Affiliation: Columbia University
- Impaired movement control in Alzheimer's diseaseM F Ghilardi
INB CNR, Milano Istituto Scientifico San Raffaele, Universita di Milano, Milan, Italy
Neurosci Lett 260:45-8. 1999..Patients' paths showed discontinuous segments and prolonged movement time; movement inaccuracy, which increased without visual feedback, correlated significantly with scores of disease severity, working memory and attention...
- Patterns of regional brain activation associated with different forms of motor learningM Ghilardi
Center for Neurobiology and Behavior, Center for Neurobiology and Behavior, NYS Psychiatric Institute, Columbia College of Physicians and Surgeons, PI Annex Room 819, 10032, New York, NY, USA
Brain Res 871:127-45. 2000..These tasks can be used to assess specific aspects of motor learning with imaging in health and disease...
- Visual feedback has differential effects on reaching movements in Parkinson's and Alzheimer's diseaseM F Ghilardi
INB CNR, Istituto Scientifico San Raffaele, Universita di Milano, Milan, Italy
Brain Res 876:112-23. 2000..Parkinsonian patients showed higher reliance on feedback commands only with cursor feedback: this could be explained by their difficulty in engaging effectively automatic routines when distractors are present...
- The differential effect of PD and normal aging on early explicit sequence learningMaria Felice Ghilardi
Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY 10032, USA
Neurology 60:1313-9. 2003..However, it is not known whether this defect is present during the earliest stages of the illness or whether it reflects specific limitations in dividing attention between cognitive and motor requirements...
- Impaired sequence learning in carriers of the DYT1 dystonia mutationMaria Felice Ghilardi
Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, New York, NY 11030, USA
Ann Neurol 54:102-9. 2003..Although localized increases in neural activity may enable normal movement execution in these subjects, this mechanism may not compensate for their defect in sequence learning...
- Differential cortical and subcortical activations in learning rotations and gains for reaching: a PET studyJohn W Krakauer
Department of Neurology and Department of Neurobiology and Behavior, Columbia University, New York 10032, USA
J Neurophysiol 91:924-33. 2004..In contrast, early gain adaptation involves only subcortical structures, which we suggest reflects a more automatic process of contextual recalibration of a scaling factor...
- Dopaminergic suppression of brain deactivation responses during sequence learningMiklos Argyelan
Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore University Hospital, Manhasset, New York 11030, USA
J Neurosci 28:10687-95. 2008..002) and with the val(158)met catechol-O-methyltransferase genotype. Our findings suggest that dopamine can influence prefrontal deactivation during learning, and that these changes are linked to baseline performance and genotype...
- Preclinical Huntington's disease: compensatory brain responses during learningAndrew Feigin
Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
Ann Neurol 59:53-9. 2006..Nonetheless, this mechanism may not be sufficient to sustain a normal level of task performance, even during the presymptomatic stage of the disease...
- Motor Learning in Parkinson's DiseaseM Ghilardi; Fiscal Year: 2002....
- Consolidation of Motor Skills & Sleep Homeostasis in Parkinson's DiseaseM Ghilardi; Fiscal Year: 2007..Consistent with the goals of NINDS, these studies will provide the basis for a rational therapeutic approach to enhancing sleep homeostasis in PD patients to improve their motor skills and quality of life. ..