Gloria M Calaf

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Neoplastic transformation of human small airway epithelial cells induced by arsenic
    Gengyun Wen
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Mol Med 14:2-10. 2008
  2. doi request reprint Differential expression of cell adhesion molecules in an ionizing radiation-induced breast cancer model system
    Gloria M Calaf
    Institute for Advanced Research, Tarapaca University, Arica, Chile
    Oncol Rep 30:285-91. 2013
  3. doi request reprint Synergistic effect of malathion and estrogen on mammary gland carcinogenesis
    Gloria M Calaf
    Institute for Advanced Research, Tarapaca University, Arica, Chile
    Oncol Rep 28:640-6. 2012
  4. doi request reprint Effect of curcumin on irradiated and estrogen-transformed human breast cell lines
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 40:436-42. 2012
  5. ncbi request reprint Morphological phenotypes in neoplastic progression of human breast epithelial cells
    G Calaf
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Submicrosc Cytol Pathol 32:83-96. 2000
  6. doi request reprint Protective role of curcumin in oxidative stress of breast cells
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Calle Antofagasta 1520, Arica, Chile
    Oncol Rep 26:1029-35. 2011
  7. doi request reprint Catechol estrogens as biomarkers for mammary gland cancer
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Antofagasta 1520, Arica, Chile
    Int J Oncol 39:177-83. 2011
  8. ncbi request reprint Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 35:1061-8. 2009
  9. ncbi request reprint BigH3 protein expression as a marker for breast cancer
    Gloria M Calaf
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Int J Mol Med 21:561-8. 2008
  10. ncbi request reprint Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells
    G M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Antofagasta 1520, Arica, Chile
    Int J Mol Med 21:261-8. 2008

Collaborators

Detail Information

Publications43

  1. pmc Neoplastic transformation of human small airway epithelial cells induced by arsenic
    Gengyun Wen
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Mol Med 14:2-10. 2008
    ..Taken together, these results strongly suggest that h-TERT immortalized human small airway epithelial cells underwent step-wise transformation after inorganic arsenic treatment...
  2. doi request reprint Differential expression of cell adhesion molecules in an ionizing radiation-induced breast cancer model system
    Gloria M Calaf
    Institute for Advanced Research, Tarapaca University, Arica, Chile
    Oncol Rep 30:285-91. 2013
    ....
  3. doi request reprint Synergistic effect of malathion and estrogen on mammary gland carcinogenesis
    Gloria M Calaf
    Institute for Advanced Research, Tarapaca University, Arica, Chile
    Oncol Rep 28:640-6. 2012
    ....
  4. doi request reprint Effect of curcumin on irradiated and estrogen-transformed human breast cell lines
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 40:436-42. 2012
    ..Therefore, targeting either PARP-1 or H2AX may provide an effective way of maximizing the therapeutic value of antioxidants for cancer prevention...
  5. ncbi request reprint Morphological phenotypes in neoplastic progression of human breast epithelial cells
    G Calaf
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Submicrosc Cytol Pathol 32:83-96. 2000
    ..These studies showed the progression of breast carcinogenesis by phenotypical changes induced by the carcinogen and the insertion of the c-Ha-ras oncogene...
  6. doi request reprint Protective role of curcumin in oxidative stress of breast cells
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Calle Antofagasta 1520, Arica, Chile
    Oncol Rep 26:1029-35. 2011
    ..It can be concluded that curcumin acted upon oxidative stress in human breast epithelial cells transformed by the effect of radiation in the presence of estrogen...
  7. doi request reprint Catechol estrogens as biomarkers for mammary gland cancer
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Antofagasta 1520, Arica, Chile
    Int J Oncol 39:177-83. 2011
    ..We concluded that morphological changes and alterations in the blood of the animals can be used as biomarkers for mammary gland cancer...
  8. ncbi request reprint Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes
    Gloria M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 35:1061-8. 2009
    ..It can be concluded that the organophosphorous pesticides parathion and malathion induced malignant transformation of breast cells through genomic instability altering p53 and c-Ha-ras, considered pivotal to cancer process...
  9. ncbi request reprint BigH3 protein expression as a marker for breast cancer
    Gloria M Calaf
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Int J Mol Med 21:561-8. 2008
    ..We conclude that this protein can be used as a marker for breast cancer progression...
  10. ncbi request reprint Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells
    G M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Antofagasta 1520, Arica, Chile
    Int J Mol Med 21:261-8. 2008
    ..Thus, we suggest that pesticides and estrogens affect human breast cells inducing molecular changes indicative of transformation...
  11. ncbi request reprint Cell adhesion proteins altered by 17beta estradiol and parathion in breast epithelial cells
    G M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Oncol Rep 19:165-9. 2008
    ..In conclusion, it can be suggested that pesticides affect human breast cell adhesion changes indicative of transformation...
  12. ncbi request reprint Human drug metabolism genes in parathion-and estrogen-treated breast cells
    G M Calaf
    Instituto de Alta Investigación, Universidad de Tarapaca, Calle Antofagasta 1520, Arica, Chile
    Int J Mol Med 20:875-81. 2007
    ..It can be concluded from this study that organophosphorous pesticides such as parathion in the presence of estradiol induced changes in human drug metabolism gene expression in breast cells...
  13. pmc Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells
    Gloria M Calaf
    Institute for Advanced Research, Tarapaca University, Arica, Chile
    Mol Med 13:255-65. 2007
    ..Results suggest that parathion has the potency to cause malignant transformation of breast epithelial cells through modulation of expression of cell cycle regulated genes...
  14. ncbi request reprint Gene expression signature of parathion-transformed human breast epithelial cells
    Gloria M Calaf
    Institute for Advanced Research, Tarapaca University, Arica, Chile
    Int J Mol Med 19:741-50. 2007
    ..It is suggested that parathion influences human breast epithelial cell transformation and is an initiator factor in the transformation process in breast cancer...
  15. ncbi request reprint Cell proliferation and tumor formation induced by eserine, an acetylcholinesterase inhibitor, in rat mammary gland
    G M Calaf
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Oncol Rep 17:25-33. 2007
    ..Such tumors were metastatic to the lung. These results suggest that terminal end buds are major targets related to rat mammary carcinogenesis and 17beta estradiol can be an initiator and promoter in this process...
  16. ncbi request reprint Susceptibility of human breast epithelial cells in vitro to hormones and drugs
    Gloria M Calaf
    Center for Radiological Research, VC11 218, Columbia University Medical Center, New York, NY 10032, USA
    Int J Oncol 28:285-95. 2006
    ..Thus, in vitro systems allowed to analyze the proliferative capabilities of different kind of cells under controlled experimental conditions...
  17. ncbi request reprint Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells
    G Calaf
    Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Submicrosc Cytol Pathol 32:535-45. 2000
    ..This in vitro cancer model can parallel the progression of breast cancer seen through molecular changes that occur and have been observed during the natural development of this disease...
  18. ncbi request reprint Ionizing radiation induces alterations in cellular proliferation and c-myc, c-jun and c-fos protein expression in breast epithelial cells
    G M Calaf
    Center for Radiological Research, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Int J Oncol 25:1859-66. 2004
    ..In can be concluded that the MCF-10F model of breast carcinogenesis allows us to examine various aspects of regulations in gene expression and can provide us the basis for understanding the process of breast cancer...
  19. ncbi request reprint Oncoprotein expression in human breast epithelial cells transformed by high-LET radiation
    G Calaf
    Center for Radiological Research, College of Physicians and Surgeons of Columbia Unviersity, New York, NY 10032, USA
    Int J Radiat Biol 77:31-40. 2001
    ..The aim of the present work was to analyze the expression of oncoproteins that are frequently altered in breast cancer with specific phenotypic stages in the neoplastic process...
  20. ncbi request reprint Beta catenin is associated with breast cancer progression in vitro
    Gloria M Calaf
    Department of Biology and Health, Faculty of Science, Tarapaca University, Arica, Chile
    Int J Oncol 26:913-21. 2005
    ..It can be concluded that malignant progression is a stepwise process and tumor growth occurs after a series of molecular events that parallel morphological changes indicative of cell transformation...
  21. ncbi request reprint Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells
    G M Calaf
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Oncol Rep 13:1017-27. 2005
    ..The reduced H(2)O(2) production, decrease in cell invasive capabilities and alterations in protein expression levels suggest that retinol can be used as a chemopreventive agent in human breast cancer...
  22. ncbi request reprint Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation
    Gloria M Calaf
    Center for Radiological Research, Columbia University Medical Center, P and S 11 230, 630 West 168th Street, New York, NY 10032, USA
    Histochem Cell Biol 124:261-74. 2005
    ..These results provide evidence that multiple steps with consecutive changes are involved when normal cells become tumorigenic cells as a result of alpha particle irradiation and estrogen treatments...
  23. ncbi request reprint Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene
    G M Calaf
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Oncol Rep 14:885-93. 2005
    ..This in vitro cancer model can be used as a valuable model in the study of breast carcinogenesis...
  24. ncbi request reprint Growth factor biomarkers associated with estrogen- and radiation-induced breast cancer progression
    G M Calaf
    Biology and Health Department, Faculty of Science, Tarapaca University, Arica, Chile
    Int J Oncol 28:87-93. 2006
    ....
  25. ncbi request reprint Establishment of a radiation- and estrogen-induced breast cancer model
    G M Calaf
    Center for Radiological Research, VC11 218, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Carcinogenesis 21:769-76. 2000
    ..These studies showed that high LET radiation such as that emitted by radon progeny, in the presence of estrogen, induced a cascade of events indicative of cell transformation and tumorigenicity in human breast epithelial cells...
  26. pmc Transforming growth factor-β-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway
    Gengyun Wen
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA
    Int J Oncol 39:1001-9. 2011
    ..These findings suggest that TGFBI may repress mesothelioma tumorigenesis and progression via the PI3K/Akt signaling pathway...
  27. ncbi request reprint Organophosphorous pesticides in breast cancer progression
    G Cabello
    Research Center for the Man in the Desert, University of Tarapaca, Arica, Chile
    J Submicrosc Cytol Pathol 35:1-9. 2003
    ....
  28. doi request reprint Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment
    Gengyun Wen
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, United States
    Sci Total Environ 407:1174-81. 2009
    ..To confirm the involvement of p38 in the regulation of apoptosis we pretreated cells with the p38 kinase inhibitor, SB 203580 and observed a significant decrease in apoptosis...
  29. ncbi request reprint Malignant transformation of human bronchial epithelial cells with the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Int J Cancer 106:821-6. 2003
    ..These data suggested that NNK can induce malignant transformation of human bronchial epithelial cells, and the tumor cell lines established are useful models in investigating the carcinogenic mechanism(s) of NNK...
  30. pmc TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells
    Gengyun Wen
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Cancer Lett 308:23-32. 2011
    ..Taken together, these data suggest that TGFBI moderates the metastatic potential of cancer cells...
  31. pmc Malignant transformation of rat kidney induced by environmental substances and estrogen
    Susana Alfaro-Lira
    Instituto de Alta Investigación, Universidad de Tarapaca, Calle Antofagasta 1520, Arica, Chile
    Int J Environ Res Public Health 9:1630-48. 2012
    ..It can be concluded that an increased risk of kidney malignant transformation can be induced by exposure to environmental and endogenous substances...
  32. pmc Human RecQL4 helicase plays critical roles in prostate carcinogenesis
    Yanrong Su
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 70:9207-17. 2010
    ..Collectively, our study shows that RecQL4 is an essential factor for prostate carcinogenesis...
  33. doi request reprint Deleterious MnSOD signals lead to abnormal breast cell proliferation by radiation and estrogen exposure
    Carlos Echiburú-Chau
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 38:1703-11. 2011
    ....
  34. ncbi request reprint Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression
    D Roy
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 11973, USA
    Int J Oncol 28:667-74. 2006
    ..It also represents the first indication of allele loss at these loci in human breast epithelial cells induced by radiation and estrogen treatment suggesting a potential interventional target in breast carcinogenesis...
  35. ncbi request reprint Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model
    N J Emenaker
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nutr 131:3041S-6S. 2001
    ....
  36. ncbi request reprint Phosphoproteomic profiling of arsenite-treated human small airway epithelial cells
    G Wen
    Centre for Radiological Research, Columbia University, New York, NY 10032, USA
    Oncol Rep 23:405-12. 2010
    ..It can be concluded that analysis of phosphoprotein by using phosphoproteomic profiling can be very useful to understand the mechanism of arsenite-induced carcinogenesis...
  37. pmc Vimentin and Notch as biomarkers for breast cancer progression
    Gloria M Calaf
    Institute for Advanced Research, Tarapac University, Arica 8097877, Chile Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Oncol Lett 7:721-727. 2014
    ..These biomarkers can be considered important indicators of breast cancer progression and can be added to the diagnostic panel when overall survival is a primary end-point...
  38. ncbi request reprint Rat lung cancer induced by malathion and estrogen
    C Echiburu-Chau
    Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 33:603-11. 2008
    ..These results indicated an increase in risk of rodent lung tumor formation by environmental and endogenous substances...
  39. ncbi request reprint PAC1 is a direct transcription target of E2F-1 in apoptotic signaling
    J Wu
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 26:6526-35. 2007
    ..Our findings establish a functional link between E2F-1 and mitogen-activated protein kinases. The E2F-1-PAC1 cascade in cancer cell killing may provide a molecular basis for cancer therapeutic intervention...
  40. doi request reprint Allelic loss at chromosome 11q13 alters FGF3 gene expression in a human breast cancer progression model
    Debasish Roy
    Department of Natural Sciences, Hostos College of the City University of New York, Bronx, NY, USA
    Oncol Rep 32:2445-52. 2014
    ..These deregulations could be utilized as an appropriate target for therapeutic intervention in breast cancer...
  41. doi request reprint Mutation of β-catenin in a radiation and estrogen breast cancer model
    Debasish Roy
    Department of Natural Sciences, Hostos College, The City University of New York, Bronx, NY, USA
    Int J Oncol 46:153-60. 2015
    ..It can be concluded that mutation of β-catenin and its interaction with other associated proteins may be an early event during radiation and estrogen induced progression of human breast carcinogenesis. ..
  42. ncbi request reprint Patterns of recurrence and survival in breast cancer
    Daniela Navarrete Montalvo
    Hospital Gustavo Fricke, Universidad de Valparaiso, Valparaiso, Chile
    Oncol Rep 20:531-5. 2008
    ..0001). The global probability of survival of the patients reached 72% after 5 years. It can be concluded that early detection of breast cancer allows for control of the disease and avoids remissions, or at least extends survival...