W T Dauer
Affiliation: Columbia University
- The ons and offs of inducible transgenic technology: a reviewA Yamamoto
Department of Pharmacology, Columbia University, New York, New York 10032, USA
Neurobiol Dis 8:923-32. 2001..These regulatable systems are a new and powerful tool for the neurobiologist and allow one to address a new set of important questions in an in vivo setting...
- Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTPWilliam Dauer
Department of Neurology, Columbia University, New York, NY 10027, USA
Proc Natl Acad Sci U S A 99:14524-9. 2002....
- Neurotrophic factors and Parkinson's disease: the emergence of a new player?William Dauer
Departments of Neurology and Pharmacology, Columbia University, Neurological Institute of New York, Box 204, 710 West 168th Street, New York, NY 10032, USA
Sci STKE 2007:pe60. 2007....
- alpha-Synuclein produces a long-lasting increase in neurotransmitter releaseShumin Liu
Department of Pathology, Columbia University, New York, NY, USA
EMBO J 23:4506-16. 2004..Thus, alpha-synuclein is involved in synaptic plasticity by augmenting transmitter release from the presynaptic terminal...
- Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targetsNikolai Kholodilov
Department of Neurology, Psychiatry, Pharmacology, and Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 24:3136-46. 2004..GDNF in VTA targets, however, is sufficient to regulate the adult number of DA neurons...
- Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagyMarta Martinez-Vicente
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
J Clin Invest 118:777-88. 2008..As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons...
- Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKIIShumin Liu
Department of Pathology, Taub Institute, Columbia University, New York, NY 10032, USA
Eur J Neurosci 25:3583-96. 2007..Thus, our results suggest that NO, cGMP, GMP-dependent protein kinase and calmodulin-dependent protein kinase II play a key role in the redistribution of alpha-synuclein during plasticity...
- Parkinson's disease: mechanisms and modelsWilliam Dauer
Department of Neurology, Columbia University, New York, NY 10032, USA
Neuron 39:889-909. 2003..PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process...
- Mouse models of torsinA dysfunctionWilliam Dauer
Departments of Neurology and Pharmacology, Columbia University, New York, New York, USA
Adv Neurol 94:67-72. 2004
- The kinase domain of mitochondrial PINK1 faces the cytoplasmChun Zhou
Department of Neurology, Columbia University, 650 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 105:12022-7. 2008..These results are critical in rectifying the location and orientation of PINK1 in mitochondria, and they should help decipher its normal physiological function and potential pathogenic role in PD...
- The biology and pathology of the familial Parkinson's disease protein LRRK2William Dauer
Department of Neurology, Columbia University, New York, New York, USA
Mov Disord 25:S40-3. 2010..This review will summarize current knowledge of the clinical and cell biological features of LRRK2, the most common inherited cause of Parkinsonism...
- Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelopeRose E Goodchild
Department of Neurology, Columbia University, New York, New York 10032, USA
Neuron 48:923-32. 2005..These observations demonstrate that neurons have a unique requirement for nuclear envelope localized torsinA function and suggest that loss of this activity is a key molecular event in the pathogenesis of DYT1 dystonia...
- Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neuronsHardy J Rideout
Department of Neurology, Columbia University, Black Building Room 326, 650 W 168th Street, New York, NY 10032, USA
J Neurochem 84:803-13. 2003..These results suggest that distinct growth factors may thus mediate plasticity responses or influence disease states in ventral midbrain dopaminergic neurons...
- Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neuronsLeonidas Stefanis
Department of Neurology, Columbia University, New York, NY, USA
Eur J Neurosci 20:1969-72. 2004..Therefore, alpha-synuclein is unlikely to play a significant role in apoptotic signalling in catecholaminergic neurons of the neonatal nervous system...
- alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neuronsHardy J Rideout
Departments of Neurology and Pathology, Columbia University, New York, New York 10032, USA
J Biol Chem 279:46915-20. 2004..The lack of effect on survival in alpha-synuclein knock-out cultures further suggests that the fibrillar nature of the inclusions does not contribute to neuronal degeneration in this model...
- Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenanceHasan O Akman
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Hum Mol Genet 17:2433-40. 2008..The H126N TK2 mouse is the first knock-in animal model of human MDS and demonstrates that the severity of TK2 deficiency in tissues may determine the organ-specific phenotype...
- Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in miceNoelia V Weisstaub
Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
Science 313:536-40. 2006..These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment...
- The mechanism of MPTP resistance in synuclein null mice.William Dauer; Fiscal Year: 2007..This proposal exemplifies the type of clinically related fundamental neurobiological research I plan to pursue during my career. ..