RICHARD FOLTIN

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi The effects of smoked cocaine during the follicular and luteal phases of the menstrual cycle in women
    Suzette M Evans
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Psychopharmacology (Berl) 159:397-406. 2002
  2. ncbi Substance use and psychosocial outcomes following participation in residential laboratory studies of marijuana, methamphetamine and zolpidem
    Nehal P Vadhan
    Columbia University, New York, New York, USA
    Am J Drug Alcohol Abuse 32:589-97. 2006
  3. ncbi Gabapentin does not reduce smoked cocaine self-administration: employment of a novel self-administration procedure
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, Columbia University, Columbia, New York 10032, USA
    Behav Pharmacol 18:71-5. 2007
  4. pmc The behavioral pharmacology of anorexigenic drugs in nonhuman primates: 30 years of progress
    Richard W Foltin
    Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Behav Pharmacol 23:461-77. 2012
  5. ncbi "Tasting and wasting" behavior in non-human primates: aberrant behavior or normal behavior in "times of plenty"
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Physiol Behav 89:587-97. 2006
  6. ncbi The effects of venlafaxine on the subjective, reinforcing, and cardiovascular effects of cocaine in opioid-dependent and non-opioid-dependent humans
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Exp Clin Psychopharmacol 11:123-30. 2003
  7. ncbi Baclofen decreases feeding in non-human primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
    Pharmacol Biochem Behav 82:608-14. 2005
  8. ncbi Effects of amphetamine, dexfenfluramine, diazepam, and dietary manipulations on responding reinforced by stimuli paired with food in nonhuman primates
    Richard W Foltin
    Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 77:471-9. 2004
  9. pmc A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Psychopharmacology (Berl) 199:583-92. 2008
  10. ncbi Intranasal cocaine in humans: acute tolerance, cardiovascular and subjective effects
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032 USA
    Pharmacol Biochem Behav 78:93-101. 2004

Research Grants

Detail Information

Publications79

  1. ncbi The effects of smoked cocaine during the follicular and luteal phases of the menstrual cycle in women
    Suzette M Evans
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Psychopharmacology (Berl) 159:397-406. 2002
    ..Few studies have systematically determined whether the response to cocaine in human females is related to hormonal fluctuations at different phases of the menstrual cycle...
  2. ncbi Substance use and psychosocial outcomes following participation in residential laboratory studies of marijuana, methamphetamine and zolpidem
    Nehal P Vadhan
    Columbia University, New York, New York, USA
    Am J Drug Alcohol Abuse 32:589-97. 2006
    ..However, the administration of substances from drug classes with abuse potential to human volunteers raises ethical questions regarding potential risk to study volunteers...
  3. ncbi Gabapentin does not reduce smoked cocaine self-administration: employment of a novel self-administration procedure
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, Columbia University, Columbia, New York 10032, USA
    Behav Pharmacol 18:71-5. 2007
    ..Together, the data indicate that gabapentin does not show promise as a treatment medication for cocaine dependence...
  4. pmc The behavioral pharmacology of anorexigenic drugs in nonhuman primates: 30 years of progress
    Richard W Foltin
    Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Behav Pharmacol 23:461-77. 2012
    ..Results obtained in nonhuman primates did not always confirm those observed in rodents. Future studies looking at sex differences and social factors may provide insight into factors related to human obesity...
  5. ncbi "Tasting and wasting" behavior in non-human primates: aberrant behavior or normal behavior in "times of plenty"
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Physiol Behav 89:587-97. 2006
    ..Periodic access to a preferred candy food engendered large amounts of candy consumption in all baboons, and periodic access to M & Ms engendered food tasting and wasting behavior in 5 of 8 baboons...
  6. ncbi The effects of venlafaxine on the subjective, reinforcing, and cardiovascular effects of cocaine in opioid-dependent and non-opioid-dependent humans
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Exp Clin Psychopharmacol 11:123-30. 2003
    ..Although the reduction in cocaine's effects was small, further studies using a longer venlafaxine maintenance period or a larger venlafaxine dose are warranted...
  7. ncbi Baclofen decreases feeding in non-human primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
    Pharmacol Biochem Behav 82:608-14. 2005
    ..The findings suggest that the effects of large doses of baclofen in non-human primates may, in part, be due to non-specific behavioral disruptions...
  8. ncbi Effects of amphetamine, dexfenfluramine, diazepam, and dietary manipulations on responding reinforced by stimuli paired with food in nonhuman primates
    Richard W Foltin
    Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 77:471-9. 2004
    ..The effects of AMPH and caloric prefeeding on food seeking are dependent upon the type of stimuli, paired with primary reinforcement...
  9. pmc A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Psychopharmacology (Berl) 199:583-92. 2008
    ..Procedures for studying the effects of medications on satiation will assist the development of obesity medications...
  10. ncbi Intranasal cocaine in humans: acute tolerance, cardiovascular and subjective effects
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032 USA
    Pharmacol Biochem Behav 78:93-101. 2004
    ..These data demonstrate that, as observed with smoked and intravenous cocaine, acute within-session tolerance develops during repeated intranasal cocaine administration...
  11. ncbi Effects of amphetamine, dexfenfluramine, and diazepam on responding during extinction in nonhuman primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 79:325-30. 2004
    ..Low doses of amphetamine (AMPH) increased responding during extinction. Thus, DZP and AMPH increased and DFEN decreased the conditioned reinforcing effects of stimuli paired with food...
  12. ncbi Effects of dietary and pharmacological manipulations on appetitive and consummatory aspects of feeding in non-human primates
    Richard W Foltin
    Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Appetite 45:110-20. 2005
    ....
  13. pmc Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Pharmacol Biochem Behav 86:766-73. 2007
    ..Thus, although effective in decreasing food intake, there was no evidence of a specific effect of CB(1) receptor antagonism on consumption of a large meal or a palatable food...
  14. ncbi Effects of sibutramine on the appetitive and consummatory aspects of feeding in non-human primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Physiol Behav 87:280-6. 2006
    ..The behavioral mechanism by which sibutramine decreases food intake is distinct from other anorectic drugs, including dexfenfluramine, that have been tested in this paradigm...
  15. ncbi The effects of escalating doses of smoked cocaine in humans
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
    Drug Alcohol Depend 70:149-57. 2003
    ..e., "binge", of cocaine use can increment the effects of cocaine, but administering the same cocaine dose maintains, but does not increment the effects of cocaine...
  16. ncbi Effect of response-independent candy on responding maintained by candy using a novel model of commodity acquisition and consumption in nonhuman primates
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Pharmacol Biochem Behav 72:729-39. 2002
    ..The present procedure, which combines operant and place preference measures of commodity acquisition, when used in combination with methods of studying reinstatement of responding, may prove useful in analyzing factors affecting relapse...
  17. ncbi Residual effects of repeated cocaine smoking in humans
    R W Foltin
    Division on Substance Abuse, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Drug Alcohol Depend 47:117-24. 1997
    ....
  18. ncbi Location preference related to smoked heroin self-administration by rhesus monkeys
    R W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 155:419-25. 2001
    ..Although common in humans, little is known about the reinforcing efficacy of smoked heroin in laboratory animals...
  19. ncbi The effects of D-amphetamine on responding for candy and fruit drink using a fixed ratio and a progressive ratio schedule of reinforcer delivery
    R W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute, Unit 120, 1051 Riverside Drive, New York, NY 10032, USA
    Pharmacol Biochem Behav 69:125-31. 2001
    ..The results failed to support the hypothesis that responding under PR schedules of reinforcement would be disrupted by lower doses of AMPH...
  20. ncbi Conditioned effects of environmental stimuli paired with smoked cocaine in humans
    R W Foltin
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Psychopharmacology (Berl) 149:24-33. 2000
    ..Clinical data suggest that stimuli paired with cocaine use acquire emergent stimulus effects, such as the ability to elicit cocaine craving...
  21. ncbi A laboratory model of cocaine withdrawal in humans: intravenous cocaine
    R W Foltin
    Division on Substance Abuse, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Exp Clin Psychopharmacol 5:404-11. 1997
    ..Responsiveness to cocaine cues also varied as a function of the length of the previous cocaine binge...
  22. ncbi Effects of amphetamine on food and fruit drink self-administration
    R W Foltin
    New York State Psychiatric Institute, New York 10032, USA
    Exp Clin Psychopharmacol 8:37-46. 2000
    ..Findings indicate that choice procedures can provide baselines that allow the evaluation of the specificity of a manipulation on intake of a commodity...
  23. pmc Food and cocaine self-administration by baboons: effects of alternatives
    R W Foltin
    New York State Psychiatric Institute, New York 10032, USA
    J Exp Anal Behav 72:215-34. 1999
    ..Thus, the effects of self-administered cocaine on responding maintained by food pellets differed from the effects of experimenter-given cocaine on responding maintained by food pellets...
  24. ncbi Effects of "binge" use of intravenous cocaine in methadone-maintained individuals
    R W Foltin
    Division on Substance Abuse, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Addiction 93:825-36. 1998
    ..To examine the effects of heavy cocaine use followed by abstinence...
  25. ncbi Ethanol and food pellet self-administration by baboons
    R W Foltin
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, USA
    Alcohol 16:183-8. 1998
    ..Increasing the cost of ethanol did not affect food intake...
  26. ncbi Effects of amphetamine, dexfenfluramine, diazepam, and other pharmacological and dietary manipulations on food "seeking" and "taking" behavior in non-human primates
    R W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 158:28-38. 2001
    ..Feeding consists of appetitive or foraging behavior followed by consummatory behavior...
  27. pmc Consumption of palatable food decreases the anorectic effects of serotonergic, but not dopaminergic drugs in baboons
    Richard W Foltin
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Physiol Behav 103:493-500. 2011
    ..We hypothesize that tolerance to the effects of dexfenfluramine reflects a decrease in the satiating effect of serotonin release due to repeatedly eating large amounts of palatable food...
  28. ncbi Memantine increases cardiovascular but not behavioral effects of cocaine in methadone-maintained humans
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 83:47-55. 2006
    ..Taken together, these findings corroborate earlier data suggesting that this dose of memantine will not be helpful in the pharmacotherapy of cocaine abuse...
  29. pmc Modafinil does not serve as a reinforcer in cocaine abusers
    Suzanne K Vosburg
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States
    Drug Alcohol Depend 106:233-6. 2010
    ..Results suggest that modafinil does not have abuse liability in cocaine abusers...
  30. doi Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes
    Matthew G Kirkpatrick
    Department of Psychology, Columbia University, New York, USA
    Psychopharmacology (Berl) 203:771-80. 2009
    ..Methamphetamine attenuates disruptions that occur after changes in work shifts. The reinforcing effects of the drug during shift work have yet to be characterized...
  31. pmc Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropsychopharmacology 34:1774-82. 2009
    ....
  32. pmc Residual effects of intranasal methamphetamine on sleep, mood, and performance
    Audrey Y Perez
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 94:258-62. 2008
    ..Methamphetamine did not produce any negative residual effects on early next-day performance. Future studies should assess methamphetamine-related residual effects following repeated doses administered over consecutive days...
  33. ncbi The effects of acute pretreatment with high-dose memantine on the cardiovascular and behavioral effects of cocaine in humans
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Exp Clin Psychopharmacol 15:228-37. 2007
    ..However, memantine pretreatment did not alter the choice to self-administer cocaine. These data suggest that memantine pretreatment may not be helpful in the treatment of cocaine dependence...
  34. ncbi Acute effects of smoked marijuana on decision making, as assessed by a modified gambling task, in experienced marijuana users
    Nehal P Vadhan
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 29:357-64. 2007
    ..These data are consistent with previous findings that indicated that speed of performance on tests of executive function, but not accuracy, is disrupted in experienced marijuana users during marijuana intoxication...
  35. doi Modafinil decreases food intake in humans subjected to simulated shift work
    Gydmer A Perez
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Pharmacol Biochem Behav 90:717-22. 2008
    ..These findings show that modafinil produced clear reductions in food intake and suggest that future prospective studies should examine the drug in obese participants...
  36. ncbi Relative reinforcing value of exercise in inpatients with anorexia nervosa: model development and pilot data
    Janet E Schebendach
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, The New York State Psychiatric Institute, NewYork, USA
    Int J Eat Disord 40:446-53. 2007
    ..This study sought to quantify, among patients hospitalized for the treatment of anorexia nervosa (AN), the reinforcing value of exercise, defined as the amount of work a patient would expend for the opportunity to exercise...
  37. pmc Intranasal cocaine in humans: effects of sex and menstrual cycle
    Stephanie L Collins
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Pharmacol Biochem Behav 86:117-24. 2007
    ....
  38. pmc Does the response to cocaine differ as a function of sex or hormonal status in human and non-human primates?
    Suzette M Evans
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Horm Behav 58:13-21. 2010
    ....
  39. ncbi Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  40. ncbi Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 45:545-54. 2007
    ..This placebo-controlled within-subjects study evaluated marijuana and dronabinol across a range of behaviors: eating topography, mood, cognitive performance, physiologic measures, and sleep...
  41. pmc Using a novel alternative to drug choice in a human laboratory model of a cocaine binge: a game of chance
    Suzanne K Vosburg
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, United States
    Drug Alcohol Depend 110:144-50. 2010
    ..The current model could be used to evaluate whether behavioral and pharmacological manipulations shift choice from cocaine to a non-drug alternative...
  42. pmc Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans
    Margaret Haney
    College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Biol Psychiatry 67:59-65. 2010
    ..The objective of this human laboratory study was to measure the relationship between antibody titers and the effects of smoked cocaine on ratings of intoxication, craving, and cardiovascular effects...
  43. pmc Behavioral assessment of the reinforcing effect of exercise in women with anorexia nervosa: further paradigm development and data
    Diane A Klein
    Department of Psychiatry, Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    Int J Eat Disord 43:611-8. 2010
    ..To use a Progressive Ratio (PR) computerized "work" paradigm to measure course and correlates of exercise motivation in in-patients with Anorexia Nervosa (AN)...
  44. pmc The effects of oral micronized progesterone on smoked cocaine self-administration in women
    Stephanie Collins Reed
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Horm Behav 59:227-35. 2011
    ..However, based on previous literature, further research assessing the role of oral progesterone for the treatment of cocaine dependence in women is warranted...
  45. ncbi Attentional bias towards cocaine-related stimuli: relationship to treatment-seeking for cocaine dependence
    Nehal P Vadhan
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, Columbia University New York, New York 10032, USA
    Am J Drug Alcohol Abuse 33:727-36. 2007
    ..The purpose of this study was to compare attentional bias towards cocaine-related verbal stimuli between treatment-seeking and nontreatment-seeking cocaine abusers...
  46. pmc Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA
    Psychopharmacology (Berl) 197:157-68. 2008
    ..Individuals seeking treatment for their marijuana use rarely achieve sustained abstinence...
  47. pmc Stimulus-response learning in long-term cocaine users: acquired equivalence and probabilistic category learning
    Nehal P Vadhan
    Columbia University, New York, NY 10027 6902, USA
    Drug Alcohol Depend 93:155-62. 2008
    ..The purpose of this study was to examine stimulus-response (S-R) learning in active cocaine users...
  48. ncbi Acute physiological and behavioral effects of intranasal methamphetamine in humans
    Carl L Hart
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:1847-55. 2008
    ..Of interest is the dissociation between methamphetamine plasma concentrations with cardiovascular measures and positive subjective effects, which might have important implications for potential toxicity after repeated doses...
  49. pmc Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 211:233-44. 2010
    ..Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed...
  50. ncbi Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 86:274-7. 2007
    ....
  51. ncbi Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  52. ncbi Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans
    Eric D Collins
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
    Pharmacol Biochem Behav 76:401-7. 2003
    ..These findings, taken together with the decidedly mixed literature, suggest that amantadine (100 mg bid) will not have a role in the treatment of cocaine dependence...
  53. ncbi Zolpidem-related effects on performance and mood during simulated night-shift work
    Carl L Hart
    Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Exp Clin Psychopharmacol 11:259-68. 2003
    ..Food intake was unaffected by zolpidem. These data indicate that shift changes produce performance impairments, mood alterations, and decreases in food intake, and that zolpidem attenuates some shift-change-related disruptions...
  54. ncbi Marijuana withdrawal in humans: effects of oral THC or divalproex
    Margaret Haney
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:158-70. 2004
    ..Divalproex worsened mood and cognitive performance during marijuana abstinence. These data suggest that oral THC, but not divalproex, may be useful in the treatment of marijuana dependence...
  55. ncbi Smoked heroin in rhesus monkeys: effects of heroin extinction and fluid availability on measures of heroin seeking
    Suzette M Evans
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Pharmacol Biochem Behav 74:723-37. 2003
    ..These data suggest that in nondependent rhesus monkeys, measures of heroin seeking decreased when heroin was not available and seeking behavior shifted to the available alternative commodity...
  56. ncbi Interaction between naltrexone and oral THC in heavy marijuana smokers
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 166:77-85. 2003
    ..Studies in non-human animals suggest that opioid antagonists block the reinforcing effects of cannabinoids...
  57. ncbi Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:407-15. 2002
    ..Yet, there has been no systematic comparison of repeated doses of oral delta(9)-THC with repeated doses of smoked marijuana in the same individuals...
  58. ncbi Effects of the NMDA antagonist memantine on human methamphetamine discrimination
    Carl L Hart
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:376-84. 2002
    ..To date, no published study has assessed their ability to alter methamphetamine-related discriminative stimulus effects in humans...
  59. ncbi Nefazodone decreases anxiety during marijuana withdrawal in humans
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 165:157-65. 2003
    ..Symptoms of marijuana withdrawal include increased irritability, depression and anxiety, and decreased sleep quality. Nefazodone, which is an antidepressant with sedative properties, may attenuate symptoms of marijuana withdrawal...
  60. ncbi Effects of buprenorphine on candy and sweetened fluid self-administration by rhesus monkeys
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:200-6. 2002
    ....
  61. ncbi Effects of oral THC maintenance on smoked marijuana self-administration
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 67:301-9. 2002
    ..These data indicate that participants' choice to self-administer marijuana was unaltered by the oral Delta(9)-THC dosing regimen used in the present investigation...
  62. ncbi Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 73:279-87. 2004
    ....
  63. ncbi Pharmacokinetics of intravenous cocaine across the menstrual cycle in rhesus monkeys
    Suzette M Evans
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
    Neuropsychopharmacology 29:1889-900. 2004
    ..Rather, the change in LH levels depended on menstrual cycle phase and cocaine dose. In summary, there is little evidence that the pharmacokinetics of cocaine vary as a function of menstrual cycle phase...
  64. ncbi Exercise "addiction" in anorexia nervosa: model development and pilot data
    Diane A Klein
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    CNS Spectr 9:531-7. 2004
    ..However, many questions remain as to the exact role exercise plays in this disorder. In particular, it has been suggested that exercise holds "addictive" properties in persons with AN, but that remains to be demonstrated...
  65. ncbi Pharmacokinetics of repeated doses of intravenous cocaine across the menstrual cycle in rhesus monkeys
    Suzette M Evans
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Pharmacol Biochem Behav 83:56-66. 2006
    ....
  66. ncbi Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers
    Margaret Haney
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and the Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:1814-21. 2006
    ..The distinct pattern of effects in methadone-maintained participants suggests baclofen may not be effective in opioid-dependent cocaine users...
  67. ncbi Modafinil attenuates disruptions in cognitive performance during simulated night-shift work
    Carl L Hart
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 31:1526-36. 2006
    ..Therapeutic doses of modafinil attenuated night-shift-associated disruptions, but the larger dose produced some sleep impairments when administered during day-shift work...
  68. ncbi Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD
    Stephanie L Collins
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Drug Alcohol Depend 82:158-67. 2006
    ..Thus, oral MPH-SR is safe in combination with repeated cocaine doses and decreases some of the positive and reinforcing effects of cocaine in cocaine abusers with ADHD...
  69. ncbi Exogenous progesterone attenuates the subjective effects of smoked cocaine in women, but not in men
    Suzette M Evans
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 31:659-74. 2006
    ..These results indicate that progesterone modulates the response to cocaine in women and suggests that fluctuations in endogenous progesterone levels account for some of the sex differences observed in humans...
  70. ncbi Smoked cocaine discrimination in humans: effects of gabapentin
    Margaret Haney
    Division on Substance Abuse, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Drug Alcohol Depend 80:53-61. 2005
    ..The results suggest gabapentin may not produce effects sufficiently robust to be clinically useful, at least at this dose regimen...
  71. ncbi An evaluation of the reinforcing effects of memantine in cocaine-dependent humans
    Suzanne K Vosburg
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Drug Alcohol Depend 79:257-60. 2005
    ..Memantine was not reinforcing and subjective-effects ratings were not altered as a function of dose. Results suggest that these doses of memantine do not have abuse liability in cocaine-dependent individuals...
  72. ncbi Combined effects of methamphetamine and zolpidem on performance and mood during simulated night shift work
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
    Pharmacol Biochem Behav 81:559-68. 2005
    ..Zolpidem, given alone or in combination with methamphetamine, did not alleviate most shift-change mood and performance effects...
  73. ncbi Reinforcing effects of oral Delta9-THC in male marijuana smokers in a laboratory choice procedure
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians, Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 181:237-43. 2005
    ..Oral Delta-9-tetrahydrocannabinol (Delta(9)-THC; Marinol) is medically available for the treatment of nausea associated with cancer chemotherapy and for wasting syndromes related to HIV/AIDS. Little is known about its reinforcing effects...
  74. ncbi Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood
    Margaret Haney
    New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 181:170-8. 2005
    ..No studies to date have directly compared the tolerability and efficacy of smoked marijuana and oral dronabinol in HIV(+) marijuana smokers...
  75. pmc Cardiovascular and subjective effects of repeated smoked cocaine administration in experienced cocaine users
    Stephanie Collins Reed
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 102:102-7. 2009
    ..These data indicate modest tolerance rather than sensitization to the positive subjective effects of cocaine with repeated exposure...
  76. ncbi Smoked cocaine self-administration is decreased by modafinil
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:761-8. 2008
    ..Thus, our data support the potential of modafinil as a pharmacotherapy for cocaine dependence...
  77. ncbi Methamphetamine attenuates disruptions in performance and mood during simulated night-shift work
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 169:42-51. 2003
    ..Increased sleepiness while working and sleep disruptions are common complaints among shift workers. Consequently, shift workers may be more susceptible to diminished performance and work-related accidents...
  78. ncbi Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests
    Gerald Zernig
    Experimental Psychiatry Unit, Department of Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    Pharmacology 80:65-119. 2007
    ..The review concludes by making suggestions on how to improve the current behavioral experimental approaches...
  79. pmc Use of an operant task to estimate food reinforcement in adult humans with and without BED
    Jennifer A Nasser
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 16:1816-20. 2008
    ..We hypothesized that food reinforcement after a caloric preload would be related to BED status, but not hunger...

Research Grants38

  1. ANORECTIC DRUGS: ABUSE & BEHAVIORAL MECHANISMS OF ACTION
    RICHARD FOLTIN; Fiscal Year: 2004
    ..A better understanding of the neuropharmacological systems that are involved in motivation will be an asset in the development of drugs that affect eating behavior and other appetitive behaviors, including drug abuse. ..
  2. IV COCAINE ABUSE TREATMENT: A LABORATORY MODEL
    RICHARD FOLTIN; Fiscal Year: 2007
    ..abstract_text> ..
  3. LABORATORY ANALYSIS OF COCAINE ABSTINENCE
    RICHARD FOLTIN; Fiscal Year: 2007
    ..abstract_text> ..
  4. Anorectic Drugs: Abuse and Behavioral Mechanisms of Action
    RICHARD FOLTIN; Fiscal Year: 2007
    ..These studies will provide insight into both food abuse and drug abuse, and possible mechanisms mediating these two major health problems. ..
  5. Translational Approach to Models in Relapse
    RICHARD FOLTIN; Fiscal Year: 2007
    ....
  6. Translational Approach to Models in Relapse
    RICHARD FOLTIN; Fiscal Year: 2009
    ....
  7. Anorectic Drugs: Abuse and Behavioral Mechanisms of Action
    RICHARD FOLTIN; Fiscal Year: 2009
    ..These studies will provide insight into both food abuse and drug abuse, and possible mechanisms mediating these two major health problems. ..
  8. Anorectic Drugs: Abuse and Behavioral Mechanisms of Action
    Richard W Foltin; Fiscal Year: 2010
    ..These studies will provide insight into both food abuse and drug abuse, and possible mechanisms mediating these two major health problems. ..
  9. ANORECTIC DRUGS--ABUSE & BEHAVIORAL MECHANISMS OF ACTION
    RICHARD FOLTIN; Fiscal Year: 1993
    ..g., effects on meal size and patterning. Such information will be useful both in evaluation of therapeutic efficacy and in understanding the basic processes involved in eating behavior...
  10. ANORECTIC DRUGS--ABUSE AND BEHAVIORAL MECHANISMS OF ACTI
    RICHARD FOLTIN; Fiscal Year: 1999
    ..The possibility that these three drug effects can be differentiated pharmacologically holds promise for understanding drug self-administration, food intake and the complex interaction between behavior maintained by these commodities. ..
  11. IV COCAINE ABUSE TREATMENT--A LABORATORY MODEL
    RICHARD FOLTIN; Fiscal Year: 2001
    ..The data collected will suggest more efficacious approaches to treating cocaine abusers. ..
  12. LABORATORY ANALYSIS OF COCAINE ABSTINENCE
    RICHARD FOLTIN; Fiscal Year: 2002
    ..The proposed studies will provide data relevant to the behavioral and neurochemical mechanisms impacting the likelihood of relapse to cocaine use. ..
  13. Translational Approach to Models in Relapse
    Richard W Foltin; Fiscal Year: 2010
    ....