Affiliation: Columbia University
- Telomerase is essential to alleviate pif1-induced replication stress at telomeresMichael Chang
Department of Genetics, Columbia University Medical Center, New York, New York 10032, USA
Genetics 183:779-91. 2009..At chromosome ends, collapsed forks result in truncated telomeres that must be rapidly elongated by telomerase to maintain viability...
- Long telomeres are preferentially extended during recombination-mediated telomere maintenanceMichael Chang
Department of Genetics and Development, Columbia University Medical Center, New York, New York, USA
Nat Struct Mol Biol 18:451-6. 2011..We speculate that telomere length may be important in determining whether cancer cells use telomerase or ALT to bypass replicative senescence...
- Telomere length homeostasis responds to changes in intracellular dNTP poolsAmitabha Gupta
Department of Cellular, Molecular and Biophysical Studies, Columbia University Medical Center, New York, NY 10032, USA
Genetics 193:1095-105. 2013..Our findings are consistent with in vitro data showing dGTP-dependent stimulation of telomerase activity in multiple organisms and suggest that telomerase activity is modulated in vivo by dGTP levels...