Serge Cremers

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls
    Serge Cremers
    Department of Medicine, Endocrinology, Columbia University, New York, NY, USA
    Drugs 66:2031-58. 2006
  2. pmc Inhibition of oral mucosal cell wound healing by bisphosphonates
    Regina Landesberg
    Columbia University, College of Dental Medicine, Division of Oral and Maxillofacial Surgery, New York, NY 10032, USA
    J Oral Maxillofac Surg 66:839-47. 2008
  3. doi request reprint Biochemical markers of bone turnover in osteonecrosis of the jaw in patients with osteoporosis and advanced cancer involving the bone
    Serge Cremers
    Department of Medicine, Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Ann N Y Acad Sci 1218:80-7. 2011
  4. doi request reprint Pharmacology of bisphosphonates
    Serge Cremers
    Columbia University Medical Center, New York, NY, USA
    Bone 49:42-9. 2011
  5. ncbi request reprint Bone markers--new aspects
    Serge Cremers
    Department of Medicine, Endocrinology, Columbia University, New York, NY 10032, USA
    Clin Lab 54:461-71. 2008
  6. pmc Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study
    Adi Cohen
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:1971-81. 2013
  7. pmc Rapid cortical bone loss in patients with chronic kidney disease
    Thomas L Nickolas
    Columbia University Medical Center, Department of Medicine, Division of Nephrology, New York, NY, USA
    J Bone Miner Res 28:1811-20. 2013
  8. pmc Prevention of bone loss by zoledronic acid in premenopausal women undergoing adjuvant chemotherapy persist up to one year following discontinuing treatment
    Dawn L Hershman
    M S, Columbia University, 161 Fort Washington Avenue, 10 1068, New York, New York 10032, USA
    J Clin Endocrinol Metab 95:559-66. 2010
  9. pmc Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study
    Adi Cohen
    Department of Medicine, Columbia University, College of Physicians and Surgeons, PH8 864 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:2562-72. 2013
  10. pmc Effects of pamidronate on human alveolar osteoblasts in vitro
    Darja Marolt
    Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA
    J Oral Maxillofac Surg 70:1081-92. 2012

Detail Information

Publications35

  1. ncbi request reprint Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls
    Serge Cremers
    Department of Medicine, Endocrinology, Columbia University, New York, NY, USA
    Drugs 66:2031-58. 2006
    ..Correctly manipulating these may improve clinical development of drugs for the treatment of patients with metabolic bone diseases such as osteoporosis and cancer metastatic to the bone...
  2. pmc Inhibition of oral mucosal cell wound healing by bisphosphonates
    Regina Landesberg
    Columbia University, College of Dental Medicine, Division of Oral and Maxillofacial Surgery, New York, NY 10032, USA
    J Oral Maxillofac Surg 66:839-47. 2008
    ..Whether the ONJ lesion initiates in the oral mucosa or derives from the underlying bone is not well understood. In this report we describe the effect of pamidronate, a second-generation BP, on oral mucosal cells...
  3. doi request reprint Biochemical markers of bone turnover in osteonecrosis of the jaw in patients with osteoporosis and advanced cancer involving the bone
    Serge Cremers
    Department of Medicine, Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Ann N Y Acad Sci 1218:80-7. 2011
    ..At this time, data are limited with regard to the utility of bone turnover markers in assessing risk for ONJ and whether bone marker-directed bisphosphonate holidays would be useful in prevention or treatment of ONJ...
  4. doi request reprint Pharmacology of bisphosphonates
    Serge Cremers
    Columbia University Medical Center, New York, NY, USA
    Bone 49:42-9. 2011
    ..We review here the pharmacokinetic and pharmacodynamic data of bisphosphonates that are relevant for their clinical application and for the potential choice of a given compound, focusing on uncertainties that still exist...
  5. ncbi request reprint Bone markers--new aspects
    Serge Cremers
    Department of Medicine, Endocrinology, Columbia University, New York, NY 10032, USA
    Clin Lab 54:461-71. 2008
    ..This review discusses some of these new aspects in a perspective that has utility for clinical studies and individual patient care...
  6. pmc Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study
    Adi Cohen
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:1971-81. 2013
    ..Premenopausal women with idiopathic osteoporosis (IOP) have abnormal cortical and trabecular bone microarchitecture...
  7. pmc Rapid cortical bone loss in patients with chronic kidney disease
    Thomas L Nickolas
    Columbia University Medical Center, Department of Medicine, Division of Nephrology, New York, NY, USA
    J Bone Miner Res 28:1811-20. 2013
    ..Future investigations are required to determine whether these cortical losses can be attenuated by treatments that reduce PTH levels and remodeling rates. ..
  8. pmc Prevention of bone loss by zoledronic acid in premenopausal women undergoing adjuvant chemotherapy persist up to one year following discontinuing treatment
    Dawn L Hershman
    M S, Columbia University, 161 Fort Washington Avenue, 10 1068, New York, New York 10032, USA
    J Clin Endocrinol Metab 95:559-66. 2010
    ..BMD remained stable 1 yr after completion of ZA. Serum CTX increased significantly by 12 and 24 months. More frequent administration may be required to suppress bone resorption in this patient population...
  9. pmc Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study
    Adi Cohen
    Department of Medicine, Columbia University, College of Physicians and Surgeons, PH8 864 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:2562-72. 2013
    ..It is controversial whether effects of obesity on bone are mediated by increased bone resorption or decreased bone formation...
  10. pmc Effects of pamidronate on human alveolar osteoblasts in vitro
    Darja Marolt
    Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA
    J Oral Maxillofac Surg 70:1081-92. 2012
    ....
  11. pmc PTH(1-84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism
    Mishaela R Rubin
    Department of Medicine, Division of Endocrinology, Metabolic Bone Diseases Unit, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Bone Miner Res 26:2727-36. 2011
    ..These changes suggest that PTH(1-84) improves abnormal skeletal properties in hypoparathyroidism and restores bone metabolism toward normal euparathyroid levels...
  12. pmc Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University Medical Center, New York, NY, USA
    Clin Endocrinol (Oxf) 79:491-8. 2013
    ..We evaluated the association between vitamin D metabolites and clinical outcomes among patients with AKI...
  13. pmc Trabecular bone score (TBS)--a novel method to evaluate bone microarchitectural texture in patients with primary hyperparathyroidism
    Barbara Campolina Silva
    Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 98:1963-70. 2013
    ....
  14. pmc Dynamics of bone turnover markers in patients with heart failure and following haemodynamic improvement through ventricular assist device implantation
    Christina Wu
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Eur J Heart Fail 14:1356-65. 2012
    ..We hypothesized that mechanical unloading through implantation of a ventricular assist device (VAD) with subsequent haemodynamic improvement would correct abnormal bone metabolism in patients with advanced HF...
  15. doi request reprint Serum N-telopeptide and bone-specific alkaline phosphatase levels in patients with osteonecrosis of the jaw receiving bisphosphonates for bone metastases
    Patrick G Morris
    Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Oral Maxillofac Surg 70:2768-75. 2012
    ..We investigated N-telopeptide of type I collagen (NTX) and bone-specific alkaline phosphatase (BAP) as potential predictors of ONJ onset...
  16. pmc Higher rates of bone loss in postmenopausal HIV-infected women: a longitudinal study
    Michael T Yin
    Columbia University Medical Center, New York, New York 10032, USA
    J Clin Endocrinol Metab 97:554-62. 2012
    ..The objective of the study was to assess the effects of HIV infection and antiretroviral therapy on change in bone mineral density (BMD) in postmenopausal minority women...
  17. pmc High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy
    Katherine D Crew
    Department of Medicine, Division of Oncology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Clin Oncol 27:2151-6. 2009
    ....
  18. ncbi request reprint Presurgical trial of metformin in overweight and obese patients with newly diagnosed breast cancer
    Kevin Kalinsky
    Department of Medicine, College of Physicians and Surgeons, 1 Herbert Irving Comprehensive Cancer Center, 2 Departments of Epidemiology and Biostatistics, Mailman School of Public Health, 3 Department of Surgery, College of Physicians and Surgeons, 4 Department of Medicine, Laboratory Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, 5 Department of Pathology and Cell Biology, 6 College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Invest 32:150-7. 2014
    ..We conducted a presurgical trial to assess the tissue-related effects of metformin in overweight/obese breast cancer (BC) patients...
  19. pmc Association of intact parathyroid hormone levels with subsequent hip BMD loss: the Osteoporotic Fractures in Men (MrOS) Study
    Jeffrey R Curtis
    Department of Medicine, Division of Clinical Immunology Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Endocrinol Metab 97:1937-44. 2012
    ..This association was evaluated in relation to conditions related to higher iPTH [e.g. decreased renal function, low serum 25-hydroxyvitamin D (25[OH]D)]...
  20. pmc Novel therapy to reverse the cellular effects of bisphosphonates on primary human oral fibroblasts
    Matthew Cozin
    College of Dental Medicine, Columbia University, New York, NY 10032, USA
    J Oral Maxillofac Surg 69:2564-78. 2011
    ..We examined the effects of the nitrogen-containing BPs pamidronate and zoledronate on primary human gingival fibroblasts...
  21. pmc Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women
    Emily M Stein
    Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Bone Miner Res 28:1029-40. 2013
    ..These results provide evidence that in PHPT, microstructural abnormalities are pervasive and not limited to the cortical compartment, which may help to account for increased global fracture risk in PHPT...
  22. pmc Circulating sclerostin in disorders of parathyroid gland function
    Aline G Costa
    Department of Medicine, Division of Endocrinology, Metabolic Bone Diseases Unit, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 96:3804-10. 2011
    ..Sclerostin, a protein encoded by the SOST gene in osteocytes and an antagonist of the Wnt signaling pathway, is down-regulated by PTH administration. Disorders of parathyroid function are useful clinical settings to study this relationship...
  23. pmc Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis
    Adi Cohen
    Department of Radiology, Columbia University, New York, New York 10032, USA
    J Clin Endocrinol Metab 96:3095-105. 2011
    ..It is unclear whether women with idiopathic low bone mineral density and no history of fragility fractures have osteoporosis...
  24. pmc A UPLC-MS/MS method for therapeutic drug monitoring of etonogestrel
    Tiffany Thomas
    Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, New York Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York and INHA University School of Medicine, Incheon, South Korea
    Ther Drug Monit 35:844-8. 2013
    ....
  25. pmc FGF-23 levels in patients with AKI and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University, New York, New York, USA
    Clin J Am Soc Nephrol 7:1217-23. 2012
    ..Whether fibroblast growth factor 23 levels are elevated and associated with adverse outcomes in patients with AKI has not been studied...
  26. doi request reprint Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis
    Aline G Costa
    Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Nat Rev Rheumatol 7:447-56. 2011
    ..The antiresorptive properties of cathepsin K inhibitors have been studied in phase I and phase II clinical trials. Phase III studies are currently underway for odanacatib, a selective cathepsin K inhibitor...
  27. pmc Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer
    Dawn L Hershman
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, College of Physicians andSurgeons, Columbia University, New York, NY 10032, USA
    J Clin Oncol 26:4739-45. 2008
    ..We examined whether zoledronic acid (ZA) prevents bone loss in premenopausal women receiving chemotherapy for early-stage BC...
  28. pmc Association between plasma 25-hydroxyvitamin D and breast cancer risk
    Katherine D Crew
    Department of Medicine, Division of Hematology Oncology, Columbia University, New York, New York 10032, USA
    Cancer Prev Res (Phila) 2:598-604. 2009
    ..Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention...
  29. pmc Using changes in binding globulins to assess oral contraceptive compliance
    Carolyn L Westhoff
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10032, USA
    Contraception 87:176-81. 2013
    ..This analysis evaluated the usefulness of measuring increases in corticosteroid-, sex-hormone- and thyroxine-binding globulins (CBG, SHBG and TBG, respectively) as measures of OCP compliance...
  30. pmc Short-term bone loss in HIV-infected premenopausal women
    Michael T Yin
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 53:202-8. 2010
    ..Low bone mineral density (BMD) has been reported in HIV+ women, but less is known about the longitudinal evolution of BMD and fracture incidence...
  31. pmc Discriminants of prevalent fractures in chronic kidney disease
    Thomas L Nickolas
    Department of Medicine, Divisions of Nephrology, Columbia University Medical Center, New York, New York, USA
    J Am Soc Nephrol 22:1560-72. 2011
    ..In summary, these cross-sectional data suggest that measurement of bone turnover markers may increase the diagnostic accuracy of densitometry to identify patients with CKD at high risk for fracture...
  32. doi request reprint Sublingual tacrolimus: a pharmacokinetic evaluation pilot study
    Demetra Tsapepas
    NewYork Presbyterian Hospital, Columbia University Medical Center, New York, New York 10032, USA
    Pharmacotherapy 33:31-7. 2013
    ..To evaluate and compare the pharmacokinetic parameters of sublingual and oral tacrolimus in the presence and absence of a drug that interacts with tacrolimus at the intestinal level...
  33. pmc Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways
    Marit Westerterp
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY 10032, USA
    Cell Stem Cell 11:195-206. 2012
    ..Our data identify a role of cholesterol efflux pathways in the control of HSPC mobilization. This may translate into therapeutic strategies for atherosclerosis and hematologic malignancies...
  34. pmc Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal-weight and obese women
    Carolyn L Westhoff
    Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Obstet Gynecol 207:39.e1-6. 2012
    ..Limited data indicate higher failure rates among obese contraceptive patch users. Data regarding contraceptive vaginal ring performance in obese women are needed...
  35. pmc High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma
    Tiffany A Thomas
    Irving Institute for Clinical and Translational Research, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    Ther Drug Monit 34:398-405. 2012
    ..However, current dosing regimens are largely empiric as clinical pharmacological characterization of the drug has been hindered by the lack of assays to measure polymyxin B in human plasma...