Frances A Champagne

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse
    Shayna A Liberman
    Department of Environmental Health Sciences, University of Michigan School of Public Health Ann Arbor, Michigan, 48109
    Ecol Evol 2:3123-31. 2012
  2. pmc Developmental timing of the effects of maternal care on gene expression and epigenetic regulation of hormone receptor levels in female rats
    Catherine Jensen Peña
    Department of Psychology, Columbia University, 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, New York 10027
    Endocrinology 154:4340-51. 2013
  3. pmc Epigenetics and developmental plasticity across species
    Frances A Champagne
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, Room 406 Schermerhorn Hall, New York, NY 10027, USA
    Dev Psychobiol 55:33-41. 2013
  4. doi request reprint Epigenetic mechanisms mediating the long-term effects of maternal care on development
    Frances A Champagne
    Department of Psychology, Columbia University, 406 Schermerhorn, 1190 Amsterdam Avenue, New York, NY 10025, United States
    Neurosci Biobehav Rev 33:593-600. 2009
  5. pmc Epigenetic mechanisms and the transgenerational effects of maternal care
    Frances A Champagne
    Department of Psychology, Columbia University, Room 406, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10017, USA
    Front Neuroendocrinol 29:386-97. 2008
  6. pmc Maternal regulation of estrogen receptor alpha methylation
    Frances A Champagne
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Curr Opin Pharmacol 8:735-9. 2008
  7. pmc Maternal imprints and the origins of variation
    Frances A Champagne
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, Room 406, Schermerhorn Hall, New York, NY 10027, USA
    Horm Behav 60:4-11. 2011
  8. doi request reprint Paternal influence on female behavior: the role of Peg3 in exploration, olfaction, and neuroendocrine regulation of maternal behavior of female mice
    Frances A Champagne
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Behav Neurosci 123:469-80. 2009
  9. doi request reprint Epigenetic influence of social experiences across the lifespan
    Frances A Champagne
    Department of Psychology, Columbia University, Room 406, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Dev Psychobiol 52:299-311. 2010
  10. ncbi request reprint Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty
    Frances A Champagne
    Columbia University, Department of Psychology, New York, NY 10027, USA
    Behav Neurosci 121:1353-63. 2007

Detail Information

Publications45

  1. pmc Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse
    Shayna A Liberman
    Department of Environmental Health Sciences, University of Michigan School of Public Health Ann Arbor, Michigan, 48109
    Ecol Evol 2:3123-31. 2012
    ..Thus, although these findings may be specific to the Nr3c1 gene, we urge caution when interpreting DNA methylation patterns from noninvasive tissues, and offer suggestions for further research in this field...
  2. pmc Developmental timing of the effects of maternal care on gene expression and epigenetic regulation of hormone receptor levels in female rats
    Catherine Jensen Peña
    Department of Psychology, Columbia University, 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, New York 10027
    Endocrinology 154:4340-51. 2013
    ..These studies contribute significantly to our understanding of the molecular, neurobiological, and behavioral pathways through which variation in maternal behavior is transmitted from one generation to the next. ..
  3. pmc Epigenetics and developmental plasticity across species
    Frances A Champagne
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, Room 406 Schermerhorn Hall, New York, NY 10027, USA
    Dev Psychobiol 55:33-41. 2013
    ....
  4. doi request reprint Epigenetic mechanisms mediating the long-term effects of maternal care on development
    Frances A Champagne
    Department of Psychology, Columbia University, 406 Schermerhorn, 1190 Amsterdam Avenue, New York, NY 10025, United States
    Neurosci Biobehav Rev 33:593-600. 2009
    ..In this review we explore evidence for the influence of mother-infant interactions on the epigenome and consider evidence for and the implications of such epigenetic effects for human mental health...
  5. pmc Epigenetic mechanisms and the transgenerational effects of maternal care
    Frances A Champagne
    Department of Psychology, Columbia University, Room 406, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10017, USA
    Front Neuroendocrinol 29:386-97. 2008
    ....
  6. pmc Maternal regulation of estrogen receptor alpha methylation
    Frances A Champagne
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Curr Opin Pharmacol 8:735-9. 2008
    ..The methylation status of ERalpha has implications for reproductive behavior, cancer susceptibility, and recovery from ischemic injury, suggesting an epigenetic basis for risk and resilience across the life span...
  7. pmc Maternal imprints and the origins of variation
    Frances A Champagne
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, Room 406, Schermerhorn Hall, New York, NY 10027, USA
    Horm Behav 60:4-11. 2011
    ..Evolving concepts of inheritance and the interplay between genes and the environment may advance our understanding of the origins of individual differences in phenotype...
  8. doi request reprint Paternal influence on female behavior: the role of Peg3 in exploration, olfaction, and neuroendocrine regulation of maternal behavior of female mice
    Frances A Champagne
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Behav Neurosci 123:469-80. 2009
    ....
  9. doi request reprint Epigenetic influence of social experiences across the lifespan
    Frances A Champagne
    Department of Psychology, Columbia University, Room 406, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Dev Psychobiol 52:299-311. 2010
    ....
  10. ncbi request reprint Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty
    Frances A Champagne
    Columbia University, Department of Psychology, New York, NY 10027, USA
    Behav Neurosci 121:1353-63. 2007
    ....
  11. ncbi request reprint Natural variations in postpartum maternal care in inbred and outbred mice
    Frances A Champagne
    Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, CB3 8AA Cambridge United Kingdom
    Physiol Behav 91:325-34. 2007
    ..These variations represent strain specific strategies for promoting growth and survival of offspring during infancy that may also mediate "epigenetic" differences in phenotype in adulthood...
  12. pmc Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure
    Marija Kundakovic
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 110:9956-61. 2013
    ....
  13. doi request reprint The paternally expressed gene Peg3 regulates sexual experience-dependent preferences for estrous odors
    William T Swaney
    Sub Department of Animal Behaviour, University of Cambridge, Cambridge, United Kingdom
    Behav Neurosci 122:963-73. 2008
    ....
  14. pmc Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring
    Catherine Jensen Peña
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Behav Neurosci 127:33-46. 2013
    ....
  15. pmc Paternal social enrichment effects on maternal behavior and offspring growth
    Rahia Mashoodh
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 109:17232-8. 2012
    ..These results suggest that maternal-paternal interactions at mating may guide offspring development, with significant implications for the transgenerational transmission of paternal environmental experiences...
  16. pmc The meaning of weaning: influence of the weaning period on behavioral development in mice
    James P Curley
    Department of Psychology, Columbia University, New York, N Y 10027, USA
    Dev Neurosci 31:318-31. 2009
    ..These results indicate that altering weaning age in mice may be a useful model for investigating the development of sexual dimorphism in neurobiology and behavior...
  17. pmc Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice
    William T Swaney
    Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, United Kingdom
    Proc Natl Acad Sci U S A 104:6084-9. 2007
    ....
  18. doi request reprint Paternal transmission of complex phenotypes in inbred mice
    Mark D Alter
    Columbia University, New York, New York, USA
    Biol Psychiatry 66:1061-6. 2009
    ..Although maternal effects have been reported in biparental and uniparental strains, there have been no investigations of paternal effects in non-biparental strains in which offspring are reared exclusively by mothers...
  19. doi request reprint Nurturing nature: social experiences and the brain
    Frances A Champagne
    Department of Psychology, Columbia University, New York NY, USA
    J Neuroendocrinol 21:867-8. 2009
    ..These studies provide new insights into the inheritance of behaviour and the interactions between genes and the social environment across the lifespan...
  20. pmc Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways
    Catherine Monk
    Columbia University, New York, NY 10027, USA
    Dev Psychopathol 24:1361-76. 2012
    ..Integrating studies of prenatal exposures, placental function, and postnatal maternal care with the exploration of epigenetic mechanisms may provide novel insights into the pathophysiology induced by maternal distress...
  21. pmc Epigenetic influence of stress and the social environment
    Kathryn Gudsnuk
    Department of Psychology, Columbia University, New York, NY 10027, USA
    ILAR J 53:279-88. 2012
    ....
  22. pmc Candidate endophenotypes for genetic studies of suicidal behavior
    J John Mann
    Department of Psychiatry, NewYork State Psychiatric Institute ColumbiaUniversity, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 65:556-63. 2009
    ..Other candidate endophenotypes requiring further investigation include serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits...
  23. ncbi request reprint DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs
    Michele Wan
    Department of Psychology, Columbia University, 1190 Amsterdam Ave, New York, NY, 10027, USA
    Anim Genet 44:717-27. 2013
    ..However, the prevalence of variants of these genes differs across breeds, and the functional role of specific variants is unclear. ..
  24. doi request reprint Interplay between social experiences and the genome: epigenetic consequences for behavior
    Frances A Champagne
    Department of Psychology, Columbia University, New York, NY, USA
    Adv Genet 77:33-57. 2012
    ..In addition, the role of epigenetic mechanisms in shaping variation in social behavior and the implications of epigenetics for our understanding of the transmission of traits across generations will be discussed...
  25. pmc Epigenetics and the origins of paternal effects
    James P Curley
    Department of Psychology, Columbia University, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Horm Behav 59:306-14. 2011
    ....
  26. pmc A theoretically based model of rat personality with implications for welfare
    Becca Franks
    Department of Psychology, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e95135. 2014
    ..05), suggesting a mechanism by which prevention motivation may be enhanced. These results point toward the potential utility of RFT as a model for animal behavior and welfare. ..
  27. pmc How enrichment affects exploration trade-offs in rats: implications for welfare and well-being
    Becca Franks
    Department of Psychology, Columbia University, New York, New York, United States of America
    PLoS ONE 8:e83578. 2013
    ..This novel test contributes to the body of knowledge examining the importance of exploration in humans and other animals; implications for animal welfare and human well-being are discussed. ..
  28. pmc Evidence for individual differences in regulatory focus in rats, Rattus norvegicus
    Becca Franks
    Department of Psychology Columbia University, New York, NY 10027, USA
    J Comp Psychol 126:347-54. 2012
    ..Regulatory focus theory, however, was uniquely able to predict the overall pattern, which may be an indication that it could contribute to future research in animal personality, motivation, and welfare...
  29. ncbi request reprint How social experiences influence the brain
    Frances A Champagne
    Sub Department of Animal Behaviour, University of Cambridge, High Street Madingley, Cambridge, CB3 8AA, UK
    Curr Opin Neurobiol 15:704-9. 2005
    ....
  30. doi request reprint Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring
    Catherine Jensen Peña
    Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Neurosci 39:946-56. 2014
    ....
  31. pmc Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior
    Zoe R Donaldson
    1 Departments of Neuroscience and Psychiatry, Columbia University, New York, NY, USA 2 Division of Integrative Neuroscience, The New York State Psychiatric Institute, New York, NY, USA
    Neuropsychopharmacology 39:291-302. 2014
    ....
  32. pmc Epigenetic effects of prenatal stress on 11β-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain
    Catherine Jensen Peña
    Department of Psychology, Columbia University, New York, New York, United States of America
    PLoS ONE 7:e39791. 2012
    ..These findings highlight the tissue specificity of epigenetic effects, but also raise the intriguing possibility of using the epigenetic status of placenta to predict corresponding changes in the brain...
  33. doi request reprint Epigenetic effects of early developmental experiences
    Kathryn M A Gudsnuk
    Department of Psychology, Columbia University, Room 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Clin Perinatol 38:703-17. 2011
    ....
  34. pmc Epigenetic perspective on the developmental effects of bisphenol A
    Marija Kundakovic
    Columbia University, Department of Psychology, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Brain Behav Immun 25:1084-93. 2011
    ..Based on this evidence, we will suggest future directions in the study of BPA-induced epigenetic effects and discuss the transgenerational implications of exposure to endocrine disrupting chemicals...
  35. ncbi request reprint The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
    Nicole M Cameron
    McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, Montreal, Que, Canada H4H 1R3
    Neurosci Biobehav Rev 29:843-65. 2005
    ..Ultimately, we will need to contend with the reality that neural development, function and health are defined by social and economic influences...
  36. ncbi request reprint Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Nat Neurosci 7:847-54. 2004
    ..Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible...
  37. ncbi request reprint Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
    Frances A Champagne
    McGill Program for the Study of Behavior, Genes and Environment and Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Biol Psychiatry 59:1227-35. 2006
    ..We addressed the question of whether stressors can directly affect parental behavior using a rodent model of stable, individual differences in maternal behavior...
  38. ncbi request reprint Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 24:4113-23. 2004
    ..Such differences may serve as neural substrates for individual differences in the motivational component of maternal behavior...
  39. ncbi request reprint Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Canada H4H 1R3
    Endocrinology 144:4720-4. 2003
    ..These findings suggest that natural variations in maternal care are associated with differences in ER alpha expression in the MPOA and that such differences are transmitted from the mother to her female offspring...
  40. ncbi request reprint Variations in maternal care in the rat as a mediating influence for the effects of environment on development
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Physiol Behav 79:359-71. 2003
    ..Overall, these findings indicate considerable, normal variations in licking/grooming in the rat that are a stable, individual characteristic of rat dams...
  41. ncbi request reprint Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
    ..These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain...
  42. ncbi request reprint Epigenetic mechanisms and gene networks in the nervous system
    Christine M Colvis
    Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 25:10379-89. 2005
  43. ncbi request reprint Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring
    Frances A Champagne
    Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    Endocrinology 147:2909-15. 2006
    ....