Nuria Flames

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Gene regulatory logic of dopamine neuron differentiation
    Nuria Flames
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 458:885-9. 2009
  2. pmc The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types
    Feifan Zhang
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Development 141:422-35. 2014
  3. pmc A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans
    Maria Doitsidou
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Genes Dev 27:1391-405. 2013
  4. pmc The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation
    Peter Weinberg
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
    Genetics 194:189-98. 2013
  5. pmc Automated screening for mutants affecting dopaminergic-neuron specification in C. elegans
    Maria Doitsidou
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Methods 5:869-72. 2008
  6. doi Transcriptional control of the terminal fate of monoaminergic neurons
    Nuria Flames
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
    Annu Rev Neurosci 34:153-84. 2011
  7. ncbi Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies
    Daniel A Lim
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain Res Bull 57:759-64. 2002

Collaborators

Detail Information

Publications7

  1. pmc Gene regulatory logic of dopamine neuron differentiation
    Nuria Flames
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 458:885-9. 2009
    ..Our studies reveal a simple and apparently conserved regulatory logic of dopamine neuron terminal differentiation and may provide new entry points into the diagnosis or therapy of conditions in which dopamine neurons are defective...
  2. pmc The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types
    Feifan Zhang
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Development 141:422-35. 2014
    ..In conclusion, transcription factors operate as terminal selectors in distinct combinations in different neuron types, defining neuron type-specific identity features. ..
  3. pmc A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans
    Maria Doitsidou
    Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Genes Dev 27:1391-405. 2013
    ..Dopaminergic neurons in the mouse olfactory bulb express a similar combinatorial transcription factor collective of Ets/Dlx/Pbx factors, suggesting deep phylogenetic conservation of dopaminergic regulatory programs. ..
  4. pmc The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation
    Peter Weinberg
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
    Genetics 194:189-98. 2013
    ....
  5. pmc Automated screening for mutants affecting dopaminergic-neuron specification in C. elegans
    Maria Doitsidou
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Methods 5:869-72. 2008
    ..This methodology is considerably more efficient than comparable manual screens and enabled us to isolate mutants in which dopamine neurons do not differentiate appropriately...
  6. doi Transcriptional control of the terminal fate of monoaminergic neurons
    Nuria Flames
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York 10032, USA
    Annu Rev Neurosci 34:153-84. 2011
    ....
  7. ncbi Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies
    Daniel A Lim
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain Res Bull 57:759-64. 2002
    ..In this review, we outline some of these hurdles and discuss recent experiments that investigate the potential of using neural precursor cells found in the subventricular zone of the adult brain for brain repair...