Alex Dranovsky

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Is there a role for young hippocampal neurons in adaptation to stress?
    Alex Dranovsky
    Department of Psychiatry, Division of Integrative Neuroscience, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr Box 87, New York, NY 10032, USA
    Behav Brain Res 227:371-5. 2012
  2. ncbi request reprint Hippocampal neurogenesis: regulation by stress and antidepressants
    Alex Dranovsky
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 59:1136-43. 2006
  3. ncbi request reprint DISC1 puts the brakes on neurogenesis
    Alex Dranovsky
    Departments of Psychiatry and Neuroscience, Columbia University, New York, NY 10032, USA
    Cell 130:981-3. 2007
  4. pmc Experience dictates stem cell fate in the adult hippocampus
    Alex Dranovsky
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuron 70:908-23. 2011
  5. pmc Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety
    Jesse W Richardson-Jones
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 31:6008-18. 2011
  6. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
  7. doi request reprint The when and where of BDNF and the antidepressant response
    Jing Wen Wang
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    Biol Psychiatry 63:640-1. 2008
  8. pmc 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
    Jesse W Richardson-Jones
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuron 65:40-52. 2010
  9. pmc Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice
    Maxime Cazorla
    Neurobiology and Molecular Pharmacology, Centre de Psychiatrie et de Neurosciences, UMR 894 INSERM Université Paris Descartes, Paris, France
    PLoS ONE 5:e9777. 2010
  10. pmc Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors
    Benjamin A Samuels
    Departments of Psychiatry and Neuroscience, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e85136. 2014

Collaborators

Detail Information

Publications10

  1. pmc Is there a role for young hippocampal neurons in adaptation to stress?
    Alex Dranovsky
    Department of Psychiatry, Division of Integrative Neuroscience, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Dr Box 87, New York, NY 10032, USA
    Behav Brain Res 227:371-5. 2012
    ..Finally, we will speculate that a key function of adult-born neurons within hippocampal function may be to modulate the stress response and perhaps assign stress salience to the sensory context...
  2. ncbi request reprint Hippocampal neurogenesis: regulation by stress and antidepressants
    Alex Dranovsky
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 59:1136-43. 2006
    ..Focusing on neurogenic response to experimental paradigms of stress and antidepressant treatment is particularly interesting for understanding the pathophysiology of major depressive disorder...
  3. ncbi request reprint DISC1 puts the brakes on neurogenesis
    Alex Dranovsky
    Departments of Psychiatry and Neuroscience, Columbia University, New York, NY 10032, USA
    Cell 130:981-3. 2007
    ..Surprisingly, DISC1 appears to have opposite effects on neurogenesis during development and in adulthood...
  4. pmc Experience dictates stem cell fate in the adult hippocampus
    Alex Dranovsky
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuron 70:908-23. 2011
    ..Our findings suggest that, in the hippocampus, fate specification may act as a form of cellular plasticity for adapting to environmental changes...
  5. pmc Serotonin-1A autoreceptors are necessary and sufficient for the normal formation of circuits underlying innate anxiety
    Jesse W Richardson-Jones
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Neurosci 31:6008-18. 2011
    ....
  6. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
    ....
  7. doi request reprint The when and where of BDNF and the antidepressant response
    Jing Wen Wang
    Department of Biological Sciences, Columbia University, New York, New York 10032, USA
    Biol Psychiatry 63:640-1. 2008
  8. pmc 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
    Jesse W Richardson-Jones
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuron 65:40-52. 2010
    ..These results establish a causal relationship between 5-HT(1A) autoreceptor levels, resilience under stress, and response to antidepressants...
  9. pmc Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice
    Maxime Cazorla
    Neurobiology and Molecular Pharmacology, Centre de Psychiatrie et de Neurosciences, UMR 894 INSERM Université Paris Descartes, Paris, France
    PLoS ONE 5:e9777. 2010
    ....
  10. pmc Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors
    Benjamin A Samuels
    Departments of Psychiatry and Neuroscience, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e85136. 2014
    ..However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems respond to treatments may be critical for understanding antidepressant resistance...

Research Grants3

  1. The contribution of adult-born neurons to hippocampal structure and connectivity.
    Alex Dranovsky; Fiscal Year: 2007
    ....
  2. Mechanisms and Significance of Stem Cell Fate Plasticity in the Adult Hippocampus
    Alex Dranovsky; Fiscal Year: 2010
    ..Finally, investigators will explore what role this "experience-directed" stem cell fate plasticity plays in adaptation to stress. ..