Pamela Flood

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Intranasal nicotine for postoperative pain treatment
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York, USA
    Anesthesiology 101:1417-21. 2004
  2. ncbi Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, NY 10032, USA
    Anesthesiology 97:902-5. 2002
  3. ncbi Isoflurane hyperalgesia is modulated by nicotinic inhibition
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 97:192-8. 2002
  4. ncbi Sensitivity of the alpha7 nicotinic acetylcholine receptor to isoflurane may depend on receptor inactivation
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Anesth Analg 95:83-7, table of contents. 2002
  5. ncbi Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected
    P Flood
    Columbia University, Department of Anesthesiology, New York, New York 10032, USA
    Anesthesiology 86:859-65. 1997
  6. ncbi Postdural puncture headache in obstetrics
    Pamela Flood
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Semin Perinatol 26:146-53. 2002
  7. ncbi Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 96:987-93. 2002
  8. ncbi The importance of myorelaxants in anesthesia
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 169th St, New York, NY 10032, USA
    Curr Opin Pharmacol 5:322-7. 2005
  9. ncbi Intravenous anesthetics differentially modulate ligand-gated ion channels
    P Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 92:1418-25. 2000
  10. ncbi Pronociceptive actions of isoflurane: a protective role for estrogen
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Anesthesiology 99:476-9. 2003

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi Intranasal nicotine for postoperative pain treatment
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York, USA
    Anesthesiology 101:1417-21. 2004
    ....
  2. ncbi Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, NY 10032, USA
    Anesthesiology 97:902-5. 2002
    ..Despite clear evidence for nicotinic inhibition at relevant isoflurane concentrations, it is unclear what behavioral result ensues, if any...
  3. ncbi Isoflurane hyperalgesia is modulated by nicotinic inhibition
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 97:192-8. 2002
    ..Because nicotinic agonists act as analgesics, the authors hypothesized that inhibition of nicotinic transmission by isoflurane causes hyperalgesia...
  4. ncbi Sensitivity of the alpha7 nicotinic acetylcholine receptor to isoflurane may depend on receptor inactivation
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Anesth Analg 95:83-7, table of contents. 2002
    ..The increase in inhibition with isoflurane preexposure and large agonist concentration raises the possibility that isoflurane interacts preferentially with a closed or closed-desensitized state of the channel...
  5. ncbi Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected
    P Flood
    Columbia University, Department of Anesthesiology, New York, New York 10032, USA
    Anesthesiology 86:859-65. 1997
    ..The effects of general anesthetics on another family of ligand-gated ion channel in the CNS, the nAChRs, have not been defined...
  6. ncbi Postdural puncture headache in obstetrics
    Pamela Flood
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Semin Perinatol 26:146-53. 2002
    ....
  7. ncbi Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 96:987-93. 2002
    ....
  8. ncbi The importance of myorelaxants in anesthesia
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 169th St, New York, NY 10032, USA
    Curr Opin Pharmacol 5:322-7. 2005
    ..These novel approaches to pharmaceuticals, along with improved understanding of the physiology of the neuromuscular junction in health and disease, have made surgical treatment possible in a wide breadth of clinical situations...
  9. ncbi Intravenous anesthetics differentially modulate ligand-gated ion channels
    P Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 92:1418-25. 2000
    ..Information about the effects of intravenous anesthetics with different behavioral profiles on specific ligand-gated ion channels may lead to hypotheses as to which ion channel effect produces a specific anesthetic behavior...
  10. ncbi Pronociceptive actions of isoflurane: a protective role for estrogen
    Pamela Flood
    Department of Anesthesiology, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Anesthesiology 99:476-9. 2003
    ..Low concentrations of inhaled anesthetics present in the early postoperative period can increase pain sensitivity. Changes in pain threshold associated with inhaled anesthetics have been reported in male mice, rats, and humans...
  11. doi Anesthesia matters: patients anesthetized with propofol have less postoperative pain than those anesthetized with isoflurane
    Sean S Cheng
    Department of Anesthesiology, Columbia University, New York City, New York 10032, USA
    Anesth Analg 106:264-9, table of contents. 2008
    ....
  12. doi A transdermal nicotine patch is not effective for postoperative pain management in smokers: a pilot dose-ranging study
    Luke C Olson
    Department of Anesthesiology, Columbia University Medical Center, New York, New York, USA
    Anesth Analg 109:1987-91. 2009
    ..In this study, we examined the postoperative analgesic effect of a transdermal nicotine patch in smokers in a parallel design to a previous study in nonsmokers...
  13. ncbi The role of nicotinic inhibition in ketamine-induced behavior
    Julia O Udesky
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesth Analg 101:407-11, table of contents. 2005
    ..Such a phase is possibly obscured by analgesia induced as a result of N-methyl-d-aspartic acid antagonism by ketamine...
  14. ncbi The antinociceptive response to nicotinic agonists in a mouse model of postoperative pain
    Thomas J Rowley
    Department of Anesthesiology, Columbia University, 630 West 168th St, New York NY 10032, USA
    Anesth Analg 107:1052-7. 2008
    ..In an effort to determine what nicotinic subtypes might be targeted in future clinical studies, we tested agonists selective for alpha 4 beta 2 and alpha 7 containing nicotinic receptors in a mouse model of postoperative pain...
  15. ncbi Isoflurane prevents nicotine-evoked norepinephrine release from the mouse spinal cord at low clinical concentrations
    Thomas J Rowley
    Department of Anesthesiology, Columbia University, New York City, New York, USA
    Anesth Analg 107:885-9. 2008
    ..These studies are intended as a "proof of concept" that alteration of the nicotinic facilitation of norepinephrine release is a potential mechanism for isoflurane-induced pronociception...
  16. doi Mathematical modeling of the pain and progress of the first stage of nulliparous labor
    Jozef Debiec
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 111:1093-110. 2009
    ..Patient characteristics may contribute to the progress and pain of labor. Quantitative evaluation of the effects of patient characteristics requires robust mathematical models of labor progress and labor pain...
  17. ncbi Single amino acid residue in the extracellular portion of transmembrane segment 2 in the nicotinic alpha7 acetylcholine receptor modulates sensitivity to ketamine
    Kenny K Ho
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 100:657-62. 2004
    ..Ketamine inhibits the activation of both heteromeric and homomeric nicotinic acetylcholine receptors. The site of molecular interaction is unknown...
  18. doi Nicotine nasal spray as an adjuvant analgesic for third molar surgery
    Benjamin Yagoubian
    Department of Oral and Maxillofacial Surgery, College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Oral Maxillofac Surg 69:1316-9. 2011
    ..To determine the efficacy of preoperatively administered nicotine nasal spray (3 mg) for analgesia after third molar (TM) surgery...
  19. ncbi Transdermal nicotine patch for postoperative pain management: a pilot dose-ranging study
    Daewha Hong
    Department of Anesthesiology, Columbia University Medical Center, New York, NY 10032, USA
    Anesth Analg 107:1005-10. 2008
    ..In this pilot study, we examined the analgesic effect of a transdermal nicotine patch applied before surgery in nonsmokers...
  20. doi The side effects of morphine and hydromorphone patient-controlled analgesia
    Daewha Hong
    Department of Anesthesiology, Columbia University Medical Center, 630 West 168th St New York City, NY 10032, USA
    Anesth Analg 107:1384-9. 2008
    ..In this study, we compared the efficacy and side-effect profiles of morphine and hydromorphone at concentrations producing equivalent drug effect measured by pain score and miosis...
  21. ncbi The role of adrenergic and cholinergic transmission in volatile anesthetic-induced pain enhancement
    Thomas J Rowley
    Department of Anesthesiology, Columbia University, 630 West 168th Street, NY, NY 10032, USA
    Anesth Analg 100:991-5. 2005
    ..Isoflurane may act by inhibiting tonically active nicotinic receptors that modulate the release of norepinephrine in the spinal cord...
  22. ncbi The pronociceptive effect of ondansetron in the setting of P-glycoprotein inhibition
    Jason A Scott
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesth Analg 103:742-6. 2006
    ..Even with direct spinal application, ondansetron does not alter isoflurane MAC, supporting the idea that 5HT3 modulation does not play a role in general anesthetic immobility...
  23. doi Unintentional dural puncture with a Tuohy needle increases risk of chronic headache
    Christopher Allen John Webb
    College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Anesth Analg 115:124-32. 2012
    ..We investigated the incidence of and risk factors for chronic headache and chronic back pain in parturients who experienced unintentional dural puncture with a 17-gauge Tuohy needle compared with matched controls...
  24. ncbi Volatile anesthetics reduce agonist affinity at nicotinic acetylcholine receptors in the brain
    Erin M Rada
    Columbia College, Hunter College High School, New York, New York, USA
    Anesth Analg 96:108-11, table of contents. 2003
    ..05). Although there is a slight decrease in agonist affinity at anesthetic concentrations, the marked reductions in nAChR function at subanesthetic concentrations cannot be attributed to changes in agonist affinity...
  25. pmc β2-adrenergic receptor genotype and other variables that contribute to labor pain and progress
    Elena Reitman
    Division of Obstetrical Anesthesiology, Columbia University, New York, New York, USA
    Anesthesiology 114:927-39. 2011
    ..2-Adrenergic receptor (β2AR) activity influences labor. Its genotype affects the incidence of preterm delivery. We determined the effect of β2AR genotype on term labor progress and maternal pain...
  26. ncbi Prophylactic ephedrine and combined spinal epidural: maternal blood pressure and fetal heart rate patterns
    Jane Cleary-Goldman
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York 10032, USA
    Obstet Gynecol 106:466-72. 2005
    ..The purpose of this study was to estimate whether prophylactic intramuscular ephedrine before combined spinal epidural prevents these complications...
  27. doi The development and validation of a dynamic model to account for the progress of labor in the assessment of pain
    Jessamyn Conell-Price
    Department of Anesthesiology, Columbia University, New York City, New York, USA
    Anesth Analg 106:1509-15, table of contents. 2008
    ..Previous studies have used average pain scores. The aim of this study was to develop and validate a model that would allow for the statistical analysis of factors that affect pain throughout labor...
  28. pmc Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept
    Carolyn I Rodriguez
    1 New York State Psychiatric Institute, New York, NY, USA 2 Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 38:2475-83. 2013
    ..This is the first randomized, controlled trial to demonstrate that a drug affecting glutamate neurotransmission can reduce OCD symptoms without the presence of an SRI and is consistent with a glutamatergic hypothesis of OCD...
  29. doi Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms
    Steven L Shafer
    Department of Anesthesiology, Columbia University Medical Center, 622 W 168th St, PH 5 505, New York, NY 10032 3725, USA
    Anesth Analg 107:507-24. 2008
    ..Synergy implies multiple sites of action by definition. In this essay, we explore the converse: does additivity imply a single site of action?..
  30. pmc Epidemiology of anesthesia-related complications in labor and delivery, New York State, 2002-2005
    Khadeen Cheesman
    Department of Anesthesiology, Columbia University, 622 West 168th St, PH5 505, New York, NY 10032, USA
    Anesth Analg 109:1174-81. 2009
    ..We aimed to fill this research gap by exploring the epidemiologic patterns and risk factors of anesthesia-related complications in a large sample of women giving birth in New York hospitals...
  31. doi Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats
    Edmond I Eger
    Department of Anesthesia, S 455, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 107:479-85. 2008
    ....
  32. ncbi Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143, USA
    Anesth Analg 95:1611-5, table of contents. 2002
    ..00091 atm and 0.062 atm for flurothyl and 2N, respectively) that approximate those that produce convulsions (0.0015 atm and 0.04 atm)...
  33. ncbi Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 94:1500-4, table of contents. 2002
    ..We conclude that acetylcholine receptors do not seem to play a role as mediators of immobilization by inhaled anesthetics...
  34. ncbi Advances in neurobiology of the neuromuscular junction: implications for the anesthesiologist
    Mohamed Naguib
    Department of Anesthesia, University of Iowa College of Medicine, Iowa City, 52242 1009, USA
    Anesthesiology 96:202-31. 2002
  35. ncbi Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Anesth Analg 97:718-40. 2003
    ..g., gamma-aminobutyric acid A, acetylcholine, potassium, 5-hydroxytryptamine-3, opioids, and alpha(2)-adrenergic), whereas other receptors/channels (e.g., glycine, N-methyl-D-aspartate, and sodium) remain credible candidates...
  36. doi Galloping in full pursuit of the mechanism of anesthetic immobility
    Hugh C Hemmings
    Anesthesiology 108:975-6. 2008
  37. ncbi A new treatment for hypoxic brain injury?
    Pamela Flood
    Anesth Analg 105:559-60. 2007

Research Grants1

  1. ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORS
    Pamela Flood; Fiscal Year: 2003
    ..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..