Research Topics
| Edward DwyerSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Ischemia-reperfusion-induced lung injuryMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Respir Crit Care Med 167:490-511. 2003....- Validating the prognostic value of marker genes derived from a non-small cell lung cancer microarray studyFiona H Blackhall
Division of Cellular and Molecular Biology, University Health Network, Ontario Cancer Institute, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
Lung Cancer 46:197-204. 2004.... - Instability of cytokines at body temperatureMichiharu Suga
J Heart Lung Transplant 24:504-5. 2005 - Retransplantation of the lung comes of ageShaf Keshavjee
J Thorac Cardiovasc Surg 132:226-8. 2006 - Surrogate end points for pulmonary arterial hypertensionSteven M Kawut
Lung Transplant Program, Division of Pulmonary, Allergy, and Critical Care Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Am Heart J 148:559-65. 2004..Further studies should focus on validating the most promising of these surrogate end points, so that future investigators, subjects, and patients may benefit from the advantages they confer on clinical trials and patient care... - New predictors of outcome in idiopathic pulmonary arterial hypertensionSteven M Kawut
Department of Internal Medicine, Joseph L Mailman School of Public Health, Columbia University, 622 West 168th Street, New York, NY 10032, USA
Am J Cardiol 95:199-203. 2005..Race is identified as a new risk factor, which may be attributable to biologic or socioeconomic differences. Cardiac function and acute reactivity of the pulmonary vascular bed remain strong independent predictors of outcome... - Outcomes of extended donor lung recipients after lung transplantationSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Transplantation 79:310-6. 2005..Many lung-transplant programs use lungs that do not meet the formal criteria for acceptability; however, the immediate and long-term consequences of this approach remain unclear... - Hemodynamics and survival of patients with portopulmonary hypertensionSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Liver Transpl 11:1107-11. 2005..Future studies of the specific mechanisms of and therapy for pulmonary arterial hypertension should focus on the distinctions between the different forms of this disease... - Exercise testing determines survival in patients with diffuse parenchymal lung disease evaluated for lung transplantationSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Respir Med 99:1431-9. 2005..We hypothesized that cardiopulmonary exercise test results and the distance walked in 6min (6MWTD) would be associated with survival in patients with diffuse parenchymal lung disease referred for lung transplantation... - Risk factors and outcomes of hypogammaglobulinemia after lung transplantationSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA
Transplantation 79:1723-6. 2005..METHODS.: The authors performed a retrospective cohort study of 57 lung transplant recipients at their center. Quantitative total and subclass immunoglobulin (Ig) G levels were obtained from patients... - von Willebrand factor independently predicts long-term survival in patients with pulmonary arterial hypertensionSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Joseph L Mailma School of Public Health, Columbia University, New York, NY, USA
Chest 128:2355-62. 2005.... - Pulmonary capillary hemangiomatosis: results of gene expression analysisSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, New York, NY, USA
Chest 128:575S-5766S. 2005 - Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertensionSteven M Kawut
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York City, NY, USA
Pulm Pharmacol Ther 19:370-4. 2006..We therefore hypothesized that PAH patients treated with high-affinity selective serotonin reuptake inhibitors (SSRIs) would have a reduced risk of death compared to PAH patients not treated with SSRIs... - Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosisSteven M Kawut
Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, USA
Chest 123:344-50. 2003..The goal of this study was to determine whether the survival of patients with pulmonary hypertension related to systemic sclerosis (SScPH) was different from that of patients with other forms of pulmonary arterial hypertension... 
Clinical risk factors for portopulmonary hypertensionSteven M Kawut
Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 8E, Room 101, New York, NY 10032, USA
Hepatology 48:196-203. 2008..Hormonal and immunologic factors may therefore be integral to the development of portopulmonary hypertension...- Outcomes after lung retransplantation in the modern eraSteven M Kawut
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Respir Crit Care Med 177:114-20. 2008..Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown... - Immunoglobulin G levels before and after lung transplantationNatalie H Yip
Department of Medicine ad Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Am J Respir Crit Care Med 173:917-21. 2006..Baseline IgG levels and treatment with mycophenolate mofetil affect post-transplant IgG levels... 
Refractory urticarial vasculitis as a complication of ulcerative colitis successfully treated with rituximabArun Swaminath
Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
J Clin Rheumatol 17:281-3. 2011..Treatment with anti-B-cell therapy may be a new treatment option for patients with gammopathy-associated leukocytoclastic vasculitis...- Rheumatoid leptomeningitis after heart transplantationJan Claassen
Division of Stroke and Critical Care Neurology, Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Neurology 66:948-9. 2006 - The changing pattern of humoral rejection in cardiac transplant recipientsKhalid Almuti
Division of Cardiology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA
Transplantation 84:498-503. 2007..Late cases of HR (>6 months after transplant) have been reported. We examined the differences in clinical characteristics and outcomes in patients presenting with HR in the early (<6 months) and late transplant periods... - Dynamic optical imaging of vascular and metabolic reactivity in rheumatoid jointsJoseph M Lasker
Columbia University, Department of Biomedical Engineering, 500 West 120th Street, ET351 Mudd Building, MC8904, New York, New York 10027, USA
J Biomed Opt 12:052001. 2007..Focusing on three cases studies, we illustrated our major finds. These studies support our hypothesis that differences in the vascular reactivity exist between affected and unaffected joints... - The New York City Rheumatology Objective Structured Clinical Examination: five-year data demonstrates its validity, usefulness as a unique rating tool, objectivity, and sensitivity to changeJessica R Berman
New York Hospital The Hospital for Special Surgery, New York, NY, USA
Arthritis Rheum 61:1686-93. 2009.... - Primary graft dysfunction: definition, risk factors, short- and long-term outcomesJames C Lee
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Semin Respir Crit Care Med 31:161-71. 2010..Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes... - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methodsJason D Christie
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Heart Lung Transplant 24:1451-3. 2005 - Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteriaDenis Hadjiliadis
Department of Medicine, Division of Pulmonary Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 10104, USA
J Heart Lung Transplant 26:834-8. 2007..The impact of panresistant bacteria, other than Burkholderia cepacia, on the survival after lung transplantation in patients with cystic fibrosis (CF) remains controversial... - Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodelingMasaaki Sato
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Semin Thorac Cardiovasc Surg 20:173-82. 2008..From this viewpoint, we review current therapeutic strategies and revisit the role of transplant surgeons in attenuating the initial transplant-related injuries to prevent the lung grafts from entering the remodeling-injury cycle... - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatmentYaron Shargall
Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
J Heart Lung Transplant 24:1489-500. 2005 - De novo pulmonary capillary hemangiomatosis occurring rapidly after bilateral lung transplantationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 22:698-700. 2003..This case supports the theory that persistent infection or inflammation may be an inciting factor in uncontrolled angiogenesis, leading ultimately to diffuse pulmonary capillary hemangiomatosis... - Donor-recipient gender mismatch in lung transplantation: Impact on obliterative bronchiolitis and survivalMasaaki Sato
J Heart Lung Transplant 24:2000-1. 2005 - Non-utilization of hearts and lungs after consent for donation: a Canadian multicentre studyKaren Hornby
Division of Critical Care, Montreal Children's Hospital, McGill University Health Centre, Quebec, Canada
Can J Anaesth 53:831-7. 2006..Although there is considerable pressure to increase organs for transplantation, any such mechanism will not be judged successful unless recipient graft survival rates remain acceptable... - The effect of gender combinations on outcome in human lung transplantation: the International Society of Heart and Lung Transplantation Registry experienceMasaaki Sato
Division of Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 25:634-7. 2006..Interestingly, F to F appears to be potentially beneficial in lung transplantation. Gender combinations do appear to significantly impact outcome after lung transplantation... - International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung TransplantationJonathan B Orens
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Heart Lung Transplant 25:745-55. 2006 - Interleukin-8 release during early reperfusion predicts graft function in human lung transplantationMarc de Perrot
Division of Thoracic Surgery, Thoracic Surgery Research Laboratory and The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 165:211-5. 2002..In addition, we showed that donor age and ischemic time may influence release of specific cytokines during ischemia-reperfusion... - Impact of donors aged 60 years or more on outcome after lung transplantation: results of an 11-year single-center experienceMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Canada
J Thorac Cardiovasc Surg 133:525-31. 2007..We examined the outcome of lung transplantation with the use of donors aged 60 years or more... - Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registryStefan Fischer
The Toronto Lung Transplant Program, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
J Heart Lung Transplant 26:472-7. 2007..A few single-center experiences have been reported with relatively few cases of ECMO after LTx... - Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesotheliomaMarc de Perrot
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Ann Thorac Surg 85:1206-10. 2008.... - Potential refinements of the International Society for Heart and Lung Transplantation primary graft dysfunction grading systemJason Christie
J Heart Lung Transplant 27:138. 2008 - Induction chemoradiation therapy followed by surgical resection for non-small cell lung cancer (NSCLC) invading the thoracic inletStefan Fischer
Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, University Health Network, 200 Elizabeth Street, 9th Floor, Toronto, Ontario, Canada M5G 2C4
Eur J Cardiothorac Surg 33:1129-34. 2008..The role of induction therapy for non-small cell lung cancer (NSCLC) invading the thoracic inlet is unclear. We reviewed our experience with induction chemoradiation followed by surgical resection for NSCLC invading the thoracic inlet... - Mycobacterium abscessus infections in lung transplant recipients: the international experienceSusan M Chernenko
Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 25:1447-55. 2006..Concurrent infections are common and may contribute to mortality in this immunosuppressed population... - Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplantFrank D'Ovidio
Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
Ann Thorac Surg 80:1254-60. 2005..It is not clear whether gastroesophageal reflux is a preexisting condition or secondary to intraoperative vagal injury or drug-induced prolonged gastric emptying... - Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantationMarco Mura
Toronto Lung Transplant Program, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
J Thorac Cardiovasc Surg 129:1144-52. 2005..Elevated BALF bile acids may promote early BOS development via an inflammatory process, possibly mediated by IL-8 and alveolar neutrophilia... - Twenty-year experience of lung transplantation at a single center: Influence of recipient diagnosis on long-term survivalMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 127:1493-501. 2004..Differences in the complications and long-term survival show the important contribution of the recipient diagnosis to the success of lung transplantation... - A novel model for post-transplant obliterative airway disease reveals angiogenesis from the pulmonary circulationAndre E Dutly
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, Toronto, ON, Canada
Am J Transplant 5:248-54. 2005..This model has revealed new insights into angiogenic potential of the pulmonary circulation... - Risk quantification of early outcome after lung transplantation: donor, recipient, operative, and post-transplant parametersYasuo Sekine
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 23:96-104. 2004..This scoring system also will facilitate standardization among transplant centers in evaluating post-transplant severity of illness... - Independent ventilation of the graft and native lungs in vivo after rat lung transplantationMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada
Ann Thorac Surg 79:2169-71. 2005.... - Risk of a right pneumonectomy: role of bronchopleural fistulaGail E Darling
Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada
Ann Thorac Surg 79:433-7. 2005..The purpose of this study is to compare the morbidity and mortality of right versus left pneumonectomy... - Role of lung transplantation in the treatment of bronchogenic carcinomas for patients with end-stage pulmonary diseaseMarc de Perrot
Toronto Lung Transplant Program, University of Toronto, Canada
J Clin Oncol 22:4351-6. 2004..CONCLUSION: This study demonstrates that long-term survival can be achieved after lung transplantation in patients with stage I bronchogenic carcinoma or with advanced multifocal BAC... - Lung transplantation. Lung preservationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, EN 10-224, Toronto, Ontario M5G 2C4, Canada
Chest Surg Clin N Am 13:443-62. 2003..Hopefully, this information will provide new insights into the mechanisms of injury and reveal potential new strategies and targets for therapies to improve lung preservation... - Strategies to optimize the use of currently available lung donorsMarc de Perrot
University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 23:1127-34. 2004 - A review of lung transplant donor acceptability criteriaJonathan B Orens
Johns Hopkins University, Baltimore, Maryland 21287, USA
J Heart Lung Transplant 22:1183-200. 2003 - Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplantDeepali Kumar
Infectious Diseases and Multi Organ Transplant, University of Toronto, Toronto, Ontario, Canada
Am J Transplant 5:2031-6. 2005..Community-acquired respiratory viruses may be associated with the development of acute rejection and BOS... - Lung transplantation: donor and recipient critical care aspectsAndrew F Pierre
Division of Thoracic Surgery, University of Toronto, Toronto, Ontario, Canada
Curr Opin Crit Care 11:339-44. 2005..SUMMARY: Patients undergoing lung transplantation continue to be very challenging in the intensive care unit. A multidisciplinary approach to care, and early recognition of serious problems, will help improve outcomes... - Bilateral lung transplantation using a donor with a tracheal right upper lobe bronchusYasuo Sekine
Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Ann Thorac Surg 73:308-10. 2002..The anastomosis was completed using a telescoping technique without any complication. This case demonstrates the possibility of successfully using donor lungs with such anatomic abnormality for transplantation... - Caspase inhibition improves ischemia-reperfusion injury after lung transplantationSyed M Quadri
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network - Toronto General Hospital, Toronto, Ontario, Canada
Am J Transplant 5:292-9. 2005..Clearly, this needs to be investigated further with more experiments to validate the potential role of caspase inhibition as a therapeutic modality in ischemia-reperfusion-induced lung injury... - Everting mattress running suture: an improved technique of atrial anastomosis in human lung transplantationMarc de Perrot
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
Ann Thorac Surg 73:1663-4. 2002..This technique should help reduce the risk of venous anastomotic complications... - A simplified model for en bloc double lung xenotransplantation from hamster to ratMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 21:286-9. 2002..This technique provides a technically easier and more reliable model to study xenotransplantation of the lung... - Accommodation after lung xenografting from hamster to ratToshiharu Tabata
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Transplantation 75:607-12. 2003..CONCLUSIONS: Accommodation may be a general phenomenon for all organs, mediated through protective genes. Induction of accommodation does not require disruption of the complement system... - 15 years single center experience with surgical resection of the superior vena cava for non-small cell lung cancerYaron Shargall
Division of Thoracic Surgery, University Health Network (Princess Margaret Hospital and Toronto General Hospital) and the University of Toronto, 10EN-233, Toronto, ON M5G 2C4, Canada
Lung Cancer 45:357-63. 2004..CONCLUSIONS: Carefully selected patients with NSCLC and SVC involvement can be operated upon with acceptable postoperative morbidity and mortality. Induction therapy appears to delay recurrence... - Improved results of induction chemoradiation before surgical intervention for selected patients with stage IIIA-N2 non-small cell lung cancerKarl L Uy
Division of Thoracic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 134:188-93. 2007..The surgical arm of the North American Intergroup 0139 trial was adopted as the standard treatment for patients with resectable N2 disease at the University Health Network. Results after 7 years of experience are reported... - Bilateral lung transplantation for metastatic leiomyosarcomaYaron Shargall
Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 23:912-5. 2004..While lung transplantation for malignancy remains a controversial area, this case illustrates that lung transplantation can provide improved quality and quantity of life for highly selected patients with malignant disease... - Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndromeYumiko Imai
Department of Critical Care, St Michael's Hospital, University of Toronto, Toronto, Ontario
JAMA 289:2104-12. 2003..This may partially explain the high rate of MODS observed in patients with ARDS and the decrease in morbidity and mortality in patients treated with a lung protective strategy... - Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter studyDenis Hadjiliadis
Department of Medicine, Division of Respirology, Toronto General Hospital, Toronto, Ontario, Canada
J Heart Lung Transplant 24:S249-54. 2005..This may be due to a direct effect of anti-HLA antibodies on the allograft. The effectiveness of treatments such as plasmapheresis and intravenous immunoglobulin prior to transplantation needs to be evaluated... - Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ PotentialSam D Shemie
Division of Pediatric Critical Care, Montreal Children's Hospital, McGill University Health Centre, , Que
CMAJ 174:S13-32. 2006 - GI complications after lung transplantation in patients with cystic fibrosisMarita Gilljam
Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
Chest 123:37-41. 2003..Prevention and early medical treatment are important in order to avoid acute surgery. Close collaboration with the CF clinic, in order to diagnose and treat CF-related complications, is recommended... - Gene therapy in lung transplantationMasaaki Sato
Thoracic Surgery Research Laboratory, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada
Curr Gene Ther 6:439-58. 2006..Based on our work and the work of others, over the last decade, we present the state of art of in gene therapy in lung transplantation and exciting future directions in the field... - High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in ratsDaisuke Okutani
Thoracic Surgery Research Laboratory, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Am J Physiol Lung Cell Mol Physiol 292:L144-53. 2007..A local expression of PTX3 induced by high-volume ventilation, either alone or in combination with other pathological conditions, suggests that it may be an important mediator in ventilator-induced lung injury... - Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant modelMarc de Perrot
Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 124:1137-44. 2002.... - Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantationSmita Sakha Pakhale
Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada
J Heart Lung Transplant 24:1260-8. 2005..CONCLUSION: Upper lobe fibrosis is a novel presentation of chronic allograft dysfunction in lung transplant recipients and is differentiated from bronchiolitis obliterans syndrome on the basis of physiologic and radiologic findings... - Toll-like receptor and cytokine gene expression in the early phase of human lung transplantationCristiano Feijó Andrade
Thoracic Surgery Research Laboratory, Toronto General Hospital, University Health Network, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Heart Lung Transplant 25:1317-23. 2006..We hypothesized that gene expression of TLRs during lung transplantation may be affected by the donor condition and the ischemia-reperfusion process, which may subsequently influence graft function...
Research Grants
- Genetic Risk Factors for Portopulmonary HypertensionSteven Kawut; Fiscal Year: 2005..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
- Neurohormonal Activation in Pulmonary HypertensionSteven Kawut; Fiscal Year: 2005..We will formulate prediction rules using neurohormone levels and clinical variables to improve prognostication and management in this disease. ..
- Endothelial Dysfunction and the RV in the Multi-Ethnic Study of AtherosclerosisSteven Kawut; Fiscal Year: 2007..This study will focus on subclinical markers of pulmonary vascular disease and RV failure, which are increasingly important diseases impacting on older and minority Americans. ..
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2007..PAH strikes young individuals, drastically shortening their lifespan. We aim to investigate safe but innovative therapies which could remodel the pulmonary vasculature and improve outcomes in this currently incurable disease. ..