Research Topics
| SANDRA D contact COMERSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleepMargaret Haney
Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
J Acquir Immune Defic Syndr 45:545-54. 2007..This placebo-controlled within-subjects study evaluated marijuana and dronabinol across a range of behaviors: eating topography, mood, cognitive performance, physiologic measures, and sleep...- Challenges in the development of prescription opioid abuse-deterrent formulationsNathaniel P Katz
Tufts University School of Medicine, Boston, MA, USA
Clin J Pain 23:648-60. 2007.... 
Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendationsSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Pain 153:2315-24. 2012..Before presenting recommendations for standardized approaches and measures to be used in AL assessments, the appropriateness of using these measures in clinical trials with patients in pain is discussed...- Non-medical use of opioids among HIV-infected opioid dependent individuals on opioid maintenance treatment: the need for a more comprehensive approachPerrine Roux
INSERM, U912 SE4S, 23 rue Stanislas Torrents, 13006 Marseille, France
Harm Reduct J 8:31. 2011..abstract:.. - Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substancesZiva D Cooper
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute and Department of Psychiatry, Division on Substance Abuse, 1051 Riverside Drive, New York, NY 10032, USA
Expert Opin Investig Drugs 21:169-78. 2012..The use of glial modulators as pharmacological tools to investigate this relationship has also yielded findings supporting their potential clinical efficacy for treating substance-use disorders... - Comparison of intravenous buprenorphine and methadone self-administration by recently detoxified heroin-dependent individualsSandra D Comer
The New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
J Pharmacol Exp Ther 315:1320-30. 2005..These results demonstrate that under these experimental conditions, buprenorphine and methadone were equally effective in producing reinforcing and subjective effects... - Abuse liability of prescription opioids compared to heroin in morphine-maintained heroin abusersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 33:1179-91. 2008..The abuse liabilities of fentanyl, morphine, oxycodone, and heroin, however, appear to be similar under these experimental conditions... - Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trialSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York 10032, USA
Arch Gen Psychiatry 63:210-8. 2006..Oral naltrexone can completely antagonize the effects produced by opioid agonists. However, poor compliance with naltrexone has been a major obstacle to the effective treatment of opioid dependence... - Memantine produces modest reductions in heroin-induced subjective responses in human research volunteersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 193:235-45. 2007..Previous studies have demonstrated an interaction between opioids and noncompetitive antagonists at N-methyl-D: -aspartate (NMDA) receptors, but few studies have examined the utility of these medications for treating opioid dependence... - Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusersSandra D Comer
Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Addiction 105:709-18. 2010..This randomized, double-blind, cross-over study was conducted to assess the intravenous abuse potential of buprenorphine/naloxone compared with buprenorphine in buprenorphine-maintained injection drug users (IDUs)... - Sustained-release naltrexone: novel treatment for opioid dependenceSandra D Comer
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Department of Psychiatry, Unit 120, New York, NY 10032, USA
Expert Opin Investig Drugs 16:1285-94. 2007..The present paper describes the development of sustained-release naltrexone formulations and discusses the clinical issues associated with their use in treating opioid dependence... - The role of human drug self-administration procedures in the development of medicationsS D Comer
Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Drug Alcohol Depend 96:1-15. 2008..Therefore, assessment of self-administration in combination with subjective effects provides a more comprehensive picture that may have improved predictive validity for translating to the clinical setting... - Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 208:45-55. 2010..To date, there have been few experimental studies investigating this effect in humans, and the conclusions have been equivocal... - Abuse liability of oxycodone as a function of pain and drug use historyS D Comer
Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Drug Alcohol Depend 109:130-8. 2010..These data suggest that an assessment of the reinforcing effects of opioids may be a sensitive method for differentiating opioid abusers from non-abusers... - Human behavioral pharmacology, past, present, and future: symposium presented at the 50th annual meeting of the Behavioral Pharmacology SocietySandra D Comer
New York State Psychiatric Institute Columbia University, 1051 Riverside Drive, NY 10032, USA
Behav Pharmacol 21:251-77. 2010..Finally, the symposium reviewed behavioral pharmacology studies conducted in drug abuse treatment settings and the therapeutic benefits that have emerged from these studies... - Buprenorphine/naloxone reduces the reinforcing and subjective effects of heroin in heroin-dependent volunteersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 181:664-75. 2005..Although buprenorphine is effective in treating opioid dependence, optimal maintenance doses of buprenorphine or the buprenorphine/naloxone combination have not yet been established... - Depot naltrexone: long-lasting antagonism of the effects of heroin in humansSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 159:351-60. 2002..However, naltrexone is generally not well accepted by patients, and medication non-compliance is a difficult obstacle to treatment. A sustained-release form of naltrexone may improve compliance... - Buprenorphine sublingual tablets: effects on IV heroin self-administration by humansS D Comer
New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
Psychopharmacology (Berl) 154:28-37. 2001..However, because recent research suggests that the liquid and tablet differ in bio-availability, it is unclear what dose of the buprenorphine tablet effectively antagonizes the reinforcing effects of heroin... - Intravenous buprenorphine self-administration by detoxified heroin abusersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Pharmacol Exp Ther 301:266-76. 2002..These results demonstrate that buprenorphine served as a reinforcer under these conditions, and that it may have abuse liability in nonopioid-dependent individuals who abuse heroin... - Comparison of intravenous and intranasal heroin self-administration by morphine-maintained humansS D Comer
New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
Psychopharmacology (Berl) 143:327-38. 1999..The results also underscore the importance of evaluating drug self-administration in the evaluation of the abuse liability of drugs... - Self-administration of intravenous buprenorphine and the buprenorphine/naloxone combination by recently detoxified heroin abusersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
J Pharmacol Exp Ther 303:695-703. 2002..These results demonstrate that both BUP and BUP/NX served as reinforcers under these conditions and that they may have similar abuse liability in recently detoxified individuals who abuse heroin... - Effects of buprenorphine on candy and sweetened fluid self-administration by rhesus monkeysSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 164:200-6. 2002.... - Choice between money and intranasal heroin in morphine-maintained humansS D Comer
Division on Substance Abuse, New York State Psychiatric Institute, New York, USA
Behav Pharmacol 8:677-90. 1997..n. heroin self-administration can be modified by the availability of an alternative reinforcer (i.e. money); and (3) that self-reported drug effects can be differentiated from drug self-administration... - Effects of an alternative reinforcer on intravenous heroin self-administration by humansS D Comer
Division on Substance Abuse, New York State Psychiatric Institute, New York 10032, USA
Eur J Pharmacol 345:13-26. 1998..Consistent with previous studies, the present results demonstrate that alternative reinforcers, depending on magnitude, are effective in reducing heroin use in opioid-dependent individuals... - Effects of caffeine withdrawal on humans living in a residential laboratoryS D Comer
College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Exp Clin Psychopharmacol 5:399-403. 1997..Furthermore, the effects of caffeine on food intake were enhanced after 2 days of caffeine abstinence... - Effects of repeated oral methamphetamine administration in humansS D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 155:397-404. 2001..Although methamphetamine use has increased over the past several years, few studies have evaluated the effects of repeated methamphetamine administration in humans... - Depot naltrexone: antagonism of the reinforcing, subjective, and physiological effects of heroinMaria A Sullivan
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 189:37-46. 2006..CONCLUSIONS: The present results extend our previous findings by showing that the reinforcing effects of heroin were reduced for 4-5 weeks after administration of 384 mg depot naltrexone... 
Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changesMatthew G Kirkpatrick
Department of Psychology, Columbia University, New York, USA
Psychopharmacology (Berl) 203:771-80. 2009..Methamphetamine attenuates disruptions that occur after changes in work shifts. The reinforcing effects of the drug during shift work have yet to be characterized...- Dextromethorphan and quinidine combination for heroin detoxificationEvaristo Akerele
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Addict 17:176-80. 2008..Future studies should examine dextromethorphan as an adjunct to other anti-withdrawal medications and focus more on the relationship between dextrorphan levels and withdrawal suppression... - Modafinil attenuates disruptions in cognitive performance during simulated night-shift workCarl L Hart
Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 31:1526-36. 2006..Therapeutic doses of modafinil attenuated night-shift-associated disruptions, but the larger dose produced some sleep impairments when administered during day-shift work... - Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapseMargaret Haney
Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 211:233-44. 2010..Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed... - Betting on change: modeling transitional probabilities to guide therapy development for opioid dependenceKenneth M Carpenter
Division on Substance Abuse, New York State Psychiatric Institute, USA
Psychol Addict Behav 23:47-55. 2009..PsycINFO Database Record (c) 2009 APA, all rights reserved)... - Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapseMargaret Haney
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY, 10032, USA
Psychopharmacology (Berl) 197:157-68. 2008..Individuals seeking treatment for their marijuana use rarely achieve sustained abstinence... - Reinforcing effects of oral Delta9-THC in male marijuana smokers in a laboratory choice procedureCarl L Hart
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians, Surgeons of Columbia University, NY 10032, USA
Psychopharmacology (Berl) 181:237-43. 2005..Oral Delta-9-tetrahydrocannabinol (Delta(9)-THC; Marinol) is medically available for the treatment of nausea associated with cancer chemotherapy and for wasting syndromes related to HIV/AIDS. Little is known about its reinforcing effects... - Smoked heroin in rhesus monkeys: effects of heroin extinction and fluid availability on measures of heroin seekingSuzette M Evans
Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 66, New York, NY 10032, USA
Pharmacol Biochem Behav 74:723-37. 2003..These data suggest that in nondependent rhesus monkeys, measures of heroin seeking decreased when heroin was not available and seeking behavior shifted to the available alternative commodity... - Comparison of smoked marijuana and oral Delta(9)-tetrahydrocannabinol in humansCarl L Hart
Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA
Psychopharmacology (Berl) 164:407-15. 2002..Yet, there has been no systematic comparison of repeated doses of oral delta(9)-THC with repeated doses of smoked marijuana in the same individuals... - Management of relapse in naltrexone maintenance for heroin dependenceMaria A Sullivan
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
Drug Alcohol Depend 91:289-92. 2007..Time retained in treatment was examined as a function of whether lapses to opioid use occurred while adherent to naltrexone (blocked use), or after having missed naltrexone doses (unblocked)... - Acute physiological and behavioral effects of intranasal methamphetamine in humansCarl L Hart
Department of Psychiatry, Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 33:1847-55. 2008..Of interest is the dissociation between methamphetamine plasma concentrations with cardiovascular measures and positive subjective effects, which might have important implications for potential toxicity after repeated doses... - Relationship between rate of infusion and reinforcing strength of oxycodone in humansSandra D Comer
Department of Psychiatry, Columbia University, New York, New York, USA
J Opioid Manag 5:203-12. 2009..Specifically, these "abuse-deterrent formulations" could prevent patients from tampering with their medications to enhance their euphoric and reinforcing effects... - Sex differences and hormonal influences on response to cold pressor pain in humansWilliam J Kowalczyk
Division on Substance Abuse, New York State Psychiatric Institute, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Pain 7:151-60. 2006.... - Sex differences and hormonal influences on response to mechanical pressure pain in humansWilliam J Kowalczyk
Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
J Pain 11:330-42. 2010.... - Quantitative analysis of naltrexone and 6beta-naltrexol in human, rat, and rabbit plasma by liquid chromatography-electrospray ionization tandem mass spectrometry with application to the pharmacokinetics of Depotrex in rabbitsMatthew H Slawson
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
J Anal Toxicol 31:453-61. 2007..In rabbits, the parent compound shows dose-dependent pharmacokinetics as seen in humans, but rabbits have much lower unconjugated metabolite, 6beta-naltrexol, than that seen in humans... - Reducing hospital presentations for opioid overdose in patients treated with sustained release naltrexone implantsGary K Hulse
School of Psychiatry and Clinical Neurosciences, University of Western Australia, QE II Medical Centre, Nedlands, WA 6009, Australia
Drug Alcohol Depend 79:351-7. 2005..However, given the high prevalence of poly-substance use among dependent heroin users, programs offering this type of treatment should also focus on preventing, detecting and managing poly-substance use...
Research Grants
- BUPRENORPHINE ABUSE BY HUMANS--LABORATORY STUDIESSandra Comer; Fiscal Year: 2002....
- Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in HumansSandra Comer; Fiscal Year: 2006....
- Precription Opioid Effects in Drug and Non-drug AbusersSandra Comer; Fiscal Year: 2007..abstract_text> ..
- Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in HumansSandra D Comer; Fiscal Year: 2010....
- Prescription Opioid Effects in Drug and Non-drug AbusersSandra D Comer; Fiscal Year: 2010....
- PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONSSandra Comer; Fiscal Year: 2002..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
- Pioglitazone for the Treatment of Opioid and of Nicotine DependenceSANDRA D contact COMER; Fiscal Year: 2010..Pioglitazone will be given in combination with buprenorphine/naloxone (Study 1) or the nicotine patch (Study 2). ..