Research Topics
| ANDREW DWORKSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Senile degeneration and cognitive impairment in chronic schizophreniaA J Dwork
Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
Am J Psychiatry 155:1536-43. 1998..This study was an investigation of the role of Alzheimer-type senile degenerative abnormalities in the cognitive impairment of chronic schizophrenia...- Absence of histological lesions in primate models of ECT and magnetic seizure therapyAndrew J Dwork
Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
Am J Psychiatry 161:576-8. 2004..The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge... - White matter and cognitive function in schizophreniaAndrew J Dwork
Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
Int J Neuropsychopharmacol 10:513-36. 2007.... 
Antidepressants increase neural progenitor cells in the human hippocampusMaura Boldrini
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
Neuropsychopharmacology 34:2376-89. 2009..009). Antidepressants increase NPC number in the anterior human DG. Whether this finding is critical or necessary for the antidepressants effect remains to be determined...- Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depressionJason Scalia
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J ECT 23:96-8. 2007..Cognition in this patient was intact as indicated by a perfect score on a Mini-Mental Status Examination administered 6 days before death at the age of 92. This case adds to the considerable evidence for the safety of ECT... - Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primatesTarique D Perera
Department of Biological Psychiatry, New York State Psychiatric Institute New York, New York 10032, USA
J Neurosci 27:4894-901. 2007..This study demonstrates that ECS is capable of inducing neurogenesis in the nonhuman primate hippocampus and supports the possibility that antidepressant interventions produce similar alterations in the human brain... - Altered subicular MAP2 immunoreactivity in schizophreniaGorazd Rosoklija
Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
Prilozi 26:13-34. 2005..The chemical or structural abnormalities underlying decreased MAP2 immunoreactivity in schizophrenia remain to be determined... - The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primatesJeremy D Coplan
SUNY Downstate Medical Center, Primate Behavior Laboratory, Brooklyn, NY, USA
Neurosci Lett 480:93-6. 2010..Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility... - Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit componentsYing Jiun J Chen
Department of Cell Biology and Pathology, School of Pubic Health, Columbia University, New York, New York, USA
J Neurosci 28:6872-83. 2008..Our findings demonstrate a role of type III Nrg1 signaling in the maintenance of corticostriatal components and in the neural circuits involved in sensorimotor gating and short-term memory... - Lifelong course of positive and negative symptoms in chronically institutionalized patients with schizophreniaBranislav Mancevski
Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
Psychopathology 40:83-92. 2007..We sought to describe this course, and to determine the influences of sex, age of onset, and treatment on its evolution... - Optimization of Golgi methods for impregnation of brain tissue from humans and monkeysGorazd Rosoklija
New York State Psychiatric Institute and Columbia University, Unit 62, 722 West 168th Street, 1051 Riverside Drive, New York, NY 10032, USA
J Neurosci Methods 131:1-7. 2003..When the appropriate method is chosen, Golgi impregnation is a useful technique for the neuropathologist... - Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victimsIlona Gurevich
Mount Sinai Graduate School of Biological Sciences, New York, NY 10029, USA
Neuron 34:349-56. 2002..Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims... - Altered volume and hemispheric asymmetry of the superficial cortical layers in the schizophrenia planum temporaleJohn F Smiley
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Eur J Neurosci 30:449-63. 2009..In schizophrenia, the thinner upper layers of the caudal PT suggest disrupted corticocortical processing, possibly affecting the multisensory integration and phonetic processing of this region... - Genome-wide divergence of DNA methylation marks in cerebral and cerebellar corticesYurong Xin
Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, New York, United States of America
PLoS ONE 5:e11357. 2010..Our observed differences in DNA methylation profiles in these regions underscores the potential role of DNA methylation in chromatin structure and organization in CNS, reflecting functional specialization within cortical regions... - Reduced spinophilin in schizophreniaAndrew J Dwork
Am J Psychiatry 162:1389; author reply 1389-90. 2005 - Hippocampal complexin proteins and cognitive dysfunction in schizophreniaKen Sawada
Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan
Arch Gen Psychiatry 62:263-72. 2005..CONCLUSIONS: The pathology of hippocampal complexin proteins might play an important role in schizophrenia, especially concerning cognitive disturbances... - Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkeyJeppe Romme Christensen
Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark
Anat Rec (Hoboken) 290:330-40. 2007..The results are phylogenetically consistent, apart from the neuron/glia ratio, which is remarkably higher than what is found in other species... - Fahr's disease and schizophrenia in a patient with secondary hypoparathyroidismBoro Ilievski
J Neuropsychiatry Clin Neurosci 14:357-8. 2002 - Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illnessWilliam G Honer
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Cereb Cortex 12:349-56. 2002..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders...
Research Grants
- Myelin Pathology in SchizophreniaAndrew J Dwork; Fiscal Year: 2010....
- Myelin Pathology in SchizophreniaANDREW DWORK; Fiscal Year: 2009....
- Myelin Pathology in SchizophreniaANDREW DWORK; Fiscal Year: 2007....
- Golgi Studies of SchizophreniaANDREW DWORK; Fiscal Year: 2005..4) To evaluate prefrontal cortex, primary visual cortex, and additional areas of hippocampus, in order to determine whether spine loss in schizoprhenia is localized or generalized. ..
- Golgi Studies of SchizophreniaAndrew J Dwork; Fiscal Year: 2010..We have developed improved procedures to visualize these processes in human brain tissue from autopsies, and we will use these methods to determine whether there are consistent abnormalities of brain structure in schizophrenia. ..