Research Topics
| E D CollinsSummaryAffiliation: Columbia University Country: USA Publications
|
Detail Information
Publications
Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humansEric D Collins
Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
Pharmacol Biochem Behav 76:401-7. 2003..These findings, taken together with the decidedly mixed literature, suggest that amantadine (100 mg bid) will not have a role in the treatment of cocaine dependence...- Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trialEric D Collins
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
JAMA 294:903-13. 2005..Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence... - The effects of memantine on the subjective, reinforcing and cardiovascular effects of cocaine in humansE D Collins
Division on Substance Abuse, New York State Psychiatric Institute, New York, USA
Behav Pharmacol 9:587-98. 1998..These data suggest that NMDA antagonists may have limited usefulness as treatment medications for cocaine abuse... - Effects of an alternative reinforcer on intravenous heroin self-administration by humansS D Comer
Division on Substance Abuse, New York State Psychiatric Institute, New York 10032, USA
Eur J Pharmacol 345:13-26. 1998..Consistent with previous studies, the present results demonstrate that alternative reinforcers, depending on magnitude, are effective in reducing heroin use in opioid-dependent individuals... - Comparison of intravenous and intranasal heroin self-administration by morphine-maintained humansS D Comer
New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
Psychopharmacology (Berl) 143:327-38. 1999..The results also underscore the importance of evaluating drug self-administration in the evaluation of the abuse liability of drugs... - Buprenorphine sublingual tablets: effects on IV heroin self-administration by humansS D Comer
New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, NY 10032, USA
Psychopharmacology (Berl) 154:28-37. 2001..However, because recent research suggests that the liquid and tablet differ in bio-availability, it is unclear what dose of the buprenorphine tablet effectively antagonizes the reinforcing effects of heroin... - Effect of a selective dopamine D1 agonist (ABT-431) on smoked cocaine self-administration in humansM Haney
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Psychopharmacology (Berl) 143:102-10. 1999..Data in laboratory animals suggest that D1 receptor agonists may have potential utility for the treatment of cocaine abuse... - Ketoconazole attenuates the cortisol response but not the subjective effects of smoked cocaine in humansA S Ward
Division on Substance Abuse, New York State Psychiatric Institute, NY 10032, USA
Behav Pharmacol 9:577-86. 1998..To the extent that self-administration can be predicted by subjective effects, these results further argue that the HPA axis does not play a critical role in cocaine self-administration by humans... - Blockade of cocaine-induced increases in adrenocorticotrophic hormone and cortisol does not attenuate the subjective effects of smoked cocaine in humansA S Ward
Division on Substance Abuse, New York State Psychiatric Institute, NY 10032, USA
Behav Pharmacol 10:523-9. 1999..These data are concordant with findings in non-human primates, but contrast with findings in laboratory rodents, thus underscoring the importance of validation of rodent models with laboratory studies in humans... - Sensitive and selective liquid chromatographic assay of memantine in plasma with fluorescence detection after pre-column derivatizationR F Suckow
Analytical Psychopharmacology Laboratory, New York State Psychiatric Institute, NY 10032, USA
J Chromatogr B Biomed Sci Appl 729:217-24. 1999..The limit of quantitation was 3 ng/ml, and no major antidepressant, neuroleptic or their respective metabolites interfered with the quantitation of memantine. This method could also be applied to the quantitation of amantadine... - Choice between money and intranasal heroin in morphine-maintained humansS D Comer
Division on Substance Abuse, New York State Psychiatric Institute, New York, USA
Behav Pharmacol 8:677-90. 1997..n. heroin self-administration can be modified by the availability of an alternative reinforcer (i.e. money); and (3) that self-reported drug effects can be differentiated from drug self-administration... - Using buprenorphine to facilitate entry into residential therapeutic community rehabilitationEric D Collins
Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Subst Abuse Treat 32:167-75. 2007..The findings suggest the potential for buprenorphine to serve as a bridge, improving the viability of long-term residential treatment for managing opioid dependence... - Memantine increases cardiovascular but not behavioral effects of cocaine in methadone-maintained humansEric D Collins
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Pharmacol Biochem Behav 83:47-55. 2006..Taken together, these findings corroborate earlier data suggesting that this dose of memantine will not be helpful in the pharmacotherapy of cocaine abuse... - Smoked cocaine discrimination in humans: effects of gabapentinMargaret Haney
Division on Substance Abuse, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Drug Alcohol Depend 80:53-61. 2005..The results suggest gabapentin may not produce effects sufficiently robust to be clinically useful, at least at this dose regimen... - Buprenorphine/naloxone reduces the reinforcing and subjective effects of heroin in heroin-dependent volunteersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 181:664-75. 2005..Although buprenorphine is effective in treating opioid dependence, optimal maintenance doses of buprenorphine or the buprenorphine/naloxone combination have not yet been established... - Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance dosesCarl L Hart
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
Drug Alcohol Depend 86:274-7. 2007.... - Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humansCarl L Hart
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Dr, Unit 120, New York, NY 10032, USA
Drug Alcohol Depend 73:279-87. 2004.... - The effects of venlafaxine on the subjective, reinforcing, and cardiovascular effects of cocaine in opioid-dependent and non-opioid-dependent humansRichard W Foltin
Division on Substance Abuse, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York 10032, USA
Exp Clin Psychopharmacol 11:123-30. 2003..Although the reduction in cocaine's effects was small, further studies using a longer venlafaxine maintenance period or a larger venlafaxine dose are warranted... - The effects of escalating doses of smoked cocaine in humansRichard W Foltin
Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA
Drug Alcohol Depend 70:149-57. 2003..e., "binge", of cocaine use can increment the effects of cocaine, but administering the same cocaine dose maintains, but does not increment the effects of cocaine... - Self-administration of intravenous buprenorphine and the buprenorphine/naloxone combination by recently detoxified heroin abusersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
J Pharmacol Exp Ther 303:695-703. 2002..These results demonstrate that both BUP and BUP/NX served as reinforcers under these conditions and that they may have similar abuse liability in recently detoxified individuals who abuse heroin... - Intravenous buprenorphine self-administration by detoxified heroin abusersSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Pharmacol Exp Ther 301:266-76. 2002..These results demonstrate that buprenorphine served as a reinforcer under these conditions, and that it may have abuse liability in nonopioid-dependent individuals who abuse heroin... - Depot naltrexone: long-lasting antagonism of the effects of heroin in humansSandra D Comer
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA
Psychopharmacology (Berl) 159:351-60. 2002..However, naltrexone is generally not well accepted by patients, and medication non-compliance is a difficult obstacle to treatment. A sustained-release form of naltrexone may improve compliance... - The effects of acute pretreatment with high-dose memantine on the cardiovascular and behavioral effects of cocaine in humansEric D Collins
Division on Substance Abuse, New York State Psychiatric Institute, NY, USA
Exp Clin Psychopharmacol 15:228-37. 2007..However, memantine pretreatment did not alter the choice to self-administer cocaine. These data suggest that memantine pretreatment may not be helpful in the treatment of cocaine dependence... - Should opioid analgesics be used in the management of chronic pain in opiate addicts?Eric D Collins
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
Am J Addict 12:93-100. 2003