MARY VELESCA GAMBLE

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Influence of cobalamin on arsenic metabolism in Bangladesh
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 117:1724-9. 2009
  2. pmc Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh
    Megan N Hall
    Department of Epidemiology, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 117:825-31. 2009
  3. pmc Urinary creatinine and arsenic metabolism
    Mary V Gamble
    Environ Health Perspect 113:A442; author reply A442-3. 2005
  4. pmc Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 119:113-8. 2011
  5. pmc Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room T31, New York, NY 10032, USA
    J Toxicol 2012:595307. 2012
  6. pmc Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA
    J Richard Pilsner
    Division of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 7:e37147. 2012
  7. pmc A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in bangladeshi adults
    Megan M Niedzwiecki
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 121:1306-12. 2013
  8. pmc Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 121:1068-74. 2013
  9. pmc A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh
    Christine Marie George
    Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD E5535, USA
    Environ Health 12:52. 2013
  10. pmc Mathematical model insights into arsenic detoxification
    Sean D Lawley
    Department of Mathematics, Duke University, 130 Science Drive, Durham, NC 27708, USA
    Theor Biol Med Model 8:31. 2011

Collaborators

Detail Information

Publications23

  1. pmc Influence of cobalamin on arsenic metabolism in Bangladesh
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 117:1724-9. 2009
    ..Although DMA(V) is the least toxic metabolite, increasing evidence suggests that MMA(III) may be the most cytotoxic and genotoxic As intermediary metabolite...
  2. pmc Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh
    Megan N Hall
    Department of Epidemiology, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 117:825-31. 2009
    ..Methylation of InAs to monomethylarsonic (MMA) and dimethylarsinic acids (DMA) relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic (uAs) elimination...
  3. pmc Urinary creatinine and arsenic metabolism
    Mary V Gamble
    Environ Health Perspect 113:A442; author reply A442-3. 2005
  4. pmc Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 119:113-8. 2011
    ..In addition, antagonism between As and Se, whereby each reduces toxicity of the other, has been well documented in animal models. Se status may therefore modify the health effects of As in As-exposed populations...
  5. pmc Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room T31, New York, NY 10032, USA
    J Toxicol 2012:595307. 2012
    ....
  6. pmc Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA
    J Richard Pilsner
    Division of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 7:e37147. 2012
    ..An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown...
  7. pmc A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in bangladeshi adults
    Megan M Niedzwiecki
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 121:1306-12. 2013
    ..However, As has been associated with global DNA hypermethylation in human study populations. We hypothesized that this discrepancy may reflect a nonlinear relationship between As dose and DNA methylation...
  8. pmc Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults
    Megan N Hall
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 121:1068-74. 2013
    ....
  9. pmc A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh
    Christine Marie George
    Department of International Health, Program in Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD E5535, USA
    Environ Health 12:52. 2013
    ..Recent evidence suggests that selenium may play a role in arsenic elimination by forming a selenium-arsenic conjugate in the liver before excretion into the bile...
  10. pmc Mathematical model insights into arsenic detoxification
    Sean D Lawley
    Department of Mathematics, Duke University, 130 Science Drive, Durham, NC 27708, USA
    Theor Biol Med Model 8:31. 2011
    ....
  11. pmc Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh
    Mary V Gamble
    Department of Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 81:1372-7. 2005
    ..This has been largely attributed to dietary deficiencies in cobalamin associated with vegetarianism among these Indian Asians...
  12. pmc Folic acid supplementation lowers blood arsenic
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 86:1202-9. 2007
    ..Methylation of ingested inorganic arsenic (InAs) to monomethylarsonic (MMAs) and dimethylarsinic (DMAs) acids relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic elimination...
  13. pmc Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 113:1683-8. 2005
    ..This may be particularly relevant in Bangladesh, where the prevalence of hyperhomocysteinemia is extremely high...
  14. pmc Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh
    Mary V Gamble
    Departments of Environmental Health Sciences, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1093-101. 2006
    ..Consequently, folate nutritional status may influence arsenic methylation and toxicity...
  15. ncbi request reprint Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh
    Julia E Heck
    Department of Epidemiology, Mailman School of Public Health and Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1367-74. 2007
    ..Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser proportions of MMA and InAs in urine, have a lower risk of adverse arsenic-related health outcomes...
  16. ncbi request reprint Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B1, New York, NY 10032, USA
    Am J Clin Nutr 86:1179-86. 2007
    ..It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-contaminated drinking water...
  17. pmc Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions
    J Richard Pilsner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Ave, B1, New York, NY 10032 USA
    Environ Health Perspect 117:254-60. 2009
    ..Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility...
  18. pmc Genomic DNA methylation among women in a multiethnic New York City birth cohort
    Mary Beth Terry
    Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 17:2306-10. 2008
    ..Larger studies and studies that measure within-individual changes in DNA methylation over time are a necessary next step...
  19. ncbi request reprint Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
    ....
  20. pmc Global hypomethylation of genomic DNA in cancer-associated myofibroblasts
    Le Jiang
    Institute for Cancer Genetics and Department of Medicine, Columbia University, New York, New York 10032, USA
    Cancer Res 68:9900-8. 2008
    ....
  21. ncbi request reprint Carotenoid status among preschool children with vitamin A deficiency in the Republic of the Marshall Islands
    Mary V Gamble
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Asia Pac J Clin Nutr 13:336-40. 2004
    ....
  22. ncbi request reprint Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil
    Ping Chen
    Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville 22908, USA
    J Health Popul Nutr 21:309-15. 2003
    ..001) and HAZ scores (p = 0.007) improved with supplementation. It is concluded that impaired intestinal barrier function and linear growth shortfalls improve following supplementation of vitamin A and zinc in this setting...
  23. ncbi request reprint Vitamin A deficiency, iron deficiency, and anemia among preschool children in the Republic of the Marshall Islands
    Neal A Palafox
    Department of Family Practice and Community Health, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Nutrition 19:405-8. 2003
    ..We investigated the co-occurrence of vitamin A deficiency, iron deficiency, and anemia among young children in the Republic of the Marshall Islands...

Research Grants8

  1. Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arenic
    MARY VELESCA GAMBLE; Fiscal Year: 2010
    ....
  2. Nutritional Influences on Arsenic Toxicity
    Mary Gamble; Fiscal Year: 2003
    ..abstract_text> ..
  3. Nutritional Influences on Aresenic Toxicity
    Mary Gamble; Fiscal Year: 2004
    ..abstract_text> ..
  4. Nutritional Influences on Aresenic Toxicity
    Mary Gamble; Fiscal Year: 2005
    ..abstract_text> ..
  5. Nutritional Influences on Aresenic Toxicity
    Mary Gamble; Fiscal Year: 2006
    ..abstract_text> ..
  6. Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arenic
    Mary Gamble; Fiscal Year: 2009
    ....
  7. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2010
    ....
  8. Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and Folate
    MARY VELESCA GAMBLE; Fiscal Year: 2011
    ....