ALAN STEWART BROWN

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Homocysteine and schizophrenia: from prenatal to adult life
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1175-80. 2005
  2. pmc Maternal iron deficiency and the risk of schizophrenia in offspring
    Beverly J Insel
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Arch Gen Psychiatry 65:1136-44. 2008
  3. pmc Exposure to prenatal infection and risk of schizophrenia
    Alan S Brown
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute New York, NY, USA
    Front Psychiatry 2:63. 2011
  4. pmc Infant and childhood neurodevelopmental outcomes following prenatal exposure to selective serotonin reuptake inhibitors: overview and design of a Finnish Register-Based Study (FinESSI)
    Heli Malm
    Teratology Information, HUSLAB and Helsinki University Central Hospital, Tukholmankatu 17, P, O, Box 790, 00029 HUS, Helsinki, Finland
    BMC Psychiatry 12:217. 2012
  5. pmc Parental age and risk of bipolar disorder in offspring
    Alan Brown
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatry Res 208:225-31. 2013
  6. pmc Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, New York, USA
    Dev Neurobiol 72:1272-6. 2012
  7. ncbi request reprint Elevated prenatal homocysteine levels as a risk factor for schizophrenia
    Alan S Brown
    College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 64:31-9. 2007
  8. ncbi request reprint Nonaffective psychosis after prenatal exposure to rubella
    A S Brown
    New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 157:438-43. 2000
  9. pmc Prenatal nutritional deficiency and risk of adult schizophrenia
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, New York, NY, USA
    Schizophr Bull 34:1054-63. 2008
  10. pmc Prenatal infection and cavum septum pellucidum in adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA
    Schizophr Res 108:285-7. 2009

Detail Information

Publications36

  1. ncbi request reprint Homocysteine and schizophrenia: from prenatal to adult life
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1175-80. 2005
    ..Finally, we discuss the implications of these findings for future work on nutritional etiologies of schizophrenia...
  2. pmc Maternal iron deficiency and the risk of schizophrenia in offspring
    Beverly J Insel
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Arch Gen Psychiatry 65:1136-44. 2008
    ..Adopting a life course perspective, we examined the effects of early iron deficiency on the risk of schizophrenia in adulthood...
  3. pmc Exposure to prenatal infection and risk of schizophrenia
    Alan S Brown
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute New York, NY, USA
    Front Psychiatry 2:63. 2011
    ..Given the clear genetic component to schizophrenia, future studies should include investigations of interactions between prenatal infection and susceptibility genes in the pathogenesis of schizophrenia...
  4. pmc Infant and childhood neurodevelopmental outcomes following prenatal exposure to selective serotonin reuptake inhibitors: overview and design of a Finnish Register-Based Study (FinESSI)
    Heli Malm
    Teratology Information, HUSLAB and Helsinki University Central Hospital, Tukholmankatu 17, P, O, Box 790, 00029 HUS, Helsinki, Finland
    BMC Psychiatry 12:217. 2012
    ..We describe the methods and design of a population-based study examining the association between prenatal SSRI exposure and neurodevelopment until age 14...
  5. pmc Parental age and risk of bipolar disorder in offspring
    Alan Brown
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatry Res 208:225-31. 2013
    ..These findings suggest that if advanced paternal age is a risk factor for BD, the strength of the relationship is small. ..
  6. pmc Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, New York, USA
    Dev Neurobiol 72:1272-6. 2012
    ..Moreover, this work has stimulated translational research on the neurobiological and genetic determinants of these conditions...
  7. ncbi request reprint Elevated prenatal homocysteine levels as a risk factor for schizophrenia
    Alan S Brown
    College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Arch Gen Psychiatry 64:31-9. 2007
    ....
  8. ncbi request reprint Nonaffective psychosis after prenatal exposure to rubella
    A S Brown
    New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 157:438-43. 2000
    ..The authors' goal was to investigate the suggestion of previous investigations that prenatal viral exposures might increase the later risk of psychotic disorders...
  9. pmc Prenatal nutritional deficiency and risk of adult schizophrenia
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, New York, NY, USA
    Schizophr Bull 34:1054-63. 2008
    ..Given the relatively high prevalence of nutritional deficiencies during pregnancy, this work has the potential to offer substantial benefits for the prevention of schizophrenia in the population...
  10. pmc Prenatal infection and cavum septum pellucidum in adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA
    Schizophr Res 108:285-7. 2009
    ....
  11. pmc Prenatal exposure to maternal infection and executive dysfunction in adult schizophrenia
    Alan S Brown
    New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Am J Psychiatry 166:683-90. 2009
    ..The authors examined whether prenatal infection is associated with executive dysfunction in patients with schizophrenia...
  12. pmc Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    Alan S Brown
    New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 167:261-80. 2010
    ..Finally, they discuss new approaches aimed at addressing current challenges in this area of research...
  13. pmc The environment and susceptibility to schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Prog Neurobiol 93:23-58. 2011
    ....
  14. pmc Maternal infection and schizophrenia: implications for prevention
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, NewYork, NY 10032, USA
    Schizophr Bull 37:284-90. 2011
    ..Lessons learned from previous successful public health efforts targeting these infections, including the relative advantages and disadvantages of these measures, are reviewed...
  15. pmc Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY, USA
    Psychiatry Res 188:179-86. 2011
    ..Although independent replications are warranted, maternal G/R infections were associated with verbal memory and motor function deficits in African-American patients with schizophrenia...
  16. ncbi request reprint No evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia?
    Alan S Brown
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Am J Psychiatry 163:2178-80. 2006
    ..The authors examined whether maternal exposure to herpes virus type 2 is associated with risk for adult schizophrenia...
  17. ncbi request reprint Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring
    Alan S Brown
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Am J Psychiatry 162:767-73. 2005
    ..The authors examined the relationship between maternal antibody to toxoplasmosis and the risk of schizophrenia and other schizophrenia spectrum disorders in offspring. Toxoplasmosis is known to adversely affect fetal brain development...
  18. ncbi request reprint Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring
    Alan S Brown
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 2, New York, NY 10032, USA
    Am J Psychiatry 161:889-95. 2004
    ....
  19. pmc Paternal age and risk of schizophrenia in adult offspring
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, USA
    Am J Psychiatry 159:1528-33. 2002
    ..The study examined the relation between paternal age at the time of birth and risk of schizophrenia in the adult offspring...
  20. ncbi request reprint In utero infection and adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
    Ment Retard Dev Disabil Res Rev 8:51-7. 2002
    ....
  21. ncbi request reprint Serologic evidence of prenatal influenza in the etiology of schizophrenia
    Alan S Brown
    College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Gen Psychiatry 61:774-80. 2004
    ..These studies used dates of influenza epidemics and maternal recall of infection to define influenza exposure, suggesting that discrepant findings may have resulted from exposure misclassification...
  22. pmc Prenatal infection as a risk factor for schizophrenia
    Alan S Brown
    College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Schizophr Bull 32:200-2. 2006
    ....
  23. ncbi request reprint Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia
    Vicki Babulas
    New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Am J Psychiatry 163:927-9. 2006
    ..In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring...
  24. ncbi request reprint Maternal-fetal blood incompatibility and the risk of schizophrenia in offspring
    Beverly J Insel
    Mailman School of Public Health of Columbia University Epidemiology, 722 W 168 St, NY 10032, USA
    Schizophr Res 80:331-42. 2005
    ..The relation between schizophrenia and maternal-fetal blood incompatibility, arising from the D antigen of the Rhesus (Rh) and the ABO blood group antigens, was examined in a cohort of live-births...
  25. pmc Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia
    Mark G A Opler
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Environ Health Perspect 112:548-52. 2004
    ..43 (95% CI, 0.99-5.96; p = 0.051). This finding suggests that the effects of prenatal exposure to lead and/or elevated delta-ALA may extend into later life and must be further investigated as risk factors for adult psychiatric diseases...
  26. ncbi request reprint Prenatal determinants of schizophrenia: what we have learned thus far?
    Michaeline Bresnahan
    New York State Psychiatric Institute and Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Epidemiol Psichiatr Soc 14:194-7. 2005
    ..Here we describe a few key findings from the PDS with respect to prenatal infection, nutrition, and toxic exposures...
  27. ncbi request reprint Prenatal infectious and nutritional factors and risk of adult schizophrenia
    Justin D Penner
    New York State Psychiatric Institute, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA
    Expert Rev Neurother 7:797-805. 2007
    ..This work has the potential to lead to strategies aimed at preventing this disorder and to reveal new molecular targets for pharmacotherapeutic intervention...
  28. pmc Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence
    Mark G A Opler
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1586-90. 2008
    ....
  29. ncbi request reprint Does unwantedness of pregnancy predict schizophrenia in the offspring? Findings from a prospective birth cohort study
    Daniel B Herman
    New York State Psychiatric Institute, New York, NY, USA
    Soc Psychiatry Psychiatr Epidemiol 41:605-10. 2006
    ..We sought to replicate (or refute) a previous report of an association between unwantedness of a pregnancy and the risk of schizophrenia in the offspring...
  30. pmc Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia
    Mary C Perrin
    Department of Psychiatry, School of Medicine, New York University, New York, NY, USA
    Schizophr Bull 33:1270-3. 2007
    ..This article will discuss parental imprinting on the autosomal and X chromosomes and the alterations in epigenetic regulation that may lead to such errors...
  31. doi request reprint The risk for schizophrenia from childhood and adult infections
    Alan S Brown
    Am J Psychiatry 165:7-10. 2008
  32. ncbi request reprint Intimate partner violence and preschoolers' explicit memory functioning
    Ernest N Jouriles
    Department of Psychology, Southern Methodist University, Dallas, TX 75275 0442, USA
    J Fam Psychol 22:420-8. 2008
    ....
  33. doi request reprint Congenital anomalies and early functional impairments in a prospective birth cohort: risk of schizophrenia-spectrum disorder in adulthood
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Br J Psychiatry 192:264-7. 2008
    ..Adversities operating over intrauterine life have been associated with risk of schizophrenia, but the biology of resultant developmental perturbation is poorly understood...
  34. ncbi request reprint A review of the déjà vu experience
    Alan S Brown
    Department of Psychology, Dedman College, Southern Methodist University, Dallas, Texas 75275, USA
    Psychol Bull 129:394-413. 2003
    ..Systematic research is needed on the prevalence and etiology of this culturally familiar cognitive experience, and several laboratory models may help clarify this illusion of recognition...
  35. pmc Growth trajectory during early life and risk of adult schizophrenia
    Megan A Perrin
    The Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Br J Psychiatry 191:512-20. 2007
    ..Growth abnormalities have been suggested as a precursor to schizophrenia, but previous studies have not assessed growth patterns using repeated measures...
  36. ncbi request reprint Cardiovascular risk management in clinical practice: the Midwest Heart Specialists experience
    James W Kinn
    Midwest Heart Specialists Lipid Clinic, Naperville, Illinois 60540, USA
    Am J Cardiol 89:23C-29C; discussion 30C. 2002
    ..Advances in technology now enable use of the electronic medical record in combination with a virtual lipid clinic to promote superior cholesterol management...

Research Grants19

  1. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2001
    ....
  2. Prenatal factors and risk of autism in a Finnish national birth cohort
    Alan Brown; Fiscal Year: 2009
    ....
  3. Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ..Moreover, the research described in this proposal has future potential for the identification of susceptibility genes that interact with the prenatal exposures and other developmental antecedents in the etiology of schizophrenia. ..
  4. Prenatal Factors and Risk of Bipolar Disorder
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....
  5. Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
    Alan Brown; Fiscal Year: 2009
    ..Moreover, the research described in this proposal has future potential for the identification of susceptibility genes that interact with the prenatal exposures and other developmental antecedents in the etiology of schizophrenia. ..
  6. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2009
    ....
  7. EPIDEMIOLOGY OF PRENATAL EXPOSURES IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2007
    ..In the genetics section of the proposal, I will test models of gene-environment interaction. ..
  8. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2007
    ....
  9. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2006
    ....
  10. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2004
    ....
  11. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2003
    ..This relatively new approach promises to yield more integrative, stable results than are possible with older analytic techniques that focus on separate and individual cognitive and neuroimagin 9 measures. ..
  12. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2003
    ....
  13. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2002
    ....
  14. Serologic Studies of Prenatal Factors in Schizophrenia
    Alan Brown; Fiscal Year: 2002
    ..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
  15. Serologic Studies of Prenatal Factors in Schizophrenia
    Alan Brown; Fiscal Year: 2001
    ..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
  16. Prenatal factors and risk of autism in a Finnish national birth cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....