Affiliation: Columbia University
CHALAZONITIS A, Pham T, Li Z, Roman D, Guha U, Gomes W, et al
. Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: relationship to timing of cell cycle exit. J Comp Neurol. 2008;509:474-92 pubmed publisher
..Although the function of the gut thus displays a remarkable tolerance for ENS defects, subtle functional abnormalities in motility or secretion may arise when ENS defects short of aganglionosis occur during development. ..
Chalazonitis A, Rothman T, Chen J, Vinson E, MacLennan A, Gershon M. Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. Dev Biol. 1998;198:343-65 pubmed
..These observations support the idea that a ligand for the tripartite CNTF receptor complex plays a role in ENS development. ..
CHALAZONITIS A, D Autréaux F, Pham T, Kessler J, Gershon M. Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling. Dev Biol. 2011;350:64-79 pubmed publisher
..These observations support the hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2. ..
CHALAZONITIS A, Kessler J. Pleiotropic effects of the bone morphogenetic proteins on development of the enteric nervous system. Dev Neurobiol. 2012;72:843-56 pubmed publisher
..Disruption of BMP signaling leads to defects in the gut and in ENS function commensurate with these complex developmental roles. ..
CHALAZONITIS A, Gershon M, Greene L. Cell death and the developing enteric nervous system. Neurochem Int. 2012;61:839-47 pubmed publisher
Chalazonitis A, Pham T, Rothman T, DiStefano P, Bothwell M, Blair Flynn J, et al
. Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons. J Neurosci. 2001;21:5620-36 pubmed
..A neuropoietic cytokine (CNTF) interacted with NT-3 in vitro, and if applied sequentially, compensated for NT-3 withdrawal. These observations indicate that NT-3 is required for the normal development of the ENS. ..
CHALAZONITIS A, D Autréaux F, Guha U, Pham T, Faure C, Chen J, et al
. Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset. J Neurosci. 2004;24:4266-82 pubmed
..BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC. ..