SANDRA D contact COMER

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 45:545-54. 2007
  2. ncbi request reprint Challenges in the development of prescription opioid abuse-deterrent formulations
    Nathaniel P Katz
    Tufts University School of Medicine, Boston, MA, USA
    Clin J Pain 23:648-60. 2007
  3. doi request reprint Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts
    Sandra D Comer
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Behav Pharmacol 24:504-16. 2013
  4. pmc Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Pain 153:2315-24. 2012
  5. pmc Non-medical use of opioids among HIV-infected opioid dependent individuals on opioid maintenance treatment: the need for a more comprehensive approach
    Perrine Roux
    INSERM, U912 SE4S, 23 rue Stanislas Torrents, 13006 Marseille, France
    Harm Reduct J 8:31. 2011
  6. ncbi request reprint Buprenorphine/naloxone reduces the reinforcing and subjective effects of heroin in heroin-dependent volunteers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 181:664-75. 2005
  7. ncbi request reprint Comparison of intravenous buprenorphine and methadone self-administration by recently detoxified heroin-dependent individuals
    Sandra D Comer
    The New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:1320-30. 2005
  8. ncbi request reprint Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Arch Gen Psychiatry 63:210-8. 2006
  9. pmc Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers
    Sandra D Comer
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Addiction 105:709-18. 2010
  10. ncbi request reprint Memantine produces modest reductions in heroin-induced subjective responses in human research volunteers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 193:235-45. 2007

Detail Information

Publications44

  1. ncbi request reprint Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Acquir Immune Defic Syndr 45:545-54. 2007
    ..This placebo-controlled within-subjects study evaluated marijuana and dronabinol across a range of behaviors: eating topography, mood, cognitive performance, physiologic measures, and sleep...
  2. ncbi request reprint Challenges in the development of prescription opioid abuse-deterrent formulations
    Nathaniel P Katz
    Tufts University School of Medicine, Boston, MA, USA
    Clin J Pain 23:648-60. 2007
    ....
  3. doi request reprint Comparison of a drug versus money and drug versus drug self-administration choice procedure with oxycodone and morphine in opioid addicts
    Sandra D Comer
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Behav Pharmacol 24:504-16. 2013
    ..Both self-administration procedures were effective for assessing the relative reinforcing effects of drugs; preference for one procedure should be driven by the specific research question of interest. ..
  4. pmc Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Pain 153:2315-24. 2012
    ..Before presenting recommendations for standardized approaches and measures to be used in AL assessments, the appropriateness of using these measures in clinical trials with patients in pain is discussed...
  5. pmc Non-medical use of opioids among HIV-infected opioid dependent individuals on opioid maintenance treatment: the need for a more comprehensive approach
    Perrine Roux
    INSERM, U912 SE4S, 23 rue Stanislas Torrents, 13006 Marseille, France
    Harm Reduct J 8:31. 2011
    ..abstract:..
  6. ncbi request reprint Buprenorphine/naloxone reduces the reinforcing and subjective effects of heroin in heroin-dependent volunteers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 181:664-75. 2005
    ..Although buprenorphine is effective in treating opioid dependence, optimal maintenance doses of buprenorphine or the buprenorphine/naloxone combination have not yet been established...
  7. ncbi request reprint Comparison of intravenous buprenorphine and methadone self-administration by recently detoxified heroin-dependent individuals
    Sandra D Comer
    The New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    J Pharmacol Exp Ther 315:1320-30. 2005
    ..These results demonstrate that under these experimental conditions, buprenorphine and methadone were equally effective in producing reinforcing and subjective effects...
  8. ncbi request reprint Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Arch Gen Psychiatry 63:210-8. 2006
    ..Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence...
  9. pmc Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers
    Sandra D Comer
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Addiction 105:709-18. 2010
    ..This randomized, double-blind, cross-over study was conducted to assess the intravenous abuse potential of buprenorphine/naloxone compared with buprenorphine in buprenorphine-maintained injection drug users (IDUs)...
  10. ncbi request reprint Memantine produces modest reductions in heroin-induced subjective responses in human research volunteers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 193:235-45. 2007
    ..Previous studies have demonstrated an interaction between opioids and noncompetitive antagonists at N-methyl-D: -aspartate (NMDA) receptors, but few studies have examined the utility of these medications for treating opioid dependence...
  11. pmc Abuse liability of prescription opioids compared to heroin in morphine-maintained heroin abusers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:1179-91. 2008
    ..The abuse liabilities of fentanyl, morphine, oxycodone, and heroin, however, appear to be similar under these experimental conditions...
  12. pmc Abuse liability of oxycodone as a function of pain and drug use history
    S D Comer
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 109:130-8. 2010
    ..These data suggest that an assessment of the reinforcing effects of opioids may be a sensitive method for differentiating opioid abusers from non-abusers...
  13. pmc Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 208:45-55. 2010
    ..To date, there have been few experimental studies investigating this effect in humans, and the conclusions have been equivocal...
  14. ncbi request reprint Sustained-release naltrexone: novel treatment for opioid dependence
    Sandra D Comer
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Department of Psychiatry, Unit 120, New York, NY 10032, USA
    Expert Opin Investig Drugs 16:1285-94. 2007
    ..The present paper describes the development of sustained-release naltrexone formulations and discusses the clinical issues associated with their use in treating opioid dependence...
  15. ncbi request reprint Effects of caffeine withdrawal on humans living in a residential laboratory
    S D Comer
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Exp Clin Psychopharmacol 5:399-403. 1997
    ..Furthermore, the effects of caffeine on food intake were enhanced after 2 days of caffeine abstinence...
  16. pmc Human behavioral pharmacology, past, present, and future: symposium presented at the 50th annual meeting of the Behavioral Pharmacology Society
    Sandra D Comer
    New York State Psychiatric Institute Columbia University, 1051 Riverside Drive, NY 10032, USA
    Behav Pharmacol 21:251-77. 2010
    ..Finally, the symposium reviewed behavioral pharmacology studies conducted in drug abuse treatment settings and the therapeutic benefits that have emerged from these studies...
  17. pmc Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances
    Ziva D Cooper
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute and Department of Psychiatry, Division on Substance Abuse, 1051 Riverside Drive, New York, NY 10032, USA
    Expert Opin Investig Drugs 21:169-78. 2012
    ....
  18. ncbi request reprint Effects of an alternative reinforcer on intravenous heroin self-administration by humans
    S D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, New York 10032, USA
    Eur J Pharmacol 345:13-26. 1998
    ..Consistent with previous studies, the present results demonstrate that alternative reinforcers, depending on magnitude, are effective in reducing heroin use in opioid-dependent individuals...
  19. ncbi request reprint Choice between money and intranasal heroin in morphine-maintained humans
    S D Comer
    Division on Substance Abuse, New York State Psychiatric Institute, New York, USA
    Behav Pharmacol 8:677-90. 1997
    ..n. heroin self-administration can be modified by the availability of an alternative reinforcer (i.e. money); and (3) that self-reported drug effects can be differentiated from drug self-administration...
  20. ncbi request reprint Comparison of intravenous and intranasal heroin self-administration by morphine-maintained humans
    S D Comer
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 143:327-38. 1999
    ..The results also underscore the importance of evaluating drug self-administration in the evaluation of the abuse liability of drugs...
  21. ncbi request reprint Buprenorphine sublingual tablets: effects on IV heroin self-administration by humans
    S D Comer
    New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 154:28-37. 2001
    ..However, because recent research suggests that the liquid and tablet differ in bio-availability, it is unclear what dose of the buprenorphine tablet effectively antagonizes the reinforcing effects of heroin...
  22. ncbi request reprint Effects of repeated oral methamphetamine administration in humans
    S D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 155:397-404. 2001
    ..Although methamphetamine use has increased over the past several years, few studies have evaluated the effects of repeated methamphetamine administration in humans...
  23. ncbi request reprint Depot naltrexone: long-lasting antagonism of the effects of heroin in humans
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 159:351-60. 2002
    ..However, naltrexone is generally not well accepted by patients, and medication non-compliance is a difficult obstacle to treatment. A sustained-release form of naltrexone may improve compliance...
  24. ncbi request reprint Intravenous buprenorphine self-administration by detoxified heroin abusers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Pharmacol Exp Ther 301:266-76. 2002
    ..These results demonstrate that buprenorphine served as a reinforcer under these conditions, and that it may have abuse liability in nonopioid-dependent individuals who abuse heroin...
  25. ncbi request reprint Self-administration of intravenous buprenorphine and the buprenorphine/naloxone combination by recently detoxified heroin abusers
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    J Pharmacol Exp Ther 303:695-703. 2002
    ..These results demonstrate that both BUP and BUP/NX served as reinforcers under these conditions and that they may have similar abuse liability in recently detoxified individuals who abuse heroin...
  26. ncbi request reprint Effects of buprenorphine on candy and sweetened fluid self-administration by rhesus monkeys
    Sandra D Comer
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:200-6. 2002
    ....
  27. pmc The role of human drug self-administration procedures in the development of medications
    S D Comer
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Drug Alcohol Depend 96:1-15. 2008
    ..Therefore, assessment of self-administration in combination with subjective effects provides a more comprehensive picture that may have improved predictive validity for translating to the clinical setting...
  28. ncbi request reprint Depot naltrexone: antagonism of the reinforcing, subjective, and physiological effects of heroin
    Maria A Sullivan
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 189:37-46. 2006
    ..Although it is highly effective in completely antagonizing the effects of opioids, medication noncompliance is a difficult obstacle to treatment. Therefore, a sustained-release form of naltrexone may improve treatment outcome...
  29. doi request reprint Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes
    Matthew G Kirkpatrick
    Department of Psychology, Columbia University, New York, USA
    Psychopharmacology (Berl) 203:771-80. 2009
    ..Methamphetamine attenuates disruptions that occur after changes in work shifts. The reinforcing effects of the drug during shift work have yet to be characterized...
  30. doi request reprint Dextromethorphan and quinidine combination for heroin detoxification
    Evaristo Akerele
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Addict 17:176-80. 2008
    ..Future studies should examine dextromethorphan as an adjunct to other anti-withdrawal medications and focus more on the relationship between dextrorphan levels and withdrawal suppression...
  31. pmc Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
    Psychopharmacology (Berl) 211:233-44. 2010
    ..Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed...
  32. pmc Betting on change: modeling transitional probabilities to guide therapy development for opioid dependence
    Kenneth M Carpenter
    Division on Substance Abuse, New York State Psychiatric Institute, USA
    Psychol Addict Behav 23:47-55. 2009
    ..PsycINFO Database Record (c) 2009 APA, all rights reserved)...
  33. pmc Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
    Margaret Haney
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA
    Psychopharmacology (Berl) 197:157-68. 2008
    ..Individuals seeking treatment for their marijuana use rarely achieve sustained abstinence...
  34. ncbi request reprint Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humans
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
    Psychopharmacology (Berl) 164:407-15. 2002
    ..Yet, there has been no systematic comparison of repeated doses of oral delta(9)-THC with repeated doses of smoked marijuana in the same individuals...
  35. ncbi request reprint Smoked heroin in rhesus monkeys: effects of heroin extinction and fluid availability on measures of heroin seeking
    Suzette M Evans
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
    Pharmacol Biochem Behav 74:723-37. 2003
    ..These data suggest that in nondependent rhesus monkeys, measures of heroin seeking decreased when heroin was not available and seeking behavior shifted to the available alternative commodity...
  36. ncbi request reprint Acute physiological and behavioral effects of intranasal methamphetamine in humans
    Carl L Hart
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:1847-55. 2008
    ..Of interest is the dissociation between methamphetamine plasma concentrations with cardiovascular measures and positive subjective effects, which might have important implications for potential toxicity after repeated doses...
  37. ncbi request reprint Reinforcing effects of oral Delta9-THC in male marijuana smokers in a laboratory choice procedure
    Carl L Hart
    Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians, Surgeons of Columbia University, NY 10032, USA
    Psychopharmacology (Berl) 181:237-43. 2005
    ..Oral Delta-9-tetrahydrocannabinol (Delta(9)-THC; Marinol) is medically available for the treatment of nausea associated with cancer chemotherapy and for wasting syndromes related to HIV/AIDS. Little is known about its reinforcing effects...
  38. ncbi request reprint Management of relapse in naltrexone maintenance for heroin dependence
    Maria A Sullivan
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Drug Alcohol Depend 91:289-92. 2007
    ..Time retained in treatment was examined as a function of whether lapses to opioid use occurred while adherent to naltrexone (blocked use), or after having missed naltrexone doses (unblocked)...
  39. ncbi request reprint Modafinil attenuates disruptions in cognitive performance during simulated night-shift work
    Carl L Hart
    Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 31:1526-36. 2006
    ..Therapeutic doses of modafinil attenuated night-shift-associated disruptions, but the larger dose produced some sleep impairments when administered during day-shift work...
  40. ncbi request reprint Relationship between rate of infusion and reinforcing strength of oxycodone in humans
    Sandra D Comer
    Department of Psychiatry, Columbia University, New York, New York, USA
    J Opioid Manag 5:203-12. 2009
    ..Specifically, these "abuse-deterrent formulations" could prevent patients from tampering with their medications to enhance their euphoric and reinforcing effects...
  41. ncbi request reprint Sex differences and hormonal influences on response to cold pressor pain in humans
    William J Kowalczyk
    Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Pain 7:151-60. 2006
    ..These results suggest that circulating gonadal hormones might mediate adaptation to cold pressor pain...
  42. doi request reprint Sex differences and hormonal influences on response to mechanical pressure pain in humans
    William J Kowalczyk
    Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Pain 11:330-42. 2010
    ..These results demonstrate subtle menstrual-cycle effects in NMW and OCW. Sex differences were few, with more group differences and trends emerging between OCW and men, as opposed to men and NMW...
  43. pmc Reducing hospital presentations for opioid overdose in patients treated with sustained release naltrexone implants
    Gary K Hulse
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, QE II Medical Centre, Nedlands, WA 6009, Australia
    Drug Alcohol Depend 79:351-7. 2005
    ..A sub-group of this cohort (n=146; 83 males) had previously received treatment with oral naltrexone, which also allowed a comparison of overdoses pre- and post-oral and also post-implant treatments...
  44. ncbi request reprint Quantitative analysis of naltrexone and 6beta-naltrexol in human, rat, and rabbit plasma by liquid chromatography-electrospray ionization tandem mass spectrometry with application to the pharmacokinetics of Depotrex in rabbits
    Matthew H Slawson
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 31:453-61. 2007
    ..In rabbits, the parent compound shows dose-dependent pharmacokinetics as seen in humans, but rabbits have much lower unconjugated metabolite, 6beta-naltrexol, than that seen in humans...

Research Grants20

  1. BUPRENORPHINE ABUSE BY HUMANS--LABORATORY STUDIES
    Sandra Comer; Fiscal Year: 2002
    ....
  2. Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in Humans
    Sandra Comer; Fiscal Year: 2006
    ....
  3. Precription Opioid Effects in Drug and Non-drug Abusers
    Sandra Comer; Fiscal Year: 2007
    ..abstract_text> ..
  4. Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in Humans
    Sandra D Comer; Fiscal Year: 2010
    ....
  5. Prescription Opioid Effects in Drug and Non-drug Abusers
    Sandra D Comer; Fiscal Year: 2010
    ....
  6. PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONS
    Sandra Comer; Fiscal Year: 2002
    ..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
  7. Pioglitazone for the Treatment of Opioid and of Nicotine Dependence
    SANDRA D contact COMER; Fiscal Year: 2010
    ..Pioglitazone will be given in combination with buprenorphine/naloxone (Study 1) or the nicotine patch (Study 2). ..