Kathleen M Friel

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Using motor behavior during an early critical period to restore skilled limb movement after damage to the corticospinal system during development
    KATHLEEN FRIEL
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 32:9265-76. 2012
  2. ncbi request reprint Dissociation of sensorimotor deficits after rostral versus caudal lesions in the primary motor cortex hand representation
    Kathleen M Friel
    Department of Molecular and Integrative Physiology, Landon Center on Aging, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurophysiol 94:1312-24. 2005
  3. pmc Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates
    Kathleen M Friel
    Department of Molecular and Integrative Physiology, Landon Center on Aging, and Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS, USA
    Neurorehabil Neural Repair 21:51-61. 2007
  4. ncbi request reprint Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primates
    Erik J Plautz
    Department of Molecular and Integrative Physiology, Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurol Res 25:801-10. 2003
  5. pmc Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys
    Scott Barbay
    Landon Center on Aging and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA
    Exp Brain Res 169:106-16. 2006
  6. pmc Ipsilateral connections of the ventral premotor cortex in a new world primate
    Numa Dancause
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Comp Neurol 495:374-90. 2006
  7. ncbi request reprint Topographically divergent and convergent connectivity between premotor and primary motor cortex
    Numa Dancause
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Cereb Cortex 16:1057-68. 2006
  8. pmc Pyramidal tract stimulation restores normal corticospinal tract connections and visuomotor skill after early postnatal motor cortex activity blockade
    Iran Salimi
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    J Neurosci 28:7426-34. 2008
  9. ncbi request reprint A squirrel monkey model of poststroke motor recovery
    Randolph J Nudo
    Center on Aging, Department of Physiology, University of Kansas Medical Center, Kansas City, USA
    ILAR J 44:161-74. 2003
  10. pmc Bilateral activity-dependent interactions in the developing corticospinal system
    Kathleen M Friel
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    J Neurosci 27:11083-90. 2007

Research Grants

Detail Information

Publications13

  1. pmc Using motor behavior during an early critical period to restore skilled limb movement after damage to the corticospinal system during development
    KATHLEEN FRIEL
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 32:9265-76. 2012
    ..Restraint alone only restored CST connectivity. Our findings stress the need to reestablish the integrated functions of the CS system at multiple hierarchical levels in restoring skilled motor function after developmental injury...
  2. ncbi request reprint Dissociation of sensorimotor deficits after rostral versus caudal lesions in the primary motor cortex hand representation
    Kathleen M Friel
    Department of Molecular and Integrative Physiology, Landon Center on Aging, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Neurophysiol 94:1312-24. 2005
    ..Rostral and caudal M1 lesions result in different deficits in sensory-dependent motor control that appear to correlate with broad segregation of motor outputs and previously described sensory inputs of M1...
  3. pmc Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates
    Kathleen M Friel
    Department of Molecular and Integrative Physiology, Landon Center on Aging, and Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS, USA
    Neurorehabil Neural Repair 21:51-61. 2007
    ..The goal of the present study was to determine if rehabilitative training has similar effects on functional topography of the spared M1 after rostral versus previously reported caudal M1 lesions...
  4. ncbi request reprint Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primates
    Erik J Plautz
    Department of Molecular and Integrative Physiology, Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurol Res 25:801-10. 2003
    ..Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury...
  5. pmc Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys
    Scott Barbay
    Landon Center on Aging and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, USA
    Exp Brain Res 169:106-16. 2006
    ..These results indicate that post-injury behavioral experience, such as motor skill training, may modulate peri-infarct cortical plasticity in different ways in the acute versus chronic stages following stroke...
  6. pmc Ipsilateral connections of the ventral premotor cortex in a new world primate
    Numa Dancause
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Comp Neurol 495:374-90. 2006
    ..No statistical difference between the proportions of inputs and outputs for any location was observed, supporting the reciprocity of PMv intracortical connections...
  7. ncbi request reprint Topographically divergent and convergent connectivity between premotor and primary motor cortex
    Numa Dancause
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Cereb Cortex 16:1057-68. 2006
    ..To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1...
  8. pmc Pyramidal tract stimulation restores normal corticospinal tract connections and visuomotor skill after early postnatal motor cortex activity blockade
    Iran Salimi
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    J Neurosci 28:7426-34. 2008
    ..These findings show the importance of activity-dependent processes in specifying CST connections. They also provide a strategy for harnessing activity to rescue CST axons at risk of developing aberrant connections after CNS injury...
  9. ncbi request reprint A squirrel monkey model of poststroke motor recovery
    Randolph J Nudo
    Center on Aging, Department of Physiology, University of Kansas Medical Center, Kansas City, USA
    ILAR J 44:161-74. 2003
    ..This methodology is described in detail, and many of the resulting findings that are relevant for understanding stroke recovery and the effects of rehabilitative and pharmacotherapeutic interventions are summarized...
  10. pmc Bilateral activity-dependent interactions in the developing corticospinal system
    Kathleen M Friel
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    J Neurosci 27:11083-90. 2007
    ..Our findings show that robust bilateral interactions between the developing CS systems on each side are important for achieving balance between contralateral and ipsilateral CS tract connections and visuomotor control...
  11. doi request reprint Pathophysiological mechanisms of impaired limb use and repair strategies for motor systems after unilateral injury of the developing brain
    Kathleen M Friel
    Burke Cornell Medical Research Institute, White Plains, NY, USA Department of Psychiatry, Columbia University, New York, NY, USA Department of Physiology, Pharmacology, and Neuroscience, City College of the City University of New York, New York, NY, USA
    Dev Med Child Neurol 55:27-31. 2013
    ....
  12. pmc Activity- and use-dependent plasticity of the developing corticospinal system
    John H Martin
    Center for Neurobiology and Behavior, Columbia University, N Y S Psychiatric Institute, New York, NY 10032, USA
    Neurosci Biobehav Rev 31:1125-35. 2007
    ..This finding suggests that aspects of normal CS connectivity and function might some day be restored in hemiplegic cerebral palsy...
  13. ncbi request reprint Role of sensory-motor cortex activity in postnatal development of corticospinal axon terminals in the cat
    Kathleen M Friel
    Center for Neurobiology and Behavior, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    J Comp Neurol 485:43-56. 2005
    ..Surprisingly, when a CS neuron's activity is blocked during early development, it does not recover lost connections later in development once activity resumes...

Research Grants2

  1. Corticospinal development after cortical inactivation
    KATHLEEN FRIEL; Fiscal Year: 2005
    ....