59:916-25. 2010
    ..This suggests that a myeloid cell population is recruited to the liver in obesity and contributes to nonalcoholic fatty liver disease...
  30. ncbi request reprint The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism
    Yi Hao Yu
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA
    Ann Med 36:252-61. 2004
    ..Future studies with tissue-specific overexpression and/or knockout in these animal models would be expected to shed additional light on these issues...
  31. pmc Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa
    Laurel E S Mayer
    Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York, NY, USA
    Am J Clin Nutr 90:1132-7. 2009
    ..Whether these abnormalities persist over time remains unknown...
  32. ncbi request reprint Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
    John J Liang
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 279:44938-44. 2004
    ....
  33. ncbi request reprint Cholesterol-lowering benefits of oat-containing cereal in Hispanic americans
    Wahida Karmally
    The Irving Center for Clinical Research, Columbia University Medical Center, New York, NY 10032, USA
    J Am Diet Assoc 105:967-70. 2005
    ..2+/-18.3 mg/dL; 1.1%) or LDL-C (+1.2+/-17.5 mg/dL; 2.2%). Differences between the effects of the two cereals on total cholesterol and LDL-C were significant, P =.0003 and P =.0007, respectively...
  34. pmc Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue
    Nuttaporn Wongsiriroj
    Institute of Human Nutrition, Columbia University, New York, NY 10032
    J Lipid Res 55:104-14. 2014
    ..The elevated RA-responsive gene expression was associated with elevated hepatic triglyceride levels and decreased expression of Pparδ and its downstream Pdk4 target, suggesting a role for RA in these processes in vivo...
  35. doi request reprint Development of apolipoprotein B antisense molecules as a therapy for hyperlipidemia
    Tiffany Thomas
    Columbia University, 622 West 168th Street, PH10 305, New York, NY 10032, USA
    Curr Atheroscler Rep 12:58-65. 2010
    ..The mechanisms whereby two different approaches for inhibiting apoB and triglyceride secretion have different effects on hepatic triglycerides are currently being examined...
  36. pmc Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus
    Gissette Reyes-Soffer
    Departments of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Lipid Res 50:1901-9. 2009
    ..PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM...
  37. ncbi request reprint Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Henry N Ginsberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Cardiol 99:56i-67i. 2007
    ..The current protocol is designed to provide an ethically justifiable test of combined statin plus fibrate treatment consistent with the highest level of safety and lipid treatment standards of care...
  38. ncbi request reprint Postprandial response to a physiologic caloric load in HIV-positive patients receiving protease inhibitor-based or nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy
    Asha Thomas-Geevarghese
    Department of Medicine and the General Clinical Research Center, Harlem Hospital Center and Columbia University, New York, NY, USA
    Am J Clin Nutr 82:146-54. 2005
    ..Features of the dyslipidemic pattern reported with the use of antiretroviral therapy predict enhanced postprandial lipemia, which is an emerging cardiovascular disease risk factor...
  39. ncbi request reprint Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods
    John B Buse
    Division of Endocrinology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7172, USA
    Am J Cardiol 99:21i-33i. 2007
    ....
  40. ncbi request reprint Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins
    Edward A Fisher
    Cardiovascular Institute and Departments of Medicine and Biochemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:17377-80. 2002
  41. ncbi request reprint Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of Dgat1 in adipose tissue
    Nancy Chen
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th St, PH 10 305J, New York, New York 10032, USA
    Diabetes 54:3379-86. 2005
    ..Thus, adipose overexpression of Dgat1 gene in FVB mice leads to diet-inducible insulin resistance, which is secondary to redistribution of fat from adipose tissue to the liver in the absence of obesity...
  42. pmc Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    Meihui Pan
    The Zena and Michael A Wiener Cardiovascular Institute and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 113:1277-87. 2004
    ....
  43. pmc Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus
    Gissette Reyes-Soffer
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Metabolism 59:1365-71. 2010
    ..This finding may be relevant to the greater early and late morbidity and mortality observed in patients with both CAD and T2DM...
  44. ncbi request reprint The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis
    Meihui Pan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 277:4413-21. 2002
    ..We conclude that neither MTP nor newly synthesized TG is necessary for the later stages of apoB100-lipoprotein assembly and secretion in either HepG2 or McA-RH7777 cells...
  45. ncbi request reprint Dyslipidemia in pediatric renal disease: epidemiology, pathophysiology, and management
    Jeffrey M Saland
    Department of Pediatrics, The Mount Sinai Medical Center, New York, New York 10029 6574, USA
    Curr Opin Pediatr 14:197-204. 2002
    ..Prospective investigations are required to guide clinical management...
  46. ncbi request reprint Translocation efficiency of apolipoprotein B is determined by the presence of beta-sheet domains, not pause transfer sequences
    Junji Yamaguchi
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 281:27063-71. 2006
    ..These results indicate that the translocation efficiency of apoB100 is determined mainly by the presence of beta-sheet domains. PTS do not appear to affect translocation, but may affect secretion by other mechanisms...
  47. ncbi request reprint Treatment with high-dose simvastatin reduces secretion of apolipoprotein B-lipoproteins in patients with diabetic dyslipidemia
    Merle Myerson
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 46:2735-44. 2005
    ..Activation of PPARalpha could lead to increased hepatic oxidation of fatty acids and less synthesis of TG for VLDL assembly...
  48. ncbi request reprint Effects of a 1,3-diacylglycerol oil-enriched diet on postprandial lipemia in people with insulin resistance
    Gissette Reyes
    Departments of Medicine and Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 49:670-8. 2008
    ..Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels...
  49. ncbi request reprint Dietary 1,3-diacylglycerol protects against diet-induced obesity and insulin resistance
    Shinichiro Saito
    The Division of Preventive Medicine and Nutrition, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Metabolism 56:1566-75. 2007
    ..These findings suggest that diets enriched in 1,3-DAG oil may reduce WTD-induced IR and body fat accumulation by suppressing gluconeogenesis in liver and stimulating fat oxidation in skeletal muscle...
  50. doi request reprint Combination therapy with statin and fibrate in patients with dyslipidemia associated with insulin resistance, metabolic syndrome and type 2 diabetes mellitus
    Gissette Reyes-Soffer
    Columbia University College of Physicians and Surgeons, Department of Medicine, NY 10032, USA
    Expert Opin Pharmacother 12:1429-38. 2011
    ..Contributors to this problem are the high triglyceride (TG) levels and low levels of high-density lipoprotein cholesterol (HDLC) that are commonly present in this population, even with statin therapy...
  51. ncbi request reprint Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells
    Jun shan Liang
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:23984-8. 2003
    ..Together, these results indicate that an ER-associated protein, gp78, is a bona fide E3 ligase in the apoB ER-associated degradation pathway...
  52. pmc Short sleep duration as a risk factor for hypercholesterolemia: analyses of the National Longitudinal Study of Adolescent Health
    James E Gangwisch
    Columbia University, College of Physicians and Surgeons, Department of Psychiatry, Division of Cognitive Neuroscience, 1051 Riverside Drive, Unit 74, New York, NY 10032, USA
    Sleep 33:956-61. 2010
    ..No previous published population studies have examined the longitudinal relationship between sleep duration and high cholesterol...
  53. ncbi request reprint Prevention of cardiovascular disease in persons with type 2 diabetes mellitus: current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    David C Goff
    Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Am J Cardiol 99:4i-20i. 2007
    ..The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial will test hypotheses to address these unanswered questions...
  54. ncbi request reprint Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study
    Michael H Davidson
    Radiant Research, 515 North State Street, Suite 2700, Chicago, IL 60610, USA
    Clin Ther 29:1354-67. 2007
    ..The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) has identified non-HDL-C as a secondary therapeutic target in these patients, but treatment goals may not be reached with statin monotherapy alone...
  55. pmc Effectiveness of combined statin plus omega-3 fatty acid therapy for mixed dyslipidemia
    Philip Barter
    Heart Research Institute, Camperdown, Sydney, New South Wales, Australia
    Am J Cardiol 102:1040-5. 2008
    ..In conclusion, several classes of drugs, including omega-3 fatty acids, can be used in combination with statins to achieve more global improvements in lipid profiles...
  56. doi request reprint Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 7:125-34. 2008
    ..Thus, insulin resistance at the level of the liver is sufficient to produce the dyslipidemia and increased risk of atherosclerosis associated with the metabolic syndrome...
  57. pmc Kinetic studies of the metabolism of rapidly exchangeable apolipoproteins may leave investigators and readers with exchangeable results
    Henry N Ginsberg
    Arterioscler Thromb Vasc Biol 28:1685-6. 2008
  58. doi request reprint Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease
    Michael Miller
    Division of Cardiology, University of Maryland Medical Center, Baltimore, MD, USA
    Am J Cardiol 101:1003-8. 2008
    ..In conclusion, non-HDL-C remains an important target of therapy for patients with elevated TGs, although its widespread adoption has yet to gain a foothold among health care professionals treating patients with dyslipidemia...
  59. ncbi request reprint Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association
    John B Buse
    University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Diabetes Care 30:162-72. 2007
    ..This statement will attempt to harmonize the recommendations of both organizations where possible but will recognize areas in which AHA and ADA recommendations differ...
  60. ncbi request reprint Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association
    John B Buse
    University of North Carolina, USA
    Circulation 115:114-26. 2007
    ..This statement will attempt to harmonize the recommendations of both organizations where possible but will recognize areas in which AHA and ADA recommendations differ...
  61. ncbi request reprint Cholesterol management: targeting a lower low-density lipoprotein cholesterol concentration increases adult treatment panel-III goal attainment
    John R Crouse
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 97:1667-9. 2006
  62. ncbi request reprint Dyslipidemia of insulin resistance syndrome explained; need for treatment to reduce risk emphasized
    Henry N Ginsberg
    Am J Manag Care . 2002
  63. ncbi request reprint Risk factors common to insulin resistance and atherosclerosis explain why diabetes is a cardiovascular disease
    Henry N Ginsberg
    Am J Manag Care . 2002
  64. ncbi request reprint Prevention or delay of type 2 diabetes
    Robert S Sherwin
    Diabetes Care 27:S47-54. 2004

Research Grants39

  1. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2007
    ....
  2. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry N Ginsberg; Fiscal Year: 2010
    ..Overall, our proposed studies should provide evidence for a unified model to explain the common association of increased apoB secretion, increased hepatic DNHL, and steatosis in mice and people with insulin resistance. ..
  3. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2006
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. ..
  4. Clinical and Translational Science Award
    Henry Ginsberg; Fiscal Year: 2007
    ..Pediatric and community-based G/T research will receive special attention. The IICTR and CTSA will break down the barriers impeding movement of new knowledge from the bench to the bedside and community. ..
  5. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2004
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. ..
  6. Assembly & Secretion Of Apo B Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2004
    ..We believe that completion of these studies will provide the basis for new and innovative approaches to the treatment of human dyslipidemias. ..
  7. Adapting the RAO Model to Four Types of Community-based Providers
    Henry Ginsberg; Fiscal Year: 2007
    ..The increased efficiency rendered by a nationwide network of RAO would not only accelerate advances in health care, but also decrease the cost of bringing medical research innovation into the mainstream of health care. ..
  8. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2003
    ....
  9. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2002
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. ..
  10. ASSEMBLY AND SECRETION OF APO B CONTAINING LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 1999
    ..These studies may assist scientists in designing approaches to reduce lipoprotein secretion in patients with hyperlipidemia. ..
  11. Assembly and Secretion of ApoB Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2009
    ..If ER stress partially inhibits apoB-Lp secretion that would predispose to steatosis. All of these studies will lead to a clearer understanding of, and new approaches to the treatment of dyslipidemia and hepatic steatosis. ..
  12. Postprandial Lipemia and Endothelial Function In ACCORD
    Henry Ginsberg; Fiscal Year: 2001
    ....
  13. ASSEMBLY AND SECRETION OF APO B CONTAINING LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 2000
    ..These studies may assist scientists in designing approaches to reduce lipoprotein secretion in patients with hyperlipidemia. ..
  14. Assembly and Secretion of ApoB Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2007
    ..If ER stress partially inhibits apoB-Lp secretion that would predispose to steatosis. All of these studies will lead to a clearer understanding of, and new approaches to the treatment of dyslipidemia and hepatic steatosis. ..
  15. Assembly and Secretion of ApoB Containing Lipoproteins
    Henry N Ginsberg; Fiscal Year: 2010
    ..If ER stress partially inhibits apoB-Lp secretion that would predispose to steatosis. All of these studies will lead to a clearer understanding of, and new approaches to the treatment of dyslipidemia and hepatic steatosis. ..
  16. Clinical and Translational Science Award
    Henry Ginsberg; Fiscal Year: 2007
    ..Pediatric and community-based C/T research will receive special attention. The IICTR and CTSA will break down the barriers impeding movement of new knowledge from the bench to the bedside and community. ..
  17. Clinical and Translational Science Award
    Henry Ginsberg; Fiscal Year: 2007
    ..Pediatfic and community-based G/T research will receive special attention. The IICTR and CTSA will break down the barriers impeding movement of new knowledge from the bench to the bedside and community. ..
  18. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2009
    ..Overall, our proposed studies should provide evidence for a unified model to explain the common association of increased apoB secretion, increased hepatic DNHL, and steatosis in mice and people with insulin resistance. ..
  19. POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCH
    Henry Ginsberg; Fiscal Year: 2007
    ..Dr. Henry Ginsberg, PI and Director of the training program has been actively engaged as a mentor of young basic and clinical ..
  20. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2006
    ....
  21. Assembly & Secretion Of Apo B Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2001
    ..We believe that completion of these studies will provide the basis for new and innovative approaches to the treatment of human dyslipidemias. ..
  22. Assembly & Secretion Of Apo B Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2002
    ..We believe that completion of these studies will provide the basis for new and innovative approaches to the treatment of human dyslipidemias. ..
  23. Postprandial Lipemia and Endothelial Function In ACCORD
    Henry Ginsberg; Fiscal Year: 2002
    ....
  24. Assembly & Secretion Of Apo B Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2003
    ..We believe that completion of these studies will provide the basis for new and innovative approaches to the treatment of human dyslipidemias. ..
  25. Postprandial Lipemia and Endothelial Function In ACCORD
    Henry Ginsberg; Fiscal Year: 2003
    ....
  26. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2003
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. ..
  27. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2004
    ....
  28. Postprandial Lipemia and Endothelial Function In ACCORD
    Henry Ginsberg; Fiscal Year: 2004
    ....
  29. Fatty Acid Regulation of Liver Lipoprotein Production
    Henry Ginsberg; Fiscal Year: 2005
    ....
  30. Assembly & Secretion Of Apo B Containing Lipoproteins
    Henry Ginsberg; Fiscal Year: 2005
    ..We believe that completion of these studies will provide the basis for new and innovative approaches to the treatment of human dyslipidemias. ..
  31. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2005
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. ..