Michael Gershon

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Aliment Pharmacol Ther 20:3-14. 2004
  2. pmc Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, P and S, 630 West 168th Street, New York, NY 10032, USA
    Trans Am Clin Climatol Assoc 123:268-80; discussion 280. 2012
  3. pmc 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Curr Opin Endocrinol Diabetes Obes 20:14-21. 2013
  4. pmc NPARM in PHOX2B: why some things just should not be expanded
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3056-8. 2012
  5. pmc Varicella vaccination in Europe - taking the practical approach
    Paolo Bonanni
    Department of Public Health, University of Florence, Florence, Italy
    BMC Med 7:26. 2009
  6. doi request reprint VZV infection of keratinocytes: production of cell-free infectious virions in vivo
    Michael D Gershon
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Top Microbiol Immunol 342:173-88. 2010
  7. pmc Developmental biology of the enteric nervous system: pathogenesis of Hirschsprung's disease and other congenital dysmotilities
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, 630 West 268th Street, New York, NY 10032, USA
    Semin Pediatr Surg 13:224-35. 2004
  8. ncbi request reprint Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
    J Clin Gastroenterol 39:S184-93. 2005
  9. ncbi request reprint Genes and lineages in the formation of the enteric nervous system
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Neurobiol 7:101-9. 1997
  10. ncbi request reprint The serotonin signaling system: from basic understanding to drug development for functional GI disorders
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Gastroenterology 132:397-414. 2007

Research Grants

  1. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2004
  2. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
  3. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
  4. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2007
  5. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2007
  6. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2009
  7. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2009
  8. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael D Gershon; Fiscal Year: 2010
  9. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2010
  10. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2003

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Aliment Pharmacol Ther 20:3-14. 2004
    ..The observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease. At least it is not 'all in your head'. The bowel contributes...
  2. pmc Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, P and S, 630 West 168th Street, New York, NY 10032, USA
    Trans Am Clin Climatol Assoc 123:268-80; discussion 280. 2012
    ..Mucosal 5-HT, therefore, may mobilize inflammatory effectors, which protect the gut from invasion, whereas neuronal 5-HT shields enteric neurons from inflammatory damage...
  3. pmc 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Curr Opin Endocrinol Diabetes Obes 20:14-21. 2013
    ..Although the gut contains most of the body's 5-hydroxytryptamine (5-HT), many of its most important functions have recently been discovered. This review summarizes and directs attention to this new burst of knowledge...
  4. pmc NPARM in PHOX2B: why some things just should not be expanded
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Clin Invest 122:3056-8. 2012
    ....
  5. pmc Varicella vaccination in Europe - taking the practical approach
    Paolo Bonanni
    Department of Public Health, University of Florence, Florence, Italy
    BMC Med 7:26. 2009
    ....
  6. doi request reprint VZV infection of keratinocytes: production of cell-free infectious virions in vivo
    Michael D Gershon
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Top Microbiol Immunol 342:173-88. 2010
    ..Evidence in support of these hypotheses includes observations of the VZV-infected human epidermis and studies of guinea pig neurons in an in vitro model system...
  7. pmc Developmental biology of the enteric nervous system: pathogenesis of Hirschsprung's disease and other congenital dysmotilities
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, 630 West 268th Street, New York, NY 10032, USA
    Semin Pediatr Surg 13:224-35. 2004
  8. ncbi request reprint Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
    J Clin Gastroenterol 39:S184-93. 2005
    ..Similar symptoms are seen in transgenic mice that lack SERT. The loss of mucosal SERT may thus contribute to IBS pathogenesis...
  9. ncbi request reprint Genes and lineages in the formation of the enteric nervous system
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Neurobiol 7:101-9. 1997
    ..Recent studies of the sequential actions of essential growth and transcription factors have revealed that enteric neuronal development involves a complex interaction of lineage-determined and microenvironmental elements...
  10. ncbi request reprint The serotonin signaling system: from basic understanding to drug development for functional GI disorders
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Gastroenterology 132:397-414. 2007
    ..The initial success encountered with serotonergic agents holds promise for newer and more potent insights and therapies of brain-gut disorders...
  11. pmc Transplanting the enteric nervous system: a step closer to treatment for aganglionosis
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Gut 56:459-61. 2007
  12. pmc Serotonin and neuroprotection in functional bowel disorders
    M D Gershon
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Neurogastroenterol Motil 19:19-24. 2007
    ....
  13. ncbi request reprint Plasticity in serotonin control mechanisms in the gut
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Curr Opin Pharmacol 3:600-7. 2003
    ....
  14. doi request reprint Developmental determinants of the independence and complexity of the enteric nervous system
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Trends Neurosci 33:446-56. 2010
    ..It is probable that highly prevalent disorders of gastrointestinal sensation and motility result from subtle defects in ENS development...
  15. ncbi request reprint Endothelin and the development of the enteric nervous system
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, New York, USA
    Clin Exp Pharmacol Physiol 26:985-8. 1999
    ..7. In the absence of ET-3/ETB, crest-derived cells develop as neurons and, thus, cease migrating before they complete the colonization of the bowel. This premature development leaves the terminal colon aganglionic...
  16. ncbi request reprint Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Aliment Pharmacol Ther 13:15-30. 1999
    ....
  17. pmc Behind an enteric neuron there may lie a glial cell
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10128, USA
    J Clin Invest 121:3386-9. 2011
    ..Although these new observations make it clear that clinical trials using glia to replace enteric neurons are more than premature, they are enticing for future research...
  18. ncbi request reprint Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas
    Yan Jiang
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 258:364-84. 2003
    ..Netrins also promoted the survival/development of enteric crest-derived cells. The formation of submucosal and pancreatic ganglia thus involves the attraction of DCC-expressing crest-derived cells by netrins...
  19. ncbi request reprint Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia
    Fabien D'Autréaux
    Department of Pathology and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
    Development 134:2237-49. 2007
    ..We suggest that enteric neuronal development occurs in stages and that Hand2 expression is required for terminal differentiation but not for precursors to enter the neuronal lineage...
  20. pmc The cellular localization pattern of Varicella-Zoster virus ORF29p is influenced by proteasome-mediated degradation
    Christina L Stallings
    Integrated Program in Cellular, Molecular and Biophysical Studies, and Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    J Virol 80:1497-512. 2006
    ..Although proteasome inhibition induces ORF29p nuclear accumulation, this is not sufficient to reactivate latent VZV or target the immediate-early protein ORF62p to the nucleus in cultured guinea pig enteric neurons...
  21. pmc Latency of varicella zoster virus in dorsal root, cranial, and enteric ganglia in vaccinated children
    Anne A Gershon
    Department of Pediatrics, Columbia University Medical Center, 650 West 168th St, New York, NY, 10032, USA
    Trans Am Clin Climatol Assoc 123:17-33; discussion 33-5. 2012
    ..Induction of viremia in guinea pigs led to VZV latency throughout the ENS. The possibility VZV reactivation in the ENS is an unsuspected cause of gastrointestinal disease requires future investigation...
  22. doi request reprint A model of lytic, latent, and reactivating varicella-zoster virus infections in isolated enteric neurons
    Anne A Gershon
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Infect Dis 197:S61-5. 2008
    ..This in vitro model should facilitate further understanding of latency and reactivation of VZV...
  23. pmc Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit
    ALCMENE CHALAZONITIS
    Deparment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Comp Neurol 509:474-92. 2008
    ..Although the function of the gut thus displays a remarkable tolerance for ENS defects, subtle functional abnormalities in motility or secretion may arise when ENS defects short of aganglionosis occur during development...
  24. ncbi request reprint 5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice
    Elena Fiorica-Howells
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Physiol Gastrointest Liver Physiol 282:G877-93. 2002
    ....
  25. pmc 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice
    Min Tsai Liu
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 29:9683-99. 2009
    ..This is the first demonstration of adult enteric neurogenesis; our results suggest that 5-HT(4) receptors are required postnatally for ENS growth and maintenance...
  26. pmc Combined administration of secretin and oxytocin inhibits chronic colitis and associated activation of forebrain neurons
    Martha G Welch
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurogastroenterol Motil 22:654-e202. 2010
    ..We tested the hypotheses that the chronically inflamed bowel signals to the brain through the vagi and that administration of a combination of secretin (S) and oxytocin (OT) inhibits this signaling...
  27. ncbi request reprint Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset
    ALCMENE CHALAZONITIS
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 24:4266-82. 2004
    ..BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC...
  28. ncbi request reprint Latent and lytic infection of isolated guinea pig enteric ganglia by varicella zoster virus
    Jason J Chen
    Department of Anatomy and Cell Biology, Columbia University of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Med Virol 70:S71-8. 2003
    ..This new animal model should facilitate studies of VZV latency and the efficacy of therapies designed to prevent VZV infection, latency, and reactivation...
  29. ncbi request reprint Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter
    Min Tsai Liu
    Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1398-411. 2002
    ..Adaptive changes thus occur in the subunit composition of enteric 5-HT(3) receptors of SERT -/- mice that are reflected in 5-HT(3) receptor affinity and desensitization...
  30. ncbi request reprint Expression and function of 5-HT4 receptors in the mouse enteric nervous system
    Mintsai Liu
    Dept of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 289:G1148-63. 2005
    ..Enteric neuronal 5-HT(4) receptors thus are presynaptic and probably exert their prokinetic effects by strengthening excitatory neurotransmission...
  31. ncbi request reprint Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice
    Zhi Shan Li
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:2798-807. 2006
    ..Because motility is abnormal when D2 is absent, the net inhibitory DA effect on motility is physiologically significant. The early expression of DA receptors is also consistent with the possibility that DA affects ENS development...
  32. ncbi request reprint Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut
    Elyanne M Ratcliffe
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Comp Neurol 498:567-80. 2006
    ..005); antibodies to DCC again blocked this preferential outgrowth (P < 0.05). These data suggest that netrins, which are expressed in the bowel, attract DCC-expressing vagal sensory axons...
  33. pmc Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium
    Martha G Welch
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Comp Neurol 512:256-70. 2009
    ..We suggest that OT and OTR signaling might be important in ENS development and function and might play roles in visceral sensory perception and neural modulation of epithelial biology...
  34. doi request reprint Perspectives on vaccines against varicella-zoster virus infections
    Anne A Gershon
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Top Microbiol Immunol 342:359-72. 2010
    ..Despite gaps in our understanding of the details of immunity to VZV, successful vaccines have been developed against both varicella and zoster...
  35. pmc Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression
    Zhishan Li
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 30:16730-40. 2010
    ..NET expression is essential for development and/or survival of some (5-HT- and calretinin-expressing), but not all (nNOS-expressing), of these neurons...
  36. pmc Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling
    ALCMENE CHALAZONITIS
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Dev Biol 350:64-79. 2011
    ..These observations support the hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2...
  37. ncbi request reprint Calcium receptor-induced serotonin secretion by parafollicular cells: role of phosphatidylinositol 3-kinase-dependent signal transduction pathways
    Kuo peing Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 23:2049-57. 2003
    ..The betagamma cascade subsequently activates PI3-Kbeta-dependent signaling that is coupled to PDK1 and the downstream effector PKCzeta, and results in an increase in 5-HT release...
  38. ncbi request reprint Serotonin and its implication for the management of irritable bowel syndrome
    Michael D Gershon
    Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Rev Gastroenterol Disord 3:S25-34. 2003
    ..The way in which these findings have implicated serotonin in irritable bowel syndrome is discussed...
  39. doi request reprint Advances in the understanding of the pathogenesis and epidemiology of herpes zoster
    Anne A Gershon
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Clin Virol 48:S2-7. 2010
    ..Understanding the risk factors for developing HZ and the complications associated with infection, particularly in older people, is important for prompt diagnosis and management of HZ in primary care, and they are therefore also reviewed...
  40. pmc Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis
    Vijay K Yadav
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, USA
    Nat Med 16:308-12. 2010
    ..These results provide a proof of principle that inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis...
  41. ncbi request reprint Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster
    Jason J Chen
    Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
    Cell 119:915-26. 2004
    ..Biopsies from VZV-infected human skin supported the idea that because MPRci expression is naturally lost in maturing superficial epidermal cells, these cells do not divert VZV to endosomes and constitutively secrete infectious VZV...
  42. ncbi request reprint Suppression of the melanogenic potential of migrating neural crest-derived cells by the branchial arches
    Rae J Jacobs-Cohen
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Anat Rec 268:16-26. 2002
    ..These observations suggest that a factor(s) that is normally expressed in the branchial arches, and is lacking in animals with the Silky mutation, prevents cells with a melanogenic potential from colonizing the bowel...
  43. pmc Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposure
    Dmitriy Markov
    Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Neurochem 107:1709-21. 2008
    ..Thus, under some conditions of prolonged exposure, AMPHs and other weak bases can enhance, rather than deplete, the vesicular release of catecholamines via a compensatory response resulting in vesicle acidification...
  44. ncbi request reprint Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    Matthew D Coates
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Gastroenterology 126:1657-64. 2004
    ..Our aim was to test whether enteric 5-HT signaling is defective in these disorders...
  45. ncbi request reprint Gangliogenesis in the enteric nervous system: roles of the polysialylation of the neural cell adhesion molecule and its regulation by bone morphogenetic protein-4
    Christophe Faure
    Division of Gastroenterology, Sainte Justine Hospital Research Center, University of Montreal, Montreal, Quebec, Canada
    Dev Dyn 236:44-59. 2007
    ..Observations suggest that BMP signaling enhances NCAM polysialylation, which allows precursors to migrate and form ganglionic aggregates during the remodeling of the developing ENS...
  46. pmc Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons
    Elyanne M Ratcliffe
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Dev Neurobiol 68:960-71. 2008
    ..These findings suggest that laminin terminates the attraction of vagal sensory axons towards sources of netrin in the developing bowel...
  47. pmc Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
    Yuka Morikawa
    Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Dev Biol 307:114-26. 2007
    ..Our data suggest that the major role of Hand2 during SNS development is to permit sympathetic neurons to acquire a catecholaminergic phenotype...
  48. ncbi request reprint Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
    David R Linden
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Gastrointest Liver Physiol 285:G207-16. 2003
    ..Altered 5-HT availability may contribute to the dysmotility of inflammatory bowel disease, possibly due to desensitization of 5-HT receptors...
  49. ncbi request reprint Interstitial cells of Cajal and electrical activity in ganglionic and aganglionic colons of mice
    Sean M Ward
    Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno 89557, USA
    Am J Physiol Gastrointest Liver Physiol 283:G445-56. 2002
    ..The electrical activity and neural responses of the circular layer are significantly different in aganglionic segments of ls/ls mutants...
  50. pmc Maternal serotonin is crucial for murine embryonic development
    Francine Cote
    Universite Pierre et Marie Curie, Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, CNRS, Unité Mixte de Recherche 7091, Hopital de la Pitie Salpetriere, Paris, France
    Proc Natl Acad Sci U S A 104:329-34. 2007
    ..Consideration of the maternal genotype may thus help to clarify the influence of other genes in complex diseases, such as mental illness...
  51. pmc Stimulation-dependent regulation of the pH, volume and quantal size of bovine and rodent secretory vesicles
    Emmanuel N Pothos
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 0211, USA
    J Physiol 542:453-76. 2002
    ....

Research Grants34

  1. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2004
    ..Some may be subtle and contribute to functional or inflammatory bowel disease in later life, in which the ENS component is not currently appreciated, but may be revealed (and ultimately treated) by understanding ENS development. ..
  2. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
    ..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
  3. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. ..
  4. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2007
    ..We will extend these studies to the guidance of vagal motor and sacral motor and sensory nerves and determine the roles played by laminin-1 and/or Slit proteins in limiting netrin-mediated attraction. ..
  5. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2007
    ..We now propose to identify neurons that express DA receptors, to determine whether they receive a dopaminergic innervation, and how these neurons respond to DA and to DA receptor subtype-selective agonists and antagonists. ..
  6. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2009
    ..We will extend these studies to the guidance of vagal motor and sacral motor and sensory nerves and determine the roles played by laminin-1 and/or Slit proteins in limiting netrin-mediated attraction. ..
  7. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2009
    ..This work is relevant to the pathogenesis and treatment of inflammatory bowel disease, irritable bowel syndrome, and also to the disabling intestinal manifestations of Parkinson's disease. ) ..
  8. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael D Gershon; Fiscal Year: 2010
    ..We will extend these studies to the guidance of vagal motor and sacral motor and sensory nerves and determine the roles played by laminin-1 and/or Slit proteins in limiting netrin-mediated attraction. ..
  9. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2010
    ..This work is relevant to the pathogenesis and treatment of inflammatory bowel disease, irritable bowel syndrome, and also to the disabling intestinal manifestations of Parkinson's disease. ) ..
  10. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2003
    ..The SERT - mice model provides a hyperserotonergic model of the gut, which may represent states of disease such as IBS, infection, use of antidepressants etc. ..
  11. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 1999
    ..In addition, the undesirable GI side effects of psychoactive drugs that affect 5-HT may be better understand and, if anticipated, avoided. ..
  12. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael Gershon; Fiscal Year: 2000
    ....
  13. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2009
    ..Information derived from the studies outlined in the current competitive revision is intended to facilitate future efforts to repair nerve damage or congenital defects of the bowel with a minimum of surgical intervention. ..