MARIAN B CARLSON

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Role of Tos3, a Snf1 protein kinase kinase, during growth of Saccharomyces cerevisiae on nonfermentable carbon sources
    Myoung Dong Kim
    Department of Genetics and Development and Microbiology, Columbia University, HSC922, New York, NY 10032, USA
    Eukaryot Cell 4:861-6. 2005
  2. ncbi request reprint The awesome power of yeast biochemical genomics
    M Carlson
    Department of Genetics and Development, Columbia University, 701 W 168th St, HSC922, New York, NY 10032, USA
    Trends Genet 16:49-51. 2000
  3. ncbi request reprint Glucose repression in yeast
    M Carlson
    Departments of Genetics and Development and Microbiology, Columbia University, HHSC 922, Box 136, 701 W 168th Street, New York, NY 10032, USA
    Curr Opin Microbiol 2:202-7. 1999
  4. ncbi request reprint Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD
    M Carlson
    Department of Genetics, Columbia University, New York, New York 10032, USA
    Annu Rev Cell Dev Biol 13:1-23. 1997
  5. ncbi request reprint Regulation of glucose utilization in yeast
    M Carlson
    Department of Genetics and Development, Columbia University, HHSC 922, Box 136, 701 West 168th Street, New York, New York 10032, USA
    Curr Opin Genet Dev 8:560-4. 1998
  6. pmc Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1
    W Song
    Departments of Genetics and Development, Columbia University, 701 W 168th St, New York, NY 10032, USA
    EMBO J 17:5757-65. 1998
  7. pmc Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae
    E J Hubbard
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032
    Mol Cell Biol 14:1972-8. 1994
  8. pmc Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response
    P Lesage
    Department of Genetics and Development, Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Cell Biol 16:1921-8. 1996
  9. pmc Analysis of the SIP3 protein identified in a two-hybrid screen for interaction with the SNF1 protein kinase
    P Lesage
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Nucleic Acids Res 22:597-603. 1994
  10. pmc Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes
    O Vincent
    Departments of Genetics and Development, Columbia University, 701 W 168th St, New York, NY 10032, USA
    EMBO J 17:7002-8. 1998

Research Grants

  1. Regulation of Snf1/AMPK Pathway in Yeast
    Marian Carlson; Fiscal Year: 2007
  2. Yeast Genetic Selection for Human AMPK Kinases
    Marian Carlson; Fiscal Year: 2006
  3. Role of RNA Polymerase II Holoenzyme in Regulation
    Marian Carlson; Fiscal Year: 2004
  4. SNF/SWI COMPLEX AND TRANSCRIPTIONAL ACTIVATION
    Marian Carlson; Fiscal Year: 2000
  5. Regulation of Snf1/AMPK Pathway in Yeast
    Marian Carlson; Fiscal Year: 2009

Collaborators

  • B R Cairns
  • X Yang
  • F Estruch
  • P Sanz
  • P W Sherwood
  • P Lesage
  • S Kuchin
  • O Vincent
  • I Treich
  • V K Vyas
  • Yang Liu
  • R Jiang
  • W Song
  • J Tu
  • Myoung Dong Kim
  • M A Treitel
  • L G Vallier
  • R Townley
  • H A Wiatrowski
  • Xinjing Xu
  • B C Laurent
  • K Ludin
  • P Yeghiayan
  • Seung Pyo Hong
  • E J Hubbard
  • S P Hong
  • L Ho
  • N Qian
  • J L Celenza
  • E Brewster
  • D Coons
  • T de los Santos
  • L Marshall-Carlson
  • L F Bisson
  • J Schultz
  • L Bisson
  • L Neigeborn
  • F J Eng

Detail Information

Publications57

  1. pmc Role of Tos3, a Snf1 protein kinase kinase, during growth of Saccharomyces cerevisiae on nonfermentable carbon sources
    Myoung Dong Kim
    Department of Genetics and Development and Microbiology, Columbia University, HSC922, New York, NY 10032, USA
    Eukaryot Cell 4:861-6. 2005
    ..These findings lend support to the idea that the Snf1 protein kinase kinases make different contributions to cellular regulation under different growth conditions...
  2. ncbi request reprint The awesome power of yeast biochemical genomics
    M Carlson
    Department of Genetics and Development, Columbia University, 701 W 168th St, HSC922, New York, NY 10032, USA
    Trends Genet 16:49-51. 2000
    ..Designated 'biochemical genomics', this approach represents an innovative application of genomic information...
  3. ncbi request reprint Glucose repression in yeast
    M Carlson
    Departments of Genetics and Development and Microbiology, Columbia University, HHSC 922, Box 136, 701 W 168th Street, New York, NY 10032, USA
    Curr Opin Microbiol 2:202-7. 1999
    ..Important advances include evidence that Snf1 regulates the localization of the Mig1 repressor and that Snf1 functions at multiple points to control Cat8 and Sip4, the activators of gluconeogenic genes...
  4. ncbi request reprint Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD
    M Carlson
    Department of Genetics, Columbia University, New York, New York 10032, USA
    Annu Rev Cell Dev Biol 13:1-23. 1997
    ..This review focuses on the connections between genetic analysis of transcriptional regulation and the functions of the Srb/mediator proteins associated with the RNA polymerase II CTD...
  5. ncbi request reprint Regulation of glucose utilization in yeast
    M Carlson
    Department of Genetics and Development, Columbia University, HHSC 922, Box 136, 701 West 168th Street, New York, New York 10032, USA
    Curr Opin Genet Dev 8:560-4. 1998
    ..DNA microarrays have been used to assess glucose-regulated gene expression...
  6. pmc Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1
    W Song
    Departments of Genetics and Development, Columbia University, 701 W 168th St, New York, NY 10032, USA
    EMBO J 17:5757-65. 1998
    ..We propose that Sfl1, when bound to its site, interacts with Srb/mediator proteins to inhibit transcription by RNA polymerase II holoenzyme...
  7. pmc Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae
    E J Hubbard
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032
    Mol Cell Biol 14:1972-8. 1994
    ..W. Ganster, W. Shen, and M. C. Schmidt, Mol. Cell. Biol. 13:3650-3659, 1993). Taken together, these data suggest that MSN3 modulates the regulatory response to glucose and may couple the SNF1 pathway to transcription...
  8. pmc Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response
    P Lesage
    Department of Genetics and Development, Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Cell Biol 16:1921-8. 1996
    ..These findings suggest that the SNF1 kinase interacts with a transcriptional activator to modulate its activity and provide the first direct evidence for a role of SNF1 in activating transcription in response to glucose limitation...
  9. pmc Analysis of the SIP3 protein identified in a two-hybrid screen for interaction with the SNF1 protein kinase
    P Lesage
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Nucleic Acids Res 22:597-603. 1994
    ..Taken together, these genetic data suggest that SIP3 is functionally related to the SNF1 protein kinase pathway...
  10. pmc Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes
    O Vincent
    Departments of Genetics and Development, Columbia University, 701 W 168th St, New York, NY 10032, USA
    EMBO J 17:7002-8. 1998
    ..We propose a model for activation by the CSRE in which Sip4 and Cat8 have related functions, but Cat8 is the primary regulator because it controls Sip4 expression...
  11. pmc A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex
    X Yang
    Department of Genetics, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    EMBO J 13:5878-86. 1994
    ..We propose that SIP1, SIP2 and GAL83 act as adaptors that promote the activity of SNF1 towards specific targets...
  12. ncbi request reprint Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid
    B C Laurent
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genes Dev 6:1707-15. 1992
    ..Thus, these SNF proteins appear to represent a class of intermediary proteins that facilitate transcriptional activation by gene-specific regulatory proteins...
  13. pmc A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme
    S Kuchin
    Department of Genetics and Development and Department of Microbiology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:7916-20. 2000
    ..These results suggest that direct regulatory interactions between signal transduction pathways and RNA polymerase II holoenzyme provide a mechanism for transcriptional control in response to important signals...
  14. pmc Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism
    O Vincent
    Departments of Genetics and Development and Microbiology, Molecular Biology and Biophysical Studies, Columbia University, New York, New York 10032, USA
    Genes Dev 15:1104-14. 2001
    ..Such independent regulation of the localization and the activity of the Snf1 kinase, combined with the distinct localization of kinases containing different beta subunits, affords versatility in regulating physiological responses...
  15. pmc Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I, and transcriptional corepressor Ssn6-Tup1
    S Kuchin
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 18:1163-71. 1998
    ..These genetic findings, together with previous biochemical evidence, suggest that one mechanism of repression by Ssn6-Tup1 involves functional interaction with RNA polymerase II holoenzyme...
  16. pmc Gal83 mediates the interaction of the Snf1 kinase complex with the transcription activator Sip4
    O Vincent
    Departments of Genetics and Development, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    EMBO J 18:6672-81. 1999
    ..Evidence indicates that Sip1 and Sip2 do not interact with Sip4. We propose that members of the Sip1/Sip2/Gal83 family confer specificity to the kinase complex in its interactions with target proteins...
  17. pmc SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II
    W Song
    Department of Genetics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell Biol 16:115-20. 1996
    ..We also show that SSN4 and SSN7 are the same as SIN4 and ROX3, respectively, raising the possibility that these genes also encode mediator proteins...
  18. pmc Increased dosage of the MSN1 gene restores invertase expression in yeast mutants defective in the SNF1 protein kinase
    F Estruch
    Department of Genetics, Columbia University College of Physicians and Surgeons, New York, 10032
    Nucleic Acids Res 18:6959-64. 1990
    ..A LexA-MSN1 fusion protein, when bound to a lexA operator, activates transcription of an adjacent promoter. In vitro synthesized MSN1 protein exhibits weak, nonspecific DNA-binding activity...
  19. pmc Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae
    F Estruch
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Mol Cell Biol 13:3872-81. 1993
    ..LexA-MSN2 and LexA-MSN4 fusion proteins functioned as strong transcriptional activators when bound to DNA. Functional roles of this zinc finger protein family are discussed...
  20. pmc Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein
    M A Treitel
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 92:3132-6. 1995
    ..Finally, LexA-MIG1 does not repress transcription in glucose-deprived cells, and MIG1 is differentially phosphorylated in response to glucose availability. We suggest a role for phosphorylation in regulating repression...
  21. pmc Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae
    L G Vallier
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genetics 137:49-54. 1994
    ..Finally, the regulated SUC2 expression observed in snf1 mig1 mutants indicates that signals regarding glucose availability can be transmitted independently of the SNF1 protein kinase...
  22. pmc Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae
    M A Treitel
    Departments of Genetics and Development, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 18:6273-80. 1998
    ..These studies, together with previous genetic findings, indicate that the Snf1 protein kinase regulates phosphorylation of Mig1 in response to glucose...
  23. pmc Direct interaction between Rsc6 and Rsc8/Swh3,two proteins that are conserved in SWI/SNF-related complexes
    I Treich
    Department of Genetics and Development and Institute of Cancer Research and Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nucleic Acids Res 26:3739-45. 1998
    ..These findings, together with the conservation of these proteins in the SWI/SNF complex and in mammalian SWI/SNF-related complexes, strongly suggest that these proteins form a structural core for the complex...
  24. pmc Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae
    V K Vyas
    Integrated Program in Cellular Biology, Molecular Biology and Biophysical Studies, Columbia University, New York, NY 10032, USA
    Genetics 158:563-72. 2001
    ..These results suggest that Nrg1 and Nrg2 are direct or indirect targets of the Snf1 kinase and function in glucose repression of a subset of Snf1-regulated genes...
  25. ncbi request reprint A protein kinase substrate identified by the two-hybrid system
    X Yang
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 257:680-2. 1992
    ..Thus, the two-hybrid system, which is applicable to any cloned gene, can be used to detect physical interactions between protein kinases and functionally related substrate proteins...
  26. pmc Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation
    B C Laurent
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Proc Natl Acad Sci U S A 88:2687-91. 1991
    ..These findings suggest that SNF2, SNF5, and SNF6 function interdependently in transcriptional activation, possibly forming a heteromeric complex...
  27. pmc The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex
    R Jiang
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 17:2099-106. 1997
    ..These findings indicate that the Sip1/Sip2/Gal83 family anchors Snf1 and Snf4 into a complex. Finally, the interaction of the yeast Sip2 protein with a plant Snf1 homolog suggests that this function is conserved in plants...
  28. pmc Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast
    S Kuchin
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 92:4006-10. 1995
    ..Genetic analysis indicates that the SSN3-SSN8 complex contributes to transcriptional repression of diversely regulated genes and also affects induction of the GAL1 promoter...
  29. ncbi request reprint The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation
    B C Laurent
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genes Dev 7:583-91. 1993
    ..Deletion analysis shows that the helicase-like region of SNF2 is necessary, but not sufficient, for transcriptional activation...
  30. pmc Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae
    I Treich
    Department of Genetics and Development and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell Biol 17:1768-75. 1997
    ..These findings, together with previous analysis of Sth1, indicate that Swh3 and Sth1 are associated in a complex that is functionally distinct from the Swi/Snf complex and essential for viability...
  31. pmc Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p
    P W Sherwood
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:7415-20. 1999
    ..These findings suggest that Gsf2p functions in the ER to promote the secretion of certain hexose transporters...
  32. pmc SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2
    I Treich
    Institute of Cancer Research, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 15:4240-8. 1995
    ..SNF11 interacts with a 40-residue sequence of SNF2 that is highly conserved, suggesting that SNF11 homologs exist in other organisms...
  33. pmc Molecular and genetic analysis of the SNF7 gene in Saccharomyces cerevisiae
    J Tu
    Institute of Cancer Research, Columbia University, New York, New York 10032
    Genetics 135:17-23. 1993
    ..We also mapped SNF7 to the right arm of chromosome XII near the centromere...
  34. pmc Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase
    J L Celenza
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032
    Mol Cell Biol 9:5045-54. 1989
    ..The SNF4-beta-galactosidase protein coimmunoprecipitated with the SNF1 protein kinase, thus providing evidence for the physical association of the two proteins...
  35. ncbi request reprint Role of the yeast Snf1 protein kinase in invasive growth
    S Kuchin
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Biochem Soc Trans 31:175-7. 2003
    ..Snf1 and the Nrg repressors also affect diploid pseudohyphal differentiation, which is a response to nitrogen limitation, suggesting an unexpected signalling role for the Snf1 kinase...
  36. ncbi request reprint Glucose regulates protein interactions within the yeast SNF1 protein kinase complex
    R Jiang
    Department of Genetics, Columbia University, New York, New York 10032, USA
    Genes Dev 10:3105-15. 1996
    ..Finally, these interactions have been conserved from yeast to plants, indicating that homologs of the SNF1 kinase complex respond to regulatory signals by analogous mechanisms...
  37. pmc Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae
    L G Vallier
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genetics 136:1279-85. 1994
    ..We suggest that GRR1 affects the glucose sensing process and that the association between transport and regulation may reflect the involvement of a transporter in glucose sensing...
  38. pmc Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein
    J L Celenza
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032
    Mol Cell Biol 9:5034-44. 1989
    ..C-terminal deletions of SNF1 also reduced dependence on SNF4. Our findings suggest that SNF4 acts as a positive effector of the kinase but does not serve a regulatory function in signaling glucose availability...
  39. pmc Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae
    J Schultz
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Mol Cell Biol 7:3637-45. 1987
    ..We also determined the nucleotide sequence of SSN6, which is predicted to encode a 107-kilodalton protein with stretches of polyglutamine and poly(glutamine-alanine). Possible functions of the SSN6 product are discussed...
  40. pmc Interaction of the Srb10 kinase with Sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae
    O Vincent
    Department of Genetics and Development, Columbia University, 701 W 168th Street, HSC 922, New York, NY 10032, USA
    Mol Cell Biol 21:5790-6. 2001
    ..These findings support the view that the Srb10 kinase not only plays negative roles in transcriptional control but also has broad positive roles during growth in carbon sources other than glucose...
  41. pmc N-terminal mutations modulate yeast SNF1 protein kinase function
    F Estruch
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Genetics 132:639-50. 1992
    ..Finally, we present evidence that when the C terminus is deleted, overexpression of the SNF1 kinase domain is deleterious to the cell...
  42. pmc Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase
    P Sanz
    Departments of Genetics and Development and Microbiology, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 20:1321-8. 2000
    ..These findings suggest that the phosphorylation of Reg1 by Snf1 is required for the release of Reg1-Glc7 from the kinase complex and also stimulates the activity of Glc7 in promoting closure of the complex...
  43. pmc An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family
    B C Laurent
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Mol Cell Biol 12:1893-902. 1992
    ..The large region of homology shared by STH1 and SNF2 is conserved among other eukaryotic proteins, and STH1 and SNF2 appear to define a novel family of proteins related to helicases...
  44. pmc Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae
    K Ludin
    Departments of Genetics and Development and Microbiology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 95:6245-50. 1998
    ..We propose a model in which protein phosphatase 1, targeted by Reg1, facilitates the conformational change of the kinase complex from its active state to the autoinhibited state...
  45. pmc REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae
    J Tu
    Integrated Program in Cellular Biology, Molecular Biology and Biophysics Studies, Columbia University, New York, NY 10032, USA
    EMBO J 14:5939-46. 1995
    ..These results suggest that REG1 is a regulatory subunit of PP1 that targets its activity to proteins in the glucose repression regulatory pathway...
  46. pmc The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes
    B C Laurent
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Mol Cell Biol 10:5616-25. 1990
    ..No DNA-binding activity was detected for SNF5. A LexA-SNF5 fusion protein, when bound to a lexA operator, functioned as a transcriptional activator...
  47. ncbi request reprint The SNF/SWI family of global transcriptional activators
    M Carlson
    Department of Genetics and Development, Columbia University, New York, NY 10032
    Curr Opin Cell Biol 6:396-402. 1994
    ..SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation...
  48. ncbi request reprint Molecular analysis of the SNF8 gene of Saccharomyces cerevisiae
    P Yeghiayan
    Department of Microbiology, Columbia University, New York, NY 10032, USA
    Yeast 11:219-24. 1995
    ..Mutations of SNF8 and SNF7 showed similar phenotypes and genetic interactions, and the double mutant combination caused no additional phenotypic impairment. These findings suggest that SNF7 and SNF8 are functionally related...
  49. pmc SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae
    F Estruch
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Mol Cell Biol 10:2544-53. 1990
    ..Genetic and molecular evidence suggested that SNF6 is functionally related to the SNF2 and SNF5 genes. These genes may function together to affect transcription...
  50. pmc Identification of a mutant locus by noncomplementation of a transposon insertion library in Saccharomyces cerevisiae
    H A Wiatrowski
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Genetics 158:1825-7. 2001
    ..This approach offers an alternative to cloning by complementation with a plasmid library...
  51. pmc Mutations in GSF1 and GSF2 alter glucose signaling in Saccharomyces cerevisiae
    P W Sherwood
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Genetics 147:557-66. 1997
    ..The GSF2 gene was cloned by complementation of the gsf2-1 snf1 delta slow growth phenotype and encodes a previously uncharacterized 46kD protein...
  52. pmc Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae
    J Tu
    Integrated Program in Cellular Biology, Molecular Biology and Biophysics Studies, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 16:4199-206. 1996
    ..In addition, this study indicates that the two-hybrid system offers a promising approach to understanding the multiple roles and interactions of PP1 in cellular regulation...
  53. pmc Relationship of the cAMP-dependent protein kinase pathway to the SNF1 protein kinase and invertase expression in Saccharomyces cerevisiae
    E J Hubbard
    Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genetics 130:71-80. 1992
    ..Expression of invertase was regulated in response to glucose and was dependent on SNF1 function. Thus, a cAMP-responsive cAPK is dispensable for regulation of invertase...
  54. pmc Sip5 interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase of Saccharomyces cerevisiae
    P Sanz
    Departments of Genetics and Development and Microbiology, Columbia University, New York, New York 10032, USA
    Genetics 154:99-107. 2000
    ..Genetic analysis showed that the two-hybrid interaction between Reg1 and Snf1 is reduced threefold in a sip5Delta mutant. These findings suggest that Sip5 facilitates the interaction between the Reg1/Glc7 phosphatase and the Snf1 kinase...
  55. pmc Mutational analysis of the SNF3 glucose transporter of Saccharomyces cerevisiae
    L Marshall-Carlson
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Mol Cell Biol 10:1105-15. 1990
    ..We also report the genetic mapping of the SNF3 locus on the left arm of chromosome IV...
  56. pmc Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant
    L Marshall-Carlson
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genetics 128:505-12. 1991
    ..These mutations identify genes that may regulate or encode additional glucose transport proteins...
  57. pmc Interaction of SNF1 protein kinase with its activating kinase Sak1
    Yang Liu
    Departments of Genetics and Development, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Eukaryot Cell 10:313-9. 2011
    ..These findings indicate that the C terminus of Sak1 confers its function as the primary Snf1-activating kinase and suggest that the physical association of Sak1 with SNF1 facilitates responses to environmental change...

Research Grants16

  1. Regulation of Snf1/AMPK Pathway in Yeast
    Marian Carlson; Fiscal Year: 2007
    ..The proposed work on mammalian LKB1, a tumor suppressor that activates AMPK, will provide clues for the design of activating drugs. ..
  2. Yeast Genetic Selection for Human AMPK Kinases
    Marian Carlson; Fiscal Year: 2006
    ..Hence, AMPKKs are potentially more specific therapeutic targets for treatment of diabetes and obesity than AMPK. ..
  3. Role of RNA Polymerase II Holoenzyme in Regulation
    Marian Carlson; Fiscal Year: 2004
    ..The proposed studies will further our understanding of the functional interactions of RNA polymerase II holoenzymes with regulatory proteins and signal transduction pathways. ..
  4. SNF/SWI COMPLEX AND TRANSCRIPTIONAL ACTIVATION
    Marian Carlson; Fiscal Year: 2000
    ....
  5. Regulation of Snf1/AMPK Pathway in Yeast
    Marian Carlson; Fiscal Year: 2009
    ..The proposed work on mammalian LKB1, a tumor suppressor that activates AMPK, will provide clues for the design of activating drugs. ..