Linda S Einbond
Affiliation: Columbia University
Einbond L, Shimizu M, Ma H, Wu H, Goldsberry S, Sicular S, et al
. Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells. Biochem Biophys Res Commun. 2008;375:608-13 pubmed publisher
..Actein and digitoxin may be a useful synergistic combination for cancer chemoprevention and/or therapy. ..
Einbond L, Shimizu M, Xiao D, Nuntanakorn P, Lim J, Suzui M, et al
. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res Treat. 2004;83:221-31 pubmed
..Further studies are in progress to identify the mechanisms by which actein and related compounds present in black cohosh inhibit growth of human breast cancer cells...
Einbond L, Shimizu M, Nuntanakorn P, Seter C, Cheng R, Jiang B, et al
. Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cells. Planta Med. 2006;72:1200-6 pubmed
Einbond L, Su T, Wu H, Friedman R, Wang X, Jiang B, et al
. Gene expression analysis of the mechanisms whereby black cohosh inhibits human breast cancer cell growth. Anticancer Res. 2007;27:697-712 pubmed
..Since the MeOH extract activated genes that enhance apoptosis and repressed cell cycle genes, it may be useful in the prevention and therapy of breast cancer. ..
Einbond L, Wen Cai Y, He K, Wu H, Cruz E, Roller M, et al
. Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells. Phytomedicine. 2008;15:504-11 pubmed
Einbond L, Soffritti M, Esposti D, Park T, Cruz E, Su T, et al
. Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Fundam Clin Pharmacol. 2009;23:311-21 pubmed publisher
..The serum level of actein peaked at 2.4 microg/mL at 6 h. Actein's ability to alter pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders. ..