Edward Dwyer

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Ischemia-reperfusion-induced lung injury
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 167:490-511. 2003
  2. ncbi request reprint Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study
    Fiona H Blackhall
    Division of Cellular and Molecular Biology, University Health Network, Ontario Cancer Institute, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Lung Cancer 46:197-204. 2004
  3. ncbi request reprint Instability of cytokines at body temperature
    Michiharu Suga
    J Heart Lung Transplant 24:504-5. 2005
  4. ncbi request reprint Retransplantation of the lung comes of age
    Shaf Keshavjee
    J Thorac Cardiovasc Surg 132:226-8. 2006
  5. ncbi request reprint Surrogate end points for pulmonary arterial hypertension
    Steven M Kawut
    Lung Transplant Program, Division of Pulmonary, Allergy, and Critical Care Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am Heart J 148:559-65. 2004
  6. ncbi request reprint New predictors of outcome in idiopathic pulmonary arterial hypertension
    Steven M Kawut
    Department of Internal Medicine, Joseph L Mailman School of Public Health, Columbia University, 622 West 168th Street, New York, NY 10032, USA
    Am J Cardiol 95:199-203. 2005
  7. ncbi request reprint Outcomes of extended donor lung recipients after lung transplantation
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Transplantation 79:310-6. 2005
  8. ncbi request reprint Hemodynamics and survival of patients with portopulmonary hypertension
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Liver Transpl 11:1107-11. 2005
  9. ncbi request reprint Exercise testing determines survival in patients with diffuse parenchymal lung disease evaluated for lung transplantation
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Respir Med 99:1431-9. 2005
  10. ncbi request reprint Risk factors and outcomes of hypogammaglobulinemia after lung transplantation
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA
    Transplantation 79:1723-6. 2005

Detail Information

Publications69

  1. ncbi request reprint Ischemia-reperfusion-induced lung injury
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 167:490-511. 2003
    ....
  2. ncbi request reprint Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray study
    Fiona H Blackhall
    Division of Cellular and Molecular Biology, University Health Network, Ontario Cancer Institute, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Lung Cancer 46:197-204. 2004
    ....
  3. ncbi request reprint Instability of cytokines at body temperature
    Michiharu Suga
    J Heart Lung Transplant 24:504-5. 2005
  4. ncbi request reprint Retransplantation of the lung comes of age
    Shaf Keshavjee
    J Thorac Cardiovasc Surg 132:226-8. 2006
  5. ncbi request reprint Surrogate end points for pulmonary arterial hypertension
    Steven M Kawut
    Lung Transplant Program, Division of Pulmonary, Allergy, and Critical Care Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am Heart J 148:559-65. 2004
    ..Further studies should focus on validating the most promising of these surrogate end points, so that future investigators, subjects, and patients may benefit from the advantages they confer on clinical trials and patient care...
  6. ncbi request reprint New predictors of outcome in idiopathic pulmonary arterial hypertension
    Steven M Kawut
    Department of Internal Medicine, Joseph L Mailman School of Public Health, Columbia University, 622 West 168th Street, New York, NY 10032, USA
    Am J Cardiol 95:199-203. 2005
    ..Race is identified as a new risk factor, which may be attributable to biologic or socioeconomic differences. Cardiac function and acute reactivity of the pulmonary vascular bed remain strong independent predictors of outcome...
  7. ncbi request reprint Outcomes of extended donor lung recipients after lung transplantation
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Transplantation 79:310-6. 2005
    ..Many lung-transplant programs use lungs that do not meet the formal criteria for acceptability; however, the immediate and long-term consequences of this approach remain unclear...
  8. ncbi request reprint Hemodynamics and survival of patients with portopulmonary hypertension
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Liver Transpl 11:1107-11. 2005
    ..Future studies of the specific mechanisms of and therapy for pulmonary arterial hypertension should focus on the distinctions between the different forms of this disease...
  9. ncbi request reprint Exercise testing determines survival in patients with diffuse parenchymal lung disease evaluated for lung transplantation
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Respir Med 99:1431-9. 2005
    ..We hypothesized that cardiopulmonary exercise test results and the distance walked in 6min (6MWTD) would be associated with survival in patients with diffuse parenchymal lung disease referred for lung transplantation...
  10. ncbi request reprint Risk factors and outcomes of hypogammaglobulinemia after lung transplantation
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA
    Transplantation 79:1723-6. 2005
    ..METHODS.: The authors performed a retrospective cohort study of 57 lung transplant recipients at their center. Quantitative total and subclass immunoglobulin (Ig) G levels were obtained from patients...
  11. ncbi request reprint von Willebrand factor independently predicts long-term survival in patients with pulmonary arterial hypertension
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Joseph L Mailma School of Public Health, Columbia University, New York, NY, USA
    Chest 128:2355-62. 2005
    ....
  12. ncbi request reprint Pulmonary capillary hemangiomatosis: results of gene expression analysis
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, New York, NY, USA
    Chest 128:575S-5766S. 2005
  13. ncbi request reprint Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension
    Steven M Kawut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York City, NY, USA
    Pulm Pharmacol Ther 19:370-4. 2006
    ..We therefore hypothesized that PAH patients treated with high-affinity selective serotonin reuptake inhibitors (SSRIs) would have a reduced risk of death compared to PAH patients not treated with SSRIs...
  14. ncbi request reprint Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis
    Steven M Kawut
    Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, USA
    Chest 123:344-50. 2003
    ..The goal of this study was to determine whether the survival of patients with pulmonary hypertension related to systemic sclerosis (SScPH) was different from that of patients with other forms of pulmonary arterial hypertension...
  15. pmc Clinical risk factors for portopulmonary hypertension
    Steven M Kawut
    Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 8E, Room 101, New York, NY 10032, USA
    Hepatology 48:196-203. 2008
    ..24, 95% confidence interval 0.09-0.65, P = 0.005) of portopulmonary hypertension. The severity of liver disease was not related to the risk of portopulmonary hypertension...
  16. ncbi request reprint Outcomes after lung retransplantation in the modern era
    Steven M Kawut
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Respir Crit Care Med 177:114-20. 2008
    ..Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown...
  17. pmc Immunoglobulin G levels before and after lung transplantation
    Natalie H Yip
    Department of Medicine ad Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Respir Crit Care Med 173:917-21. 2006
    ..The determinants of immunoglobulin G (IgG) level and the risk of hypogammaglobulinemia (HGG) in patients with severe lung disease before and after lung transplantation are unknown...
  18. doi request reprint Refractory urticarial vasculitis as a complication of ulcerative colitis successfully treated with rituximab
    Arun Swaminath
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Clin Rheumatol 17:281-3. 2011
    ..Treatment with anti-B-cell therapy may be a new treatment option for patients with gammopathy-associated leukocytoclastic vasculitis...
  19. ncbi request reprint Rheumatoid leptomeningitis after heart transplantation
    Jan Claassen
    Division of Stroke and Critical Care Neurology, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Neurology 66:948-9. 2006
  20. ncbi request reprint The changing pattern of humoral rejection in cardiac transplant recipients
    Khalid Almuti
    Division of Cardiology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA
    Transplantation 84:498-503. 2007
    ..Late cases of HR (>6 months after transplant) have been reported. We examined the differences in clinical characteristics and outcomes in patients presenting with HR in the early (<6 months) and late transplant periods...
  21. ncbi request reprint Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid joints
    Joseph M Lasker
    Columbia University, Department of Biomedical Engineering, 500 West 120th Street, ET351 Mudd Building, MC8904, New York, New York 10027, USA
    J Biomed Opt 12:052001. 2007
    ..Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints...
  22. doi request reprint The New York City Rheumatology Objective Structured Clinical Examination: five-year data demonstrates its validity, usefulness as a unique rating tool, objectivity, and sensitivity to change
    Jessica R Berman
    New York Hospital The Hospital for Special Surgery, New York, NY, USA
    Arthritis Rheum 61:1686-93. 2009
    ....
  23. doi request reprint Primary graft dysfunction: definition, risk factors, short- and long-term outcomes
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Respir Crit Care Med 31:161-71. 2010
    ..Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes...
  24. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methods
    Jason D Christie
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1451-3. 2005
  25. ncbi request reprint Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria
    Denis Hadjiliadis
    Department of Medicine, Division of Pulmonary Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 10104, USA
    J Heart Lung Transplant 26:834-8. 2007
    ..The impact of panresistant bacteria, other than Burkholderia cepacia, on the survival after lung transplantation in patients with cystic fibrosis (CF) remains controversial...
  26. doi request reprint Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling
    Masaaki Sato
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Semin Thorac Cardiovasc Surg 20:173-82. 2008
    ..From this viewpoint, we review current therapeutic strategies and revisit the role of transplant surgeons in attenuating the initial transplant-related injuries to prevent the lung grafts from entering the remodeling-injury cycle...
  27. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatment
    Yaron Shargall
    Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:1489-500. 2005
  28. ncbi request reprint De novo pulmonary capillary hemangiomatosis occurring rapidly after bilateral lung transplantation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 22:698-700. 2003
    ..This case supports the theory that persistent infection or inflammation may be an inciting factor in uncontrolled angiogenesis, leading ultimately to diffuse pulmonary capillary hemangiomatosis...
  29. ncbi request reprint Donor-recipient gender mismatch in lung transplantation: Impact on obliterative bronchiolitis and survival
    Masaaki Sato
    J Heart Lung Transplant 24:2000-1. 2005
  30. ncbi request reprint Non-utilization of hearts and lungs after consent for donation: a Canadian multicentre study
    Karen Hornby
    Division of Critical Care, Montreal Children s Hospital, McGill University Health Centre, Quebec, Canada
    Can J Anaesth 53:831-7. 2006
    ..A greater potential may exist in Canada to improve utilization rates for hearts and lungs given their comparatively suboptimal rates (kidneys 85%, livers 84%, hearts 35% and lungs 23% reported in 2001)...
  31. ncbi request reprint The effect of gender combinations on outcome in human lung transplantation: the International Society of Heart and Lung Transplantation Registry experience
    Masaaki Sato
    Division of Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 25:634-7. 2006
    ..In the current practice of lung transplantation, donor and recipient genders are neither directly considered nor matched...
  32. ncbi request reprint International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation
    Jonathan B Orens
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:745-55. 2006
  33. ncbi request reprint Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation
    Marc de Perrot
    Division of Thoracic Surgery, Thoracic Surgery Research Laboratory and The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 165:211-5. 2002
    ..In addition, we showed that donor age and ischemic time may influence release of specific cytokines during ischemia-reperfusion...
  34. ncbi request reprint Impact of donors aged 60 years or more on outcome after lung transplantation: results of an 11-year single-center experience
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Canada
    J Thorac Cardiovasc Surg 133:525-31. 2007
    ..We examined the outcome of lung transplantation with the use of donors aged 60 years or more...
  35. ncbi request reprint Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry
    Stefan Fischer
    The Toronto Lung Transplant Program, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 26:472-7. 2007
    ..A few single-center experiences have been reported with relatively few cases of ECMO after LTx...
  36. doi request reprint Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesothelioma
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 85:1206-10. 2008
    ....
  37. doi request reprint Potential refinements of the International Society for Heart and Lung Transplantation primary graft dysfunction grading system
    Jason Christie
    J Heart Lung Transplant 27:138. 2008
  38. doi request reprint Induction chemoradiation therapy followed by surgical resection for non-small cell lung cancer (NSCLC) invading the thoracic inlet
    Stefan Fischer
    Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, University Health Network, 200 Elizabeth Street, 9th Floor, Toronto, Ontario, Canada M5G 2C4
    Eur J Cardiothorac Surg 33:1129-34. 2008
    ..The role of induction therapy for non-small cell lung cancer (NSCLC) invading the thoracic inlet is unclear. We reviewed our experience with induction chemoradiation followed by surgical resection for NSCLC invading the thoracic inlet...
  39. ncbi request reprint Mycobacterium abscessus infections in lung transplant recipients: the international experience
    Susan M Chernenko
    Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 25:1447-55. 2006
    ..The clinical significance of Mycobacterium abscessus infection in the lung transplant population is not well understood...
  40. ncbi request reprint Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant
    Frank D'Ovidio
    Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1254-60. 2005
    ..It is not clear whether gastroesophageal reflux is a preexisting condition or secondary to intraoperative vagal injury or drug-induced prolonged gastric emptying...
  41. ncbi request reprint Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation
    Frank D'Ovidio
    Toronto Lung Transplant Program, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 129:1144-52. 2005
    ..Aspiration of gastroesophageal refluxate may contribute to lung transplant bronchiolitis obliterans syndrome (BOS). We investigated bile acids in bronchoalveolar lavage fluid (BALF) and studied its role in BOS...
  42. ncbi request reprint Twenty-year experience of lung transplantation at a single center: Influence of recipient diagnosis on long-term survival
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 127:1493-501. 2004
    ..The objective of this study was to examine the long-term patient outcomes of lung transplantation in a single center...
  43. ncbi request reprint A novel model for post-transplant obliterative airway disease reveals angiogenesis from the pulmonary circulation
    Andre E Dutly
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, Toronto, ON, Canada
    Am J Transplant 5:248-54. 2005
    ..This model has revealed new insights into angiogenic potential of the pulmonary circulation...
  44. ncbi request reprint Risk quantification of early outcome after lung transplantation: donor, recipient, operative, and post-transplant parameters
    Yasuo Sekine
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:96-104. 2004
    ..The purpose of our study was to identify risk factors for 30-day mortality and prolonged intensive care unit stay and to develop a scoring system to evaluate the severity of impairment and to predict surgical outcomes...
  45. ncbi request reprint Independent ventilation of the graft and native lungs in vivo after rat lung transplantation
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 79:2169-71. 2005
    ....
  46. ncbi request reprint Risk of a right pneumonectomy: role of bronchopleural fistula
    Gail E Darling
    Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Ann Thorac Surg 79:433-7. 2005
    ..The purpose of this study is to compare the morbidity and mortality of right versus left pneumonectomy...
  47. ncbi request reprint Role of lung transplantation in the treatment of bronchogenic carcinomas for patients with end-stage pulmonary disease
    Marc de Perrot
    Toronto Lung Transplant Program, University of Toronto, Canada
    J Clin Oncol 22:4351-6. 2004
    ..To determine the role of lung transplantation in the treatment of patients presenting with bronchogenic carcinoma and end-stage lung disease...
  48. ncbi request reprint Lung transplantation. Lung preservation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, EN 10 224, Toronto, Ontario M5G 2C4, Canada
    Chest Surg Clin N Am 13:443-62. 2003
    ..Hopefully, this information will provide new insights into the mechanisms of injury and reveal potential new strategies and targets for therapies to improve lung preservation...
  49. ncbi request reprint Strategies to optimize the use of currently available lung donors
    Marc de Perrot
    University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:1127-34. 2004
  50. ncbi request reprint A review of lung transplant donor acceptability criteria
    Jonathan B Orens
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 22:1183-200. 2003
  51. ncbi request reprint Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant
    Deepali Kumar
    Infectious Diseases and Multi Organ Transplant, University of Toronto, Toronto, Ontario, Canada
    Am J Transplant 5:2031-6. 2005
    ..Community-acquired respiratory viruses may be associated with the development of acute rejection and BOS...
  52. ncbi request reprint Lung transplantation: donor and recipient critical care aspects
    Andrew F Pierre
    Division of Thoracic Surgery, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 11:339-44. 2005
    ..The purpose of this paper is to highlight new developments in donor and recipient lung transplant issues for the critical care physician...
  53. ncbi request reprint Bilateral lung transplantation using a donor with a tracheal right upper lobe bronchus
    Yasuo Sekine
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Thorac Surg 73:308-10. 2002
    ..The anastomosis was completed using a telescoping technique without any complication. This case demonstrates the possibility of successfully using donor lungs with such anatomic abnormality for transplantation...
  54. ncbi request reprint Caspase inhibition improves ischemia-reperfusion injury after lung transplantation
    Syed M Quadri
    Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network Toronto General Hospital, Toronto, Ontario, Canada
    Am J Transplant 5:292-9. 2005
    ..Clearly, this needs to be investigated further with more experiments to validate the potential role of caspase inhibition as a therapeutic modality in ischemia-reperfusion-induced lung injury...
  55. ncbi request reprint Everting mattress running suture: an improved technique of atrial anastomosis in human lung transplantation
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Ann Thorac Surg 73:1663-4. 2002
    ..This technique should help reduce the risk of venous anastomotic complications...
  56. ncbi request reprint A simplified model for en bloc double lung xenotransplantation from hamster to rat
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 21:286-9. 2002
    ..This technique provides a technically easier and more reliable model to study xenotransplantation of the lung...
  57. ncbi request reprint Accommodation after lung xenografting from hamster to rat
    Toshiharu Tabata
    Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Transplantation 75:607-12. 2003
    ..We examined whether accommodation could be induced in hamster-to-rat lung xenografts and whether the pattern of protective genes is similar to cardiac xenografts...
  58. ncbi request reprint 15 years single center experience with surgical resection of the superior vena cava for non-small cell lung cancer
    Yaron Shargall
    Division of Thoracic Surgery, University Health Network Princess Margaret Hospital and Toronto General Hospital and the University of Toronto, 10EN 233, Toronto, ON M5G 2C4, Canada
    Lung Cancer 45:357-63. 2004
    ..To examine our results with surgery for locally advanced non-small cell lung cancer (NSCLC) invading the superior vena cava (SVC)...
  59. ncbi request reprint Improved results of induction chemoradiation before surgical intervention for selected patients with stage IIIA-N2 non-small cell lung cancer
    Karl L Uy
    Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 134:188-93. 2007
    ..The surgical arm of the North American Intergroup 0139 trial was adopted as the standard treatment for patients with resectable N2 disease at the University Health Network. Results after 7 years of experience are reported...
  60. ncbi request reprint Bilateral lung transplantation for metastatic leiomyosarcoma
    Yaron Shargall
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:912-5. 2004
    ..While lung transplantation for malignancy remains a controversial area, this case illustrates that lung transplantation can provide improved quality and quantity of life for highly selected patients with malignant disease...
  61. ncbi request reprint Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
    Yumiko Imai
    Department of Critical Care, St Michael s Hospital, University of Toronto, Toronto, Ontario
    JAMA 289:2104-12. 2003
    ..Recent clinical trials have demonstrated a decrease in multiple organ dysfunction syndrome (MODS) and mortality in patients with acute respiratory distress syndrome (ARDS) treated with a protective ventilatory strategy...
  62. ncbi request reprint Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study
    Denis Hadjiliadis
    Department of Medicine, Division of Respirology, Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:S249-54. 2005
    ..The effect of these antibodies is less clear in lung transplant recipients, although previous studies have suggested an increased incidence of allograft dysfunction...
  63. pmc Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential
    Sam D Shemie
    Division of Pediatric Critical Care, Montreal Children s Hospital, McGill University Health Centre, Montreal, Que
    CMAJ 174:S13-32. 2006
  64. ncbi request reprint GI complications after lung transplantation in patients with cystic fibrosis
    Marita Gilljam
    Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Chest 123:37-41. 2003
    ..We examined the GI complications in a cohort of patients who underwent transplantation...
  65. ncbi request reprint Gene therapy in lung transplantation
    Masaaki Sato
    Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada
    Curr Gene Ther 6:439-58. 2006
    ..Based on our work and the work of others, over the last decade, we present the state of art of in gene therapy in lung transplantation and exciting future directions in the field...
  66. ncbi request reprint High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats
    Daisuke Okutani
    Thoracic Surgery Research Laboratory, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Am J Physiol Lung Cell Mol Physiol 292:L144-53. 2007
    ..A local expression of PTX3 induced by high-volume ventilation, either alone or in combination with other pathological conditions, suggests that it may be an important mediator in ventilator-induced lung injury...
  67. ncbi request reprint Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 124:1137-44. 2002
    ..This study was undertaken to examine the effect of 2 ventilatory strategies on the development of ischemia-reperfusion injury after lung transplantation...
  68. ncbi request reprint Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation
    Smita Sakha Pakhale
    Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:1260-8. 2005
    ..We describe a case series with upper lobe fibrosis, a novel presentation of chronic allograft dysfunction...
  69. ncbi request reprint Toll-like receptor and cytokine gene expression in the early phase of human lung transplantation
    Cristiano Feijó Andrade
    Thoracic Surgery Research Laboratory, Toronto General Hospital, University Health Network, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 25:1317-23. 2006
    ..We hypothesized that gene expression of TLRs during lung transplantation may be affected by the donor condition and the ischemia-reperfusion process, which may subsequently influence graft function...

Research Grants6

  1. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
  2. Neurohormonal Activation in Pulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..We will formulate prediction rules using neurohormone levels and clinical variables to improve prognostication and management in this disease. ..
  3. Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis
    Steven Kawut; Fiscal Year: 2007
    ..This study will focus on subclinical markers of pulmonary vascular disease and RV failure, which are increasingly important diseases impacting on older and minority Americans. ..
  4. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2007
    ..PAH strikes young individuals, drastically shortening their lifespan. We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..