ANDREW DWORK

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Senile degeneration and cognitive impairment in chronic schizophrenia
    A J Dwork
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    Am J Psychiatry 155:1536-43. 1998
  2. ncbi request reprint Absence of histological lesions in primate models of ECT and magnetic seizure therapy
    Andrew J Dwork
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 161:576-8. 2004
  3. ncbi request reprint White matter and cognitive function in schizophrenia
    Andrew J Dwork
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Int J Neuropsychopharmacol 10:513-36. 2007
  4. pmc Antidepressants increase neural progenitor cells in the human hippocampus
    Maura Boldrini
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    Neuropsychopharmacology 34:2376-89. 2009
  5. ncbi request reprint Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depression
    Jason Scalia
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J ECT 23:96-8. 2007
  6. ncbi request reprint Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates
    Tarique D Perera
    Department of Biological Psychiatry, New York State Psychiatric Institute New York, New York 10032, USA
    J Neurosci 27:4894-901. 2007
  7. ncbi request reprint Altered subicular MAP2 immunoreactivity in schizophrenia
    Gorazd Rosoklija
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Prilozi 26:13-34. 2005
  8. pmc The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates
    Jeremy D Coplan
    SUNY Downstate Medical Center, Primate Behavior Laboratory, Brooklyn, NY, USA
    Neurosci Lett 480:93-6. 2010
  9. pmc Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components
    Ying Jiun J Chen
    Department of Cell Biology and Pathology, School of Pubic Health, Columbia University, New York, New York, USA
    J Neurosci 28:6872-83. 2008
  10. ncbi request reprint Lifelong course of positive and negative symptoms in chronically institutionalized patients with schizophrenia
    Branislav Mancevski
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Psychopathology 40:83-92. 2007

Research Grants

  1. Myelin Pathology in Schizophrenia
    Andrew J Dwork; Fiscal Year: 2010
  2. Myelin Pathology in Schizophrenia
    ANDREW DWORK; Fiscal Year: 2009
  3. Myelin Pathology in Schizophrenia
    ANDREW DWORK; Fiscal Year: 2007
  4. Golgi Studies of Schizophrenia
    ANDREW DWORK; Fiscal Year: 2005
  5. Golgi Studies of Schizophrenia
    Andrew J Dwork; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Senile degeneration and cognitive impairment in chronic schizophrenia
    A J Dwork
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    Am J Psychiatry 155:1536-43. 1998
    ..This study was an investigation of the role of Alzheimer-type senile degenerative abnormalities in the cognitive impairment of chronic schizophrenia...
  2. ncbi request reprint Absence of histological lesions in primate models of ECT and magnetic seizure therapy
    Andrew J Dwork
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 161:576-8. 2004
    ..The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge...
  3. ncbi request reprint White matter and cognitive function in schizophrenia
    Andrew J Dwork
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Int J Neuropsychopharmacol 10:513-36. 2007
    ....
  4. pmc Antidepressants increase neural progenitor cells in the human hippocampus
    Maura Boldrini
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    Neuropsychopharmacology 34:2376-89. 2009
    ..009). Antidepressants increase NPC number in the anterior human DG. Whether this finding is critical or necessary for the antidepressants effect remains to be determined...
  5. ncbi request reprint Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depression
    Jason Scalia
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J ECT 23:96-8. 2007
    ..Cognition in this patient was intact as indicated by a perfect score on a Mini-Mental Status Examination administered 6 days before death at the age of 92. This case adds to the considerable evidence for the safety of ECT...
  6. ncbi request reprint Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates
    Tarique D Perera
    Department of Biological Psychiatry, New York State Psychiatric Institute New York, New York 10032, USA
    J Neurosci 27:4894-901. 2007
    ..This study demonstrates that ECS is capable of inducing neurogenesis in the nonhuman primate hippocampus and supports the possibility that antidepressant interventions produce similar alterations in the human brain...
  7. ncbi request reprint Altered subicular MAP2 immunoreactivity in schizophrenia
    Gorazd Rosoklija
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Prilozi 26:13-34. 2005
    ..The chemical or structural abnormalities underlying decreased MAP2 immunoreactivity in schizophrenia remain to be determined...
  8. pmc The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates
    Jeremy D Coplan
    SUNY Downstate Medical Center, Primate Behavior Laboratory, Brooklyn, NY, USA
    Neurosci Lett 480:93-6. 2010
    ..Adverse rearing in monkeys persistently impaired frontal white matter tract integrity, a novel substrate for understanding affective susceptibility...
  9. pmc Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components
    Ying Jiun J Chen
    Department of Cell Biology and Pathology, School of Pubic Health, Columbia University, New York, New York, USA
    J Neurosci 28:6872-83. 2008
    ..Our findings demonstrate a role of type III Nrg1 signaling in the maintenance of corticostriatal components and in the neural circuits involved in sensorimotor gating and short-term memory...
  10. ncbi request reprint Lifelong course of positive and negative symptoms in chronically institutionalized patients with schizophrenia
    Branislav Mancevski
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY, USA
    Psychopathology 40:83-92. 2007
    ..We sought to describe this course, and to determine the influences of sex, age of onset, and treatment on its evolution...
  11. ncbi request reprint Optimization of Golgi methods for impregnation of brain tissue from humans and monkeys
    Gorazd Rosoklija
    New York State Psychiatric Institute and Columbia University, Unit 62, 722 West 168th Street, 1051 Riverside Drive, New York, NY 10032, USA
    J Neurosci Methods 131:1-7. 2003
    ..When the appropriate method is chosen, Golgi impregnation is a useful technique for the neuropathologist...
  12. ncbi request reprint Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims
    Ilona Gurevich
    Mount Sinai Graduate School of Biological Sciences, New York, NY 10029, USA
    Neuron 34:349-56. 2002
    ..Thus, one outcome of fluoxetine treatment may be to reverse the abnormalities in 5-HT2C pre-mRNA editing seen in depressed suicide victims...
  13. pmc Altered volume and hemispheric asymmetry of the superficial cortical layers in the schizophrenia planum temporale
    John F Smiley
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Eur J Neurosci 30:449-63. 2009
    ..In schizophrenia, the thinner upper layers of the caudal PT suggest disrupted corticocortical processing, possibly affecting the multisensory integration and phonetic processing of this region...
  14. pmc Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices
    Yurong Xin
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, New York, United States of America
    PLoS ONE 5:e11357. 2010
    ..Large-scale whole genome DNA methylation profiling of the normal human brain offers tremendous potential in understanding the role of DNA methylation in brain development and function...
  15. ncbi request reprint Reduced spinophilin in schizophrenia
    Andrew J Dwork
    Am J Psychiatry 162:1389; author reply 1389-90. 2005
  16. ncbi request reprint Hippocampal complexin proteins and cognitive dysfunction in schizophrenia
    Ken Sawada
    Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan
    Arch Gen Psychiatry 62:263-72. 2005
    ..A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II...
  17. ncbi request reprint Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey
    Jeppe Romme Christensen
    Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark
    Anat Rec (Hoboken) 290:330-40. 2007
    ..The results are phylogenetically consistent, apart from the neuron/glia ratio, which is remarkably higher than what is found in other species...
  18. ncbi request reprint Fahr's disease and schizophrenia in a patient with secondary hypoparathyroidism
    Boro Ilievski
    J Neuropsychiatry Clin Neurosci 14:357-8. 2002
  19. ncbi request reprint Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Cereb Cortex 12:349-56. 2002
    ..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders...

Research Grants14

  1. Myelin Pathology in Schizophrenia
    Andrew J Dwork; Fiscal Year: 2010
    ....
  2. Myelin Pathology in Schizophrenia
    ANDREW DWORK; Fiscal Year: 2009
    ....
  3. Myelin Pathology in Schizophrenia
    ANDREW DWORK; Fiscal Year: 2007
    ....
  4. Golgi Studies of Schizophrenia
    ANDREW DWORK; Fiscal Year: 2005
    ..4) To evaluate prefrontal cortex, primary visual cortex, and additional areas of hippocampus, in order to determine whether spine loss in schizoprhenia is localized or generalized. ..
  5. Golgi Studies of Schizophrenia
    Andrew J Dwork; Fiscal Year: 2010
    ..We have developed improved procedures to visualize these processes in human brain tissue from autopsies, and we will use these methods to determine whether there are consistent abnormalities of brain structure in schizophrenia. ..