Research Topics
| Marco Di TullioSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Higher ambulatory blood pressure is associated with aortic valve calcification in the elderly: a population-based studyShinichi Iwata
Cardiology Division, Department of Medicine, Columbia University, New York, NY, USA
Hypertension 61:55-60. 2013..Diastolic ABP is independently associated with advanced calcification. This finding may have important implications in gaining further insight into the mechanism of AVC...- Arterial stiffness and wave reflection: sex differences and relationship with left ventricular diastolic functionCesare Russo
Department of Medicine, Columbia University, New York, NY, USA
Hypertension 60:362-8. 2012..Women's higher arterial stiffness, independent of body size, may contribute to their greater susceptibility to develop HFNEF... - Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic functionCesare Russo
Division of Cardiology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Heart 98:813-20. 2012..The authors hypothesised that LAV(min) may be a better correlate of LV diastolic function than LAV(max)... - A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genesDavid Della-Morte
Department of Neurology, Evelyn F McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
BMC Med Genet 12:100. 2011..In the present study, we use association analysis to further study the genetic effect on LVM... - Novel quantitative trait locus is mapped to chromosome 12p11 for left ventricular mass in Dominican families: the Family Study of Stroke Risk and Carotid AtherosclerosisLiyong Wang
Department of Human Genetics, Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA
BMC Med Genet 10:74. 2009..The genetic basis of LVM is unclear although a high heritability has been suggested. We sought to map quantitative trait loci (QTL) for LVM using large Dominican families... - Endothelial dysfunction is associated with carotid plaque: a cross-sectional study from the population based Northern Manhattan StudyTatjana Rundek
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
BMC Cardiovasc Disord 6:35. 2006..The objective of this study was to determine whether endothelial dysfunction is independently associated with carotid plaque in a community of northern Manhattan... - Moderate alcohol consumption is associated with better endothelial function: a cross sectional studyKeiko Suzuki
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, USA
BMC Cardiovasc Disord 9:8. 2009.... 
Patent foramen ovale: echocardiographic detection and clinical relevance in strokeMarco R Di Tullio
Division of Cardiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Am Soc Echocardiogr 23:144-55; quiz 220. 2010..Some cofactors possibly involved in the association between PFO and stroke are discussed, along with the various therapeutic options to prevent recurrent cerebral ischemic events in stroke patients with a PFO...
Left atrial size and the risk of ischemic stroke in an ethnically mixed populationM R Di Tullio
Department of Medicine, Columbia Presbyterian Medical Center, New York, NY, USA
Stroke 30:2019-24. 1999..Data are available almost exclusively for white patients. The purpose of this study was to evaluate the association between left atrial size and ischemic stroke in a multiethnic population...- Aortic arch plaques and risk of recurrent stroke and deathMarco R Di Tullio
Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Circulation 119:2376-82. 2009..Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated the efficacy of antithrombotic therapies in preventing recurrent events... - Patent foramen ovale and the risk of ischemic stroke in a multiethnic populationMarco R Di Tullio
Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
J Am Coll Cardiol 49:797-802. 2007..We sought to assess the risk of ischemic stroke from a patent foramen ovale (PFO) in the multiethnic prospective cohort of northern Manhattan... - Left ventricular mass and geometry and the risk of ischemic strokeMarco R Di Tullio
Department of Medicine, Sergievsky Center, Columbia Presbyterian Medical Center, 630 W 168th St, New York, NY 10032, USA
Stroke 34:2380-4. 2003..The effect of LV geometry on stroke risk has not been defined. The aim of the present study was to evaluate whether LVH and LV geometry are independently associated with increased ischemic stroke risk in a multiethnic population... - Aortic atheroma morphology and the risk of ischemic stroke in a multiethnic populationM R Di Tullio
Departments of Medicine, Neurology, and Public Health Epidemiology, Sergievsky Center, Columbia Presbyterian Medical Center, New York, NY 10032, USA
Am Heart J 139:329-36. 2000..Moreover, data have been obtained in predominantly white populations, and little is known about the association between atheromas and stroke in minorities... - Mechanisms of cardioembolic strokeMarco R Di Tullio
Cardiology Division, Columbia Presbyterian Medical Center, 630 West 168th Street, New York, NY 10032, USA
Curr Cardiol Rep 4:141-8. 2002..This article reviews the current understanding of cardiac embolism as a mechanism for stroke, and the preventive options that are currently adopted to decrease the stroke risk... - Aortic atherosclerosis, hypercoagulability, and stroke the APRIS (Aortic Plaque and Risk of Ischemic Stroke) studyMarco R Di Tullio
Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
J Am Coll Cardiol 52:855-61. 2008..Our goal was to assess the effect of hypercoagulability on the risk of stroke in patients with aortic plaques... - Patent foramen ovale and stroke: what should be done?Marco R Di Tullio
Division of Cardiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Curr Opin Hematol 16:391-6. 2009..Also, associated conditions that may guide the therapeutic choices are being investigated... - Transesophageal echocardiography aortic plaque imagingMarco R Di Tullio
Cardiology Division, Columbia Presbyterian Medical Center, 630 West 168th Street, New York, NY 10032, USA
Neuroimaging Clin N Am 12:445-59. 2002..Improvement in tissue characterization and three-dimensional capabilities may further improve the diagnostic accuracy of TEE for aortic plaque detection and evaluation... - Race-ethnic differences in patent foramen ovale, atrial septal aneurysm, and right atrial anatomy among ischemic stroke patientsCarlos J Rodriguez
Columbia University, College of Physicians and Surgeons, Department of Medicine, Division of Cardiology, 630 W 168th St, New York, NY 10032, USA
Stroke 34:2097-102. 2003..These may be relatively more important risk factors for stroke among whites and Hispanics than among blacks... - Left ventricular systolic dysfunction and the risk of ischemic stroke in a multiethnic populationAllison G Hays
Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
Stroke 37:1715-9. 2006..CONCLUSIONS: LVD, even of mild degree, is independently associated with an increased risk of ischemic stroke. The assessment of LV function should be considered in the assessment of the stroke risk... - Association between social isolation and left ventricular massCarlos J Rodriguez
Department of Medicine, Columbia University, New York, NY 10032, USA
Am J Med 124:164-70. 2011..Increased left ventricular mass is a predictor of cardiovascular morbidity and mortality. It is not yet clear whether social isolation is a determinant of increased left ventricular mass... - Impact of aortic stiffness on ischemic stroke in elderly patientsKenichi Sugioka
Department of Medicine, Columbia-Presbyterian Medical Center, New York, NY 10032, USA
Stroke 33:2077-81. 2002..This suggests that aortic stiffness by TEE may add prognostic information when assessing the risk of ischemic stroke in the elderly... - Impact of mitral annular calcification on cardiovascular events in a multiethnic community: the Northern Manhattan StudyShun Kohsaka
Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
JACC Cardiovasc Imaging 1:617-23. 2008..We sought to determine the magnitude of the association between mitral annular calcification (MAC) and vascular events in a multiethnic cohort... - Soluble tumor necrosis factor receptor 1 level is associated with left ventricular hypertrophy: the northern Manhattan studyYasuyoshi Takei
Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Am J Hypertens 22:763-9. 2009..We sought to evaluate whether inflammatory markers were independently associated with LVH in a multiethnic population in northern Manhattan... - Additional impact of electrocardiographic over echocardiographic diagnosis of left ventricular hypertrophy for predicting the risk of ischemic strokeShun Kohsaka
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am Heart J 149:181-6. 2005..Electrocardiographic results can provide independent information for left ventricular myocardial changes and should be considered together with echocardiographic results to fully assess the risk of ischemic stroke... - Impaired flow-mediated vasodilatation is associated with increased left ventricular mass in a multiethnic population. The Northern Manhattan StudyTakuya Hasegawa
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
Am J Hypertens 23:413-9. 2010..We tested the hypothesis that impaired flow-mediated vasodilatation (FMD) is associated with increased LV mass in a population-based multiethnic cohort... - Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitusGissette Reyes-Soffer
Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
Metabolism 59:1365-71. 2010..This finding may be relevant to the greater early and late morbidity and mortality observed in patients with both CAD and T2DM... - The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohortDaichi Shimbo
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, United States
Atherosclerosis 192:197-203. 2007..Whether FMD testing predicts cardiovascular events in asymptomatic, lower risk individuals from the general population is unknown... - Physical activity attenuates the effect of increased left ventricular mass on the risk of ischemic stroke: The Northern Manhattan Stroke StudyCarlos J Rodriguez
Department of Medicine, Columbia University, New York, New York 10032, USA
J Am Coll Cardiol 39:1482-8. 2002..Recommending PA may be a nonpharmacologic tool to reduce the stroke risk, especially among patients with increased LVM... - Atherosclerotic disease of the proximal aorta and the risk of vascular events in a population-based cohort: the Aortic Plaques and Risk of Ischemic Stroke (APRIS) studyCesare Russo
Departments of Medicine, Columbia University, New York, NY 10032, USA
Stroke 40:2313-8. 2009..However, this association in the general population is unclear. We sought to assess whether proximal aortic plaques are associated with vascular events in a community-based cohort... - Usefulness of fasting blood glucose to predict vascular outcomes among individuals without diabetes mellitus (from the Northern Manhattan Study)Kazuo Eguchi
Center for Behavioral Cardiovascular Health, Division of General Medicine, Columbia University Medical Center, New York, NY, USA
Am J Cardiol 100:1404-9. 2007..The effects were more apparent for MI than for ischemic stroke; however, FBG was a strong predictor of ischemic stroke among African-American subjects... - Race/ethnic disparities in left ventricular diastolic function in a triethnic community cohortCesare Russo
Department of Medicine, Columbia University, New York, NY 10032, USA
Am Heart J 160:152-8. 2010..We sought to assess whether race-ethnic differences in diastolic function exist. Such differences may contribute to the observed disparities in cardiovascular outcomes... - Partial loading of the left ventricle during mechanical assist device support is associated with improved myocardial function, blood flow and metabolism and increased exercise capacitySimon Maybaum
Division of Circulatory Physiology, Columbia University, New York, New York, USA
J Heart Lung Transplant 21:446-54. 2002..The purpose of this study was to assess the effect of the degree of left ventricular decompression, during left ventricular assist device support, on myocardial function and exercise capacity... - Leukocyte count is associated with aortic arch plaque thicknessMitchell S V Elkind
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
Stroke 33:2587-92. 2002..Leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies. We hypothesized that white blood cell count is associated with aortic arch plaque thickness (AAPT)... - Patent foramen ovale and strokeShunichi Homma
Division of Cardiology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
J Cardiol 56:134-41. 2010..The present article will review the evidence regarding this association, the technical aspects of PFO detection, and the preventive options to decrease the risk of recurrent cerebral events... - Self-reported peripheral arterial disease predicts future vascular events in a community-based cohortMaya J Salameh
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Gen Intern Med 23:1423-8. 2008..Lower extremity peripheral arterial disease (PAD) is highly prevalent and strongly associated with cardiovascular morbidity and mortality. The ankle-brachial index used to screen for PAD is not routinely performed in primary care settings... - Effect of medical treatment in stroke patients with patent foramen ovale: patent foramen ovale in Cryptogenic Stroke StudyShunichi Homma
Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Circulation 105:2625-31. 2002..Patent foramen ovale (PFO) is associated with stroke, but there are no randomized studies to evaluate the efficacy of antithrombotic therapies... - Prognostic implications of left ventricular mass among Hispanics: the Northern Manhattan StudyCarlos J Rodriguez
Department of Medicine, Columbia University, New York, NY 10032, USA
Hypertension 48:87-92. 2006..Our findings identify the Hispanic population with increased LVM as a high-risk subgroup... - Feasibility of using a real-time 3-dimensional technique for contrast dobutamine stress echocardiographyTodd Pulerwitz
Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA
J Am Soc Echocardiogr 19:540-5. 2006..RT3D dobutamine contrast stress echocardiography is feasible, greatly improves image quality compared with noncontrast images, and quickly acquires full data sets for subsequent analysis... - Seropositivity to Chlamydia pneumoniae is associated with risk of first ischemic strokeMitchell S V Elkind
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Stroke 37:790-5. 2006..The objective of this study is to determine whether serological evidence of C pneumoniae infection is associated with risk of ischemic stroke... - Relation of plasma glucose and endothelial function in a population-based multiethnic sample of subjects without diabetes mellitusCarlos J Rodriguez
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
Am J Cardiol 96:1273-7. 2005..These results further support the role of hyperglycemia in the pathogenesis of vascular dysfunction at different stages of diabetes development and the role of impaired fasting glucose as a risk factor for macrovascular disease... - Leukocyte count is associated with reduced endothelial reactivityMitchell S V Elkind
Department of Neurology, College of Physicians and Surgeons, Columbia University, and the Columbia University Medical Center of New York Presbyterian Hospital, New York, NY, USA
Atherosclerosis 181:329-38. 2005..Leukocyte count has been associated with cardiovascular and cerebrovascular disease in several studies. We hypothesized that white blood cell count is associated with endothelial reactivity... - High lipoprotein(a) levels and small apolipoprotein(a) sizes are associated with endothelial dysfunction in a multiethnic cohortHenry D Wu
Department of Medicine, Columbia University, New York, New York 10032, USA
J Am Coll Cardiol 43:1828-33. 2004..This study sought to determine the effect of lipoprotein(a), or Lp(a), levels and apolipoprotein(a), or apo(a), sizes on endothelial function and to explore ethnic differences in their effects... - Hypopharyngeal perforation near-miss during transesophageal echocardiographyJonathan E Aviv
Department of Otolaryngology Head and Neck Surgery, Columbia University Medical Center, New York Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Laryngoscope 114:821-6. 2004.... - Effect of aspirin and warfarin therapy in stroke patients with valvular strandsShunichi Homma
Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Stroke 35:1436-42. 2004..The recurrent rate of adverse events in stroke patients with valvular strands has not been defined and, importantly, there are no randomized studies to evaluate efficacy of antithrombotic therapies in these patients... - Atrial anatomy in non-cardioembolic stroke patients: effect of medical therapyShunichi Homma
Department of Medicine, New York, New York 10032, USA
J Am Coll Cardiol 42:1066-72. 2003.... - Ultrasound assessment of subclinical cardiovascular disease in a community-based multiethnic population and comparison to the Framingham scoreYukio Abe
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Am J Cardiol 98:1374-8. 2006..In the intermediate FRS category, FRS appears to underestimate the coronary risk more in women than in men and more in whites and especially in blacks than in Hispanics... - Genetic contribution to brachial artery flow-mediated dilation: the Northern Manhattan Family StudyKeiko Suzuki
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Atherosclerosis 197:212-6. 2008..The importance of genetic contribution to FMD and baseline brachial artery diameter has not been shown in Hispanic populations. The purpose of this study was to estimate the heritability of FMD... - Effect of social support on nocturnal blood pressure dippingCarlos J Rodriguez
Division of Cardiology, Columbia University, 622 W 168th Street, PH 3 342, New York, NY 10032, USA
Psychosom Med 70:7-12. 2008..Non-Hispanic blacks have higher rates of cardiovascular morbidity and mortality from hypertension and are more likely to have ambulatory blood pressure (ABP) that remains high at night (nondipping)... - Left ventricular mobile thrombus associated with ventricular assist device: diagnosis by transesophageal echocardiographyYumiko Miyake
Division of Cardiology, Department of Medicine, Columbia University, New York, NY 10032, USA
Circ J 68:383-4. 2004..A 61-year-old woman supported with VAD with LV apical cannulation had a mobile LV thrombus adjacent to the inflow cannula diagnosed by transesophageal echocardiography... - Association between carotid intima-media thickness and aortic arch plaquesElena Tessitore
Department of Medicine, Columbia University, New York, New York 10032, USA
J Am Soc Echocardiogr 23:772-7. 2010..The aim of this study was to investigate this association in an elderly asymptomatic cohort and to assess the possibility of using CIMT to predict the presence or absence of large aortic arch plaques... - Carotid bruit for detection of hemodynamically significant carotid stenosis: the Northern Manhattan StudyElizabeth V Ratchford
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurol Res 31:748-52. 2009..We aimed to establish the prevalence of carotid bruits and the diagnostic accuracy of auscultation for detection of hemodynamically significant carotid stenosis, using carotid duplex as the gold standard... - Coronary vasomotor function is abnormal in first-degree relatives of patients with type 2 diabetesKumiko Hirata
Department of Medicine, Columbia University, New York, New York, USA
Diabetes Care 30:150-3. 2007 - Stroke location and association with fatal cardiac outcomes: Northern Manhattan Study (NOMAS)Fred Rincon
Department of Neurology, College of Physicians and Surgeons Columbia University, New York, NY 10032, USA
Stroke 39:2425-31. 2008..We sought to determine the association between stroke location and cardiac death or MI in a multiethnic community-based cohort... - Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the Northern Manhattan Study (NOMAS)Takeki Suzuki
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am Heart J 156:405-10. 2008..We tested the hypothesis that both MetS and endothelial dysfunction are vascular risk factors and provide additive prognostic values in predicting cardiovascular events in a multiethnic community sample... - Clinical utility of new real time three-dimensional transthoracic echocardiography in assessment of mitral valve prolapseKumiko Hirata
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Echocardiography 25:482-8. 2008..We sought to evaluate the feasibility of RT3D for the assessment of MVP segments when compared with transesophageal echocardiography (TEE) and intraoperative findings... - Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aortaShun Kohsaka
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Int J Stroke 5:257-63. 2010..We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta... - Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS)Tatjana Rundek
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Circulation 118:1419-24. 2008..The objective of this study was to examine the association between PFO and migraine among stroke-free individuals in an urban, population-based, multiethnic cohort... - Diastolic dysfunction does ethnicity matter?Marco R Di Tullio
J Am Coll Cardiol 52:1022-3. 2008 - Heritability of left ventricular mass and other morphologic variables in Caribbean Hispanic subjects: the Northern Manhattan Family StudySuh-Hang Hank Juo
J Am Coll Cardiol 46:735-7. 2005 - Quantitative assessment of severity of mitral regurgitation by serial echocardiography in a multicenter clinical trial of percutaneous mitral valve repairElyse Foster
Department of Cardiology, University of California, San Francisco, California, USA
Am J Cardiol 100:1577-83. 2007..0; p <0.0018). In conclusion, quantitative assessment of MR is feasible in a multicenter trial, and percutaneous mitral repair with the MitraClip produces a sustained decrease in MR severity to moderate or less for > or =6 months... - Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic populationKazuo Eguchi
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
Am J Cardiol 101:1787-91. 2008..Presence of T2DM increased the risk of LV hypertrophy by about 1.5-fold, and it possibly interacted with central obesity... - Electrocardiographic left atrial abnormalities and risk of ischemic strokeShun Kohsaka
Department of Cardiology, Texas Heart Institute, Baylor College of Medicine, Houston, Texas, USA
Stroke 36:2481-3. 2005..58; 95% CI, 0.20 to 1.65; P=0.0008). CONCLUSIONS: ECG-LAA can supplement 2D echocardiography in assessing the risk of ischemic stroke, especially in subjects with increased left ventricular mass... - Mitral valve hemodynamic effects of percutaneous edge-to-edge repair with the MitraClip device for mitral regurgitationHoward C Herrmann
Cardiac Catheterization Laboratories, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Catheter Cardiovasc Interv 68:821-8. 2006..The effects on the mitral valve gradient (MVG) and mitral valve area (MVA) are not known...
Research Grants
- ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMMMarco Di Tullio; Fiscal Year: 2003..This study will be the first prospective cohort study to evaluate the role of multiple echocardiographic risk factors for ischemic stroke in a community of whites, blacks and Hispanics living in the same area. ..
- ARCH PLAQUES AND STROKE IN AN ETHNICALLY MIXED COMMUNITYMarco Di Tullio; Fiscal Year: 2001..The study will provide important data on stroke pathophysiology and set the ground for clinical trials to assess the efficacy of therapeutic options in treating elderly patients with stroke and aortic arch atheromas. ..
- Aortic, Cardiovascular Disease and Silent Brain InfarctsMarco Di Tullio; Fiscal Year: 2009..The present application will help fill gaps in knowledge on silent brain infarcts and their risk factors in the elderly, and identify subjects at higher risk before a symptomatic stroke or other vascular event occurs. ..