JEANINE M D'ARMIENTO

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Identification of the benign mesenchymal tumor gene HMGA2 in lymphangiomyomatosis
    Jeanine D'Armiento
    Department of Medicine, Surgery, and Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY, USA
    Cancer Res 67:1902-9. 2007
  2. pmc Second hand smoke and COPD: lessons from animal studies
    Monica P Goldklang
    Department of Medicine, Columbia University New York, NY, USA
    Front Physiol 4:30. 2013
  3. pmc Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process
    Patrick Geraghty
    Department of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Chron Obstruct Pulmon Dis 6:309-19. 2011
  4. pmc Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy
    Daniel C Andersson
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Skelet Muscle 2:9. 2012
  5. pmc Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice
    Monica Goldklang
    Department of Medicine, Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1200-8. 2012
  6. pmc The role of collagenase in emphysema
    R Foronjy
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Respir Res 2:348-52. 2001
  7. ncbi request reprint Tissue, temporal and inducible expression pattern of haptoglobin in mice
    J D'ARMIENTO
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Gene 195:19-27. 1997
  8. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
  9. pmc Decreased elastin in vessel walls puts the pressure on
    Jeanine D'Armiento
    Department of Medicine, Columbia University College of Physicians and Surgeons, Physicians and Surgeons 9 449, 622 West 168th Street, New York, New York 10032, USA
    J Clin Invest 112:1308-10. 2003
  10. ncbi request reprint Matrix metalloproteinase disruption of the extracellular matrix and cardiac dysfunction
    Jeanine D'Armiento
    Division of Molecular and Pulmonary Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Cardiovasc Med 12:97-101. 2002

Research Grants

  1. Smoke Induced Airway Injury in COPD
    JEANINE D ARMIENTO; Fiscal Year: 2007
  2. Smoke Induced Airway Injury in COPD
    JEANINE D ARMIENTO; Fiscal Year: 2009
  3. Smoke Induced Airway Injury in COPD
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
  4. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 1999
  5. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2000
  6. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2001
  7. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Identification of the benign mesenchymal tumor gene HMGA2 in lymphangiomyomatosis
    Jeanine D'Armiento
    Department of Medicine, Surgery, and Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY, USA
    Cancer Res 67:1902-9. 2007
    ..These results suggest that HMGA2 plays a central role in the pathogenesis of LAM and is a potential candidate as a therapeutic target...
  2. pmc Second hand smoke and COPD: lessons from animal studies
    Monica P Goldklang
    Department of Medicine, Columbia University New York, NY, USA
    Front Physiol 4:30. 2013
    ..Finally, alternatives to rodent models of lung disease are presented...
  3. pmc Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process
    Patrick Geraghty
    Department of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Chron Obstruct Pulmon Dis 6:309-19. 2011
    ..Here, we investigate whether cigarette smoke-induced ER stress is cell specific and correlates with acute and chronic cigarette smoke exposure...
  4. pmc Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy
    Daniel C Andersson
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Skelet Muscle 2:9. 2012
    ..This pathological intracellular calcium leak contributes to reduced calcium release and decreased muscle force production. It is unknown whether RyR1 dysfunction occurs also in other muscular dystrophies...
  5. pmc Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice
    Monica Goldklang
    Department of Medicine, Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1200-8. 2012
    ..Our findings indicate that, in Apoe(-/-) mice fed with an atherogenic diet, abnormal cholesterol efflux leads to increased systemic inflammation with subsequent lung damage and emphysema formation...
  6. pmc The role of collagenase in emphysema
    R Foronjy
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Respir Res 2:348-52. 2001
    ..It is hoped that this expanded understanding of the pathophysiology of emphysema will lead to improved therapy in the treatment of the disease...
  7. ncbi request reprint Tissue, temporal and inducible expression pattern of haptoglobin in mice
    J D'ARMIENTO
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Gene 195:19-27. 1997
    ..In conclusion, these studies demonstrate that haptoglobin is not an adult liver specific gene, and its role as an acute phase reactant may well be more diverse than previously suspected...
  8. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
    ..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
  9. pmc Decreased elastin in vessel walls puts the pressure on
    Jeanine D'Armiento
    Department of Medicine, Columbia University College of Physicians and Surgeons, Physicians and Surgeons 9 449, 622 West 168th Street, New York, New York 10032, USA
    J Clin Invest 112:1308-10. 2003
    ..The results evoke the possibility that alterations in elastin may contribute to the development of essential hypertension in patients...
  10. ncbi request reprint Matrix metalloproteinase disruption of the extracellular matrix and cardiac dysfunction
    Jeanine D'Armiento
    Division of Molecular and Pulmonary Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Cardiovasc Med 12:97-101. 2002
    ..Future studies will determine whether inhibition of MMP activity improves morbidity and mortality in patients with heart failure...
  11. pmc Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema
    JEANINE M D'ARMIENTO
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e56352. 2013
    ..This study aimed to determine whether bronchoalveolar lavage (BALF) or plasma MMP measurements correlated with disease severity or functional decline in emphysema...
  12. pmc The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction
    Patrick Geraghty
    1 St Luke s Roosevelt Hospital Center, New York, New York
    Am J Respir Cell Mol Biol 49:721-30. 2013
    ..In conclusion, these findings establish that the GPx-1-PTP1B-PP2A axis plays a critical role in countering the inflammatory and proteolytic responses that result in lung-tissue destruction in response to cigarette smoke exposure...
  13. pmc Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice
    Robert F Foronjy
    Department of Medicine, Columbia University, 630 West 168th Street, P and S 8 401, New York, NY 10032, USA
    Am J Respir Crit Care Med 173:623-31. 2006
    ..Oxidants are believed to play a major role in the development of emphysema...
  14. pmc Protein phosphatase 2A regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung
    Alison M Wallace
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, New York 10032, USA
    Toxicol Sci 126:589-99. 2012
    ..Together, these findings suggest that manipulation of PP2A activity may be a plausible means to treat COPD and other inflammatory diseases...
  15. doi request reprint Transgenic expression of matrix metalloproteinase-1 inhibits myocardial fibrosis and prevents the transition to heart failure in a pressure overload mouse model
    Robert F Foronjy
    Division of Pulmonary and Critical Care, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Hypertens Res 31:725-35. 2008
    ..In conclusion, these results suggest that strategies aimed at improving the MMP-1/TIMP balance in the myocardium may help to prevent the onset and progression of hypertensive heart disease...
  16. pmc Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter
    Becky A Mercer
    Department of Medicine, Division of Molecular and Pulmonary Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Am J Respir Cell Mol Biol 40:4-12. 2009
    ..This characterization of a smoke response region in the distal MMP-1 promoter has implications for smoking-related diseases such as cancer, heart disease, and emphysema...
  17. pmc Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study
    Alison M Wallace
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Respir Res 13:79. 2012
    ..Prior studies have demonstrated that the distal 1.5 kb of the MMP-1 promoter is fundamental in directing the induction of the MMP-1 gene by cigarette smoke...
  18. pmc Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties
    Monica P Goldklang
    1S O M, Columbia University, 630 West 168th St, P and S 9 420, New York, NY 10032, USA A R M, Columbia University, Russ Berrie Medical Science Pavilion, 1150 St Nicholas Avenue, Room 520, New York, NY 10032, USA E mail
    FASEB J 27:4975-86. 2013
    ..These findings suggest that rottlerin, with both anti-inflammatory and ASM relaxation properties, may have benefit in treating asthma...
  19. pmc Emerging role of MAP kinase pathways as therapeutic targets in COPD
    Becky A Mercer
    Institute of Human Nutrition, Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA
    Int J Chron Obstruct Pulmon Dis 1:137-50. 2006
    ..This review explores the biological functions of the MAP kinase pathways in the pathogenesis of COPD, their activation by cigarette smoke, and discusses the potential role of MAP kinase inhibitors in COPD therapy...
  20. pmc TLR3 deficiency protects against collagen degradation and medial destruction in murine atherosclerotic plaques
    Minako Ishibashi
    Division of Molecular Medicine, Department of Medicine, Columbia University, P and S 8 401, 630 West 168th Street, New York, NY 10032, USA
    Atherosclerosis 229:52-61. 2013
    ..While secretion of proteases and inflammatory cytokines are likely involved in the development of plaque instability, the precise mechanistic pathways are not well understood...
  21. pmc Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury
    Anita I Sen
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Exp Lung Res 36:615-24. 2010
    ..In ALI in the MMP-13 KO mice, MCP-1 could therefore remain active and potentially attract macrophages to the BAL. This study suggests a direct role for MMP-13 in modifying the inflammatory response in the lung after ALI...
  22. ncbi request reprint The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor
    Han Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, 630 West 168th Street, Box 91, New York, New York 10032, USA
    Am J Respir Cell Mol Biol 29:694-701. 2003
    ..These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage...
  23. ncbi request reprint Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice
    Carrie L Welch
    Columbia University, Department of Medicine, P and S 8 401, 630 W 168th St, New York, NY 10032, USA
    Circulation 116:2444-52. 2007
    ..However, other species are highly resistant to plaque complications, and the specific processes predisposing to plaque destabilization and thrombosis are poorly understood...
  24. pmc Platelet activation in the postoperative period after lung transplantation
    David I Sternberg
    Lung Transplant Program, Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Thorac Cardiovasc Surg 135:679-84. 2008
    ..The platelet response to the pulmonary allograft, however, has never been studied. Here we report significant platelet activation immediately after lung transplantation...

Research Grants9

  1. Smoke Induced Airway Injury in COPD
    JEANINE D ARMIENTO; Fiscal Year: 2007
    ..The identification of transcription factors regulating protease expression in post smoke exposure will provide novel insight into the pathogenesis of COPD. ..
  2. Smoke Induced Airway Injury in COPD
    JEANINE D ARMIENTO; Fiscal Year: 2009
    ..The identification of transcription factors regulating protease expression in post smoke exposure will provide novel insight into the pathogenesis of COPD. ..
  3. Smoke Induced Airway Injury in COPD
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
    ..The identification of transcription factors regulating protease expression in post smoke exposure will provide novel insight into the pathogenesis of COPD. ..
  4. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 1999
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
  5. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2000
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
  6. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2001
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
  7. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..