Research Topics
| Anne GershonSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Latency of varicella zoster virus in dorsal root, cranial, and enteric ganglia in vaccinated childrenAnne A Gershon
Department of Pediatrics, Columbia University Medical Center, 650 West 168th St, New York, NY, 10032, USA
Trans Am Clin Climatol Assoc 123:17-33; discussion 33-5. 2012..Induction of viremia in guinea pigs led to VZV latency throughout the ENS. The possibility VZV reactivation in the ENS is an unsuspected cause of gastrointestinal disease requires future investigation...- Varicella zoster vaccines and their implications for development of HSV vaccinesAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, NY, NY 10032, USA
Virology 435:29-36. 2013.... - Varicella vaccination in Europe - taking the practical approachPaolo Bonanni
Department of Public Health, University of Florence, Florence, Italy
BMC Med 7:26. 2009.... 
Perspective on live varicella vaccineAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Infect Dis 197:S242-5. 2008....
Samuel L. Katz: pioneer in development of and international advocate for vaccinesAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Semin Pediatr Infect Dis 13:221-31. 2002..He has demonstrated a unique ability to make the world a better place for children and remains an inspiration to many...- Varicella vaccine in the United States: a decade of prevention and the way forwardAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Infect Dis 197:S39-40. 2008 - Prevention and treatment of VZV infections in patients with HIVA A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, 650West 168th Street, New York, NY, USA
Herpes 8:32-6. 2001..It is hoped that immunization of VZV seropositive HIV-infected patients will decrease the incidence of zoster. Studies to determine this are under way... - A model of lytic, latent, and reactivating varicella-zoster virus infections in isolated enteric neuronsAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Infect Dis 197:S61-5. 2008..This in vitro model should facilitate further understanding of latency and reactivation of VZV... - Live-attenuated varicella vaccineA A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
Infect Dis Clin North Am 15:65-81, viii. 2001..It is expected to have a major impact on the epidemiology of varicella and zoster in countries with high vaccine uptake... - A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicellaAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Pediatr Infect Dis J 28:653-5. 2009..There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster... - Perspectives on vaccines against varicella-zoster virus infectionsAnne A Gershon
Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Curr Top Microbiol Immunol 342:359-72. 2010..Despite gaps in our understanding of the details of immunity to VZV, successful vaccines have been developed against both varicella and zoster... - Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatmentAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
J Acquir Immune Defic Syndr 52:17-24. 2009..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment... - Control of varicella: why is a two-dose schedule necessary?Ann Arvin
Stanford Medical School, Department of Pediatrics, Stanford, CA, USA
Pediatr Infect Dis J 25:475-6. 2006 - VZV meningitis following varicella vaccineDahlene Fusco
New York Presbyterian Hospital, Division of Infectious Diseases, New York, NY, USA
J Clin Virol 48:275-7. 2010..We report a case of disseminated herpes zoster in a previously healthy elderly woman hours after Oka strain vaccination. PCR and restriction enzyme analysis revealed that symptoms were caused by wild type virus... - Persistence of immunity to varicella-zoster virus after vaccination of healthcare workersL Saiman
Department of Pediatrics, Columbia University, College of Phyicians and Surgeons, New York City, New York 10032, USA
Infect Control Hosp Epidemiol 22:279-83. 2001..CONCLUSIONS: The VZV vaccine effectively protected HCWs from varicella, particularly from serious disease. Currently available serological tests are not optimal, and improved assays are needed... - Evidence of latent varicella-zoster virus in rat dorsal root gangliaP Annunziato
Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Infect Dis 178:S48-51. 1998..Although all animals received unilateral injections of virus, VZV DNA was in ipsilateral and contralateral ganglia in 6 animals, suggesting that virus replication and viremia had occurred... - Varicella-zoster virus proteins in skin lesions: implications for a novel role of ORF29p in chickenpoxP W Annunziato
Departments of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Virol 74:2005-10. 2000..In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis... - Viral strain identification in varicella vaccinees with disseminated rashesP LaRussa
Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Pediatr Infect Dis J 19:1037-9. 2000..Although some vaccinees will develop zoster, it is less common in recipients of vaccine than in those who have had natural varicella... - Persistence of immunity to live attenuated varicella vaccine in healthy adultsKrow Ampofo
Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY, 10032, USA
Clin Infect Dis 34:774-9. 2002..This study demonstrated that the varicella vaccine was effective in providing adults with long-term protection from serious VZV disease... - The effectiveness of the varicella vaccine in clinical practiceM Vazquez
Department of Pediatrics, Yale University School of Medicine, New Haven, Conn 06520 8064, USA
N Engl J Med 344:955-60. 2001..A live attenuated varicella vaccine was approved for use in the United States in March 1995 and is recommended for all susceptible persons 12 months of age or older... - The rate of serious bacterial infections among HIV-infected children with immune reconstitution who have discontinued opportunistic infection prophylaxisSharon Nachman
Department of Pediatrics, Stony Brook University, Stony Brook, NY 11794 8111, USA
Pediatrics 115:e488-94. 2005.... - Cholesterol dependence of varicella-zoster virion entry into target cellsS Hambleton
Department of Paediatric, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Virol 81:7548-58. 2007..Lipid rafts are likely to contribute directly to viral envelope integrity and, in the host membrane, may influence endocytosis, evoke downstream signaling, and/or facilitate membrane fusion... - The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryoA A Gershon
Department of Developmental Neurobiology, The Rockefeller University, New York, NY 10021, USA
Development 127:2945-54. 2000..One role of Xdbx during normal development may therefore be to restrict spatially neuronal differentiation within the neural plate, possibly by altering the neuronal differentiation function of Xash3... - The role of the trans-Golgi network in varicella zoster virus biologyS Hambleton
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 650 W 168th Street, New York, New York 10032, USA
Cell Mol Life Sci 61:3047-56. 2004..Knowledge of VZV's use of endogenous trafficking pathways from the TGN sheds light on important aspects of viral behaviour in vitro and in vivo... - Varicella-zoster virus infectionsAnne A Gershon
Columbia University College of Physicians and Surgeons, New York, NY, USA
Pediatr Rev 29:5-10; quiz 11. 2008 - Use and limitations of varicella-zoster virus-specific serological testing to evaluate breakthrough disease in vaccinees and to screen for susceptibility to varicellaJudith Breuer
Skin Virus Laboratory, Centre for Infectious Disease, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary College, London, United Kingdom
J Infect Dis 197:S147-51. 2008..Although several of these methods are useful for various specific applications, simpler and more accurate tests to measure antibodies to VZV are a high priority for future research and development... - The safety profile of varicella vaccine: a 10-year reviewSusan A Galea
Merck Research Laboratories, Clinical Risk Management and Safety Surveillance, North Wales, Pennsylvania 19454 1099, USA
J Infect Dis 197:S165-9. 2008..Disseminated Oka VZV was identified in 6 immunocompromised patients and 1 patient with Down syndrome. This review has shown that the vaccine is generally safe and well tolerated... - Risk of herpes zoster in adults immunized with varicella vaccineSophie Hambleton
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Infect Dis 197:S196-9. 2008..00 case/1000 person-years. Overall, the incidence of HZ in this cohort, therefore, is similar to published data for the US population in the prevaccine era... - Latent and lytic infection of isolated guinea pig enteric ganglia by varicella zoster virusJason J Chen
Department of Anatomy and Cell Biology, Columbia University of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
J Med Virol 70:S71-8. 2003..This new animal model should facilitate studies of VZV latency and the efficacy of therapies designed to prevent VZV infection, latency, and reactivation... - Varicella vaccine--are two doses better than one?Anne A Gershon
N Engl J Med 347:1962-3. 2002 - Consensus: varicella vaccination of healthy children--a challenge for EuropeBernard Rentier
Fundamental Virology Unit, University of Liege, Belgium
Pediatr Infect Dis J 23:379-89. 2004..However, such a policy is recommended only if a very high coverage rate can be achieved. This could be reached with a measles-mumps-rubella-varicella combined vaccine... - Primary vaccine failure after 1 dose of varicella vaccine in healthy childrenDavid E Michalik
Division of Pediatric Infectious Diseases, Columbia University Medical Center, New York, New York 10032, USA
J Infect Dis 197:944-9. 2008..A second dose of varicella vaccine is expected to increase seroconversion rates and vaccine effectiveness... - Vaccine Oka varicella-zoster virus genotypes are monomorphic in single vesicles and polymorphic in respiratory tract secretionsMark A Quinlivan
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, England
J Infect Dis 193:927-30. 2006..We hypothesize that some clones are more trophic than others for skin... - Vaccination against Herpes Zoster and Postherpetic NeuralgiaMichael N Oxman
VA San Diego Healthcare System, San Diego, California, USA
J Infect Dis 197:S228-36. 2008..VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adults against HZ and PHN... - The cellular localization pattern of Varicella-Zoster virus ORF29p is influenced by proteasome-mediated degradationChristina L Stallings
Integrated Program in Cellular, Molecular and Biophysical Studies, and Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
J Virol 80:1497-512. 2006..Although proteasome inhibition induces ORF29p nuclear accumulation, this is not sufficient to reactivate latent VZV or target the immediate-early protein ORF62p to the nucleus in cultured guinea pig enteric neurons... - Preventing varicella-zoster diseaseSophie Hambleton
Columbia University College of Physicians and Surgeons, 650 W. 168th Street, New York, NY 10032, USA
Clin Microbiol Rev 18:70-80. 2005..However, the huge pool of latent wild-type virus in the population represents a continuing threat. Both the biology and the epidemiology of VZV disease suggest that new vaccination strategies will be required over time... - Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zosterJason J Chen
Department of Anatomy and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
Cell 119:915-26. 2004..Biopsies from VZV-infected human skin supported the idea that because MPRci expression is naturally lost in maturing superficial epidermal cells, these cells do not divert VZV to endosomes and constitutively secrete infectious VZV... - Effectiveness over time of varicella vaccineMarietta Vazquez
Department of Pediatrics, Yale University School of Medicine, New Haven, Conn 06520 8064, USA
JAMA 291:851-5. 2004..Reports of outbreaks of varicella in highly immunized groups have increased concern about the effectiveness of varicella vaccine... - An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella-zoster virusMark Quinlivan
Skin Virus Laboratory, Institute of Cell and Molecular Medicine, 25-29 Ashfield Street, White Chapel, London E1 1BB, United Kingdom
J Med Virol 75:174-80. 2005..These sites are also present variably in the vaccine viruses causing rashes following vaccination, and are therefore unreliable markers for differentiating vOka and wild type VZV strains... - Natural selection for rash-forming genotypes of the varicella-zoster vaccine virus detected within immunized human hostsMark L Quinlivan
Centre for Infectious Disease, Institute for Cell and Molecular Science, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom
Proc Natl Acad Sci U S A 104:208-12. 2007..These findings are of practical importance for reducing the incidence of vaccine-associated rash and promoting public acceptance of the vaccine... - Rashes occurring after immunization with a mixture of viruses in the Oka vaccine are derived from single clones of virusMark L Quinlivan
Skin Virus Laboratory, Institute of Cell and Molecular Medicine, London, United Kingdom
J Infect Dis 190:793-6. 2004..This finding suggests that, between the time of inoculation of the vaccine and development of rash, selection of single strains occurs. The results have general implications for the pathogenesis of varicella-zoster virus... - Varicella vaccineAnne A Gershon
N Engl J Med 356:2648-9; author reply 2648-9. 2007 - The impact of varicella vaccination in the United StatesSophie Hambleton
Department of Pediatrics, Columbia University, New York, NY 10032, USA
Semin Pediatr Infect Dis 16:38-43. 2005..Vaccination strategies likely will need to be adjusted as the epidemiology of VZV in the United States continues to evolve... - The Oka varicella vaccines are more equal than differentBernard Rentier
Vaccine 22:3225-6; author reply 3227. 2004 - Varicella vaccine for susceptible adults: do it todayAnne A Gershon
Clin Infect Dis 39:1640-1. 2004 - Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)Rafael Harpaz
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, USA
MMWR Recomm Rep 57:1-30; quiz CE2-4. 2008..Before administration of zoster vaccine, patients do not need to be asked about their history of varicella (chickenpox) or to have serologic testing conducted to determine varicella immunity... - DNA sequence variability in Oka vaccine isolatesJudith Breuer
J Infect Dis 196:801-2; author reply 802-3. 2007 - Guidelines for quality standards for immunizationPierce Gardner
Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Clin Infect Dis 35:503-11. 2002 - Varicella vaccine: rare serious problems--but the benefits still outweigh the risksAnne A Gershon
J Infect Dis 188:945-7. 2003 - Administration of live varicella vaccine to HIV-infected children with current or past significant depression of CD4(+) T cellsMyron J Levin
University of Colorado School of Medicine, Denver, Denver, CO 80262, USA
J Infect Dis 194:247-55. 2006..The licensed, live attenuated varicella vaccine is safe and immunogenic in HIV-infected children with minimal symptoms and good preservation of CD4(+) T cells (Centers for Disease Control and Prevention immunologic category 1)... - Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ... - Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccineM J Levin
University of Colorado Health Sciences Center, Denver, Colorado, USA
J Infect Dis 197:825-35. 2008..The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome... - Severe varicella caused by varicella-vaccine strain in a child with significant T-cell dysfunctionPatrick Jean-Philippe
Department of Pediatrics, New York University School of Medicine, New York, New York, USA
Pediatrics 120:e1345-9. 2007..We report here an 18-month-old girl with cell-mediated immunodeficiency who developed a severe vaccine-associated rash and clinical evidence of vaccine-associated pneumonia 1 month after inadvertent receipt of varicella vaccine...
Research Grants
- VARICELLA ZOSTER VIRUSAnne Gershon; Fiscal Year: 2002..They will investigate gene expression during putative latency, including the comparative virulence of wild type and vaccine type VZV. ..
- PEDIATRICS AIDS CLINICAL TRIALS GROUPAnne Gershon; Fiscal Year: 2006..We have competent, outstanding staff whose aim is not only to provide compassionate medical care to HIV-infected patients but also to perform meaningful and useful research on prevention and treatment of HIV infection. ..
- VZV Receptors and Infective MechanismsAnne Gershon; Fiscal Year: 2007..It may also make it possible to develop a safer and more efficacious vaccine. ..
- TRAINING IN PEDIATRIC INFECTIOUS DISEASEAnne Gershon; Fiscal Year: 2007..The renewal of this training grant will enable us to continue a training program that has so far been highly successful at this University during the past 5 years. ..
- VARICELLA ZOSTER--RECEPTORS AND INFECTIVE MECHANISMSAnne Gershon; Fiscal Year: 2000....