Research Topics
Species | Steven J FruchtSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Parkinson disease: an updateSteven J Frucht
Columbia Presbyterian Medical Center, New York, NY 10032, USA
Neurologist 10:185-94. 2004..For neurologists faced with the task of treating PD patients, the available array of medications may be confusing and intimidating...
Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish populationXinmin Liu
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
BMC Med Genet 12:104. 2011..Collectively the associations identified in these GWAS account for only a small proportion of the estimated total heritability of PD suggesting that an 'unknown' component of the genetic architecture of PD remains to be identified...- A pilot tolerability and efficacy study of levetiracetam in patients with chronic myoclonusS J Frucht
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neurology 57:1112-4. 2001..Levetiracetam was well tolerated. Three of five patients with cortical myoclonus experienced reductions in their myoclonus scores, providing support for a larger, placebo-controlled trial in cortical myoclonus... - Marked amelioration of alcohol-responsive posthypoxic myoclonus by gamma-hydroxybutyric acid (Xyrem)Steven J Frucht
Department of Neurology, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA
Mov Disord 20:745-51. 2005..The possible mechanisms of action and potential uses of this agent in other alcohol-responsive movement disorders are discussed... - A pilot tolerability and efficacy trial of sodium oxybate in ethanol-responsive movement disordersSteven J Frucht
Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
Mov Disord 20:1330-7. 2005..Tolerability was satisfactory, with dose-dependent sedation as the most common side effect. Further studies of this drug in hyperkinetic movement disorders are warranted... - Movement disorder emergenciesSteven J Frucht
Department of Neurology, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 5:284-93. 2005..The text of this article has appeared in nearly the same form as the Academy syllabus accompanying our course. It is being presented here so that readers of the journal may review the material... - A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremorS J Frucht
Columbia University Medical Center, New York, USA
Neurology 65:1967-9. 2005..Tolerability was acceptable, and more than half of the patients chose to continue treatment after the trial. Double-blind placebo-controlled studies in these disorders are warranted... - Emergency treatment of movement disordersShu Ching Hu
Steven J Frucht, MD Department of Neurology, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA
Curr Treat Options Neurol 9:103-14. 2007..When focal hyperkinetic movements dominate the picture, botulinum toxin injection is a useful adjunct to medications... 
Focal task-specific dystonia of the musicians' hand--a practical approach for the clinicianSteven J Frucht
Columbia University Medical Center, Department of Neurology, The Neurological Institute, New York, NY 10032, USA
J Hand Ther 22:136-42; quiz 143. 2009..Effective treatments including sensory rehabilitation and botulinum toxin injection offer real hope for symptomatic relief and also afford scientists the opportunity to investigate sensorimotor networks in the normal and abnormal state...- Embouchure dystonia--Portrait of a task-specific cranial dystoniaSteven J Frucht
The Neurological Institute, Columbia University Medical Center, New York, New York 10032, USA
Mov Disord 24:1752-62. 2009..Once present, symptoms of ED did not remit and often disrupted careers and livelihoods. Better treatments are urgently needed for this unusual disorder of oral motor control... - The metabolic topography of posthypoxic myoclonusSteven J Frucht
Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
Neurology 62:1879-81. 2004..Interventions such as deep brain stimulation that interrupt networks that involve these structures may be useful in patients with severe PHM... - Movement disorder emergencies in the perioperative periodSteven J Frucht
Columbia Presbyterian Medical Center, Department of Neurology, 710 West 168th Street, New York, NY 10032, USA
Neurol Clin 22:379-87. 2004..By paying attention to the phenomenology of the movement disorder, the effects of medications administered in the operating room, and unusual sequelae of surgery, neurologists can have a positive impact on the outcome of these patients... - Visual hallucinations in PDSteven J Frucht
Columbia-Presbyterian Medical Center, Department of Neurology, 710 West 168th Street, New York, NY 10032, USA
Neurology 59:1965. 2002 - The natural history of embouchure dystoniaS J Frucht
Columbia Presbyterian Medical Center, The Neurological Institute, New York, New York 10032, USA
Mov Disord 16:899-906. 2001..Dystonia not infrequently spread to other oral tasks, often producing significant disability. Effective treatments are needed for this challenging and unusual disorder... - Dystonia, athetosis, and epilepsia partialis continua in a patient with late-onset Rasmussen's encephalitisSteven Frucht
Columbia Presbyterian Medical Center, The Neurological Institute, New York, New York 1032, USA
Mov Disord 17:609-12. 2002..Intravenous immunoglobulin improved both hyperkinetic movements and EPC, but benefit was transient. The clinical significance and implications of these findings are discussed... - Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's diseaseRoy N Alcalay
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
J Clin Exp Neuropsychol 32:775-9. 2010..GBA carriers reported more impairment, but MMSE performance did not differ among genetic groups. Detailed neuropsychological testing is required to explore the association between cognitive impairment and GBA mutations... - Movement disorder emergenciesKathleen L Poston
Dept of Neurology, Columbia University Medical Center, 710 West 168th Street, 10032, New York, NY, USA
J Neurol 255:2-13. 2008.... - Diagnosis and management of pergolide-induced fibrosisPinky Agarwal
Department of Neurology, Columbia-Presbyterian Medical Center, Division of Movement Disorders, New York, New York, USA
Mov Disord 19:699-704. 2004..Based on our experience with these patients and a review of cases of pergolide-induced fibrosis in the English-language literature, we propose guidelines for the diagnosis and management of this rare complication... - Classification conundrums in paroxysmal dyskinesias: a new subtype or variations on classic themes?Michael H Pourfar
Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
Mov Disord 20:1047-51. 2005..We describe 4 cases that do not fit easily into the current classification scheme, compare them with four others recently described in the literature, and raise the question as to whether they constitute a new subtype... - Supine head tremor: a clinical comparison of essential tremor and spasmodic torticollis patientsAngus Agnew
GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Neurol Neurosurg Psychiatry 83:179-81. 2012..There is an anecdotal sense that head tremor in ET is positional rather than resting, a feature which could aid in the diagnosis, yet no published data exist... - Ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus increases midbrain size: a potential mechanism for gait improvementJ Mocco
Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
Neurosurgery 59:847-50; discussion 850-1. 2006..The current study was undertaken to determine the effect of ventriculoperitoneal shunt placement on midbrain dimensions in INPH patients... - Treatment options for sleep dysfunction in Parkinson's diseaseMary Ann Thenganatt
Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY, 10032, USA
Curr Treat Options Neurol 13:473-87. 2011..The goal of therapy is to restore quality nighttime sleep without excessive daytime sedation and to improve the patient's daily mental and physical function and overall quality of life... - MyoclonusVictoria C Chang
Victoria C Chang, MD Neurological Institute, Columbia University Medical Center, 710 West 168th Street, 3rd Floor, New York, NY 10032, USA
Curr Treat Options Neurol 10:222-9. 2008..Meanwhile, the clinical approach to diagnosing and classifying myoclonus remains largely unchanged. This review updates readers on current investigations and suggests guidelines for diagnosing and treating myoclonus... - The clinical challenge of posthypoxic myoclonusSteven J Frucht
Department of Neurology, Columbia-Presbyterian Medical Center, Neurological Institute, New York, New York, USA
Adv Neurol 89:85-8. 2002 - Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson diseaseRoy N Alcalay
Department of Neurology, Columbia University, New York, NY 10032, USA
Arch Neurol 66:1517-22. 2009.... - The hand that has forgotten its cunning--lessons from musicians' hand dystoniaAnna M Conti
The Neurological Institute, Columbia University Medical Center, New York, New York, USA
Mov Disord 23:1398-406. 2008..The clinical implications of these findings and their possible relationship to the pathophysiology of focal task-specific dystonia are explored... - Geste antagonistes in idiopathic lower cranial dystoniaSteven E Lo
The Neurological Institute, Columbia University Medical Center, New York, New York, USA
Mov Disord 22:1012-7. 2007..In most patients, dystonia was task-specific. Taking advantage of the improvement with a sensory geste, we manufactured oral appliances that mimicked the geste in 8 patients, and 3 continue to use it... - Severe cervical dystonia in pathologically proven Parkinson's disease and dementiaOren Cohen
Department of Neurology, Columbia-Presbyterian Medical Center, New York, New York, USA
Mov Disord 18:1381-2. 2003..The clinical diagnosis of Parkinson's disease and dementia (PDD) was confirmed at autopsy... - Prevalence of essential tremor in patients with Parkinson's disease vs. Parkinson-plus syndromesElan D Louis
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Mov Disord 22:1402-7. 2007..Patients with PD were three to thirteen times more likely to have diagnoses of ET than were patients with Parkinson-plus syndromes. These data further confirm the link between ET and PD, and possibly, between ET and Lewy body disease... - Focal task-specific dystonia in musiciansSteven J Frucht
Department of Neurology, Columbia University, New York, New York, USA
Adv Neurol 94:225-30. 2004 - Chemotherapy-induced parkinsonism responsive to levodopa: an underrecognized entityCathy Chuang
The Neurological Institute, Columbia Presbyterian Medical Center, New York, NY, USA
Mov Disord 18:328-31. 2003..All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated... - MyoclonusPinky Agarwal
Department of Neurology, Columbia-Presbyterian Medical Center, New York, NY 10032, USA
Curr Opin Neurol 16:515-21. 2003..Nonetheless, there is a logic to the choice and dosing of antimyoclonic drugs, and we hope that by applying a few simple principles, neurologists will approach the care of these patients with confidence... - Tetrabenazine in the treatment of severe pediatric choreaAnjan Chatterjee
Department of Neurology, Columbia-Presbyterian Medical Center, New York, New York, USA
Mov Disord 18:703-6. 2003..We report on 5 children with severe chorea who were treated with TBZ. TBZ effectively controlled chorea in 4 patients, and despite the need for relatively high doses, it was well tolerated... - Identification and management of deep brain stimulation intra- and postoperative urgencies and emergenciesTakashi Morishita
Department of Neurology, University of Florida College of Medicine Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
Parkinsonism Relat Disord 16:153-62. 2010..We have included ten illustrative (and actual) case vignettes to augment the discussion of each issue... - Tetrabenazine therapy of pediatric hyperkinetic movement disordersSamay Jain
Department of Neurology, Movement Disorders Division, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Mov Disord 21:1966-72. 2006..When compared to adult patients, pediatric patients required higher doses. Side effects were similar to the adult population; however, children had a lower incidence of drug-induced Parkinsonism... - The Unified Myoclonus Rating ScaleSteven J Frucht
Department of Neurology, Columbia University, Columbia-Presbyterian Medical Center, Neurological Institute, New York, New York, USA
Adv Neurol 89:361-76. 2002 - Subthalamic stimulation for Parkinson disease: determination of electrode location necessary for clinical efficacyShearwood McClelland
Department of Neurological Surgery and Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Neurosurg Focus 19:E12. 2005..Future studies may be warranted to evaluate prospectively the degree to which MER modification of the anatomically and/or image-determined target improves clinical efficacy of DBS electrodes... - Is focal task-specific dystonia limited to the hand and face?Steven E Lo
The Neurological Institute, Columbia University Medical Center, New York, New York 10032, USA
Mov Disord 22:1009-11. 2007..Our patients appear to demonstrated that task-specificity in focal dystonia may not be limited to skilled, rehearsed actions and that FTSD may occur in an activity that is relatively autonomic...